This document discusses buccal mucosa drug delivery (BMDD) and mucoadhesive drug delivery systems. It describes the anatomy of the oral mucosa, mechanisms of mucoadhesion, commonly used mucoadhesive polymers, and buccal dosage forms including matrix and reservoir patches. Some advantages of BMDD are avoidance of first-pass metabolism, rapid drug absorption from abundant blood vessels, and ease of administration/termination. Disadvantages include a small absorptive surface area and interference from salivation. The conclusion states that BMDD is promising for systemic delivery of orally inefficient drugs and a noninvasive alternative to other dosage forms.