Lipid Transport And Storage

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An interactive lecture on lipid transportation and storage in humans.

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Lipid Transport And Storage

  1. 1. Lipid Transport and Storage Dr. Bibi Kulsoom Assistant Professor Department of Biochemistry
  2. 2. Countrywide Transport
  3. 3. Structure of Small Intestine
  4. 4. Structure of Small Intestine
  5. 5. Triglyceride Packing & Transport
  6. 6. Chylomicron A-II A-II
  7. 7. Lymphatic system
  8. 8. Blood Circulation
  9. 9. Chylomicron Apo C II, E B 48 E C II A II HDL
  10. 10. Deloading of Chylomicrons http://www.richmond.edu
  11. 11. Triacylgycerol Storage
  12. 12. Triacylgycerol Storage http://www.trudicanavan.com http://www.vivo.colostate.edu Brown Adipose Tissue
  13. 13. Chylomicron Transport to Liver
  14. 14. Countrywide Transport
  15. 15. Hepatic uptake of Chylomicron Remnants
  16. 16. Fate of Chylomicron Remnants Chol TG FFA PhoL
  17. 17. Secretion of VLDL
  18. 18. Lipoproteins
  19. 19. Lipoprotein Structure
  20. 21. Composition of Lipoproteins
  21. 22. Free Fatty acid Adipose tissue Free fatty acids with Albumin A-I, A-II, A-IV, C-I,C-II, C-III, D, E Phospholipids, Cholesterol Liver, Intestine HDL B-100 Cholesterol IDL LDL B-100, E Triacylgycerol VLDL IDL B-100, C-I, C-II, C-III Triacylgycerol, Cholesterol Liver VLDL B-48, E Triacylgycerol, Phospholipids, Cholesterol Chylomicron Chylomicron remnants A-I, A-II, A-IV, B-48, C-I, C-II, C-III, E Triacylgycerol Intestine Chylomicron Apolipoproteins Main Lipid Sources Lipoprotein
  22. 23. Apolipoproteins
  23. 24. Closely associated with LCAT. ApoD Inhibits LPL. ApoC-III Activates LPL. ApoC-II Probably activates LCAT. ApoC-I Binds to LDL receptors. ApoE Binds LDL receptor. ApoB-100 Contributes to structure. ApoB-48 Contributes to structure. ApoA-IV Enhanced hepatic lipase activity. ApoA-II Activates LCAT. ApoA-I Function Apoprotein
  24. 25. Triacylglycerol Transport
  25. 26. Bood circulation Harper’s Illustrated Biochemistry
  26. 27. Triacylglycerol & Cholesterol Transport
  27. 28. Harper’s Illustrated Biochemistry
  28. 29. Reverse Cholesterol Transport
  29. 30. Harper’s Illustrated Biochemistry
  30. 32. Dislioproteinemias <ul><li>Hypoliproteinemias </li></ul><ul><ul><li>abetalipoproteinemia </li></ul></ul><ul><li>Hyperliproteinemias </li></ul><ul><ul><li>Deficiency of </li></ul></ul><ul><ul><ul><li>LPL </li></ul></ul></ul><ul><ul><ul><li>Hepatic lipase </li></ul></ul></ul><ul><ul><ul><li>LCAT </li></ul></ul></ul><ul><ul><ul><li>LDL receptor </li></ul></ul></ul><ul><ul><ul><li>Apo E </li></ul></ul></ul><ul><ul><ul><li>etc </li></ul></ul></ul>
  31. 33. THANK YOU <ul><li>Suggested Reading: </li></ul><ul><li>Harper’s Illustrated Biochemistry, 28 Ed. McGraw-Hill. </li></ul><ul><li>Lehninger Principles of Biochemistry, 5 Ed. WHFreeman & Co. </li></ul>Lipid Transport and Storage

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