The document discusses two quantitative imaging projects using ITK at GE Research. Both projects analyze diseases from an imaging perspective by reducing images to numerical measurements of volumes, areas, and percent changes. One project studies Alzheimer's disease by quantifying brain iron concentrations in different brain structures. The other analyzes chronic obstructive pulmonary disease through emphysema and airway wall segmentation in CT images.

1. ITK in an Industrial Research Lab GE Research Jim Miller Bill Lorensen Dan Blezek Majeid Alyassin John Schenck Zhu Li Matt Turek Paulo Mendon ç a Dirk Padfield James Ross

4. Brain Iron as AD Marker Alzheimer’s Disease Normal HIV

6. Longitudinal MRI with no registration Checkerboard Source Original image Difference Target Original image

7. Longitudinal MRI with mutual information registration Checkerboard Source Original image Difference Target Original image

8. Design of Experiments

14. Chronic Bronchitis Inlier model TPS Higher order shape models Inlier model TPS Strong model, robust fits

16. 120-2 Lumen Error: 4.2% Wall Error: 38.3% 120-3 Lumen Error: 38.3% Wall Error: 54.1% 177-3 Lumen Error: 57.7% Wall Error: 410.9% 12-2 Lumen Error: 24.6% Wall Error: 25.7% 103-1 Lumen Error: 2.9% Wall Error: 6.2%

17. Pig Airway 102-1 (9 mm Lumen Diameter) Pathology Measurements Automatic CT Measurements Lumen Area: 75.02 mm 2 Wall Area: 101.15 mm 2 Lumen Area: 75.27 mm 2 (0.32 % Error) Wall Area: 107.38 mm 2 (6.2 % Error)

18. Pig Airway 177-3 (~1 mm Lumen Diameter) Pathology Measurements Automatic CT Measurements Lumen Area: 1.36 mm 2 Wall Area: 2.54 mm 2 Lumen Area: 2.14 mm 2 (57.7 % Error) Wall Area: 12.96 mm 2 (410.9 % Error)

20. Histogram Tumor Background

21. Life at an Industrial Research Lab Academia Publish Publish Publish How Why Industry Product Product Product What When Industrial Research Evaluate Accelerate Harden Extend Invent