Interleukin.pptx
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Interleukins are a group of cytokines that play a critical role in immunological regulation and homeostasis. They are produced by leukocytes and other cells like macrophages. Interleukin-1 triggers inflammatory responses. Interleukin-6 regulates immune response and inflammation. Interleukin-10 is an anti-inflammatory cytokine that suppresses immune function. Interleukin-12 stimulates Th1 cellular immune responses by dendritic cells and phagocytes during infection. The Interleukin-17 family activates antibacterial responses through various pathways.
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Acquire immunity
The acquired immune system consists of cell-mediated and antibody-mediated immunity. Cell-mediated immunity involves T cells like helper T cells and cytotoxic T cells that recognize and destroy infected or abnormal cells. Antibody-mediated immunity involves B cells and antibodies that neutralize toxins, viruses, and opsonize bacteria. Both responses exhibit diversity, memory, and specificity targeting pathogens for destruction through recognition of antigens by immune cells.
Cell Tolerance
This document summarizes a presentation about tolerance pathways in B and T cells. It discusses central and peripheral tolerance mechanisms that prevent immune responses against self-antigens. Central tolerance involves deletion of self-reactive lymphocytes in the thymus and bone marrow. Peripheral tolerance involves anergy, deletion, suppression, or ignorance of self-reactive lymphocytes in tissues. The document also reviews central and peripheral tolerance mechanisms specifically for B cells, such as deletion or receptor editing of self-reactive immature B cells in the bone marrow.
Cell mediated immune response
This document discusses cellular immune response and the roles of its key components. It describes how antigen presenting cells present antigens to T lymphocytes via MHC molecules, providing the necessary stimulatory and co-stimulatory signals for T cell activation. Activated T cells then differentiate into effector and memory T cells. Effector CD8+ T cells induce apoptosis of infected cells, while effector CD4+ T cells secrete cytokines to activate macrophages. The interactions between these immune cells are regulated by cytokines. The document also discusses antigen presentation pathways, T cell maturation in the thymus, and the roles of superantigens and cytokines in the immune response.
Cytokines
Cytokines are cell signaling molecules that aid cell-to-cell communication and stimulate cell movement. They are produced by immune cells and mediate processes like immunity, inflammation, and blood cell production. Cytokines bind to receptors on target cells and alter gene expression through signal transduction pathways. They exhibit properties like redundancy, synergy, and antagonism that allow for coordinated regulation of cellular activity. Diseases have been linked to overproduction or underproduction of cytokines, such as septic shock resulting from excessive cytokine levels during bacterial infection.
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B cell activation and antibody productionChulalongkorn Allergy and Clinical Immunology Research Group
The document provides an overview of humoral immune responses, including B cell activation, antigen recognition, and antibody production. It discusses helper T cell-dependent antibody responses to protein antigens, outlining the key steps: initial activation and migration of B and T cells; antigen presentation; CD40L-CD40 interaction; extrafollicular B cell activation; the germinal center reaction involving follicular dendritic cells and follicular helper T cells; isotype switching; affinity maturation; plasma cell and memory B cell differentiation. The roles of cytokines, transcriptional regulators, and the SAP protein in T follicular helper cell generation and germinal center development are also summarized.T CELL ACTIVATION AND IT'S TERMINATION
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The document discusses T cells and B cells. It explains that T cells mature in the thymus gland and recognize antigens bound to MHC molecules, while B cells mature in the bone marrow and recognize free antigens. The document then describes the processes of T cell and B cell activation, differentiation, positive and negative selection, and how they contribute differently to the adaptive immune response.
The complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime.
consists of three pathways: 1. alternative
2. classical
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The acquired immune system consists of cell-mediated and antibody-mediated immunity. Cell-mediated immunity involves T cells like helper T cells and cytotoxic T cells that recognize and destroy infected or abnormal cells. Antibody-mediated immunity involves B cells and antibodies that neutralize toxins, viruses, and opsonize bacteria. Both responses exhibit diversity, memory, and specificity targeting pathogens for destruction through recognition of antigens by immune cells.
Cell Tolerance
This document summarizes a presentation about tolerance pathways in B and T cells. It discusses central and peripheral tolerance mechanisms that prevent immune responses against self-antigens. Central tolerance involves deletion of self-reactive lymphocytes in the thymus and bone marrow. Peripheral tolerance involves anergy, deletion, suppression, or ignorance of self-reactive lymphocytes in tissues. The document also reviews central and peripheral tolerance mechanisms specifically for B cells, such as deletion or receptor editing of self-reactive immature B cells in the bone marrow.
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T cell activation requires two signals: 1) recognition of antigens displayed on antigen-presenting cells by T cell receptors and 2) co-stimulatory signals through molecules like CD28. This leads T cells to proliferate, differentiate into effector and memory cells, and perform effector functions. Proper activation requires interaction between T cells and antigen-presenting cells in lymphoid tissues, where costimulatory molecules are highly expressed. Dysregulation of T cell activation can lead to autoimmunity or susceptibility to infection.
T cells and b-cells
The document discusses T cells and B cells. It explains that T cells mature in the thymus gland and recognize antigens bound to MHC molecules, while B cells mature in the bone marrow and recognize free antigens. The document then describes the processes of T cell and B cell activation, differentiation, positive and negative selection, and how they contribute differently to the adaptive immune response.
The complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime.
consists of three pathways: 1. alternative
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T cells
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1) Generation in the bone marrow or fetal liver
2) Activation in the lymph nodes through interaction with antigens and T cells
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1. DEFINITION.
2. CHEMICAL NATURE OF ANTIGEN.
3. TYPES OF ANTIGEN.
4. HAPTENS.
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6. DETERMINANTS OF ANTIGENICITY.
7. ADJUVANTS.
8. EPITOPES.
9 . USES.
10. ANTIGEN DETECTION METHOD.
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1. Humoral immunity is mediated by antibodies that are secreted and perform effector functions at distant sites from their production. Antibodies neutralize microbes and microbial toxins.
2. The complement system assists antibodies in lysing bacteria. It involves a cascade of proteins that are activated sequentially and amplify the immune response. Activation can occur via the classical, lectin, or alternative pathways.
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The document discusses major histocompatibility complexes (MHCs), which are glycoproteins found on cell surfaces that present antigen fragments to T cells. It describes MHC Class I and Class II molecules, which present antigens from intracellular and extracellular pathogens, respectively. MHC genes were first identified as important in tissue graft rejection and show high polymorphism between individuals.
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Interleukins are a group of cytokines that were first seen to be expressed by white blood cells and act as signaling molecules between immune cells. They promote the development and differentiation of T and B lymphocytes. The majority of interleukins are synthesized by helper T cells, monocytes, macrophages, and endothelial cells. There are several common families of interleukins that play various roles, such as interleukin 1 which participates in immune responses and inflammation, interleukin 2 which induces T cell proliferation, and interleukin 6 which stimulates antibody production.
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Cell mediated immunity (presentation)
Immunity involves both specific and non-specific components of the immune system. The non-specific components act as barriers or eliminate a wide range of pathogens, while the specific components adapt to each new disease and generate pathogen-specific immunity. Cell-mediated immunity is mediated by activated macrophages, natural killer cells, cytotoxic T-lymphocytes, and cytokines and does not involve antibodies. It is responsible for phagocytosing and killing intracellular pathogens and virus-infected cells. Memory T cells provide long-term immunity against past infections upon reexposure to the pathogen.
Major histocompatibility complex
The major histocompatibility complex (MHC) is a cluster of genes found in all mammals that encodes proteins important for the immune system to distinguish self from non-self. MHC molecules are expressed on the cell surface and present peptide antigens to T cells. There are three main classes of MHC genes - class I presents endogenous peptides to cytotoxic T cells, class II presents exogenous peptides to helper T cells, and class III encodes non-antigen presenting proteins involved in immunity. MHC molecules have binding sites that allow them to bind a variety of peptide antigens through anchor residues, helping the immune system recognize a diverse array of pathogens. Polymorphism of MHC alleles within populations helps provide protection against rapidly mutating pathogens.
Vaccine preparation part 1 ppt
The document outlines the general methods used for vaccine production, which includes 5 main steps: 1) generating the antigen by growing pathogens, 2) releasing and isolating the antigen from growth materials, 3) purifying the antigen using various separation techniques, 4) adding other components like adjuvants and preservatives, 5) packaging the vaccine for distribution while protecting it and the environment. Vaccines work by improving immunity but may not guarantee full protection against disease.
Immunological tolerance
Immunological tolerance is the specific non-reactivity to an antigen due to previous exposure. Tolerance can be induced to self-antigens to prevent autoimmunity or to non-self antigens like donor tissues. Burnet and Medawar discovered that exposure to antigens early in life can induce lifelong tolerance. Tolerance occurs through central tolerance in the thymus during development and peripheral tolerance after lymphocytes leave primary lymphoid organs. Mechanisms of tolerance include clonal deletion, clonal anergy, and receptor editing.
Cytokines
Cytokines are proteins that act as chemical messengers and are produced by immune cells to mediate and regulate immune responses and inflammation. They exist in different classes including interleukins, interferons, chemokines, and tumor necrosis factor. Cytokines act by binding to specific receptors on target cells and triggering signaling pathways that alter gene expression. This allows cytokines to influence diverse biological functions such as immune cell development, activation and communication.
MHC and TCR
The document summarizes key aspects of major histocompatibility complex (MHC) molecules and T cell receptor (TCR) recognition. It discusses how MHC genes were found to be important in transplant rejection and immune responses. There are three classes of MHC molecules - Class I found on nucleated cells, Class II on antigen presenting cells, and Class III molecules like complement components. The TCR recognizes antigen peptides bound to MHC molecules. Both MHC and TCR are highly polymorphic and recognize antigens in a MHC-restricted manner.
Natural killer cells
NK cells are lymphocytes that constitute 5-10% of cells in human peripheral blood. They play an important role in the innate immune response by killing infected or abnormal cells. NK cells are divided into two main subpopulations, CD56dim NK cells which are highly cytotoxic and mediate antibody-dependent cellular cytotoxicity, and CD56bright NK cells which rapidly produce cytokines and chemokines upon activation. A specialized NK cell population in the uterus, uterine NK cells, help form the placenta during pregnancy by enlarging blood vessels to supply the growing fetus.
T cells
T-cells develop in the thymus and include CD4+ T-helper cells, CD8+ cytotoxic T-cells, and regulatory T-cells. T-cells are activated by antigens and signaling molecules and then clonally expand. Activated T-cells have various functions - T-helper cells activate B-cells and mediate cytokine responses; cytotoxic T-cells kill infected or abnormal cells; regulatory T-cells suppress immune responses. T-cells secrete cytokines that regulate immune responses and are involved in B-cell activation, cell-mediated immunity, and autoimmune diseases when dysregulated. T-cells play a crucial role in connecting humoral and cell-mediated immunity.
effector mechanism of humoral immunity
The document summarizes the effector mechanisms of humoral immunity, including antibody-mediated opsonization, phagocytosis, complement activation, and antibody-dependent cellular cytotoxicity. It describes the classical and alternative pathways of complement activation and the membrane attack complex. It also discusses regulation of complement activation on host cells, transport of IgA, passive immunity in newborns, and evasion of humoral immunity by microbes.
B cell generation-activation_and_differentiation
B cells develop through several stages:
1) Generation in the bone marrow or fetal liver
2) Activation in the lymph nodes through interaction with antigens and T cells
3) Differentiation into plasma cells, which secrete antibodies, or memory B cells
The key events in B cell activation and differentiation are Ig gene rearrangement, affinity maturation through somatic hypermutation, class switch recombination, and formation of plasma cells and memory cells mediated by AID and specific cytokines in germinal centers. B cells can be activated through T cell dependent or independent pathways.
Antigen concept made easy
1. DEFINITION.
2. CHEMICAL NATURE OF ANTIGEN.
3. TYPES OF ANTIGEN.
4. HAPTENS.
5. SUPER ANTIGEN.
6. DETERMINANTS OF ANTIGENICITY.
7. ADJUVANTS.
8. EPITOPES.
9 . USES.
10. ANTIGEN DETECTION METHOD.
Cytokines
Cytokines are low molecular weight polypeptides or glycoproteins that are secreted by cells and have various functions including mediating and regulating immune responses and inflammatory reactions. Cytokines are produced by lymphocytes, monocytes, macrophages, mast cells, glial cells and other cells. They act through autocrine, paracrine or endocrine mechanisms and initiate their actions by binding to specific membrane receptors. Cytokines have pleiotropic, redundant, synergistic and antagonistic effects and form a cytokine network. The major classes of cytokines include interleukins, tumor necrosis factors, interferons, colony stimulating factors, transforming growth factors and chemokines. Cytokines play important roles in various diseases and their therapeutic uses include treatment
Immunologic memory
Dr. Ashish Warghane is a professor in the Department of Life Sciences at Mandsaur University in India. The document discusses immunological memory, which allows the immune system to mount a stronger and faster response when encountering an antigen for the second or subsequent times. Immunological memory is responsible for adaptive immunity and is created after an initial exposure to an antigen. It involves memory B and T cells that remain in the body in a resting state and can respond quickly when the same antigen is detected again. Immunological memory forms the basis of vaccination.
Antigen processing and presentation
Antigen processing and presentation allows T cells to recognize antigens by requiring their presentation on major histocompatibility complex (MHC) molecules on cell surfaces. There are two pathways for antigen presentation: class I MHC presents endogenous antigens from inside cells to CD8 T cells, while class II MHC presents exogenous antigens from outside cells to CD4 T cells. The endogenous pathway involves cytosolic degradation and transport of antigens to the endoplasmic reticulum for binding to class I MHC, while the exogenous pathway involves antigen phagocytosis and degradation within endosomes and lysosomes before binding to class II MHC. These pathways keep self and non-self antigens separated and allow the appropriate T cell response to be activated.
Adaptive immunity
The document discusses adaptive immunity and the specific immune response. It describes how adaptive immunity provides lifelong protective immunity through antigen-specific responses that are mediated by lymphocytes, including B cells, T cells, helper T cells, and killer T cells. Lymphocytes have antigen receptors like the B cell receptor and T cell receptor that provide specificity. The adaptive immune response develops over a person's lifetime through somatic recombination and clonal selection that generates a diverse repertoire of lymphocytes each with a unique receptor.
Complement system
1. Humoral immunity is mediated by antibodies that are secreted and perform effector functions at distant sites from their production. Antibodies neutralize microbes and microbial toxins.
2. The complement system assists antibodies in lysing bacteria. It involves a cascade of proteins that are activated sequentially and amplify the immune response. Activation can occur via the classical, lectin, or alternative pathways.
3. The classical pathway is initiated by the binding of the C1 complex to antibodies bound to pathogens. This activates a protease cascade leading to formation of the membrane attack complex that lyses microbes. The lectin pathway uses mannose-binding lectin and ficolins instead of antibodies. The alternative pathway is antibody
Autoimmunity
This document provides an overview of autoimmune diseases including causes, types, links to HLA genes, treatment approaches, and mouse models. It discusses three main types of autoimmune diseases: haemolytic, localized, and systemic. Examples like Hashimoto's thyroiditis, myasthenia gravis, multiple sclerosis, type 1 diabetes, systemic lupus erythematosus, and rheumatoid arthritis are explained. The roles of HLA genes and immunosuppressive drugs in treatment are also summarized. Mouse models that replicate human autoimmune conditions are noted.
Mhc
The document discusses major histocompatibility complexes (MHCs), which are glycoproteins found on cell surfaces that present antigen fragments to T cells. It describes MHC Class I and Class II molecules, which present antigens from intracellular and extracellular pathogens, respectively. MHC genes were first identified as important in tissue graft rejection and show high polymorphism between individuals.
Tumor immunology
This document discusses tumor immunology and cancer immunotherapy. It provides information on tumor antigens, how tumors stimulate an immune response, and mechanisms tumors use to evade the immune system. The document also outlines several approaches to cancer immunotherapy, including monoclonal antibodies, cytokines, and adoptive cell therapy. A brief history of cancer immunotherapy is given, noting early experiments in the 1890s using bacterial toxins to treat tumors and discoveries in the 1960s about antibody receptors and T cells recognizing cancer cells.
Antigens and immunogens immunogenecity
Immunogens are substances that can induce an immune response, while antigens are substances that can bind to antibodies or T-cell receptors. Not all antigens are immunogenic. The properties of an effective immunogen include foreignness, molecular size over 100,000 Daltons, chemical complexity, and the ability to be processed and presented by antigen-presenting cells. The immunogenicity of a substance depends on additional factors like dosage, route of administration, use of adjuvants, and host genetics. Antigens can be classified as exogenous, endogenous, autoantigens, or complete versus incomplete antigens.
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interleukins
Interleukins are a group of cytokines that were first seen to be expressed by white blood cells and act as signaling molecules between immune cells. They promote the development and differentiation of T and B lymphocytes. The majority of interleukins are synthesized by helper T cells, monocytes, macrophages, and endothelial cells. There are several common families of interleukins that play various roles, such as interleukin 1 which participates in immune responses and inflammation, interleukin 2 which induces T cell proliferation, and interleukin 6 which stimulates antibody production.
Cytokines.pptx
This document provides an overview of cytokines. It discusses that cytokines are proteins secreted by immune cells that mediate inflammation and immune responses. It categorizes cytokines into pro-inflammatory cytokines like interleukin-1 (IL-1), tumor necrosis factor (TNF), and interleukin-6 (IL-6) and anti-inflammatory cytokines like interleukin-4 (IL-4), interleukin-10 (IL-10), and transforming growth factor beta (TGF-β). The document also describes the properties, receptors, and functions of some important cytokines like IL-1, TNF, IL-6, IL-4, IL-10, and TGF-β in inflammation and immune responses.
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This presentation covers the content and information on "Cytokines " and their role in immune regulation .
Interleukins
Initially, interleukins were thought to be produced by leukocytes and act on other leukocytes, leading to their name. Interleukins stimulate immune cell growth and differentiation and activate effector mechanisms. They are cytokines secreted by activated immune cells like macrophages and lymphocytes. Interleukins modulate immune and inflammatory responses.
Cytokines
describes classification of cytokines and also its role in brief. you can use this for a quick reference.
Cytokines.pptx
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cytokines
Cytokines are small proteins that are secreted by cells and mediate communication between cells. They have a variety of functions including regulating immune responses and inflammation. Cytokines can act on nearby cells or distant cells and are often redundant or synergistic in their effects. Major cytokines include interleukins, monokines, interferons, colony stimulating factors, and tumor necrosis factors. Interleukins have specific roles such as stimulating immune cell growth and differentiation.
Cytokines
This document discusses cytokines, which are low molecular weight proteins that mediate communication between cells of the immune system. Cytokines are secreted by white blood cells and other cells to regulate immune responses. They belong to four main families and signal to target cells by binding specific receptors. Cytokines play roles in processes like immune cell development, inflammation, hematopoiesis, and wound healing. Their effects are targeted through selective receptor expression and localized secretion between interacting cells.
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This document discusses the pathophysiology of fever. It defines fever as an elevated body temperature regulated by the hypothalamus in response to pyrogens like cytokines. Cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α are produced by immune cells in response to infection or injury and act as endogenous pyrogens, inducing fever by raising the hypothalamic temperature set point. The acute phase response and production of proteins like C-reactive protein are also discussed. Thermoregulation aims to maintain a constant body temperature through balancing heat production and loss.
CYTOKINES (Introduction and Description) by Mohammedfaizan Shaikh
Secreted, low-molecular-weight proteins that
Regulate the nature, intensity and duration of the immune
Response by exerting a variety of effects on lymphocytes and/or
Other cells.
- Cytokines bind to specific receptors on target cells.
- Originally were called lymphokines because they were initially
- Thought to be produced only by lymphocytes. Then monokines
Because they were secreted by monocytes and macrophages.
- Then interleukin because they are produced by some
Leukocytes and affect other leukocytes. The term “cytokine” is
Now used more widely and covers all of the above.
- Don’t forget chemokines, they are also considered cytokines.
Cytokines
cytokines play a key role in controlling the immune system. It facilitate other cells and organs to work, with this presentation you will be able to learn about what are cytokines, their types, & their biological roles along with diseases related to cytokines and cytokines based therapies.
lecture series-7-1.pptx
This document provides information about cytokines. Some key points:
- Cytokines are small secreted proteins that regulate immune cell communication and function. They stimulate immune cell movement and interactions.
- Cytokines can have autocrine, paracrine, or endocrine effects. They exhibit properties like pleiotropy, redundancy, synergy, and antagonism.
- Major classes of cytokines include lymphokines, monokines, chemokines, and interleukins. They have various roles like attracting immune cells, activating macrophages, and stimulating antibody production.
- Cytokines act by binding specific receptors on target cells and altering gene expression. They have high affinity for receptors and can function at pic
Cytokines and Chemokines.pdf
The document discusses cytokines and chemokines. It defines them, classifies them into six families, and describes their general properties and functions. The six families are: interleukin 1, hematopoietin/class 1, interferon/class 2, chemokine, tumor necrosis factor, and interleukin 17 families. Cytokines have pleiotropic, redundant, synergistic, antagonistic, and cascade induction effects. They are important in innate and adaptive immunity.
Biochemistry of interferons and interleukins
This document discusses cytokines, specifically interferons and interleukins. It provides definitions and classifications of interferons, including three main types - alpha, beta, and gamma. Interferons are proteins that help fight viral infections and regulate the immune system. The document also defines interleukins as proteins that mediate communication between cells, regulating cell growth and immune responses. It describes two major interleukin families - interleukin-1 and interleukin-2 families - and provides examples of interleukins in each.
Cytokines
The document discusses cytokines, which are proteins that mediate communication between cells of the immune system. It describes the different types of cytokines, including interleukins produced by T-helper cells, lymphokines produced by lymphocytes, and monokines produced by monocytes. The document outlines the roles and functions of specific cytokines like IL-1, IL-2, TNF, IFN-γ and GM-CSF. It also discusses how cytokines are classified based on their structure and roles in innate versus adaptive immunity.
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Cytokines and their role in immune regulation.pptx
Cytokines and their role in immune regulation.pptx
CYTOKINES (Introduction and Description) by Mohammedfaizan Shaikh
CYTOKINES (Introduction and Description) by Mohammedfaizan Shaikh
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存档可查的(USC毕业证)南加利福尼亚大学毕业证成绩单制做办理
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我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
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Gen Z and the marketplaces - let's translate their needs
The product workshop focused on exploring the requirements of Generation Z in relation to marketplace dynamics. We delved into their specific needs, examined the specifics in their shopping preferences, and analyzed their preferred methods for accessing information and making purchases within a marketplace. Through the study of real-life cases , we tried to gain valuable insights into enhancing the marketplace experience for Generation Z.
The workshop was held on the DMA Conference in Vienna June 2024.
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APNIC Foundation, presented by Ellisha Heppner at the PNG DNS Forum 2024
Ellisha Heppner, Grant Management Lead, presented an update on APNIC Foundation to the PNG DNS Forum held from 6 to 10 May, 2024 in Port Moresby, Papua New Guinea.
重新申请毕业证书(RMIT毕业证)皇家墨尔本理工大学毕业证成绩单精仿办理
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1客户提供办理信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询）；
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3毕业证成绩单电子版做好以后发送给您确认；
4毕业证成绩单电子版您确认信息无误之后安排制作成品；
5成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快读邮寄）。
成绩单ps(UST毕业证)圣托马斯大学毕业证成绩单快速办理
一比一原版制作UST毕业证【微信176555708】圣托马斯大学毕业证书原版↑制作圣托马斯大学学历认证文凭办理圣托马斯大学留信网认证,留学回国办理毕业证成绩单文凭学历认证【微信176555708】专业为海外学子办理毕业证成绩单、文凭制作，学历仿制，回国人员证明、做文凭，研究生、本科、硕士学历认证、留信认证、结业证、学位证书样本、美国教育部认证百分百真实存档可查】（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
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留信网认证的作用:
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3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
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一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
学历顾问：微信：176555708
一比一原版(CSU毕业证)加利福尼亚州立大学毕业证成绩单专业办理
CSU毕业证原版定制【微信：176555708】【加利福尼亚州立大学毕业证成绩单-学位证】【微信：176555708】（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
学历顾问：微信：176555708
Explore-Insanony: Watch Instagram Stories Secretly
Instagram has become one of the most popular social media platforms, allowing people to share photos, videos, and stories with their followers. Sometimes, though, you might want to view someone's story without them knowing.
Understanding User Behavior with Google Analytics.pdf
Unlocking the full potential of Google Analytics is crucial for understanding and optimizing your website’s performance. This guide dives deep into the essential aspects of Google Analytics, from analyzing traffic sources to understanding user demographics and tracking user engagement.
Traffic Sources Analysis:
Discover where your website traffic originates. By examining the Acquisition section, you can identify whether visitors come from organic search, paid campaigns, direct visits, social media, or referral links. This knowledge helps in refining marketing strategies and optimizing resource allocation.
User Demographics Insights:
Gain a comprehensive view of your audience by exploring demographic data in the Audience section. Understand age, gender, and interests to tailor your marketing strategies effectively. Leverage this information to create personalized content and improve user engagement and conversion rates.
Tracking User Engagement:
Learn how to measure user interaction with your site through key metrics like bounce rate, average session duration, and pages per session. Enhance user experience by analyzing engagement metrics and implementing strategies to keep visitors engaged.
Conversion Rate Optimization:
Understand the importance of conversion rates and how to track them using Google Analytics. Set up Goals, analyze conversion funnels, segment your audience, and employ A/B testing to optimize your website for higher conversions. Utilize ecommerce tracking and multi-channel funnels for a detailed view of your sales performance and marketing channel contributions.
Custom Reports and Dashboards:
Create custom reports and dashboards to visualize and interpret data relevant to your business goals. Use advanced filters, segments, and visualization options to gain deeper insights. Incorporate custom dimensions and metrics for tailored data analysis. Integrate external data sources to enrich your analytics and make well-informed decisions.
This guide is designed to help you harness the power of Google Analytics for making data-driven decisions that enhance website performance and achieve your digital marketing objectives. Whether you are looking to improve SEO, refine your social media strategy, or boost conversion rates, understanding and utilizing Google Analytics is essential for your success.
Bridging the Digital Gap Brad Spiegel Macon, GA Initiative.pptx
Brad Spiegel Macon GA’s journey exemplifies the profound impact that one individual can have on their community. Through his unwavering dedication to digital inclusion, he’s not only bridging the gap in Macon but also setting an example for others to follow.
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Imagine a world where data flows freely, yet remains secure. A world where trust is built into the fabric of every transaction. This is the promise of blockchain, a revolutionary technology poised to reshape our digital landscape.
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一比一原版(LBS毕业证)伦敦商学院毕业证成绩单专业办理
LBS毕业证原版定制【微信：176555708】【伦敦商学院毕业证成绩单-学位证】【微信：176555708】（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
学历顾问：微信：176555708
制作毕业证书(ANU毕业证)莫纳什大学毕业证成绩单官方原版办理
在线办理莫纳什大学毕业证【微信：176555708】(ANU毕业证书)成绩单学位证【微信：176555708】，留信认证（真实可查，永久存档）纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。#一整套莫纳什大学文凭证件办理#—包含莫纳什大学莫纳什大学毕业证文凭证书学历认证|使馆认证|归国人员证明|教育部认证|留信网认证永远存档教育部学历学位认证查询办理国外文凭国外学历学位认证#我们提供全套办理服务。
一整套留学文凭证件服务：
一：莫纳什大学莫纳什大学毕业证文凭证书毕业证 #成绩单等全套材料从防伪到印刷水印底纹到钢印烫金
二：真实使馆认证（留学人员回国证明）使馆存档
三：真实教育部认证教育部存档教育部留服网站永久可查
四：留信认证留学生信息网站永久可查
国外毕业证学位证成绩单办理方法：
1客户提供办理莫纳什大学莫纳什大学毕业证文凭证书信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询）；
2开始安排制作毕业证成绩单电子图；
3毕业证成绩单电子版做好以后发送给您确认；
4毕业证成绩单电子版您确认信息无误之后安排制作成品；
5成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快读邮寄）。
教育部文凭学历认证认证的用途：
如果您计划在国内发展那么办理国内教育部认证是必不可少的。事业性用人单位如银行国企公务员在您应聘时都会需要您提供这个认证。其他私营 #外企企业无需提供！办理教育部认证所需资料众多且烦琐所有材料您都必须提供原件我们凭借丰富的经验帮您快速整合材料让您少走弯路。
实体公司专业为您服务如有需要请联系我: 微信176555708
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- 1. INTERLEUKIN
- 2. DEFENITION • Interleukin is a kind of cytokines • which plays a critical role in immunological regulation and homeostasis • It is originally discovered from leukocytes. • It is found to be produced by a lot of cells including macrophages, lymphocytic cells
- 3. INTERLEUKIN - 1 • linked to the innate immune response • IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ triggers MPKK and NF-κB leading to inflammatory response • can excrete as co-stimulation of T helper cells, maturation and proliferation of B cells, activation of NK cells and is relation to inflammation.
- 4. INTERLEUKIN-6 • discovered as a B-cell differentiation factor • Pleiotropic cytokine that regulates immune response, acute-phase response, hematopoiesis, and inflammation
- 5. INTERLEUKIN-10 • An anti-inflammatory cytokine • suppresses immune function by blocking the synthesis of proinflammatory cytokines (e.g., IL-1, IL-6, IFN-γ, and TNF-α) in T cells, monocytes, and macrophages
- 6. INTERLEUKIN-12 • IL-12 involves in the stimulation and maintenance of Th1 cellular immune responses • Dendritic cells (DCs) and phagocytes produce IL-12 in response to pathogens during infection
- 7. INTERLEUKIN 17 • IL-17 (interleukin 17) is secreted by a variety of innate cells including macrophages, dendritic cells (DC), natural killer, natural killer T • The IL-17 family activates antibacterial cytokines and chemokines in MAPK, NF-κB and C/EBPs pathway.