This document discusses isotopes and atomic structure. It defines isotopes as atoms of the same element that have the same number of protons but different numbers of neutrons. Isotopes have the same chemical properties but slightly different physical properties. The document also discusses nucleon number, which is the total number of protons and neutrons in an atom's nucleus. The mass number equals the nucleon number. Radioactive isotopes are unstable and undergo nuclear decay over time into stable daughter isotopes.
objective
theory of atom
dalton`theory
Thomson, s model of atom
atomic number and mass number
isotopes, molecules formula, empirical formula
ions, formula of ionic compound, polyatomic ions, chemical nomenclature
objective
theory of atom
dalton`theory
Thomson, s model of atom
atomic number and mass number
isotopes, molecules formula, empirical formula
ions, formula of ionic compound, polyatomic ions, chemical nomenclature
Richard's aventures in two entangled wonderlandsRichard Gill
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A brief information about the SCOP protein database used in bioinformatics.
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In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
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Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
1. THE NATURE OF MATTER
Chapter # 02
Topic :ISOTOPES
Objective
Define nucleon number
Define and state isotope of same atoms with
different nucleon number
3. ATOMIC STRUCTUREATOMIC STRUCTURE
the number of protons in an atom
the number of protons and
neutrons in an atom
HeHe
22
44Atomic mass
Atomic number
number of electrons = number of protons
4. 4
O
16
8
chemical symbol
mass number
(nucleon number)
proton number
(atomic number)
P=E
No. of
protons= no.
of electrons
atomic number (proton number) is the number of
protons in an atom.
Each oxygen atom has 8 protons.
As the number of electrons is equal to the number of
protons in an atom, each oxygen atom contains 8
electrons.
Mass=P+N
mass number is the total number
of protons and neutrons in an
atom.
Number of neutrons in the
oxygen atom is: 16 – 8 = 8.
Interpreting Chemical Symbol
5. Definition of Isotopes
Isotopes are atoms of the same
element which contains the same
number of protons but different
number of neutrons.
10. 10
The atomic mass of an element
• is listed below the symbol of each element on
the periodic table.
• Gives the mass of an “average” atom of each
element compared to 12C.
11. 11
The calculation for atomic mass requires the
• percent(%) abundance of each isotope.
• atomic mass of each isotope of that element.
• sum of the weighted averages.
mass of isotope(1)x (%) + mass of isotope(2) x (%) =Ar
100 100
Ar=(Average atomic mass)
12. 12
24Mg = 23.99 amu x 78.70/100 = 18.88 amu
25Mg = 24.99 amu x 10.13/100 = 2.531 amu
26Mg = 25.98 amu x 11.17/100 = 2.902 amu
Atomic mass (average mass) Mg = 24.31 amu
16. Stable vs. Unstable
• A stable isotope does NOT
undergo radioactive (or nuclear)
decay.
• An unstable isotope undergoes
radioactive (or nuclear) decay.
Unstable isotopes are also known
as radioisotopes or radionucleides
17. Uses of Radioactive Isotopes
• Food irradiation
• Archaeological dating (carbon-dating)
• Smoke detectors
• Radioactive tracers
22. • Stable isotopes:
• They do not naturally decay but exist in
natural materials in differing proportions
• Unstable iso tope
• Isotopes that continously break down into
lower atomic weight isotopes