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BMDDS BY   :  JAIDEEP  SARKAR
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INTRODUCTION
[object Object],[object Object],[object Object],[object Object],ENVIRONMENT AND ROLE OF BUCCAL  MUCOSA
[object Object],DRUG DELIVERY PATHWAYS
 
[object Object],[object Object],[object Object],[object Object],[object Object],BUCCAL DRUG DELIVERY AND MUCOADHESIVITY
 
Bioadhesive  polymer  chains  Mucus polymer chains FUSION OF MUCUS LAYER AND BIOADHESIVE POLYMER APPROACHING POLYMERS MECHANISM OF BIOADHESIVE  FOR MUCOSAL DRUG DELIVERY
[object Object],MUCOADHESIVE POLYMERS Predominantly anionic hydrophilicity , suitable surface property, sufficient flexibility Carboxymethyl cellulose Carbopol Polycarbophil Sodium Alginate Hydroxyethyl cellulose Hydroxypropyl methylcellulose Chitosan Gelatin Pectin
[object Object],BUCCAL MUCOADHESIVE DOSAGE FORMS
Drug + Mucoadhesive Matrix ………………………………………………………………… . ………………………………………………………………… . DESIGN OF BUCCAL DOSAGE FORM ,[object Object],Bi-directional patches release drug in both the mucosa and the mouth
[object Object],Impermeable backing is applied to control the direction of drug delivery; to reduce patch deformation and disintegration while in the mouth; and to prevent drug loss Backing Layer Drug + Mucoadhesive Matrix ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Contd…
ACTIVE INGREDIENTS DELIVERED VIA A BUCCAL ROUTE
MARKET FORMULATIONS
[object Object],[object Object],[object Object],[object Object],[object Object],RECENT & FUTURE OF BDDS
THIS  RECENT SCAN IMAGE OF  PFIZER   PROVES THAT BMDDS HAS SYSTEMIC EFFECT AND SO IS  BENEFICIAL FOR THOSE PATIENTS THAT ARE UNCOOPERATIVE FOR OTHER DOSAGE FORM
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ADVANTAGES
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DISADVANTAGES
[object Object],[object Object],CONCLUSION
 

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