1) Infarction refers to the death of cells in a tissue due to an inadequate blood supply. 2) There are two main types of infarction - red and white - which are distinguished by their color and the type of tissue affected. 3) The development and severity of an infarction depends on factors like the anatomy of a tissue's blood supply, how quickly the blood flow is blocked, and the tissue's vulnerability to low oxygen levels.

1. INFARCTION
BY
DR. YASIR SHABBIR
PATHOLOGY DEPARTMENT

2. Area of Ischemic Necrosis
Pulmonary
Bowel
Extremities Gangrene DM
INFARCTION

3. • Vasospasm
• Haemhrrage
• Tumor
• Edema ANT. Compartment Syndrome
• Venous Thrombosis Testies + Ovaries
CAUSES

4. Red Infarct
• Venous Occulsion
• Lung Intestine
• Spongy Tissue
• Dual Circulation
• Flow Reestablished at previous arterial occulsion
MORPHOLOGY

5. MORPHOLOGY
• Red Infarct • White Infarct

6. WHITE INFARCT
• Arterial occlusion
• Solid Organs Heart, Spleen, Kidney
• Wedge Shape
• Paller, Necrotic Cells
• Macrophages Hemosidern + Residum

7. • 4-12 Hours
• Acute Inlamation
• Stable or Liable Tissues Parynchymal Regeration
ISCHEMIC COAGULATIVE NECROSIS

8. FACTOR OF INFARCT
• Development
• Anatomy of Vascular Supply
• Rate of Occlusion
• Tissue Vulnerability to hypoxia

9. • Dual Supply Liver Lung
• Single Supply Heart Spleen
ANATOMY OF
VASCULAR SUPPLY

10. RATE OF OCCLUSION
• Slow
• Rapid

11. TISSUE VULNERABILITY TO HYPOXIA
• Neurons 3-4 Min
• Myocardial Cells 20-30 Min 4-12 Hr
• Fibroblast Many Hr