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Systematic Reviews
Lynn Kysh, MLIS
kysh@usc.edu
Information Services Librarian
Norris Medical Library
Evidence Pyramid – Publication Types
Evidence-Based
Guidelines

Systematic
Review & Metaanalysis

Higher Quality of Information

Fewer Articles

Randomized Controlled
Trials

Cohort Studies
Case Control Studies

Lower Quality of Information

More Articles
Case Series, Case Reports
Agenda
• Distinguish a systematic review from a standard literature
review
• Locate the following in PubMed
• Reviews
• Systematic Reviews
• Meta-Analyses

• Introduce Cochrane Database of Systematic Reviews
Source: Evidence-Based Living Blog (Cornell University) http://evidencebasedliving.human.cornell.edu/
Definition
Literature Review

Systematic Review

Qualitatively summarizes
evidence on a topic using
informal or subjective methods
to collect and interpret studies.

High-level overview of primary
research that
identifies, selects, synthesizes, an
d appraises all relevant high
quality research evidence
Goal
Literature Review
• Provide summary or
overview of topic

Systematic Review
• Answer a focused clinical
question
• Eliminate bias
Questio
n
Literature Review
• Can be a general topic or a
specific question

Systematic Review
• Clearly defined and
answerable clinical question
• Recommend using PICO as a
guide
Componen
ts
Literature Review
• Introduction
• Methods
• Discussion
• Conclusion
• Reference list

Systematic Review
• Pre-specified eligibility
criteria
• Systematic search strategy
• Assessment of the validity of
findings
• Interpretation and
presentation of results
• Reference list
Hormone therapy for preventing cardiovascular
disease in post-menopausal women
Main Cm Knight B, Moxham T, Sanchez
RG, Sanchez Gomex LM, Figuls MR, Cosp XB.
Hormone therapy for preventing cardiovascular
disease in post-menopausal women
Main Cm Knight B, Moxham T, Sanchez
RG, Sanchez Gomex LM, Figuls MR, Cosp XB.
Literature Review
• 1 or more

Author
s

Systematic Review
• 3 or more

Skills
Literature Review
• Understanding of topic
• Perform searches in one or
more database

Systematic Review
• Thorough knowledge of topic
• Perform searches in all relevant
database
• Statistical analysis resources
(meta-analysis)
Tim
e
Literature Review
• Weeks to months

Systematic Review
• Months to years
• Average eighteen months
Valu
e
Literature Review
• Provides summary of the
literature on a topic

Systematic Review
• Connects practicing
clinicians to high quality
evidence
• Supports evidence-based
practice
Meta-Analyses

Systematic Reviews

All Review Articles
Adapted from: Pai M, McCulloch M, Gorman JD, Pai N, Enanoria W, Kennedy G, Tharyan P, and Colford JM.
“Systematic reviews and meta-analyses: An illustrated, step-by-step guide”
The National Medical Journal of India (2004)
Finding review articles:
Use “Article Type” filter
Finding systematic reviews:
Use Basic Search
Agenda
• Distinguish a systematic review from a standard literature
review
• Locate the following in PubMed
• Reviews
• Systematic Reviews
• Meta-Analyses

• Introduce Cochrane Database of Systematic Reviews
Questions?
Lynn Kysh, MLIS
Information Services Librarian
kysh@usc.edu
(323) 442-1124
Thanks!
Lynn Kysh, MLIS
Information Services Librarian
kysh@usc.edu
(323) 442-1124

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Keck Year 2 Evidence Based Medicine - Systematic Reviews

  • 1. Systematic Reviews Lynn Kysh, MLIS kysh@usc.edu Information Services Librarian Norris Medical Library
  • 2. Evidence Pyramid – Publication Types Evidence-Based Guidelines Systematic Review & Metaanalysis Higher Quality of Information Fewer Articles Randomized Controlled Trials Cohort Studies Case Control Studies Lower Quality of Information More Articles Case Series, Case Reports
  • 3. Agenda • Distinguish a systematic review from a standard literature review • Locate the following in PubMed • Reviews • Systematic Reviews • Meta-Analyses • Introduce Cochrane Database of Systematic Reviews
  • 4. Source: Evidence-Based Living Blog (Cornell University) http://evidencebasedliving.human.cornell.edu/
  • 5. Definition Literature Review Systematic Review Qualitatively summarizes evidence on a topic using informal or subjective methods to collect and interpret studies. High-level overview of primary research that identifies, selects, synthesizes, an d appraises all relevant high quality research evidence
  • 6. Goal Literature Review • Provide summary or overview of topic Systematic Review • Answer a focused clinical question • Eliminate bias
  • 7. Questio n Literature Review • Can be a general topic or a specific question Systematic Review • Clearly defined and answerable clinical question • Recommend using PICO as a guide
  • 8. Componen ts Literature Review • Introduction • Methods • Discussion • Conclusion • Reference list Systematic Review • Pre-specified eligibility criteria • Systematic search strategy • Assessment of the validity of findings • Interpretation and presentation of results • Reference list
  • 9. Hormone therapy for preventing cardiovascular disease in post-menopausal women Main Cm Knight B, Moxham T, Sanchez RG, Sanchez Gomex LM, Figuls MR, Cosp XB.
  • 10. Hormone therapy for preventing cardiovascular disease in post-menopausal women Main Cm Knight B, Moxham T, Sanchez RG, Sanchez Gomex LM, Figuls MR, Cosp XB.
  • 11. Literature Review • 1 or more Author s Systematic Review • 3 or more Skills Literature Review • Understanding of topic • Perform searches in one or more database Systematic Review • Thorough knowledge of topic • Perform searches in all relevant database • Statistical analysis resources (meta-analysis)
  • 12. Tim e Literature Review • Weeks to months Systematic Review • Months to years • Average eighteen months
  • 13. Valu e Literature Review • Provides summary of the literature on a topic Systematic Review • Connects practicing clinicians to high quality evidence • Supports evidence-based practice
  • 14. Meta-Analyses Systematic Reviews All Review Articles Adapted from: Pai M, McCulloch M, Gorman JD, Pai N, Enanoria W, Kennedy G, Tharyan P, and Colford JM. “Systematic reviews and meta-analyses: An illustrated, step-by-step guide” The National Medical Journal of India (2004)
  • 15. Finding review articles: Use “Article Type” filter
  • 16.
  • 18. Agenda • Distinguish a systematic review from a standard literature review • Locate the following in PubMed • Reviews • Systematic Reviews • Meta-Analyses • Introduce Cochrane Database of Systematic Reviews
  • 19. Questions? Lynn Kysh, MLIS Information Services Librarian kysh@usc.edu (323) 442-1124
  • 20. Thanks! Lynn Kysh, MLIS Information Services Librarian kysh@usc.edu (323) 442-1124