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LIKELIHOOD RATIOS -Agathokleous 2013 Meta-analysis 2nd trimester T 21.
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Meta-analysis of second-trimester markers for trisomy 21. Pregnancy Down Syndrome
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LIKELIHOOD RATIOS -Agathokleous 2013 Meta-analysis 2nd trimester T 21.
1.
Second-trimester screening for
trisomy 21 257 Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%)FPR (%) Detectionrate(%) 0 20 40 60 80 100(a) (b) (c) (d) (e) (f) (g) (h) (i) (j) 0 2010 Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Detectionrate(%) 0 20 40 60 80 100 0 2010 FPR (%) Figure 1 Summary receiver–operating characteristics curves with detection rate and false-positive rate (FPR) of sonographic markers of trisomy 21: (a) intracardiac echogenic foci, (b) ventriculomegaly, (c) nuchal fold thickness, (d) echogenic bowel, (e) hydronephrosis, (f) short humerus, (g) short femur, (h) aberrant right subclavian artery, (i) absent nasal bone and (j) absent or hypoplastic nasal bone. Table 11 Pooled estimates of detection rate (DR), false positive rate (FPR) and positive and negative likelihood ratios (LR+ and LR−) of sonographic markers for trisomy 21 and estimated likelihood ratio (LR) of individual isolated markers Marker DR (95% CI) (%) FPR (95% CI) (%) LR+ (95% CI) LR– (95% CI) LR isolated marker* Intracardiac echogenic focus 24.4 (20.9–28.2) 3.9 (3.4–4.5) 5.83 (5.02–6.77) 0.80 (0.75–0.86) 0.95 Ventriculomegaly 7.5 (4.2–12.9) 0.2 (0.1–0.4) 27.52 (13.61–55.68) 0.94 (0.91–0.98) 3.81 Increased nuchal fold 26.0 (20.3–32.9) 1.0 (0.5–1.9) 23.30 (14.35–37.83) 0.80 (0.74–0.85) 3.79 Echogenic bowel 16.7 (13.4–20.7) 1.1 (0.8–1.5) 11.44 (9.05–14.47) 0.90 (0.86–0.94) 1.65 Mild hydronephrosis 13.9 (11.2–17.2) 1.7 (1.4–2.0) 7.63 (6.11–9.51) 0.92 (0.89–0.96) 1.08 Short humerus 30.3 (17.1–47.9) 4.6 (2.8–7.4) 4.81 (3.49–6.62) 0.74 (0.63–0.88) 0.78 Short femur 27.7 (19.3–38.1) 6.4 (4.7–8.8) 3.72 (2.79–4.97) 0.80 (0.73–0.88) 0.61 ARSA 30.7 (17.8–47.4) 1.5 (1.0–2.1) 21.48 (11.48–40.19) 0.71 (0.57–0.88) 3.94 Absent or hypoplastic NB 59.8 (48.9–69.9) 2.8 (1.9–4.0) 23.27 (14.23–38.06) 0.46 (0.36–0.58) 6.58 *Derived by multiplying the positive LR for the given marker by the negative LR of each of all other markers, except for short humerus. ARSA, aberrant right subclavian artery; NB, nasal bone. Copyright 2012 ISUOG. Published by John Wiley & Sons, Ltd. Ultrasound Obstet Gynecol 2013; 41: 247–261.
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