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GA
(weeks)
Centiles
n Mean 95% CI 10 25 50 75 90
14
15
16
17–18
19–20
21
22
23
24
25
26
27
28
29
30–31
32–33
34–36
10
26
25
19
23
19
26
21
19
13
16
14
21
23
24
24
26
5.2
6.1
6.6
7.3
9.8
10.5
10.4
10.7
11.6
11.2
12.7
13.0
13.0
13.9
14.2
14.4
15.8
4.8–5.7
5.9–6.3
6.3–6.9
6.7–7.8
9.3–10.2
10.0–10.9
10.0–10.7
10.4–11.1
11.3–11.8
11.4–12.4
12.0–13.4
12.4–13.5
12.7–13.3
13.4–14.4
13.8–14.5
13.7–15.1
15.4–16.2
4.5
5.4
5.8
6.2
8.6
9.4
9.5
9.6
10.7
10.3
11.0
11.9
12.1
12.6
13.3
12.2
14.6
5.0
5.5
6.2
6.5
9.0
9.9
9.6
10.0
11.0
11.0
11.0
12.0
12.0
13.0
13.0
13.0
15.0
5.3
6.2
6.5
6.7
10.0
10.0
10.5
10.5
11.5
12.2
12.7
12.9
13.1
13.7
13.9
14.1
15.7
5.7
6.5
7.0
9.0
10.1
11.0
11.0
11.4
12.0
12.5
13.8
13.4
13.3
14.6
14.7
14.8
16.5
5.7
6.7
7.6
9.0
11.3
12.0
11.3
11.5
12.5
12.8
14.5
14.8
14.1
15.7
15.4
17.5
16.9
Table 1 The fetal orbital diameter (mm). GA, gestational age;
CI, confidence interval
GA
(weeks)
Centiles
n Mean 95% CI 10 25 50 75 90
14
15
16
17–18
19–20
21
22
23
24
25
26
27
28
29
30–31
32–33
34–36
10
26
25
19
23
19
26
21
19
13
16
14
21
23
24
24
26
16.4
19.1
20.7
22.9
30.6
32.9
32.6
33.7
36.3
37.5
40.0
40.7
40.8
43.7
44.58
45.3
49.7
15.1–17.8
18.4–19.8
19.9–21.6
21.2–24.6
29.3–31.9
31.5–34.3
31.5–33.6
32.6–34.8
35.4–37.2
35.8–39.1
37.8–42.1
39.0–42.4
39.9–41.7
42.2–45.1
43.5–45.6
43.0–47.5
48.5–50.8
14.1
17.0
18.1
19.3
26.9
29.4
29.7
30.2
33.5
32.4
34.7
37.4
38.0
39.6
41.9
38.3
46.0
15
17
19
20
28
31
30
31
35
36
36
38
39
40
42
41
47
16.5
19.5
20.4
20.9
31.4
31.4
33.0
33.0
36.1
38.3
39.8
40.5
41.0
42.9
43.8
44.4
49.4
17.9
20.4
21.9
28.3
31.7
34.6
34.5
35.8
37.7
39.3
43.4
42.0
41.6
45.9
46.0
46.4
51.7
17.9
21.0
23.8
28.3
35.5
37.7
35.4
36.1
39.3
40.3
45.5
46.4
44.4
49.4
48.2
54.9
52.9
Table 2 The fetal orbital circumference (mm). GA, gestational
age; CI, confidence interval
0.6
0.5
0.4
0.3
0.2
10 20 30 40
(a)
Lensdiameter/
orbitaldiameter
r = 0.55
p < 0.00001
y = 0.53 −0.05 × GA
0.3
0.4
0.5
0.6
10 20 30 40
(b)
Lenscircumference/
orbitalcircumference
r = 0.57
p < 0.00001
y = 0.54 −0.05 × GA
0.3
0.4
0.2
0.1
0.0
10 20 30 40
(c)
Lensarea/orbitalarea
r = 0.57
p < 0.00001
y = 0.3 −0.04 × GA
Gestational age (weeks)
Figure 5 Relationships between the fetal lens/orbital diameter
ratio (a), lens/orbital circumference ratio (b) and lens/orbital area
ratio (c) and gestational age (GA)
GA
(weeks)
Centiles
n Mean 95% CI 10 25 50 75 90
14
15
16
17–18
19–20
21
22
23
24
25
26
27
28
29
30–31
32–33
34–36
10
26
25
19
23
19
26
21
19
13
16
14
21
23
24
24
26
21.6
29.2
34.4
42.7
75.3
86.5
84.9
90.5
105.2
112.2
128.2
132.4
132.6
152.5
158.3
165.1
196.6
18.0–25.2
27.1–31.3
31.6–37.3
36.2–49.3
68.7–81.8
79.0–94.1
79.4–90.4
84.6–96.5
100.2–110.3
102.8–121.5
114.4–142.0
120.8–144.0
127.0–138.3
142.0–162.9
150.5–166.2
148.2–182.1
187.9–205.3
15.9
23.0
26.2
29.7
57.4
68.7
70.2
72.4
89.1
84.2
95.8
111.0
114.0
124.0
139.0
117.0
167.0
19.3
23.8
30.2
33.2
63.6
76.2
72.8
79.8
100.0
103.0
106.0
116.0
124.0
131.0
143.0
137.0
181.0
21.7
30.2
32.9
34.7
78.6
78.6
86.6
86.6
103.0
116.0
126.0
130.0
133.0
146.0
152.0
156.0
194.0
25.5
32.9
38.2
63.6
80.2
95.1
94.4
102.1
113.1
122.8
149.7
140.4
137.9
167.5
168.8
170.9
212.6
25.5
35.1
44.9
63.6
100.5
113.1
99.5
103.9
122.8
129.2
165.2
170.9
157.0
194.3
185.1
240.0
222.9
Table 3 The fetal orbital area (mm2
). GA, gestational age; CI, confidence interval
A96/186
Fetal orbits and lens in normal pregnancies Goldstein et al.
AMA: First Proof
178 Ultrasound in Obstetrics and Gynecology

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Fetal orbital diameter (mm)- gestational age

  • 1. GA (weeks) Centiles n Mean 95% CI 10 25 50 75 90 14 15 16 17–18 19–20 21 22 23 24 25 26 27 28 29 30–31 32–33 34–36 10 26 25 19 23 19 26 21 19 13 16 14 21 23 24 24 26 5.2 6.1 6.6 7.3 9.8 10.5 10.4 10.7 11.6 11.2 12.7 13.0 13.0 13.9 14.2 14.4 15.8 4.8–5.7 5.9–6.3 6.3–6.9 6.7–7.8 9.3–10.2 10.0–10.9 10.0–10.7 10.4–11.1 11.3–11.8 11.4–12.4 12.0–13.4 12.4–13.5 12.7–13.3 13.4–14.4 13.8–14.5 13.7–15.1 15.4–16.2 4.5 5.4 5.8 6.2 8.6 9.4 9.5 9.6 10.7 10.3 11.0 11.9 12.1 12.6 13.3 12.2 14.6 5.0 5.5 6.2 6.5 9.0 9.9 9.6 10.0 11.0 11.0 11.0 12.0 12.0 13.0 13.0 13.0 15.0 5.3 6.2 6.5 6.7 10.0 10.0 10.5 10.5 11.5 12.2 12.7 12.9 13.1 13.7 13.9 14.1 15.7 5.7 6.5 7.0 9.0 10.1 11.0 11.0 11.4 12.0 12.5 13.8 13.4 13.3 14.6 14.7 14.8 16.5 5.7 6.7 7.6 9.0 11.3 12.0 11.3 11.5 12.5 12.8 14.5 14.8 14.1 15.7 15.4 17.5 16.9 Table 1 The fetal orbital diameter (mm). GA, gestational age; CI, confidence interval GA (weeks) Centiles n Mean 95% CI 10 25 50 75 90 14 15 16 17–18 19–20 21 22 23 24 25 26 27 28 29 30–31 32–33 34–36 10 26 25 19 23 19 26 21 19 13 16 14 21 23 24 24 26 16.4 19.1 20.7 22.9 30.6 32.9 32.6 33.7 36.3 37.5 40.0 40.7 40.8 43.7 44.58 45.3 49.7 15.1–17.8 18.4–19.8 19.9–21.6 21.2–24.6 29.3–31.9 31.5–34.3 31.5–33.6 32.6–34.8 35.4–37.2 35.8–39.1 37.8–42.1 39.0–42.4 39.9–41.7 42.2–45.1 43.5–45.6 43.0–47.5 48.5–50.8 14.1 17.0 18.1 19.3 26.9 29.4 29.7 30.2 33.5 32.4 34.7 37.4 38.0 39.6 41.9 38.3 46.0 15 17 19 20 28 31 30 31 35 36 36 38 39 40 42 41 47 16.5 19.5 20.4 20.9 31.4 31.4 33.0 33.0 36.1 38.3 39.8 40.5 41.0 42.9 43.8 44.4 49.4 17.9 20.4 21.9 28.3 31.7 34.6 34.5 35.8 37.7 39.3 43.4 42.0 41.6 45.9 46.0 46.4 51.7 17.9 21.0 23.8 28.3 35.5 37.7 35.4 36.1 39.3 40.3 45.5 46.4 44.4 49.4 48.2 54.9 52.9 Table 2 The fetal orbital circumference (mm). GA, gestational age; CI, confidence interval 0.6 0.5 0.4 0.3 0.2 10 20 30 40 (a) Lensdiameter/ orbitaldiameter r = 0.55 p < 0.00001 y = 0.53 −0.05 × GA 0.3 0.4 0.5 0.6 10 20 30 40 (b) Lenscircumference/ orbitalcircumference r = 0.57 p < 0.00001 y = 0.54 −0.05 × GA 0.3 0.4 0.2 0.1 0.0 10 20 30 40 (c) Lensarea/orbitalarea r = 0.57 p < 0.00001 y = 0.3 −0.04 × GA Gestational age (weeks) Figure 5 Relationships between the fetal lens/orbital diameter ratio (a), lens/orbital circumference ratio (b) and lens/orbital area ratio (c) and gestational age (GA) GA (weeks) Centiles n Mean 95% CI 10 25 50 75 90 14 15 16 17–18 19–20 21 22 23 24 25 26 27 28 29 30–31 32–33 34–36 10 26 25 19 23 19 26 21 19 13 16 14 21 23 24 24 26 21.6 29.2 34.4 42.7 75.3 86.5 84.9 90.5 105.2 112.2 128.2 132.4 132.6 152.5 158.3 165.1 196.6 18.0–25.2 27.1–31.3 31.6–37.3 36.2–49.3 68.7–81.8 79.0–94.1 79.4–90.4 84.6–96.5 100.2–110.3 102.8–121.5 114.4–142.0 120.8–144.0 127.0–138.3 142.0–162.9 150.5–166.2 148.2–182.1 187.9–205.3 15.9 23.0 26.2 29.7 57.4 68.7 70.2 72.4 89.1 84.2 95.8 111.0 114.0 124.0 139.0 117.0 167.0 19.3 23.8 30.2 33.2 63.6 76.2 72.8 79.8 100.0 103.0 106.0 116.0 124.0 131.0 143.0 137.0 181.0 21.7 30.2 32.9 34.7 78.6 78.6 86.6 86.6 103.0 116.0 126.0 130.0 133.0 146.0 152.0 156.0 194.0 25.5 32.9 38.2 63.6 80.2 95.1 94.4 102.1 113.1 122.8 149.7 140.4 137.9 167.5 168.8 170.9 212.6 25.5 35.1 44.9 63.6 100.5 113.1 99.5 103.9 122.8 129.2 165.2 170.9 157.0 194.3 185.1 240.0 222.9 Table 3 The fetal orbital area (mm2 ). GA, gestational age; CI, confidence interval A96/186 Fetal orbits and lens in normal pregnancies Goldstein et al. AMA: First Proof 178 Ultrasound in Obstetrics and Gynecology