This document contains questions from various units of the Industrial Pharmacy course. The units cover topics like preformulation studies, tablets, capsules, parenteral products, ophthalmic products, cosmetics, pharmaceutical aerosols, and packaging material science. The questions are short answer questions assessing key concepts from each unit, such as the definition of polymorphism, methods for studying solid forms, quality control tests for tablets and capsules, components of the aerosol system, and factors influencing the selection of packaging materials.

1. Industrial Pharmacy – I
(BP502T)
Questioners
By Ankita Burande
Assistant Professor
Nagpur College of Pharmacy Nagpur

2. Unit1: Preformulation Studies
Questions : (10 x 2 = 20 Marks)
 What is Racemization? Give example.
 Write the methods to study of solid forms of a substance
 What is the need of preformulation studies in pharmaceutical product
development?
 Write the differences between crystalline and amorphous forms of solid.
 Define preformulation studies.
 Write the BCS classification of drugs.
 What is preformulation study
 Define bulk density and write its importance in Pharmacy

3. Unit1: Preformulation Studies
Questions : (2 x 10 = 20 Marks)
 (a) Discuss about crystallinity of solid substances. (b) Describe the
chemical reactions involved in degradation of API
 Explain the study of physical characteristics during preformulation
Questions : (7 x 5 = 35 Marks)
 How flow properties of powders are measured?
 Explain polymorphism.
 Write a note on polymorphism and its applications.
 What is BCS classification? Discuss its importance.

4. Unit 2: Tablets
Questions : (10 x 2 = 20 Marks)
 Explain friability test for tablets.
 Explain the importance of enteric coating of tablet.
 Describe the granulation methods for tablet manufacturing.
 Classify tablets and give ideal characteristics of tablets.
 What are the unofficial tests for evaluation of tablets.
 Define Enteric coating and give its advantages.
 Define buccal and sublingual tablets.
 Enlist various types of coating materials of tablets.
 Why coating tablets are required
 Classify tablets.
 What is Orange peel effect in tablet coating

5. Unit 2: Tablets
Questions : (2 x 10 = 20 Marks)
 a) Describe the compression cycle for tablet manufacturing. (b) Explain in
process quality control tests for tablet compression.
 (a) Explain perforated coating pans. (b) Write a brief note on filing of
capsules.
 Enlist the excipients used in tablet manufacture with examples. Write their
role and mechanism of action.
 Explain quality control tests of tablets.
 (a) Explain about disintegration and dissolution test for tablets. (b) Write in
detail about evaluation of containers

6. Unit 2: Tablets
Questions : (7 x 5 = 35 Marks)
 Discuss the steps involved in sugar coating of tablets
 Discuss the tablet additives with examples of each class.
 Explain about hardness and friability testing of tablets.
 Write a brief note on manufacturing defects in tablet coating.
 Explain weight variation test and content uniformity test for capsules
 Explain sugar coating of tablets.
 Explain defects in tablet coating

7. Unit 2: Liquid Orals
Questions : (10 x 2 = 20 Marks)
 What are the tests used for detecting type of emulsion
 Give formulation of suspension
 Define emulsion & suspension
Questions : (7 x 5 = 35 Marks)
 Describe the evaluation of liquid orals as per pharmacopoeia
 Write the differences between flocculated and deflocculated
suspensions.
 Discuss the method for preparation of emulsion.
 Explain formulation considerations of liquid dosage forms.
 Write a brief note on filling and packaging of oral liquids.

8. Unit 3: Capsules
Questions : (10 x 2 = 20 Marks)
 Write the differences between type A and type B gelatin
 Outline the steps of manufacturing of hard gelatin capsule SHELL
 Write a note on sizes of hard gelatin capsules
 Mention different sealing methods for hard gelatin capsules
 Define Base adsorption
Questions : (2 x 10 = 20 Marks)
 Explain in detail about manufacturing of hard gelatin capsules and soft gelatin capsules.
 (a) Explain perforated coating pans. (b) Write a brief note on filing of capsules.
 Explain the formulation and quantity control tests for hard gelatin or soft gelatin
capsules
 (a) Write in brief about the manufacture of Aerosols. (b) Explain about the defects in
capsules.

9. Unit 3: Capsules
Questions : (7 x 5 = 35 Marks)
 Describe the manufacturing defects of hard gelatin capsules
 Explain weight variation test and content uniformity test for capsules.
 Explain method of preparation of hard gelatin capsule shell.
 Describe the manufacturing of soft gelatin capsules.

10. Unit 3: Pellets
Questions : (10 x 2 = 20 Marks)
 Write the advantages of pellets.
 Enlist the pelletization techniques
 What are pellets? Give advantages of pellets
Questions : (7 x 5 = 35 Marks)
 Explain in detail about extrusion-spheronization technique
 Enlist techniques of pelletization. Explain advantages of pallets over
conventional dosage forms.
 Write a note on palletization process.
 Write in detail about solution layering.
 Explain powder and liquid layering methods for pelletization, with a note
on equipment used for the same.

11. Unit 4: Parenteral products
Questions : (10 x 2 = 20 Marks)
 Explain the concept of aseptic processing
 Plastic bottles are preferred over glass bottles for saline. Justify.
 Write the type of glass with their uses for pharmaceutical products
 What is isotonicity? Explain its importance for parenteral products.
 Write the principle involved in LAL test for injectables
 What are Tonicity modifiers
 Write the significance of isotonicity in parenterals
 What are the vehicles used in the preparation of parenterals?
 Classify parenteral with suitable examples.
 What are pyrogens?
 What is aseptic area?
 What are the vehicles used in the preparation of parenterals.
 Classify parenteral with suitable example

12. Unit 4: Parenteral products
Questions : (2 x 10 = 20 Marks)
 (a) Describe sterility test procedures as per official books. (b) Discuss formulation considerations for
ophthalmic products.
 (a) Explain pyrogen test for parenterals. (b) Discuss about the formulation of pharmaceutical aerosols.
 Write a note on production facilities required for parenteral preparations.
 Give the layout for manufacture of parenteral formulations
 Explain formulation and the production of parenterals.
Questions : (7 x 5 = 35 Marks)
 Elaborate the parenteral additives with their examples.
 What are pyrogens? Discuss the pyrogen test for injectables.
 Elaborate water attack test USP and powder glass test USP for packaging glass.
 Discuss quality control of parenteral products.
 Write a note on LAL test & sterility test.
 Explain the process of freeze drying.
 Write a note on injectable suspensions

13. Unit 4: Ophthalmic Products
Questions : (10 x 2 = 20 Marks)
 What are the special instructions to be printed on the eye drop container
according to drugs and cosmetics act.
Questions. (2 x 10 = 20 Marks)
 (a) Describe sterility test procedures as per official books. (b) Discuss
formulation considerations for ophthalmic products.
Questions. (7 x 5 = 35 Marks)
 Explain Draize eye test for opthalmics.
 Explain sterility test for ophthalmic products.
 Write a note on formulation & lebelling of eye drops
 Explain quality control tests of eye ointment
 ite a note on formulation & lebelling of eye drops

14. Unit 5: Cosmetics:
Questions. (10 x 2 = 20 Marks)
 Define cosmetics and give classification of cosmetics with examples
 List out various ingredients used in tooth paste.
 List out various ingredients used in tooth paste
 What is the difference between cold cream & Vanishing cream.
 How sunscreen products help to protect skin against UV radiation?
Questions. (2 x 10 = 20 Marks)
 a) Elucidate the manufacturing of lipstick. (b) What are the possible interactions
between content and packaging material.
Questions. (7 x 5 = 35 Marks)
 Discuss the manufacturing, and uses of cold cream and vanishing cream
 Describe ingredients for toothpaste manufacturing
 Write the formulation of cold cream.
 Write a note on formulation of hair dyes.

15. Unit 5: Pharmaceutical Aerosols:
Questions. (10 x 2 = 20 Marks)
 Illustrate the components of aerosol system with the help of neat diagram.
 Define Propellant.
 What are different types of aerosols?
Questions. (2 x 10 = 20 Marks)
 (a) Describe the components of aerosol system with the help of a neat diagram. (b)
Discuss the types of aerosol system.
 a) Explain pyrogen test for parenterals. (b) Discuss about the formulation of
pharmaceutical aerosols.
 (a) Write in brief about the manufacture of Aerosols. (b) Explain about the defects
in capsules.
 Explain the formulation and evaluation of aerosols.
Questions. (7 x 5 = 35 Marks)
 Write a brief note on propellants in Aerosols

16. Unit 5: Packaging Material Science
Questions. (10 x 2 = 20 Marks)
 Write the type of glass with their uses for pharmaceutical products
 What are the different materials used for packaging?
Questions. (2 x 10 = 20 Marks)
 a) Elucidate the manufacturing of lipstick. (b) What are the possible interactions
between content and packaging material
Questions. (7 x 5 = 35 Marks)
 Explain the criteria for selection of packaging materials.
 Explain the factors affecting selection of pharmaceutical packaging materials.
 Write a note on factors influencing choice of containers