This document discusses the sustainable and inclusive transformation of animal food systems. It outlines both the opportunities and challenges of livestock, including meeting growing demand, supporting economic growth, and addressing development needs, while also mitigating environmental harms. The document proposes a framework to facilitate partnerships and coordinate efforts to deliver tailored livestock solutions at scale. This would involve harnessing CGIAR research, ensuring translation into impacts, accounting for diversity, and enabling functions like communications. The goal is to transform animal health, empower women, build capacity, and create appropriate portfolios to double productivity and incomes from livestock.