The Northern Health Science Alliance (NHSA) is a collaboration of eight universities and NHS trusts in Northern England aimed at improving health science research and services across a population of 15 million. The NHSA focuses on promoting the strengths in precision medicine, healthy aging, and population health, while fostering partnerships to secure private and public sector investments in health research. The organization also addresses health inequalities and develops new models of care through data-driven initiatives and community engagement.

1. NHSA, HEALTH NORTH AND CONNECTED HEALTH CITIES
Dr Hakim Yadi, NHSA, Chief Executive Officer
Hakim.Yadi@theNHSA.co.uk

2. • Health Science Scotland: Front door for Scotland - a partnership of medical universities and
their associated NHS Health Boards
• Northern Health Science Alliance: Front door for the North - 8 Universities / 8 NHS Trusts
across the North of England (Liverpool, Manchester, Leeds, Sheffield, Newcastle, Durham,
Lancaster, York / Hull)
• Invest Northern Ireland :Front door for Ireland - a partnership of medical universities, NHS
and government
• MedCity: Front door for London - The three London Academic Health Science Centres
• Life Sciences Hub Wales: Nerve centre of a vibrant and prosperous Welsh Life Sciences
eco-system
The UK life and health science clusters

3. To maximize the impact of the health
science research and to provide a go-to
center for healthcare companies we have
created the Northern Health Science
Alliance (NHSA), a collaboration across
eight of England's great cities across a
population of 15m people.
A functioning health partnership for the North of England

4.  Promote the combined value of the NHSA members
 Act as a front door for the North’s Health Science Research
 Work with industry to secure private sector R&D in the North
 Work with research funders to secure greater public sector
investment in the North
 Work with members to maximize the impact of their research
and service reform for the health of the North & UK
What we do

5. The North’s Research Strengths
Precision Medicine Population / Digital HealthHealthy Ageing
Research Themes
eHEALTH & DATA ANALYTICSCLINICAL TRIALS & Health Economics
The Health Science Ecosystem in the Northern Powerhouse has deep expertise in Precision
Medicine, Healthy Ageing and Population Health. This is underpinned by world leading clinical
trials infrastructure, health economics and health informatics and eHealth.
Digital Health approaches and technologies are deployed across all research themes.
• Two Precision Medicine Catapults
• Four Genomic England Centres
• Two NIHR Diagnostic Evidence Cooperatives
(Leeds / Newcastle)
• Two MRC / EPSRC Pathology Nodes
• New Medicines Technology Catapult
• Two MRC Single Cell Genomic Centres
• The UK AMR Centre at Alderley Park
• Cancer Research UK Manchester Institute
• Cancer Research UK Leeds Centre
• Cancer Research UK Newcastle Centre
• Astbury Centre (Leeds)
• National Centre for Ageing Science &
Innovation in Newcastle
• MRC Arthritis UK Centre for Integrative
Musculoskeletal Ageing
• NIHR Newcastle Biomedical Research
Centre in Ageing & Chronic Disease
• Alder Hey Children’s Hospital
• York Neuroimaging Centre (YNiC)
• Centre for Hyperpolarisation in Magnetic
Resonance (CHyM)
• SITraN in Sheffield
• Centre for Ageing Research (Lancaster)
• NIHR funded centres for Public
Health research
• ESRC Centre for Translational
Research in Public Health
• Institute of Infection & Global Health,
University of Liverpool
• Well North
• Three NHS England Test Beds
• Liverpool John Moores University's
Research Institute for Sport and
Exercise Sciences (RISES)
• CATCH in Sheffield
• NIHR Clinical Research Networks
• Several Clinical Research Facilities, three in Manchester alone
• MRC Network of Hubs for Trials Methodology Research
• Sheffield School for Health Related Research
• York Health Economics
• NWeHealth FARSITE trials recruitment tool
• MRC eHerc, Farr Institute, NorthWest eHealth at Manchester
• MRC Medical Bioinformatics Centre in Leeds
• EPSRC Postgraduate Centre for Cloud Computing in Newcastle
• Sci-Tech Daresbury and The Hartree Centre
• eHealth SME cluster (Liverpool City Region)
• Connected Health Cities
• CHICAS, School of Health and Medicine.

6. Health Data Science
• Sci-Tech Daresbury
• MRC eHerc
• Farr Institute in Manchester
• NorthWest eHealth
• Leeds Institute of Data Analytics
• EPSRC Postgraduate Centre for Cloud
Computing in Newcastle
• National Smart Data Institute in
Newcastle
• The Insigneo Institute for in silico
Medicine in Sheffield
• NHS Digital (HSCIC)
The North of England has a critical mass of data science expertise and know-how, with
government and research council investment across NHSA members.

7. Our challenge in health and equality
North West
78.0
Yorkshire and Humber
78.5
South West
80.1
South East
80.4
London
80.0
East of England
80.3
West Midlands
78.8
East Midlands
79.3
Wales
North East
78.0
Boundaries of Government Office Regions in Northern and Southern England Showing
North to South Gradient in Life Expectancy at Birth 2011-2013 (source: ONS)
Male Life Expectancy at birth 2011-2013
North West
81.8
Yorkshire and Humber
82.2
South West
83.8
South East
83.9
London
84.1
East of England
83.8
West Midlands
82.8
East Midlands
83.0
Wales
North East
81.7
Female Life Expectancy at birth 2011-13

8. COPD
Liver
Cancer
Lung
Cancer
Heart
Disease
Our challenge in health and equality

9. Health North
New
models
of care
Oct 2014: NHSA White Paper
presented to government.
• Health Data
• Precision Medicine
• Population Health

10. Health North
New
models
of care
Oct 2014: NHSA White Paper
presented to government.
Jan 2015: NHSA round table
with PM, CX and George
Freeeman.
• Health Data Analytics Centre
• Precision Medicine Academy
• Connected Health Cities

11. Health North: Connected Health Cities
New
models
of care
March 2015: Health North
CHC announcement
Oct 2014: NHSA White Paper
presented to government.
Jan 2015: NHSA round table
with PM, CX and George
Freeeman.

12. Health North: Connected Health Cities
New
models
of care
Nov 2015:
Grant Award
Letter
Jan – May 2016:
Project set up
March 2015: Health North
CHC announcement
Jan 2016:
Official
project start
Oct 2014: NHSA White Paper
presented to government.
Jan 2015: NHSA round table
with PM, CX and George
Freeeman.

13. New understanding and models of care
New models
of care

14. Data
Public
sector
encounters
Services
Targeted
by need
Targeting
Tools
Ark
Involved Citizens
Problem Owners
Data Managers
Public Health Analysts
Care Service Analysts
Statisticians
Informaticians
Social Scientists
Health Economists
Health Service
Researchers
Communications Experts
Service
Planning
and PolicyInsights
SME Global Corp.
Which services and how?
Spin-in/out Laboratory
Farr Institute & NIHR Centres
Connected Health Cities

15. 2015: Dilute, Duplicated Data Processing 2020: Ark Integrated Data Processing
NHS Commissioning
Research and
Innovation
Public Health
Intelligence
Social Care
Management
Raw
Data
NHS Quality
Intelligence
Extract, clean, describe x 5
One size fits all
Ark
Public Involvement
NHS Commissioning
NHS Quality Intelligence
Public Health Intelligence
Social Care Management
Self-care and Personal Health
Raw
Data
Extract, clean, describe x 1
Combinatorial
Research and Innovation
Literature
Policies
Literature
Policies
Targeting
System
Transparent
Interface with
Industry
Economies of Scale

16. De-identified
Records
Identified
Records
Study
Protocol
/Assessment
Study
Recruit
ClinicianResearcher
Commons of Metadata and Information Governance (Clinical &
Research)
Clinical Care
Patient
Research Safe Haven
Encrypted (SHA1 & AES256);
Certified (ISO 27001)
City 1
City 3
City 2
City 4
Linkable Data
Providers
Research
Objects
RAPID REPLICATION
• Research protocol
• Codes for the data
• Statistical scripts
• Results in progress
• Draft manuscript
• Slides etc.
Cities learning from one another

17. Learning Health Systems
Combining Health Data Uses to Ignite Health
System Learning. Ainsworth and Buchan
Methods of Information in Medicine
Issue:2015 (Vol. 54): Issue 6 2015Pages:479-487

18. NHSA CHC Therapeutic Areas / Care pathways:
North West Coast Connected Health Cities
• Alcohol misuse
• Unplanned Care
Greater Manchester
• Building rapid interventions to reduce
microbial resistance and over-prescribing of
antibiotics
• Stroke care
North East and North Cumbria
• Frail elderly and long term conditions (with
Parkinson’s Disease as a potential early
exemplar)
• Citizens with social deprivation
Connected Yorkshire
• Healthy childhood
• Healthy ageing
Confidential between NHSA and N8
The Northern Health Science Alliance: Pipeline

19. Branding and Launch