Ernst Otto Fischer demonstrated usage of organometallic or sandwich compounds in different fields. First person who predicted the structure of ‘Ferrocene’ synthetic compound.Organometallic chemistry is the study of chemical compounds containing bonds between carbon and a metal. It is the combination of inorganic chemistry and organic chemistry. Organometallic compounds can be used in stoichiometric and catalytic processes, in the production of polyethylene and polypropylene
Inorganic and organometallic chemistry: The Reaxys solution_may24_cfAnn-Marie Roche
Our Reaxys webinar, presented by Chris Flemming on May 24th showed attendees how to:
- Draw and search for organometallic compounds
- Set up search strategies for finding inorganics and organometallics
- Use ligand codes
Organic compounds are almost 60% of all compounds. because of carbons tendency to form a compound as it has more than1 electron(4electrons) to form covallent compounds. SO a wide range of everything we eat is formed from carbon and hydrogen, which is the second important element to form organic compounds.
A optimized process for the synthesis of a key starting material for etodolac...IOSR Journals
Abstract An optimized process developed for the synthesis of 7-ethyltryptophol, a key starting material for etodolac, a non steroidal anti- inflammatory drug. Starting from commercially available 2-ethylphenylhydrazine. HCl and dihydro furan with con. H2SO4 as a catalyst in N, N- dimethyl acetamide ( DMAc). H2O (1:1) as a solvent in 75% yield . the method is easy, inexpensive , without purification getting pure solid. The process is very clean, high yielding & high quality and operationally simple.
Keywords: Etodolac, 7-ethyl tryptophol, 2-ethyl phenyl hydrazine hydrochloride, N,N-dimethyl acetamide.
“Synthesis, Characterization, and Antipsychotic Evaluation of Some Aryl Piper...BRNSS Publication Hub
In this proposal research work aryl piperazine derivatives will be synthesised because aryl piperazine currently the most important building blocks in drug discovery with a high number of positive hits encountered in biological screens of this heterocyclic and its congeners. A series N-(4-(benzo[d]thiazol-2-yl)phenyl)-2-[4- (arylsubstituted)piperazines-1-yl]acetamide and N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4-(arylsubstituted)piperazines-1-yl]acetamide will be synthesized with different aryl piperzine substituents and their characterization such as melting point determination and Thin layer chromatography (TLC) also performed. After that pharmacological evaluation will be done for synthesized compounds. In pharmacological evaluation the antipsychotic activity determined by behaviour symptoms, Inhibition of 5-hydoxytryptophan (5-HTP) induced head twitches behavior and Induction of catalepsy.
Ernst Otto Fischer demonstrated usage of organometallic or sandwich compounds in different fields. First person who predicted the structure of ‘Ferrocene’ synthetic compound.Organometallic chemistry is the study of chemical compounds containing bonds between carbon and a metal. It is the combination of inorganic chemistry and organic chemistry. Organometallic compounds can be used in stoichiometric and catalytic processes, in the production of polyethylene and polypropylene
Inorganic and organometallic chemistry: The Reaxys solution_may24_cfAnn-Marie Roche
Our Reaxys webinar, presented by Chris Flemming on May 24th showed attendees how to:
- Draw and search for organometallic compounds
- Set up search strategies for finding inorganics and organometallics
- Use ligand codes
Organic compounds are almost 60% of all compounds. because of carbons tendency to form a compound as it has more than1 electron(4electrons) to form covallent compounds. SO a wide range of everything we eat is formed from carbon and hydrogen, which is the second important element to form organic compounds.
A optimized process for the synthesis of a key starting material for etodolac...IOSR Journals
Abstract An optimized process developed for the synthesis of 7-ethyltryptophol, a key starting material for etodolac, a non steroidal anti- inflammatory drug. Starting from commercially available 2-ethylphenylhydrazine. HCl and dihydro furan with con. H2SO4 as a catalyst in N, N- dimethyl acetamide ( DMAc). H2O (1:1) as a solvent in 75% yield . the method is easy, inexpensive , without purification getting pure solid. The process is very clean, high yielding & high quality and operationally simple.
Keywords: Etodolac, 7-ethyl tryptophol, 2-ethyl phenyl hydrazine hydrochloride, N,N-dimethyl acetamide.
“Synthesis, Characterization, and Antipsychotic Evaluation of Some Aryl Piper...BRNSS Publication Hub
In this proposal research work aryl piperazine derivatives will be synthesised because aryl piperazine currently the most important building blocks in drug discovery with a high number of positive hits encountered in biological screens of this heterocyclic and its congeners. A series N-(4-(benzo[d]thiazol-2-yl)phenyl)-2-[4- (arylsubstituted)piperazines-1-yl]acetamide and N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4-(arylsubstituted)piperazines-1-yl]acetamide will be synthesized with different aryl piperzine substituents and their characterization such as melting point determination and Thin layer chromatography (TLC) also performed. After that pharmacological evaluation will be done for synthesized compounds. In pharmacological evaluation the antipsychotic activity determined by behaviour symptoms, Inhibition of 5-hydoxytryptophan (5-HTP) induced head twitches behavior and Induction of catalepsy.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
Naturally occurring insecticides
Obtained from plants
Nontoxic to human ,
Biodegradable hence not pollute environment.
Types of insecticides:
1) Neurotoxins eg. Pyrethrums
2) Anti-feedant eg. Azadirachtin
Pyretrum is the natural insecticides obtained from the dried flowers of chrysanthemum cinerarifolium and chrysanthemum coccineum. Flower heads are crushed and mixed with water and used as insecticides
The active substance : Pyrethrins
Pyrethrum
Pyrethrum
Pyrethrums are among the safest insecticides in the market due to their rapid degradation in the environment.
synthesis of pyrethrin by condensation of trans-crysanthemic acid methyl ester with alcohol
Rotenoids are naturally occurring substances containing a cis-fused tetrahydrochromeno[3,4-b]chromene nucleus.
it is a broad-spectrum insecticides , piscicide, ( fish killer) andpesticide .
Rotenone is mildly toxic to humans and other mammals, but extremely toxic to insects and aquatic life, including fish.
A convenient new and efficient commercial synthetic route for dasatinib (Spry...Ratnakaram Venkata Nadh
A new and efficient synthetic route for dual-Src/Abl kinase inhibitor
dasatinib (Sprycel®), an anticancer drug, is described. This commercially
viable process yields dasatinib monohydrate free of potential impurities
with consistent yield of 68% in route A and 61% in route B with HPLC
purity >99.80% over four stages.
Synthesis and Characterization O-, M- and Para-Toluyl Thiourea Substituted Pa...IOSR Journals
Abstract: Six new derivatives of carbonyl thiourea comprises of o-,m- and p-toluyl at one end of Nitrogen atom and p-methylpyridine or ethyl pyridine at another one end of Nitrogen atom has been synthesized. The compounds are, 2-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (I), 3-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (II) and 4-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (III) for Toluyl-MP while 2-methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (IV), 3- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (V) and 4- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (VI) for isomer Toluidal-AEP have been successfully synthesized and characterized by elemental analysis, Infrared Spectroscopy analysis (FT-IR), Nuclear Magnetic Resonance Spectroscopy (NMR) and Ultraviolet-visible (UV-vis). All products shown stretching modes of ν(N-H), ν(C=O), ν(C-N), and ν(C=S) around 3276 cm-1, 1671 cm-1, 1315cm-1 and 1148 cm-1 respectively. All products shown two maximum absorption around 262 nm and 290 nm respectively for carbonyl C=O and thione C=S chromophore. Those both values contributed by n -п* transition. 1H nuclear magnetic resonance spectrum showed presence of aromatic, methyl, methine and amide protons except for product III. All products showed presence of carbon thione in 13C nuclear magnetic resonance except for product III. Ionophor interpretation with acetate anion shows color changes by naked eye for compound (I) and (III).
An Efficient Synthetic Approach Towards 4-Cyano-3-(Methylthio)-5-Oxo-2H-Pyraz...inventionjournals
ABSTRACT: Synthesis of novel heterocyclic 4-cyano -3-(methylthio)-5-oxo-2H-pyrazole-1(5H)- carbothioamide (3) was prepared by condensing ethyl-2-cyano-3,3-bis (methylthio)acrylate (1) with thiosemicarbazide (2) in DMF and catalytic amount of potassium carbonate. Compound (3) has methylthio group at third position, which is replaced by different nucleophiles such as substituted anilines| phenols| hetryl amines| compounds containing active methylene group to afford 3-substituted derivatives of compound (3). All the newly synthesized compounds were screened for their antimicrobial activity.
Syntheses and Characterizations of Some New N-alkyl, Isoxazole and Dioxazole ...IJAEMSJORNAL
N-alkyl and cycloadducts derivatives of 5-Chloroisatin were synthesized in good to excellent yields. The method evidences a selective N-alkylation when using 1,2-bis (2-chloroethoxy) ethane as efficient spacer at room temperature on the 5-Chloroisatin moiety. A general method for the 1,3-dipolar cycloaddition of 4-Chlorobenzaldoxime to alkynes provides a useful alternative route to get newisoxazole et dioxazole derivatives.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
2. Dronabinol is “medical
marijuana”
Aka
'Tetrahydrocannabinol'
(THC)
Antimietic
Taken orally
Side effects
Brand names
Marinol®
What is Dronabinol?
3. What does it treat?
Nausea/vomiting
Motion sickness
Appetite
Cancer effects
Side effects from
other drugs
4. Chemistry of Dronabinol
Molecular Formula: C21H30O2
Molecular Weight: 314.4617
Solubility: Soluble in ethanol
Boiling point: 157 °C
Other notes: Very low toxicity.
Chemical found naturally in cannabis.
Represses neurotransmitters in the
brain.
5. Patent Information
Name of Patent: Synthetic route to dronabinol
Purpose: To determine a novel synthetic route for creating the compound
dronabinol, which can be distributed as an antiemetic.
Patent Number: 7,323,576
Inventors: Souza; Fabio E. S. (Mississauga, CA), Field; Jason E. (Mississauga,
CA), Pan; Ming (Mississauga, CA), Ramjit; Navindra J. (Mississauga, CA),
Tharmanathan; Tharsika (Markham, CA), Jende-Tindall; Tracey (Aurora, CA)
Assignee: Alphora Research Inc. (Mississauga, Ontario, CA)
Date of Filing: October 1, 2004
Date Patent Expires: October 1, 2024
6. Patent Information
Seven Dependent Claims
Two independent claims:
1. A process for preparing Dronabinol by esterifying cis-(1R,2S)-2-hydroxy-4-
methylcyclohex-3-ene carboxylic acid to form a lower alkyl ester. Then, subjecting the
lower alkyl ester to a nucleophilic addition reaction with an appropriate
organometallic compound to form cis-(3S,4R)-1-methyl-3-hydroxy-4-(2-hydroxyprop-2-
yl) cyclohex-1-ene. Finally, reacting said product with olivetol (1,3-dihydroxy-5-n-
pentylbenzene).
7. Patent Information
Seven Dependent Claims
Two independent claims:
1. A process for preparing Dronabinol by esterifying cis-(1R,2S)-2-hydroxy-4-
methylcyclohex-3-ene carboxylic acid to form a lower alkyl ester. Then, subjecting the
lower alkyl ester to a nucleophilic addition reaction with an appropriate
organometallic compound to form cis-(3S,4R)-1-methyl-3-hydroxy-4-(2-hydroxyprop-2-
yl) cyclohex-1-ene. Finally, reacting said product with olivetol (1,3-dihydroxy-5-n-
pentylbenzene).
8. Patent Information
2. A process of preparing dronabinol, which comprises the successive steps of: (a)
reacting 2-methyl-3-butyn-2-ol with acetic anhydride under acidic conditions, followed
by transition metal catalyzed rearrangement, to obtain 1-acetoxy-3-methyl-1,3-
butadiene; (b) subjecting the product to Diels-Alder reaction with methyl acrylate to
form methyl 2-acetoxy-4-methyl cyclohex-3-ene carboxylate; (c) isolating the racemic
cis isomer of product from (b) by crystallization; (d) converting this carboxylate to
racemic cis-2-hydroxy-4-methylcyclohex-3-ene carboxylic acid; (e) resolving the racemic
mixture to obtain significantly enantiomerically enriched cis-2-hydroxy-4-
methylcyclohex-3-ene carboxylic acid; (f) esterifying the resolved product from (e) to
form a lower alkyl ester (g) reacting the lower alkyl ester with a methyl magnesium
halide to form cis-menth-1-ene-3,8-diol; (h) reacting product from (g) with olivetol to
form 1,3-dihydroxy-2-[(1R,6R)-6-(2-hydroxyprop-2-yl)-3-methylcyclohex-2-en-1-y- l]-5-n-
pentylbenzene; and (i) cyclizing the product from (h) to obtain dronabinol.
