The document discusses research on life changes and stress. It defines stress, stressors, and the body's response to stress. It then discusses a study by Kiecolt-Glaser that found caregivers took longer to heal from a wound than controls, suggesting chronic stress weakens the immune system. Next, it defines life changes as significant disruptions to normal routine, and describes research by Holmes and Rahe that associated more life events with illness. Their study developed a scale to rate life events based on required readjustment. People scoring over 300 on this scale had an 80% chance of illness, supporting a link between life changes and stress.