1. An infarct is a localized area of ischemic necrosis that occurs in a tissue or organ due to impaired arterial blood supply or venous drainage. 2. Causes of infarcts include occlusion of arteries or veins from thrombosis, embolism, atherosclerotic plaques, or external compression, as well as spasm of arterioles. 3. There are three main types of infarcts: white (anemic) infarcts caused by arterial occlusion in organs with few collaterals; red (hemorrhagic) infarcts caused by arterial or venous occlusion in loose tissues; and septic infarcts caused by bacteria-containing emboli.

1. Pre by lect : MR ZAHID REHMAN
IPMS(KMU)

2. The formation of a localizad area of ischemic
necrosis within a tissue or organ due to impaired
arterial supply or the venous drainage
The necrosis area is called “infarct”.
An extremely important cause of clinical illness:
…myocardiac infarction
…cerebral infarction

3. Ischemia necrosis of the extremities
(gangrene) is a serous problum in the
diabetec population.
Causes
 Occlusion of arterial supply or venous drainage
Thrombosis, embolism, athermanous
plaques, external compression
 Functional spasm of arteriole
 Traumatic rupture of the artery

4. Types
 White infarcts (anemic infarcts)
 Red infarcts (hemorrhagic infarcts)
 Septic infarcts

5. White infarction
 Arterial occlusion
 Solid, compact organs
 Few collateral circulation
 (spleen, kidney, heart, brain, etc.)
Morphology
Gross
• Dull pale, dry, wedge-shaped necrotic lesion
• A hemorrhagic zone surrounding

6. Spleen infarction

7. Brain infarction (liquefied necrosis)

8. Red infarction
♦ Arterial occlusion
♦ Venous occlusion
♦ Loose tissue
♦ Dual circulations: lung , small intestine

9. Hemorrhagic infarction of the lung
Gross Roughly wedged shaped
Dark red, solid area
Base beneath the pleura Fibrin exudation
LM Coagulative necrosis
Large amounts of RBC filled in alveolar space

10. Hemorrhagic infarction of the intestine

11. Septic Infarction
 Bacteria containing emboli
 May form abscess and pus

12. Factors that influence development of an
infarct
 Nature of the vascular supply
 Rate of development of occlusion
 Vulnerability to hypoxia
 Oxygen content of blood

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