The Inca civilization, centered in Cuzco, Peru, was characterized by its mountainous environment, advanced architectural techniques, and unique counting system known as quipu. They practiced terrace farming, had a polytheistic religion focused on nature gods, and were ruled by a powerful emperor, the Sapa Inca, who maintained strict law enforcement. The empire ultimately fell due to smallpox and conquest by Spanish conquistadors led by Francisco Pizarro.