This document discusses plant biopharming, which involves producing recombinant proteins in transgenic plants. It provides an overview of the concept, strategies used, production systems, downstream processing, applications including monoclonal antibodies and edible vaccines, case studies, and biosafety issues. Specifically, it summarizes that plant biopharming is a promising approach for the large-scale, low-cost production of pharmaceuticals due to plants' high protein yields and stability. However, further work is still needed to maximize protein expression, improve purification techniques, evaluate optimal dosages, and enhance biosafety systems to ensure human and environmental safety.