This document contains 16 questions regarding various aspects of pharmaceutical dosage forms and tablet manufacturing processes. It asks about different types of tablets classified by route of administration and use, as well as the manufacturing process for uncoated tablets. It also inquires about terms related to tablet characterization and their effects on bioavailability. Further questions address topics like solubility, powder flowability, advantages of tablets over capsules, challenges of liquid dosage forms, powder characterization, granulation, factors for regulatory approval of dosage forms, uses of gelatin capsules, challenges of multiple solid forms, reasons for granulation and milling, how particle size and shape affect tablets, how bulk density affects tablets, measuring bulk density, granule manufacture methods, and the manufacture

1. MaranyanneMoupanaga{Pharmacist}
We learn more by looking for the answer to a question and not finding it than we do from
learning the answer itself.”Lloyd Alexander
As a Pharmaceutics Dosage Form Designer, study the manufacturing formula and answer the
following questions in details:
QUESTION ONE (110) MARKS
There are different types and Classes of Tablets that have been identified.in each type and
class, Please give five{5} examples of used drugs in each class(100)marks
Clearly describe the manufacturing process of uncoated tablets. (10)
1.ORAL TABLETS FOR INGESTION
Compressed tablets or standard compressed tablets
Multiple compressed tablets
-Layered tablets
-Compression coated tablets
Repeat-action tablets
Delayed-action and enteric 5.coated tablets
Sugar and chocolate coated tables
Film-coated tablets
Chewable tablets
2. TABLETS USED IN ORAL CAVITIES
Buccal tablets
Sublingual tablets
Troches and lozenges
Dental cones
3. TABLETS ADMINISTERED BY OTHER ROUTES
Implantation tablets
Vaginal tablets
Rectal tablets
4. TABLETS USED TO PREPARE SOLUTIONS

2. MaranyanneMoupanaga{Pharmacist}
Effervescent tablets
Dispensing tablets
Hypodermic tablets
Tablet triturates
QUESTION TWO{70}
Explain the following terms used in tablet characterisation and, for each, indicate briefly its
effect in drug bioavailability. {10} each
uniformity of weight
Assay
Limit of foreign substances
Dissolution
Hardness
Disintegration
friability
QUESTION 2
Define “Solubility”. (4)
Among factors that affect Solubility, Temperature is a significant factor. Describe in full how it
affects solubility, giving examples where possible. (15)
How does particle size affect Solubility? (6)
QUESTION 3
What factors affect powder flowability? For the given factors, how can they be adjusted in
order to improve flowability? (4,4)
QUESTION 5
What are the advantages and disadvantages of using a tablet over a capsule.{15}

3. MaranyanneMoupanaga{Pharmacist}
QUESTION 6
Liquid oral dosage form vs tablet,what are the shortcomings and limitations on liquid dosage
form over tablets?(10)
QUESTION 7 20 Marks
Explain the following terms used in powder characterization and, for each, indicate
briefly its effect in drug bioavailability.
(a) Particle size (6)
(b) Surface area (3)
(c) Crystal form (4)
(d) Polymorphism (7)
QUESTION 8 20 Marks
In tablet manufacture, what is “granulation”? (5)
Describe the granulation properties that affect tablet quality. (15)
QUESTION 10 20 Marks
A National Drug Regulatory Authority has to decide between a 2-colour capsule, a plain
capsule and a sugar coated tablet as the dosage form of an essential medicine. Advise on
what factors the Authority needs to take into account in their decision making process.
QUESTION 11{15}

4. MaranyanneMoupanaga{Pharmacist}
What is the value, to the pharmaceutical dosage form designer, of studying multiple solid
forms?
Describe in full the use of Gelatin Capsules in pharmaceutical industry.
Explain the process of manufacture of Gelatin Capsules.
QUESTION 12{5}
What are the challenges of ‘multiple solid forms’ in dosage design?
QUESTION 13{20}
In tablet manufacture, granulation is a process that increases particle size; milling is a process
that reduces particle size. So, why granulate tablet powders, and then mill the resultant
granules? Use named examples. (14)
Show not more than 3 challenges encountered in tablet compression. (6)
QUESTION 14 {20}
What tablet characteristics does Particle Size and Shape of granules affect? (6)
Bulk density of the granulation affects tablet quality. Describe how . (6)
Describe in detail one method of measuring bulk density of a powder. (8)
QUESTION 15
What 3 established methods are there in granule manufacture? (3)
Describe the advantages and disadvantages of direct compression in tablet manufacture.
QUESTION 16
11. Describe the manufacture of soft gelatin capsules. (20)
…….AND GOOD LUCK!!!!!