A presentation about Mucoadhesive Drug Delivery System, including its theories, advantages, disadvantages, common adhesive polymers, mechanism, factors affecting it, and its dosage form.

1. MUCOADHESIVE DRUG DELIVERY SYSTEMS
Penghuni BS

2. INTRO
• An adhesive is a material that attaches to another substrate surface and
resists separation.
• Adhesion involves the formation of attractive bonds between two
substrates that resist separation.
• Bioadhesion is a specific case of adhesion in which at least one of the
two substrates involves a biological tissue.
• If the adherent substrate surface is a mucosal surface, e.g., a mucosal
membrane, bioadhesion is specifically referred to as mucoadhesion.

3. INTRO
• Mucoadhesive formulations are capable of providing localized drug
release in desirable regions such as nasal cavity, eye, mouth (buccal),
stomach (oral), intestine, and vagina to enhance their clinical efficacy.
• The interaction between mucoadhesive formulations and mucosal
surface offers potential to prolong the residence time of the dosage
form at the site of application, thereby reducing the dosing frequency
and increasing patient compliance.

4. MUCOADHESION THEORIES
1. Wetting Theory
2. Mechanical Interlocking Theory
3. Electronic Transfer Theory
4. Adsorption Theory
5. Fracture Theory
6. Diffusion-Interpenetration Theory

5. MUCOADHESIVE POLYMERS
• The possibility of mucoadhesion and the interaction strength can be
influenced by the polymer structural and functional groups.
• At present, the most commonly used mucoadhesive polymers are
composed of polar chemical functional groups such as hydroxyl (—OH),
carboxyl (—COOH), amide (—NH2), and sulfate (—SO4H) groups that
are able to interact with the mucin glycoproteins.

6. Type Common Polymers
Anionic polymers Carbopol
Polycarbophi
Sodium alginate
Sodium carboxymethylcellulose
Cationic polymers Chitosan
Nonionic polymers Hydroxypropylmethylcellulose
Hydroxypropylcellulose
Methylcellulose
Polyethylene glycol
Polyvinylpyrrolidone
Hydroxyethylcellulose
Stimuli-sensitive polymers Poloxamer
Commonly used adhesive
polymers:

7. ADVANTAGES
• Targeting and localization of the dosage form at a specific site.
• Also, the mucoadhesive systems are known to provide intimate contact
between dosage form and the absorptive mucosa, resulting in high drug
flux at the absorbing tissue.

8. DISADVANTAGES
• Occurrence of local ulcerous effects due to prolonged contact of the
drug possessing ulcerogenic property.
• One of the major limitations in the development of oral mucosal delivery
is the lack of a good model for in vitro screening to identify drugs
suitable for such administration.
• Patient acceptability in terms to taste and irritancy.
• Eating and Drinking is prohibited.

9. MECHANISMS

10. 1. CONTACT STAGE
Characterized by the contact between the
mucoadhesive and the mucous membrane,
with spreading and swelling of the
formulation, initiating its deep contact with
the mucus layer. In some cases, such as for
ocular or vaginal formulations, the delivery
system is mechanically attached over in other
cases, the deposition is promoted by the
aerodynamics of the organ to the membrane,
the system is administered, such as for the
nasal route.

11. 2. CONSOLIDATION STAGE
The mucoadhesive materials are activated by
the presence of moisture. Moisture plasticizes
the system, allowing the mucoadhesive
molecules to break free and to link up by weak
van der Waals and hydrogen bonds.

12. FACTORS AFFECTING MUCOADHESION

13. DOSAGE FORMS

14. THANK YOU