N-alkyl and cycloadducts derivatives of 5-Chloroisatin were synthesized in good to excellent yields. The method evidences a selective N-alkylation when using 1,2-bis (2-chloroethoxy) ethane as efficient spacer at room temperature on the 5-Chloroisatin moiety. A general method for the 1,3-dipolar cycloaddition of 4-Chlorobenzaldoxime to alkynes provides a useful alternative route to get newisoxazole et dioxazole derivatives.
A series of novel 5-[2-(4-fluorobenzyl)-6-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-ylmethylene] thiazolidine-2,4-dione derivatives (4a-d) were synthesized. These final compounds (4a-d) were synthesized by Knoevenagel condensation of 2-(4-fluorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (3a-d) with thiazolidine-2,4-dione. All the newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activity in male Wister rats. The Structures of all the newly synthesized compounds were established by analytical and spectral data.
Simple and Eco-friendly Synthesis of Glycosides bearing triazolo[3,4-b][1,3,4...IOSRJAC
There is a vast variety of naturally occurring glycosides which have marked pharmacological properties. These glycosides have widely diversed functional groups modifications which result in influencing pharmacological performance of corresponding glycosides. The 3,6-disubstituted-s-triazolo[3,4- b][1,3,4]thiadiazoles were glucosidated with 2,3,4,6tetra-o-acetyl α D glulopryanosyl bromide using simple methodologies. The compounds obtained in good yield in a 80-90 minutes.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Facial and Simple Synthesis of Some New (Pyrazole and Triazole) Coumarin Deri...IOSRJAC
2-oxo-2H-coumarin-3-carbohydrazide (2) which prepared from the reaction of ethyl-2-oxo-2Hcoumarin-3-carboxylate (1) with hydrazine hydrate in ethanol containing a catalytic amount of piperidine mixture consider a good and available starting intermediate for synthesis of series of functionalized coumarins. So, compound (2) was utilized as a key for the synthesis of some new (pyrazole, triazole)-2H- coumarin-2-one derivatives by the reaction with some selected reagents.
Simple Synthesis of Some Novel Polyfunctionally Derivatives of 2H-Coumarin-2-...IOSRJAC
Compound (2) was prepared from the reaction of ethyl-2-oxo-2H-coumarin-3-carboxylate (1) with ethylcyanoacetate in ethanol containing a catalytic amount of piperidine as catalyst. Compound (2) is the key intermediate for the synthesis of several series of new compounds such as ((pyrimidine, tetrazine, piperidine, oxazepine)-2H-coumarin-2-one derivatives by reaction with selected reagents such as urea, cyanoacetamide, cyanoacetohydrazide, orthoaminophenol and 5-aminotriazole.
A series of novel 5-[2-(4-fluorobenzyl)-6-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-ylmethylene] thiazolidine-2,4-dione derivatives (4a-d) were synthesized. These final compounds (4a-d) were synthesized by Knoevenagel condensation of 2-(4-fluorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (3a-d) with thiazolidine-2,4-dione. All the newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activity in male Wister rats. The Structures of all the newly synthesized compounds were established by analytical and spectral data.
Simple and Eco-friendly Synthesis of Glycosides bearing triazolo[3,4-b][1,3,4...IOSRJAC
There is a vast variety of naturally occurring glycosides which have marked pharmacological properties. These glycosides have widely diversed functional groups modifications which result in influencing pharmacological performance of corresponding glycosides. The 3,6-disubstituted-s-triazolo[3,4- b][1,3,4]thiadiazoles were glucosidated with 2,3,4,6tetra-o-acetyl α D glulopryanosyl bromide using simple methodologies. The compounds obtained in good yield in a 80-90 minutes.
Synthesis And Antibacterial Activity Of 3-[(3-Phenyl-5-Thioxo-1, 5-Dihydro-4h...inventionjournals
A series of 3-[(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2Hindole-2-one derivatives were synthesised through the nucleophilic substitution at carbonyl carbon of Isatin. Structure of synthesized compounds were elucidated by using IR, 1H NMR & 13C NMR spectrometry. Synthesised compounds showed significant antibacterial activity against E.coli (ATCC 35218), S.aureus (ATCC 25323), E.faecalis (Clinical isolate), K. Pneumonia, P. aeruginosa (ATCC 27893) using agar well diffusion method.
Facial and Simple Synthesis of Some New (Pyrazole and Triazole) Coumarin Deri...IOSRJAC
2-oxo-2H-coumarin-3-carbohydrazide (2) which prepared from the reaction of ethyl-2-oxo-2Hcoumarin-3-carboxylate (1) with hydrazine hydrate in ethanol containing a catalytic amount of piperidine mixture consider a good and available starting intermediate for synthesis of series of functionalized coumarins. So, compound (2) was utilized as a key for the synthesis of some new (pyrazole, triazole)-2H- coumarin-2-one derivatives by the reaction with some selected reagents.
Simple Synthesis of Some Novel Polyfunctionally Derivatives of 2H-Coumarin-2-...IOSRJAC
Compound (2) was prepared from the reaction of ethyl-2-oxo-2H-coumarin-3-carboxylate (1) with ethylcyanoacetate in ethanol containing a catalytic amount of piperidine as catalyst. Compound (2) is the key intermediate for the synthesis of several series of new compounds such as ((pyrimidine, tetrazine, piperidine, oxazepine)-2H-coumarin-2-one derivatives by reaction with selected reagents such as urea, cyanoacetamide, cyanoacetohydrazide, orthoaminophenol and 5-aminotriazole.
Synthesis, Characterization, and Antibacterial Activity of Some Novel 5-Chlor...IJERA Editor
The development of potential antibacterial requires the synthesis of a new series of 5- Chloroisatin derivatives incorporating various aromatic aldehydes in the case 1,3-Dipolar Cycloaddition including Nitrile oxide, as well as the cycloaddition Alcyne-Azide Catalytic with Copper. The charcterization of the structure of the synthesized compounds was confirmed by means of their IR, 1H-NMR and 13C-NMR spectral data. In addition, the antibacterial properties in vitro were tested against certain microorganisms using the disk diffusion technique. A majority of compounds show better activity against several of the microorganisms.
Solvent Extraction Method for the Separation of Cerium(III) as
Cations From Aqueous Media By use 4-[N-(5-methyl isoxazol-3-
yl)benzene sulfonamide azo]-1- Naphthol Coupled With
Spectroscopic Method For Determination
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary
diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate
(HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2 with one equiv of tertiary
diphosphines ligands to form [Pd(k2-dppf)Cl2], [Pd(k2-dppp)Cl2] and [Pt(k2-dppmCl)Cl2] complexes
and then add the ligand HSBIBT to these complexes to form mixed ligand complexes. The prepared
complexes have been characterized by single-crystal X-ray diffraction, elemental analysis, magnetic
susceptibility, molar conductance, IR spectral data and UV-Visible. The results suggested that the
ligand HSBIBT bonded to the metal through N atom and square planner geometries were assigned
for the complexes.
Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigationsijtsrd
it was carried out synthesis of esters and their dinitro derivatives of 3,4,5-trimethoxybenzoic (eudesmic) acid. Esterification of eudesmic acid carried out n absolute methanol or ethanol and corresponding methyl and ethyl 3,4,5-trimethoxybenzoates (2, 3) have been synthesized in good yields. It was revealed that nitration of these esters gives only dinitro products. The structure of the synthesized compounds of the methyl and ethyl 2,6-dinitro-3,4,5-trimethoxybenzoates (4, 5) was determined by X-ray diffraction analysis (XRD). In the asymmetric part of the crystal structures of 4, 5 one and two molecules are observed, respectively. In crystalline structures a flat nitro groups and carboxylic groups do not participate in the conjugation with aromatic rings. In the crystal structure of 4, an intermolecular C8-H...O9 hydrogen bond is observed, these H bonds link the molecules along the [010] axis. In the crystal structure of 5, intermolecular C9B-H...O4A and C10B-H...O8A hydrogen bonds form chains along the [011] axis. The formed chains are cross linked by the intermolecular C9B-H...O5A hydrogen bonds. Olimova M.I. | Okmanov R. Ya. | Elmuradov B. Zh."Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: http://www.ijtsrd.com/papers/ijtsrd2417.pdf http://www.ijtsrd.com/chemistry/other/2417/targeted-intermediates-of-eudesmic-acid--synthesis-and-x-ray-investigations/olimova-mi
N-alkylation methods, Characterization and Evaluation of antibacterial activi...IJERA Editor
A series of new 5-Chloroisatin derivates have been synthesized by the method of N-alkylation at room temperature, in the presence of a base and a catalyst with good yields. The chemical structures of these compounds were confirmed by NMR (1H &13C), these new compounds obtained were evaluated for their antibacterial activity. The final results revealed that the majority of the compounds exhibited good antimicrobial activity against various organisms
Synthesis and Pharmacological Evaluation of Novel Heterocyclic CompoundIJSRD
2-[(4-bromo anilino)]-4-chloro-6-morpholino-1,3,5-triazine[2a] and 4-chloro-N-(4-fluorophenyl)-6-morpholino-1,3,5-triazin-2-amine [2b]were synthesized and studied for their biological activity. These compounds were prepared by the condensation of 4-bromoaniline and 4-fluoroaniline with 4-(4,6-dichloro-1,3,5-triazin-2-yl) morpholine [1] which is prepared by the reaction between 2,4,6-trichloro-1,3,5-triazine and morpholine. All the compounds were characterized by elemental analysis and spectral studies.
Synthesis, characterization, in vitro cytotoxic and antioxidant activities of...ijperSS
ABSTRACT
A series of novel (Z)-3-(2-(4-(2-oxo-2H-chromen-3-yl) thiazol-2-yl-)hydrazono)indolin-2-one (8a-8d, 9) were synthesized with various substituted indole derivatives. Structures of the newly synthesized compounds were elucidated by FT-IR, 1H-NMR, 13C-NMR and API-ES Mass spectral data. The in vitro cytotoxic activities of the complexes measurement against the human cancer T-lymphocyte cell lines. In vitro evaluation of these title complexes revealed cytotoxicity from 6.8-18µg/mL against CEM, 9.2-21µg/mL against L1210, 10-19µg/mL against Molt4/C8, 8-12µg/mL against HL60 and 8-16µg/mL against BEL7402. Coumarin derivatives 8c and 8d showed that quite significant anticancer activities. The antioxidant activity of the synthesized compounds was evaluated by DPPH scavenging method. Compounds 8c, 8d and 9 showed significant antioxidant activity compared with that of standard drug, ascorbic acid.
Key words: Coumarin, DPPH, Cytotoxic activity.
An Efficient Synthetic Approach Towards 4-Cyano-3-(Methylthio)-5-Oxo-2H-Pyraz...inventionjournals
ABSTRACT: Synthesis of novel heterocyclic 4-cyano -3-(methylthio)-5-oxo-2H-pyrazole-1(5H)- carbothioamide (3) was prepared by condensing ethyl-2-cyano-3,3-bis (methylthio)acrylate (1) with thiosemicarbazide (2) in DMF and catalytic amount of potassium carbonate. Compound (3) has methylthio group at third position, which is replaced by different nucleophiles such as substituted anilines| phenols| hetryl amines| compounds containing active methylene group to afford 3-substituted derivatives of compound (3). All the newly synthesized compounds were screened for their antimicrobial activity.
Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
ER Publication,
IJETR, IJMCTR,
Journals,
International Journals,
High Impact Journals,
Monthly Journal,
Good quality Journals,
Research,
Research Papers,
Research Article,
Free Journals, Open access Journals,
erpublication.org,
Engineering Journal,
Science Journals,
Synthesis, Characterization and Biological Evaluation of Substitutedthiazolid...paperpublications3
Abstract: A new series of substituted thiazolidin-4-ones were synthesized and evaluated for anticancer activity by means of MTT assay method for improved anticancer activity .The structures of these synthesized compounds were established by means of IR,H NMR analysis.All the compounds were evaluated for their anticancer activity .Compounds TH10 & TH19 were found most active due to presence of electron withdrawing groups at appropriate position.
An efficient synthesis, characterization and antibacterial activity of novel ...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1...IJAEMSJORNAL
A facile and simple protocol for the ‘Click’ cycloaddition of organic azides with N-propargylchloroisatine catalyzed by CuI, produces in good yields novel of 1,4-disubstituted 1,2,3-triazoles were obtained. Compared to the uncatalyzed cycloaddition, the yields are significantly improved in the presence of CuI as catalyst, without alteration of the selectivity. The regio- and stereochemistry of the cycloadducts has been corroborated by 1H, 13C NMR spectroscopy.
Synthesis, Characterization, and Antibacterial Activity of Some Novel 5-Chlor...IJERA Editor
The development of potential antibacterial requires the synthesis of a new series of 5- Chloroisatin derivatives incorporating various aromatic aldehydes in the case 1,3-Dipolar Cycloaddition including Nitrile oxide, as well as the cycloaddition Alcyne-Azide Catalytic with Copper. The charcterization of the structure of the synthesized compounds was confirmed by means of their IR, 1H-NMR and 13C-NMR spectral data. In addition, the antibacterial properties in vitro were tested against certain microorganisms using the disk diffusion technique. A majority of compounds show better activity against several of the microorganisms.
Solvent Extraction Method for the Separation of Cerium(III) as
Cations From Aqueous Media By use 4-[N-(5-methyl isoxazol-3-
yl)benzene sulfonamide azo]-1- Naphthol Coupled With
Spectroscopic Method For Determination
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary
diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate
(HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2 with one equiv of tertiary
diphosphines ligands to form [Pd(k2-dppf)Cl2], [Pd(k2-dppp)Cl2] and [Pt(k2-dppmCl)Cl2] complexes
and then add the ligand HSBIBT to these complexes to form mixed ligand complexes. The prepared
complexes have been characterized by single-crystal X-ray diffraction, elemental analysis, magnetic
susceptibility, molar conductance, IR spectral data and UV-Visible. The results suggested that the
ligand HSBIBT bonded to the metal through N atom and square planner geometries were assigned
for the complexes.
Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigationsijtsrd
it was carried out synthesis of esters and their dinitro derivatives of 3,4,5-trimethoxybenzoic (eudesmic) acid. Esterification of eudesmic acid carried out n absolute methanol or ethanol and corresponding methyl and ethyl 3,4,5-trimethoxybenzoates (2, 3) have been synthesized in good yields. It was revealed that nitration of these esters gives only dinitro products. The structure of the synthesized compounds of the methyl and ethyl 2,6-dinitro-3,4,5-trimethoxybenzoates (4, 5) was determined by X-ray diffraction analysis (XRD). In the asymmetric part of the crystal structures of 4, 5 one and two molecules are observed, respectively. In crystalline structures a flat nitro groups and carboxylic groups do not participate in the conjugation with aromatic rings. In the crystal structure of 4, an intermolecular C8-H...O9 hydrogen bond is observed, these H bonds link the molecules along the [010] axis. In the crystal structure of 5, intermolecular C9B-H...O4A and C10B-H...O8A hydrogen bonds form chains along the [011] axis. The formed chains are cross linked by the intermolecular C9B-H...O5A hydrogen bonds. Olimova M.I. | Okmanov R. Ya. | Elmuradov B. Zh."Targeted Intermediates of Eudesmic Acid: Synthesis and X-ray Investigations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: http://www.ijtsrd.com/papers/ijtsrd2417.pdf http://www.ijtsrd.com/chemistry/other/2417/targeted-intermediates-of-eudesmic-acid--synthesis-and-x-ray-investigations/olimova-mi
N-alkylation methods, Characterization and Evaluation of antibacterial activi...IJERA Editor
A series of new 5-Chloroisatin derivates have been synthesized by the method of N-alkylation at room temperature, in the presence of a base and a catalyst with good yields. The chemical structures of these compounds were confirmed by NMR (1H &13C), these new compounds obtained were evaluated for their antibacterial activity. The final results revealed that the majority of the compounds exhibited good antimicrobial activity against various organisms
Synthesis and Pharmacological Evaluation of Novel Heterocyclic CompoundIJSRD
2-[(4-bromo anilino)]-4-chloro-6-morpholino-1,3,5-triazine[2a] and 4-chloro-N-(4-fluorophenyl)-6-morpholino-1,3,5-triazin-2-amine [2b]were synthesized and studied for their biological activity. These compounds were prepared by the condensation of 4-bromoaniline and 4-fluoroaniline with 4-(4,6-dichloro-1,3,5-triazin-2-yl) morpholine [1] which is prepared by the reaction between 2,4,6-trichloro-1,3,5-triazine and morpholine. All the compounds were characterized by elemental analysis and spectral studies.
Synthesis, characterization, in vitro cytotoxic and antioxidant activities of...ijperSS
ABSTRACT
A series of novel (Z)-3-(2-(4-(2-oxo-2H-chromen-3-yl) thiazol-2-yl-)hydrazono)indolin-2-one (8a-8d, 9) were synthesized with various substituted indole derivatives. Structures of the newly synthesized compounds were elucidated by FT-IR, 1H-NMR, 13C-NMR and API-ES Mass spectral data. The in vitro cytotoxic activities of the complexes measurement against the human cancer T-lymphocyte cell lines. In vitro evaluation of these title complexes revealed cytotoxicity from 6.8-18µg/mL against CEM, 9.2-21µg/mL against L1210, 10-19µg/mL against Molt4/C8, 8-12µg/mL against HL60 and 8-16µg/mL against BEL7402. Coumarin derivatives 8c and 8d showed that quite significant anticancer activities. The antioxidant activity of the synthesized compounds was evaluated by DPPH scavenging method. Compounds 8c, 8d and 9 showed significant antioxidant activity compared with that of standard drug, ascorbic acid.
Key words: Coumarin, DPPH, Cytotoxic activity.
An Efficient Synthetic Approach Towards 4-Cyano-3-(Methylthio)-5-Oxo-2H-Pyraz...inventionjournals
ABSTRACT: Synthesis of novel heterocyclic 4-cyano -3-(methylthio)-5-oxo-2H-pyrazole-1(5H)- carbothioamide (3) was prepared by condensing ethyl-2-cyano-3,3-bis (methylthio)acrylate (1) with thiosemicarbazide (2) in DMF and catalytic amount of potassium carbonate. Compound (3) has methylthio group at third position, which is replaced by different nucleophiles such as substituted anilines| phenols| hetryl amines| compounds containing active methylene group to afford 3-substituted derivatives of compound (3). All the newly synthesized compounds were screened for their antimicrobial activity.
Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
ER Publication,
IJETR, IJMCTR,
Journals,
International Journals,
High Impact Journals,
Monthly Journal,
Good quality Journals,
Research,
Research Papers,
Research Article,
Free Journals, Open access Journals,
erpublication.org,
Engineering Journal,
Science Journals,
Synthesis, Characterization and Biological Evaluation of Substitutedthiazolid...paperpublications3
Abstract: A new series of substituted thiazolidin-4-ones were synthesized and evaluated for anticancer activity by means of MTT assay method for improved anticancer activity .The structures of these synthesized compounds were established by means of IR,H NMR analysis.All the compounds were evaluated for their anticancer activity .Compounds TH10 & TH19 were found most active due to presence of electron withdrawing groups at appropriate position.
An efficient synthesis, characterization and antibacterial activity of novel ...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1...IJAEMSJORNAL
A facile and simple protocol for the ‘Click’ cycloaddition of organic azides with N-propargylchloroisatine catalyzed by CuI, produces in good yields novel of 1,4-disubstituted 1,2,3-triazoles were obtained. Compared to the uncatalyzed cycloaddition, the yields are significantly improved in the presence of CuI as catalyst, without alteration of the selectivity. The regio- and stereochemistry of the cycloadducts has been corroborated by 1H, 13C NMR spectroscopy.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiationIOSR Journals
Various substituted Triazole-Thiol containing different functional group have been synthesized by microwave method. The title product 1-[(3H-indol-2-ylamino) methyl]-4-phenyl-4, 5-dihydro-1H-1, 2, 4-triazole-3-thiol is synthesized by using amino benzothiazole. The final structures have been established on the basis of their chemical analysis and spectral data. All micro-wave synthesized compounds results into good yield as compared to conventional method of which fluoro substituted compound shows maximum yield.
Synthesis, Characterization and Study of Antioxidant Activities of Some New P...IJRES Journal
A series of substituted pyrazoline derivatives 5(a-c) have been synthesized by the reaction of substituted chalcones 4(a-c) with isatinhydrazide. The starting materials, chalcones were prepared by clasien schimidt condensation of appropriate 1-hydroxy-2-acetonaphthone with substituted aldehydes in the presence of sodium hydroxide and in poly ethylene glycol (PEG-400). The structures of the synthesized compounds were confirmed by IR, 1HNMR & Mass spectral data. The synthesized compounds were screened for Antioxidant Activity by DPPH method.
Synthesis and Crystal Structure of Anickel (II) and Zinc (II) Complex From 1,...IOSRJAC
:The title mononuclear nickel and zinc complexes, Ni(C11H9N4S3)2andZn(C11H9N4S3)2 .2(C3H7NO), were prepared by the reaction of Nickel(II) or Zinc(II)acetate with 1,5-bis[(2- thiophenyl)methylidene]thiocarbonohydrazide in a methanol solution. It features mono-deprotonated bisbidentate ligands, which coordinate to metal (II) ions by hydrazylN and thiocarbony lS atoms, yielding a tetracoordinated metal ions complexes. In Ni(II) complex the geometry around the metal ion is described as square planar. In the Zn(II) the metal atom shows severely tetrahedral distortion from anideal square-planar coordination geometry, as reflected by the dihedral angle between ZnN2and ZnS2 planes of 73.03(13)°. Two intramolecular hydrogen bonds are observed between the solvate dmf molecules and the coordinated ligands:N2—H2N…O1i and N6—H6N…O2 ii in this complex
Synthesis and Characterization of a New Cationic Surfactant Derived from 5-Ch...IJERA Editor
:In this paper, anovel cationic surfactant is synthesized by the alkylation reaction of 5-Chloro- 1H-indole-2,3-dioneunder the conditions of phase transfer catalysis and quaternizationby trimethylamine in acetone solution.Chemical structures of synthesized compounds were confirmed by 1HNMR and 13C NMR. The micellization of cationic surfactant in aqueous solution at room temperature has been reported using the conductivity of the measurements
Synthesis, Characterization and invitro Anti- inflammatory activity of 1, 3, ...SriramNagarajan19
Oxadiazole derivatives have played a vital part in the development of heterocyclic compounds. In this present work, a series of 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione derivatives (1-10) have been synthesized by Mannich reaction. The reaction progress of the synthesized compounds was checked by TLC. The structures of the newly synthesized compounds were confirmed by IR and 1H NMR spectral data. The in-vitro anti-inflammatory activity of 1, 3, 4-oxadiazole compounds (1-10) was assessed by HRBC Membrane Stabilization Method. Among the newly synthesized 1,3,4-oxadiazole derivatives, compounds OFP, OAP, OBNP, OPBNP, ORP, OUP, OPClBP, OFD, OAD and OBND possessed highly significant anti-inflammatory activity at a dose of 1000µg/ml when compared with standard, Diclofenac potassium.
Synthesis, spectral characterization and bioactivity studies of some S-substi...Jing Zang
A new series of 5-(4-Chlorophenyl)-1,3,4-Oxadiazol-2-thiol derivatives was prepared from 4-chlorobenzoic acid (1) by converting it successively into corresponding ester (2), carbohydrazide (3) and 5-(4-Chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4). Finally the target compounds, 6a-l, were synthesized by stirring 4 with different electrophiles, 5a-l, in DMF using NaH as weak base and activator. The proposed structures of newly synthesized compounds were confirmed by spectroscopic techniques such as 1H-NMR, 13C-NMR, HR-MS and EI-MS. All synthesized compounds were evaluated for their anti-bacterial, antifungal, cytotoxicity and enzyme inhibition activities. The compounds, 6e and 6g exhibited significant inhibition activity against acetyl cholinesterase enzyme (AChE) and 6j moderate activity against butyryl cholinesterase enzyme (BChE). The molecule, 4 exhibited good MIC (minimum inhibitory concentration) value against all the bacterial and fungal strains taken into account.
Photo-Oxygenated Derivatives from EugenolEditor IJCATR
Photo-oxygenation reaction was performed on eugenol (1) (2- methoxy-4-(2'-propenyl) phenol) in chloroform as a solvent and tetraphenyl porphrine (TPP) as singlet oxygen sensitizer. Irradiation of the reaction mixture was carried out by sodium lamp at -20 °C for six hrs., during which dry oxygen was allowed to pass through the reaction mixture. Two hydroperoxides (3) and (4) were formed. Eugenol methyl ether (2) was also photo-oxygenated under the same conditions of eugenol, where only the side chain was photo-oxygenated at position C-1' to give product (5). In addition to the epoxide derivative of eugenol methyl ester (8) was prepared and its reaction with aminoantipyrine was carried out to give product (9). Product (8) could be considered as a DNA- alkylating agent.
Photo-Oxygenated Derivatives from EugenolEditor IJCATR
Photo-oxygenation reaction was performed on eugenol (1) (2- methoxy-4-(2'-propenyl) phenol) in
chloroform as a solvent and tetraphenyl porphrine (TPP) as singlet oxygen sensitizer. Irradiation of the reaction
mixture was carried out by sodium lamp at -20 °C for six hrs., during which dry oxygen was allowed to pass
through the reaction mixture. Two hydroperoxides (3) and (4) were formed. Eugenol methyl ether (2) was also
photo-oxygenated under the same conditions of eugenol, where only the side chain was photo-oxygenated at
position C-1' to give product (5). In addition to the epoxide derivative of eugenol methyl ester (8) was prepared
and its reaction with aminoantipyrine was carried out to give product (9). Product (8) could be considered as a
DNA- alkylating agent
ABSTRACT- L-Ascorbic acid derivatives was synthesized on treatment with acetone and acetyl chloride afforded 5,6-acetal of L-ascorbic acid then benzylation of C-2 and C-3 hydroxyl groups of the lactone ring was accomplished using K2CO3 and benzyl bromide in DMF, then deblocking of the 5,6-O,O-protected derivative of L-Ascorbic acid with acetic acid and methanol gave 2,3-O,O-dibenzyl-L-Ascorbic acid. Subsequently mono-tosylation at 6 position of 2,3-O, O-dibenzyl-L-Ascorbic acid was carried out with addition of p-toluenetosylchloride (PTSC) in Pyridine and MDC solvent medium gave 2,3-O,O-dibenzyl-6-O-tosyl-L-Ascorbic acid. All the structures were characterized by 1H NMR, 13C NMR and Mass Spectroscopy.
Key-words- L-Ascorbic acid, 5,6-Acetal, Benzylation, Hydrolysis, Tosylation
Similar to Syntheses and Characterizations of Some New N-alkyl, Isoxazole and Dioxazole Derivatives of 5-Chloroisatin (20)
NO1 Uk best vashikaran specialist in delhi vashikaran baba near me online vas...Amil Baba Dawood bangali
Contact with Dawood Bhai Just call on +92322-6382012 and we'll help you. We'll solve all your problems within 12 to 24 hours and with 101% guarantee and with astrology systematic. If you want to take any personal or professional advice then also you can call us on +92322-6382012 , ONLINE LOVE PROBLEM & Other all types of Daily Life Problem's.Then CALL or WHATSAPP us on +92322-6382012 and Get all these problems solutions here by Amil Baba DAWOOD BANGALI
#vashikaranspecialist #astrologer #palmistry #amliyaat #taweez #manpasandshadi #horoscope #spiritual #lovelife #lovespell #marriagespell#aamilbabainpakistan #amilbabainkarachi #powerfullblackmagicspell #kalajadumantarspecialist #realamilbaba #AmilbabainPakistan #astrologerincanada #astrologerindubai #lovespellsmaster #kalajaduspecialist #lovespellsthatwork #aamilbabainlahore#blackmagicformarriage #aamilbaba #kalajadu #kalailam #taweez #wazifaexpert #jadumantar #vashikaranspecialist #astrologer #palmistry #amliyaat #taweez #manpasandshadi #horoscope #spiritual #lovelife #lovespell #marriagespell#aamilbabainpakistan #amilbabainkarachi #powerfullblackmagicspell #kalajadumantarspecialist #realamilbaba #AmilbabainPakistan #astrologerincanada #astrologerindubai #lovespellsmaster #kalajaduspecialist #lovespellsthatwork #aamilbabainlahore #blackmagicforlove #blackmagicformarriage #aamilbaba #kalajadu #kalailam #taweez #wazifaexpert #jadumantar #vashikaranspecialist #astrologer #palmistry #amliyaat #taweez #manpasandshadi #horoscope #spiritual #lovelife #lovespell #marriagespell#aamilbabainpakistan #amilbabainkarachi #powerfullblackmagicspell #kalajadumantarspecialist #realamilbaba #AmilbabainPakistan #astrologerincanada #astrologerindubai #lovespellsmaster #kalajaduspecialist #lovespellsthatwork #aamilbabainlahore #Amilbabainuk #amilbabainspain #amilbabaindubai #Amilbabainnorway #amilbabainkrachi #amilbabainlahore #amilbabaingujranwalan #amilbabainislamabad
Saudi Arabia stands as a titan in the global energy landscape, renowned for its abundant oil and gas resources. It's the largest exporter of petroleum and holds some of the world's most significant reserves. Let's delve into the top 10 oil and gas projects shaping Saudi Arabia's energy future in 2024.
Student information management system project report ii.pdfKamal Acharya
Our project explains about the student management. This project mainly explains the various actions related to student details. This project shows some ease in adding, editing and deleting the student details. It also provides a less time consuming process for viewing, adding, editing and deleting the marks of the students.
Water scarcity is the lack of fresh water resources to meet the standard water demand. There are two type of water scarcity. One is physical. The other is economic water scarcity.
Final project report on grocery store management system..pdfKamal Acharya
In today’s fast-changing business environment, it’s extremely important to be able to respond to client needs in the most effective and timely manner. If your customers wish to see your business online and have instant access to your products or services.
Online Grocery Store is an e-commerce website, which retails various grocery products. This project allows viewing various products available enables registered users to purchase desired products instantly using Paytm, UPI payment processor (Instant Pay) and also can place order by using Cash on Delivery (Pay Later) option. This project provides an easy access to Administrators and Managers to view orders placed using Pay Later and Instant Pay options.
In order to develop an e-commerce website, a number of Technologies must be studied and understood. These include multi-tiered architecture, server and client-side scripting techniques, implementation technologies, programming language (such as PHP, HTML, CSS, JavaScript) and MySQL relational databases. This is a project with the objective to develop a basic website where a consumer is provided with a shopping cart website and also to know about the technologies used to develop such a website.
This document will discuss each of the underlying technologies to create and implement an e- commerce website.
Final project report on grocery store management system..pdf
Syntheses and Characterizations of Some New N-alkyl, Isoxazole and Dioxazole Derivatives of 5-Chloroisatin
1. International Journal of Advanced Engineering, Management and Science (IJAEMS) [Vol-3, Issue-8, Aug- 2017]
https://dx.doi.org/10.24001/ijaems.3.8.11 ISSN: 2454-1311
www.ijaems.com Page | 882
Syntheses and Characterizations of Some New
N-alkyl, Isoxazole and Dioxazole Derivatives of
5-Chloroisatin
Z. Tribak1
, M.K. Skalli1*
, O. Senhaji2
, Y. Kandri. Rodi1
1
Laboratory of Applied Chemistry, Sidi Mohamed Ben Abdellah University, Faculty of Sciences and Technology of Fez,
Morocco.
2
Laboratory of Applied Physical Chemistry, Moulay Ismaïl University, Faculty of Sciences and Technology of Errachidia,
Morocco.
Abstract— N-alkyl and cycloadducts derivatives of 5-
Chloroisatin were synthesized in good to excellent yields.
The method evidences a selective N-alkylation when using
1,2-bis (2-chloroethoxy) ethane as efficient spacer at
room temperature on the 5-Chloroisatin moiety. A
general method for the 1,3-dipolar cycloaddition of 4-
Chlorobenzaldoxime to alkynes provides a useful
alternative route to get newisoxazole et dioxazole
derivatives.
Keywords— 1, 3-dipolar cycloaddition, 4-
Chlorobenzaldoxime, N-alkylation, 1
H NMR, 13
C NMR.
I. INTRODUCTION
The interest for the synthesis of the isatin derivatives has
increased in organic and pharmaceutical chemistry. In
1988 the isatin is isolated and reported to possess a wide
range of activities involving the central nervous system as
an endogenous compound [1-3]. This heterocyclic system
is found in a number of molecules possessing biological
and pharmacological properties. The usage of some isatin
derivatives for antibacterial, antimalarial, anti-
proliferative and anti-coagulant [4-9], antimicrobial,
anticonvulsative, anticancer, antiHIV, etc. activities and
also antifungal, herbicidal agents [10-17].Many other
remarkable applications are reported in the literature, such
as the selective inhibition of corrosion in mild steel by 5-
chloro-1-(2-(dimethylamino)ethyl)indoline-2,3-dione and
5-chloro-1-octylindoline-2,3-dione[18, 19]. These 5-
Chloroisatin derivatives were synthesized using N-
alkylation reaction under catalysis by phase transfer [20-
23].
Tribak et al. have been prepared new 5-Chloroisatin
derivatives such as 5-chloro-1- ((3-(4-chlorophenyl) -4,5-
dihydroisoxazol-5-yl) methyl) indoline-2,3-dione and 5-
chloro-3'- (4-chlorophenyl) -1- ((3- (4-chlorophenyl) -4,5-
dihydroisoxazol-5-yl) methyl) spiro [indoline-3,5'- [1,4,2]
dioxazol]- 2-one that would carry medicinal properties of
mainly as antibacterial against two bacteria Gram+ and
two other bacteria Gram- [24, 25]. These derivatives have
also been synthesized by 1.3-dipolar cycloaddition
between nitrile oxydes and N-alkylchloroisatin using
Sodium hypochlorite [26].Therefore, as part of our
ongoing study, we report herein the synthesis, and
characterization of new N-alkylchloroisatin by N-
alkylation method and also new isoxazole and dioxazole
compounds formed from the condensation of 4-
Chlorobenzaldoxime with 5-chloro-1-(prop-2-yn-1-yl)
indoline-2,3-dione.
II. EXPERIMENTAL DETAILS
All chemicals were purchased from sigma - Aldrich and
used as such. Solvents hexane, methanol and CHCl3 (AR
grade) were used without further purification.
The reactions were monitored by thin-layer
chromatography (TLC) analysis by using silica gel (60
F254) plates. Compounds were visualized by UV
irradiation at 256 or 365 nm. Flash column
chromatography was performed on silica gel 60 (230–400
mesh, 0.040–0.063 mm). Melting points (m.p.[°C]) were
taken on samples in open capillary tubes and are not
corrected
1
H and 13
C NMR spectra were recorded with a Bruker
spectrometer at 300 and 75 MHz respectively. Chemical
shifts are given in parts per million (ppm) from
tetramethylsilane (TMS) as internal standard in CDCl3,
and the residual peak of DMSO in [D6] DMSO. The
following abbreviations are used for the 1
H NMR spectra
multiplicities: br. s: broad singlet, s: singlet, d: doublet, t:
triplet, q: quartet, qt: quintuplet, m: multiplet. Coupling
constants (J) are reported in Hertz [Hz].
2.1. Preparation of the compound (1a):
To a solution of (0.4 g, 2.20 mmol) 5-chloro-1H-indole-
2,3-dione in 20 ml of DMF, 0.5 g, 3.3 mmol of K2CO3
and 0.1 g , 0.3 mmol of tetran-butyl ammonium bromide
(BTBA), 0.20 mL (1.32 mmol) of 1,2-bis (2-
chloroethoxy) ethane is added dropwise.
2. International Journal of Advanced Engineering, Management and Science (IJAEMS) [Vol-3, Issue-8, Aug- 2017]
https://dx.doi.org/10.24001/ijaems.3.8.11 ISSN: 2454-1311
www.ijaems.com Page | 883
The reaction was refluxed with DMF for 48 hours. After
removal of the salts by filtration, the DMF is evaporated
under reduced pressure and the residue obtained is
dissolved in dichloromethane, the mixture obtained is
chromatographed on a silica gel column (eluent: ethyl
acetate / Hexane (4/1)). The reaction allowed the solid 22
to be isolated
1-(2-(2-(2-chloroethoxy)ethoxy)ethyl)-5chloroindoline-
2,3-dione (1a):Yield: 88% ; mp: 90-120; Rf= 0.85;
(eluent Ethyl acetate / hexane (4: 1)). 1
H NMR (CDCl3 ;
300MHz) : δ (ppm) 7.49-7.52 (m, 2H, HAr,) ; 7.05 (d, H,
HAr,3
JH-H =6Hz, ); 3.91 (t, 2H, CH2, 3
JH-H = 6Hz, 4
JH-H
=3Hz,) ; 3.75(t, 2H, CH2, 3
JH-H = 6Hz, 4
JH-H =3Hz) ; 3.67
(t, 2H, CH2, 3
JH-H = 6Hz, 4
JH-H =3Hz) ; 3.59(m, 4H, CH2,);
3.21(t, 3H, CH3, 3
JH-H = 6Hz, 4
JH-H =3Hz). 13
C NMR
(CDCl3; 75MHz): δ (ppm) 183.11 (C=O); 167.00 (N-
C=O); 143.67, 130.74, 119.51 (Cq); 134.98, 130.32,
123.75 (CHAr); 71.38, 63.11, 40.85, 20.92 (CH2).
2.2.General procedures for cycloaddition of N-
propargylchloroisatin with nitrile oxide:
0.2 g of 5-chloro-1-(prop-2-yn-1-yl)indoline-2,3-dione
and (0.17 g, 1.079 mmol) of 4-Chlorobenzaldoxime were
dissolved in 12 mL of chloroform (CHCl3) when the
mixture reaches 0°C, 4 mL of bleach (NaOCl ) was
introducted and then allowed to stir for 4 hours. The
resulting compound purified and recrystallized from
ethanol.
5-chloro-1-((3-(4-chlorophenyl)isoxazol-5-
yl)methyl)indoline-2,3-dione (1b): Yield : 77%; mp :
194-197 ; Rf= 0.77; (eluent Ethyl acetate / hexane (6: 1)).
1
H NMR (CDCl3) δppm 7.71-7.81(m, 2H, HAr); 7.57 (d,
H, HAr,J=8.4Hz); 6.97-7.04 (m, 4H, HAr); 6.55 (s, H,
CH) ;3.87 (m, H, CH2). 13
C NMR (CDCl3) δppm: 185.86
(C=O) 160.64 (N-C=O); 163.18, 157.88, 147.07, 134.14,
131.17, 130.95, 118.02(Cq)134.56, 130.11, 129.26,
128.62, 123.96 (CHAr) ; 105.51 (CH); 50.60 (CH2)
5-chloro-3'-(4-chlorophenyl)-1-((3-(4-chlorophenyl)
isoxazol-5-yl)methyl)spiro[indoline-3,5'[1,4,2]dioxazol]-
2-one (2b):Yield: 65%, mp: 197-199; Rf= 0.75; (eluent
Ethyl acetate /hexane (5: 1)). 1
H NMR (CDCl3) δppm
7.80 (d, 2H, HAr, J=9Hz); 7.73 (d, 2H, HAr, J=8.4Hz);
7.56 (d, H, HAr, J=1.8Hz); 7.48-7.46 (m, 5H, HAr); 7.05
(d, H, HAr, J=8.4Hz); 6.59 (s, H, CH); 5.05 (s, 2H, CH2).
13
C NMR (CDCl3) δppm: 168.12 (NC=O); 166.03, 162
(C=N); 141.45, 138.63, 136.51, 130.20, 126.77, 122.62,
120.05 (Cq); 133.39, 128.52, 128.10, 126.65, 111.11
(CHAr); 101.60 (CH); 35.71 (CH2).
III. RESULTS AND DISCUSSION
Based on the interest of our research group in the
synthesis of new heterocycles [27], we studied the
condensation of 5-chloroisatin with 1,2-bis (2-
chloroethoxy) ethane under the conditions of liquid/solid
phase transfer catalysis in DMF as solvent and potassium
bicarbonate as a weak base at 80°C allowed us to isolate
compound5-chloro-1-(2-(2-(2
chloroethoxy)ethoxy)ethyl)indoline-2,3-dione (scheme1 )
Scheme 1
The 1,3-dipolar cyloaddition reaction of nitrile oxide,
prepared in situ by the action of bleach on 4-
Chlorobenzaldoxime, with 5-chloro-1-(prop-2-yn-1-
yl)indoline-2,3-dione in a biphasic medium
(water/ethanol) at 0°C for 4 hours. It leads in each case to
the formation of the two cycloadducts resulting from the
1.3-dipolar cycloaddition on the dipolarophile group C-O
in position 3 and the propargyl group in position 1.
Scheme 2
3. International Journal of Advanced Engineering, Management and Science (IJAEMS) [Vol-3, Issue-8, Aug- 2017]
https://dx.doi.org/10.24001/ijaems.3.8.11 ISSN: 2454-1311
www.ijaems.com Page | 884
IV. CONCLUSION
In conclusion, we have developed an efficient synthetic
method for the selective N-alkylation of 5-Chloroisatin
using an easily available mild base K2CO3 by the action
of 1,2-bis (2-chloroethoxy) ethane. Subsequently, an easy
and general 1.3-dipolar cycloaddition method has also
been demonstrated using nitrieoxyde at 0°C temperature
with 5-chloro-1-(prop-2-yn-1-yl)indoline-2,3-dioneas
dipolarophile allows getting new cycloadducts containing
the two nuclei isoxazole and dioxazole. Their structures
has been identified by the usual spectroscopy.
ACKNOWLEDGEMENTS
The authors would like to thank all the people who helped
to carry out this work such as 1
H NMR, 13
C NMR.
REFERENCES
[1] Tribak, Z.; Skalli, M. K.; Senhaji, O. ;KandriRodi.
Y. ; DFT Study and Synthesis of New 1, 2, 3-
triazoles Obtained by 1, 3-Dipolar Cycloaddition
Derived from 5-chloro-1-(prop-2-yn-1-yl)indoline-2,
3-dione. Int.J.Sci. Res, 2017,6, 1069-1074.
[2] Tribak Z.; Ghibate, R.; Skalli M. K.; KandriRodi,
Y.; Senhaji, O.; Experimental and Theoretical
Study for Corrosion Inhibition in 1M HCl Solution
by New 5-Chloroisatin Derivative Inter. J. Sci. Tech.
Eng.2016, 3,257- 262.
[3] Tribak, Z.;Haoudi, A.; KandriRodi, Y.; Elmsellem,
H.; Skalli, M. K.; Ouzidan, Y.; Mazzah, A.; Essassi,
E.M.; Synthesis and reactivity of new heterocyclic
systems derived from 5-chloro-1H-indole-2,3-dione.
Mor. J. Chem. 2016, 4(4), 1157-1163
[4] Misra, R.N. Rawlins, D.B. Xiao, H. Shan, W.
Bursuker, I. Kellar, K.A. Mulheron, J.G. Sack, J.S.
Tokarski, J.S. Kimball, S.D. Webster, K.R. 1H-
Pyrazolo[3,4-b]pyridine inhibitors of cyclin-
dependent kinases, Bioorg. Med. Chem. Lett. 2003,
13, 1133-1136.
[5] Srivastava A, Pandeya SN: “Indole” a versatile
nucleus in the pharmaceutical field. Int J Curr
Pharm Rev Res,2011, 1, 1–17.
[6] Meijer, L. Flajolet, M. Greengard, P.
Pharmacological inhibitors of glycogen synthase
kinase 3, Trends in Pharm. Sci. 2004, 25, 471-480.
[7] Foks, H. Pancechowska-Ksepko, D..Kvdzia, A
Zwolska, Z. Janowiec, M. Augustynowicz-Kopec,
E. Synthesis and antibacterial activity of 1H-
pyrazolo[3,4-b]pyrazine and -pyridine derivatives, Il
Farmaco 60 (2005) 513-517.
[8] Goda, F.E. Abdel-Aziz, A.A.M. Attef, O.A.
Synthesis, antimicrobial activity andconformational
analysis of novel substituted pyridines: BF3-
promoted reaction ofhydrazine with 2-alkoxy
pyridines, Bioorg. Med. Chem. 2004, 12, 1845-
1852.
[9] Kundariya, D.S. Bheshdadia, B.M. .Joshi, N.K.
Patel, P.K. Synthesis, characterization and
pharmacological evaluation of some novel Schiff
bases containing 1H-pyrazolo[3,4-b]pyridine
moiety, Int. J. Chem. Tech. Res. 2011, 3, 238-243.
[10]Kini, S.; Swain, S.; Gandhi, A. Synthesis and
Evaluation of novel BenzothiazoleDerivatesagainst
Human Cervical Cancer cell lines. Ind. J. Pharm.
Sci. 2007, 46–50.
[11]Wang, M.; Gao, M.; Mock, B.; Miller, K; Sledge,
G.; Hutchins, G.; Zheng, Q Synthesis of C-11
labelled fluorinated 2-arylbenzothiazoles as novel
potential PET cancer imaging agent. Bioorg. Med.
Chem.2006, 14, 8599–8607.
[12]Pakravan, P., Kashanian S., Khodaei, M.M.,
Harding, F.J.; Biochemical and pharmacological
characterization of isatin and its derivatives: from
structure to activity, Pharmacol. Rep, 2013; 65(2),
313-335.
[13]Sriram, D., Bal, T.R., Yogeeswari, P., Synthesis,
antiviral and antibacterial activities of isatinmannich
bases, Med. Chem. Res, 2005; 14(4), 211- 228.
[14]Mondal, P., Banerjee, M., Jana, S., Bose, A.,
Synthesis and evaluation of 1,3 Di-substituted
schiff, mannich bases and spiroisatin derivatives, J.
Young Pharm, 2010; 2(2), 169-172.
[15]Wakchaure, N.D., Shejwal, S.S., Deshmukh, V.K,
Chaudhari, S.R, Review on Common Methods to
Synthesize Substituted1H-Indole-2, 3-Dione (Isatin)
Derivatives and Their Medicinal Significance,
American J. PharmTech Res2012; 2(4): 288-310.
[16]Malawska, B., New Anticonvulsant Agents, Curr.
Top. Med. Chem, 2005; 5(1): 69-85.
[17]Pandeya, S.N, Sriram, D., Yogeeswari, P., Stables,
J.P., Anticonvulsant and neurotoxicity evaluation of
5-(un)-substituted isatinimino derivatives,
Pharmazie, 2001; 56(11), 875-876
[18]Tribak, Z.; Haoudi, A.; Skalli, M.K.; KandriRodi,
Y.; El Azzouzi, M.; Aouniti, A.; Hammouti, B.
Senhaji, O. 5-Chloro-1H-indole-2,3-dione derivative
as corrosion inhibitor for mild steel in 1M H3PO4:
weight loss, electrochemical and SEM studies.J.
Mater. Environ.Sci. 2017, 8 (1), 298-309.
[19]Tribak, Z.;KandriRodi, Y.; Elmsellem, H.; Abdel-
Rahman, I.; Haoudi, A.; Skalli, M. K..; Kadmi, Y.;
Hammouti, B.; Ali Shariati, M.; Essassi, E. M. 5-
chloro-1-octylindoline-2,3-dione as a new corrosion
inhibitor for mild steel in hydrochloric acid solution
J. Mater. Environ. Sci.2017, 8 (3) 1116-1127.
[20]Tribak,Zineb.; KandriRodi, Youssef.; Haoudi,
Amal.; Essassi, El Mokhtar.; Capet Frédéric.;
4. International Journal of Advanced Engineering, Management and Science (IJAEMS) [Vol-3, Issue-8, Aug- 2017]
https://dx.doi.org/10.24001/ijaems.3.8.11 ISSN: 2454-1311
www.ijaems.com Page | 885
Zouihri, Hafid1-Benzyl-5-chloroindoline-2,3-dione.
IUCrData. 2016, 1(6) 1, x160854.
[21]Tribak,Zineb.; KandriRodi, Youssef.; Haoudi,
Amal.; Essassi, El Mokhtar.; Capet Frédéric.;
Zouihri, Hafid,1-(12-Bromododecyl)-5-
chloroindoline-2,3-dione. IUCrData1(6) (2016). 1,
x160971.
[22]Tribak,Zineb. ; KandriRodi, Youssef. ; Haoudi,
Amal.;Essassi, El Mokhtar. ; Capet Frédéric.;
Zouihri, Hafid, 1-Allyl-5-chloroindoline-2,3-
dione.IUCrData.2016, 1(6), 1, x160862.
[23]Tribak,Zineb. ; KandriRodi, Youssef. ; Haoudi,
Amal.;Essassi, El Mokhtar. ; Capet Frédéric.;
Zouihri, Hafid, 5-Chloro-1-methylindoline-2,3-
dione, IUCrData. 2016, 1(6), 1, x160913
[24]Tribak, Z. El Amin, O. Skalli, M.K. Senhaji, O.
Kandri. Rodi, Y. Houssaini. Iraqui, M. N-alkylation
methods, Characterization and Evaluation of
antibacterial activity of some Novel 5-Chloroisatin
Derivatives Int. J. Eng Res Appl..2017, 7(6)21-24
[25]Tribak, Z.; El Amin, O.; Skalli, M.K.; Senhaji, O. ;
Kandri. Rodi, Y.; Houssaini. Iraqui, M. ; Synthesis,
Characterization, and Antibacterial Activity of Some
Novel 5-Chloroisatin Derivatives Int. J. Eng Res
Appl. 2017, 7(6), 66-70.
[26]Tribak, Z. ; KandriRodi, Y.; Haoudi, A.; Skalli,
M.K.; Mazzah, A. ; Akhazzane, M. ; Essassi, E.M. ;
Cycloaddition 1,3-dipolaire des dérives de la 5-
chloro-1H-indole-2,3 dione: vers de nouvelles
isoxazolines et spirodioxazolines J. Mar. Chim.
Heterocycl, 2016, 16(1), 58-65.
[27]Tribak, Z. Ghibate, R. Skalli, M.K. KandriRodi, Y.
Mrani, D. Aouniti, A. Hammouti, B. Senhaji, O
Synthesis and Characterization of a New Cationic
Surfactant Derived from 5-Chloro-1H-indole-2,3-
dione In Aqueous Systems, Int. J. Eng Res Appl.
2017, 7 (4), 04-08.