In Vitro Fertilization
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In Vitro Fertilization (IVF) is a process where eggs are fertilized by sperm outside of the body. It involves hormonally controlling a woman's ovulation, removing her eggs and letting sperm fertilize them in a fluid medium. The fertilized egg is then transferred to the woman's uterus. The major steps are ovarian stimulation through injections, egg retrieval using a transvaginal technique, fertilizing the eggs with sperm in a growth medium, and embryo transfer through the vagina and cervix. For IVF to be successful, healthy eggs, sperm, and a uterus capable of maintaining a pregnancy are needed. While IVF can help women who have gone through menopause get pregnant, success rates average
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IVF is a process where eggs are fertilized by sperm outside of the body in a laboratory. It was developed to help couples with infertility issues conceive. The process involves stimulating a woman's ovaries to develop multiple eggs, retrieving the eggs, fertilizing them with sperm, culturing the resulting embryos for 2-6 days, and then transferring one or more embryos into the woman's uterus. The first successful IVF pregnancy resulted in the birth of Louise Brown in 1978. While IVF has helped many couples have children, it does not guarantee pregnancy and may need to be repeated to achieve success.
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This document outlines the objectives, process, complications, and nursing role of in vitro fertilization (IVF). It begins with defining IVF as a procedure where eggs are fertilized by sperm outside of the body. It then lists the objectives of understanding IVF, including its indications, advantages, disadvantages, steps of the process, complications, alternative methods, and the nursing role. The document provides detailed descriptions of the typical multi-step IVF process, from ovarian stimulation to embryo transfer. It also notes potential complications and the nursing responsibilities of providing medical and emotional support throughout treatment.
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This slide has been prepared for educational purpose using various standard medical books. This is prepared by medical student and if any mistakes are there please comment.
ART ( ASSISTED REPRODUCTIVE TECHNOLOGIES).THIS THE ARTIFICIAL REPRODUCTION TE...
This document discusses various Assisted Reproductive Technologies (ART) used to treat infertility, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), and embryo or oocyte donation. The basic principles of IVF and techniques like ICSI, GIFT, and ZIFT are explained in 1-3 sentences each. New techniques aimed at higher success rates like tubal embryo transfer, intrauterine insemination, and intracytoplasmic morphologically selected sperm injection are also outlined briefly.
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The document discusses in vitro fertilization (IVF), a type of assisted reproductive technology used to treat infertility. IVF involves fertilizing an egg outside the body, in vitro, through the mixing of sperm and egg in a laboratory dish, and then transferring the embryo to the uterus. The document outlines the IVF process, including ovarian stimulation, egg retrieval, sperm collection, fertilization in the lab, embryo culture, and embryo transfer. It notes IVF can result in 70-80% of fertilized eggs developing and the first successful IVF birth occurring in 1978. Risks of IVF are also summarized.
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ART involves surgically extracting eggs from a woman's ovaries, fertilizing them with sperm in a lab, and returning the embryos to the woman's body or donating them. There are various causes of infertility that ART can treat, such as blocked fallopian tubes or male factor infertility. Common ART procedures include IVF, where fertilization occurs outside the body, and ICSI, where a single sperm is injected into an egg. IVF involves stimulating a woman's ovaries, retrieving eggs, fertilizing them in vitro, and transferring embryos back into the uterus. ART can have risks like multiple pregnancies or ovarian hyperstimulation. Counseling supports patients through the psychological impacts of infertility and ART.
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In Vitro Fertilization (IVF) involves stimulating a woman's ovaries to develop multiple eggs, retrieving the eggs and fertilizing them with sperm in a lab, then transferring the resulting embryo(s) into the uterus. Key aspects of IVF include controlled ovarian hyperstimulation using fertility medications, egg retrieval under ultrasound guidance, fertilization via intracytoplasmic sperm injection if needed, embryo culture until blastocyst stage, and embryo transfer into the uterus. Success rates of IVF depend on factors like the woman's age, cause of infertility, and embryo quality.
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Assisted reproductive technology (ART) is a medical procedure used to address infertility issues.It involves procedures such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), cryopreservation of gametes or embryos, and/or the use of fertility medication.
Assisted reproductive technology (art)
i. Intrauterine insemination (IUI).
ii. In vitro fertilization and embryo transfer (IVF and ET).
iii. Gamete intra-fallopian transfer (GIFT).
iv. Zygote intra-fallopian transfer (ZIPT).
v. Intra-vaginal culture (IVC).
vi. Cytoplasmic transfer (CT).
Art.
ART involves medical techniques like drug therapy, artificial insemination, and IVF to treat infertility. Key ART procedures include IUI, IVF, ICSI, and surrogacy. The first successful human IVF resulted in Louise Brown's birth in 1978. While ART has helped many conceive, it also presents risks like multiple births, infection, and complications for mother and baby. Ongoing research aims to improve outcomes and access to these important infertility treatments.
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The document summarizes the basic steps in in vitro fertilization (IVF). It begins with pituitary suppression and ovarian hyperstimulation to develop multiple follicles. Mature eggs are then retrieved from the ovaries through transvaginal ultrasound-guided needle aspiration. Sperm is collected and prepared for fertilization through sperm washing. The eggs and sperm are then fertilized through either insemination or intracytoplasmic sperm injection. The fertilized eggs are cultured for 2-6 days until embryo transfer into the uterus. Success rates vary based on factors like maternal age but average live birth rates in the US range from about 30-40% per cycle for women under 35.
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This presentation consist brief introduction about the IVF (In-vitro fertilization) in humans.
There are more than 15 slides which gives you basic study about the history of IVF, causes of IVF, basic steps involved in IVF process, ethical issues and etc.
Hope it will help you and make you easy to understand the IVF.
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This document discusses various medically assisted reproductive technologies used to treat infertility, including intrauterine insemination (IUI), in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), tubal embryo stage transfer (TET), and intracytoplasmic sperm injection (ICSI). It provides details on the general protocols and advantages and disadvantages of each technique. Causes of infertility and negative aspects of assisted reproductive technologies are also addressed.
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Now a days science have a solution for infertlity. this presentation may give you some brief ideas about assisted reproductive techniques.
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IVF is most often recommended when fallopian tubes of woman are blocked or in case when men produce too few sperm.
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Infertility is defined as the failure to conceive after one year of unprotected intercourse. It affects approximately 15-20% of couples. The document defines and discusses the various causes and types of female and male infertility as well as diagnostic tests, medical and surgical treatment options, and assisted reproductive technologies. Advanced technologies like IVF, IUI, and ICSI are discussed as treatment options when other methods are unsuccessful. The nurse's role in supporting infertile couples through counseling, education and reducing stress is also summarized.
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This document provides a historical perspective on in vitro fertilization (IVF) from the 1800s to the 1990s. Some key events include the first attempts at IVF in the late 1800s, advances in hormone research and embryo culture in the early 1900s, and the first successful IVF pregnancy and birth in 1978 by Dr. Robert Edwards and Dr. Patrick Steptoe. The 1980s saw improvements in fertility drugs, ultrasound technology, and the development of techniques like ICSI and cryopreservation. By the 1990s, IVF had become an established treatment for infertility.
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The document discusses Zygote Intrafallopian Transfer (ZIFT), a fertility treatment where eggs are fertilized in vitro and the resulting zygote is then placed in the fallopian tubes. It notes ZIFT is invasive, has a low success rate of about 26%, and involves stimulating a woman's ovaries to produce multiple eggs, selecting the best zygote to implant while others may be frozen or discarded. The document argues ZIFT is morally unacceptable as it removes procreation from marriage, does not respect the sanctity of life, and can involve eugenics in selecting the best embryo.
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Explaination of in-vitro fertilization and it's types with diagrams.
Steps of In-Vitro Fertilization
In vitro fertilization is a multistage procedure for preventing fertility or genetic problems with the conception of a child. The in vitro fertilization is a complex process.IVF is the most effective form of assisted reproductive technology. There are certain steps involved in the process. The best center for in-vitro fertilization is the SCI IVF Centre.
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The document provides information about the natural menstrual cycle and the in vitro fertilization (IVF) process. It describes the hormones involved in a normal cycle and explains that IVF involves extracting eggs from a woman, fertilizing them with sperm in a lab, and then transferring the embryo into the woman's uterus. The summary discusses the six phases of an IVF cycle, including suppressing the natural cycle with medications, stimulating egg production, triggering ovulation, retrieving eggs, transferring embryos, and providing hormonal support after transfer. It also notes some risks and limitations of IVF treatment.
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The document discusses in vitro fertilization (IVF), a type of assisted reproductive technology used to treat infertility. IVF involves fertilizing an egg outside the body, in vitro, through the mixing of sperm and egg in a laboratory dish, and then transferring the embryo to the uterus. The document outlines the IVF process, including ovarian stimulation, egg retrieval, sperm collection, fertilization in the lab, embryo culture, and embryo transfer. It notes IVF can result in 70-80% of fertilized eggs developing and the first successful IVF birth occurring in 1978. Risks of IVF are also summarized.
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ART involves surgically extracting eggs from a woman's ovaries, fertilizing them with sperm in a lab, and returning the embryos to the woman's body or donating them. There are various causes of infertility that ART can treat, such as blocked fallopian tubes or male factor infertility. Common ART procedures include IVF, where fertilization occurs outside the body, and ICSI, where a single sperm is injected into an egg. IVF involves stimulating a woman's ovaries, retrieving eggs, fertilizing them in vitro, and transferring embryos back into the uterus. ART can have risks like multiple pregnancies or ovarian hyperstimulation. Counseling supports patients through the psychological impacts of infertility and ART.
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In Vitro Fertilization (IVF) involves stimulating a woman's ovaries to develop multiple eggs, retrieving the eggs and fertilizing them with sperm in a lab, then transferring the resulting embryo(s) into the uterus. Key aspects of IVF include controlled ovarian hyperstimulation using fertility medications, egg retrieval under ultrasound guidance, fertilization via intracytoplasmic sperm injection if needed, embryo culture until blastocyst stage, and embryo transfer into the uterus. Success rates of IVF depend on factors like the woman's age, cause of infertility, and embryo quality.
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This document discusses various assisted reproductive techniques (ART) used to treat infertility. It begins by defining ART and infertility. It then describes techniques like artificial insemination (IUI, ICI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), and surrogacy. For each technique, it provides details on the procedure, indications for use, and success rates. It concludes by discussing some risks associated with IVF and ICSI, like prematurity, low birth weight, and possible genetic or epigenetic abnormalities in offspring.
Embryo transfer
Embryo transfer is a step in assisted reproduction where embryos are placed in the uterus to establish a pregnancy. There are two types of embryo transfer - fresh and frozen. For frozen transfers, the uterus is prepared with estrogen and progesterone to make it receptive. During the procedure, a catheter is used to insert embryos through the cervix under ultrasound guidance. Patients then wait two weeks before a blood test checks for human chorionic gonadotropin, which would confirm a pregnancy.
ASSISTED REPRODUCTIVE TECHNOLOGY
Assisted reproductive technology (ART) is a medical procedure used to address infertility issues.It involves procedures such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), cryopreservation of gametes or embryos, and/or the use of fertility medication.
Assisted reproductive technology (art)
i. Intrauterine insemination (IUI).
ii. In vitro fertilization and embryo transfer (IVF and ET).
iii. Gamete intra-fallopian transfer (GIFT).
iv. Zygote intra-fallopian transfer (ZIPT).
v. Intra-vaginal culture (IVC).
vi. Cytoplasmic transfer (CT).
Art.
ART involves medical techniques like drug therapy, artificial insemination, and IVF to treat infertility. Key ART procedures include IUI, IVF, ICSI, and surrogacy. The first successful human IVF resulted in Louise Brown's birth in 1978. While ART has helped many conceive, it also presents risks like multiple births, infection, and complications for mother and baby. Ongoing research aims to improve outcomes and access to these important infertility treatments.
Reproductive technology
Summarizes animal/livestock reproductive technologies including artificial insemination, estrus synchronization, and cloning.
BASIC STEPS IN IN VITRO FERTILIZATION (IVF)
The document summarizes the basic steps in in vitro fertilization (IVF). It begins with pituitary suppression and ovarian hyperstimulation to develop multiple follicles. Mature eggs are then retrieved from the ovaries through transvaginal ultrasound-guided needle aspiration. Sperm is collected and prepared for fertilization through sperm washing. The eggs and sperm are then fertilized through either insemination or intracytoplasmic sperm injection. The fertilized eggs are cultured for 2-6 days until embryo transfer into the uterus. Success rates vary based on factors like maternal age but average live birth rates in the US range from about 30-40% per cycle for women under 35.
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This presentation consist brief introduction about the IVF (In-vitro fertilization) in humans.
There are more than 15 slides which gives you basic study about the history of IVF, causes of IVF, basic steps involved in IVF process, ethical issues and etc.
Hope it will help you and make you easy to understand the IVF.
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This document discusses various medically assisted reproductive technologies used to treat infertility, including intrauterine insemination (IUI), in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), tubal embryo stage transfer (TET), and intracytoplasmic sperm injection (ICSI). It provides details on the general protocols and advantages and disadvantages of each technique. Causes of infertility and negative aspects of assisted reproductive technologies are also addressed.
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Now a days science have a solution for infertlity. this presentation may give you some brief ideas about assisted reproductive techniques.
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IVF is most often recommended when fallopian tubes of woman are blocked or in case when men produce too few sperm.
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Historic perspective of ivf
This document provides a historical perspective on in vitro fertilization (IVF) from the 1800s to the 1990s. Some key events include the first attempts at IVF in the late 1800s, advances in hormone research and embryo culture in the early 1900s, and the first successful IVF pregnancy and birth in 1978 by Dr. Robert Edwards and Dr. Patrick Steptoe. The 1980s saw improvements in fertility drugs, ultrasound technology, and the development of techniques like ICSI and cryopreservation. By the 1990s, IVF had become an established treatment for infertility.
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The document discusses Zygote Intrafallopian Transfer (ZIFT), a fertility treatment where eggs are fertilized in vitro and the resulting zygote is then placed in the fallopian tubes. It notes ZIFT is invasive, has a low success rate of about 26%, and involves stimulating a woman's ovaries to produce multiple eggs, selecting the best zygote to implant while others may be frozen or discarded. The document argues ZIFT is morally unacceptable as it removes procreation from marriage, does not respect the sanctity of life, and can involve eugenics in selecting the best embryo.
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The document discusses the history and various techniques of assisted reproductive technology (ART). It describes key developments like the first successful IVF birth in 1978. Common ART procedures discussed include intrauterine insemination (IUI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), and zygote intrafallopian transfer (ZIFT). The stages of an IVF cycle from ovarian stimulation to embryo transfer are outlined. Other topics covered are indications for different procedures, sperm and egg donation, preimplantation genetic diagnosis, and surgical sperm retrieval.
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Taxi To The Dark Side
This documentary examines the torture practices of the United States after 9/11 through the story of an innocent Afghan taxi driver who was tortured and killed in 2002. It uses his case to investigate changes in US policy that led to widespread abuse of detainees in Afghanistan, Iraq, and Guantanamo Bay. Through interviews with soldiers, detainees, and lawyers, it reveals how unofficial orders from top officials allowed the CIA and untrained soldiers to use sleep deprivation, waterboarding, stress positions, and other torture tactics against many detainees, compromising American ideals. The film won an Oscar and several other awards for its critical look at these post-9/11 interrogation practices.
다시한겅
The document proposes a new plan to increase profits from a music tour. The plan includes increasing the number of concerts from 60 to 80, the number of t-shirts sold per concert from 30 to 50, and the number of CDs sold per concert from 30 to 50. This would boost total revenue from merchandise sales. Expenses would also rise with more concerts but profits would increase due to higher revenues from ticket sales and merchandise compared to the original plan.
Samsung
Samsung is a South Korean multinational conglomerate founded in 1938 and headquartered in Seoul. It is comprised of numerous subsidiaries and affiliated businesses, the largest and most widely known of which is Samsung Electronics. Samsung Electronics has been the world's largest consumer electronics manufacturer since 2005. The company was founded by Lee Byung-chul and has grown to be a top global brand with annual revenue of over $173 billion in 2008.
Coca Cola Enterprises
Coca-Cola was invented in 1886 in Georgia by John Pemberton as a carbonated, non-alcoholic version of French Wine Cola called Coca-Cola. It is now one of the largest beverage companies in the world with over 92,400 employees selling over 3000 beverages in more than 200 countries after 123 years in business. The current chairman and CEO is Muhtar Kent, a Turkish American born in 1952 in New York. The document concludes that Coca-Cola Enterprise is a good investment due to its long history and stability.
Celestica Presentation
Celestica is a global electronics manufacturing services company headquartered in Toronto, Canada. It operates over 40 manufacturing sites across the Americas, Europe, and Asia. Celestica provides end-to-end product design, manufacturing, repair, and supply chain solutions for OEM customers in industries such as computing, communications, healthcare, industrial, and clean technology. In recent years, Celestica has redeemed outstanding bonds, completed a secondary offering of shares, and continued to expand its global manufacturing footprint.
Unit 5 Research Assignment.Sam Kim.
NAFTA is a trade agreement between the US, Canada, and Mexico that went into effect in 1994. It aims to reduce tariffs between the countries over 15 years. Since NAFTA, trade between the countries has increased dramatically, though the US trade deficit with Mexico and Canada has also increased substantially. NAFTA benefits include increased household income and GDP, though its impact is debated.
The Affects Of Infrastructure.Sam Kim.
The document discusses how the United States' well-developed infrastructure has contributed to its economic success and global presence. It notes that the U.S. has the third largest land area and GDP, and is a global leader in industries like automotive manufacturing, airlines, communication technologies, and government services. The document concludes that the U.S.'s strong infrastructure has helped make its economy the largest in the world and enhanced its international significance.
Ecosoap
EcoSoap produces natural shampoo and conditioner made from ingredients found in Canadian trees and plants. Their goal is to provide these nutrient-rich hair products internationally. Specifically, they plan to export their products to South Korea, where daily hair care is important culturally. EcoSoap analyzes South Korea as a potential market, noting features like its large cities, trade partnerships, and cultural emphasis on respect and etiquette.
Sustainability Presentation
The document defines sustainable transportation as a system that meets citizens' needs in a way that satisfies humans and the ecosystem, while promoting fairness between generations. Sustainable transportation limits environmental waste within the planet's capacity, uses renewable resources sustainably, and aims to create efficient mobility for communities through policies, systems, and technologies. Currently, transportation accounts for 20-25% of global energy use and carbon emissions. The history of transportation development includes innovations like the passenger train and bicycle, while oil price drops in the 1980s-90s increased individual vehicle ownership and suburban development patterns requiring car dependency.
Ancient Mayans
The Ancient Mayans lived in areas of Central America like the Yucatan Peninsula, Guatemala, Belize, and southern Mexico between 2000 BC and 1500 AD. Their civilization was organized into kingdoms ruled by a hereditary monarchy and high priest kings. The Mayans engaged in intensive agriculture growing crops like corn and beans and had an advanced calendar and mathematical systems, leaving behind great architectural sites like temples before eventually declining.
Greek Quest
The document discusses how Greek gods and goddesses have shaped modern language and culture through expressions they introduced and stories about them that are still told today. It provides examples of words and phrases of Greek origin and references artworks and fictional works that feature Greek mythology, highlighting how Walt Disney's Hercules animation relates Greek myths to introduce children to the gods and their powers. The document expresses gratitude to the Greek gods and goddesses for bringing culture and language and shaping the world.
Film.Marketing.Plan
This marketing plan outlines strategies for promoting the action/adventure film "Raining Bullets". The target audience is teenagers and adults ages 14 and older due to graphic violence. Advertisements will appear in theaters, newspapers, television and online. Word of mouth will also be utilized. The joint production company Paramount Pictures and Warner Bros. have successful track records with action franchises. Competitors include Buena Vista, the top grossing company, and Sony Pictures. The goals are to effectively promote the film and become the leading advertising company by surpassing competitors in profit.
Brazil.Infrastructure
Brazil has the largest economy in South America and the fifth largest country in the world by area. It has a population of around 200 million people and its major exports include soybeans, coffee, beef, and orange juice. Brazil has invested heavily in developing its infrastructure through programs like PAC, expanding its transportation networks, communications systems, and technology parks to support its growing economy and international trade.
Greece Bbb
The Greek flag was officially adopted in 1978, though an earlier version with a diagonal cross was used since 1822 following Greece's independence from the Ottoman Empire. The nine stripes represent a Greek phrase meaning "Freedom or Death" and the cross represents the Greek Orthodox Church. Blue symbolizes the sea's importance to Greece and white represents ocean waves and purity. Greece has a Mediterranean climate along the coasts and a temperate climate in central and northern regions. It has few natural resources besides lignite coal and deposits of oil and gas offshore in the Aegean Sea. Germany and Italy are Greece's main EU trading partners.
Hector
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Human trafficking is an illegal business that involves kidnapping, selling, or deceiving people into situations they cannot escape from. Victims lose their rights and freedoms and are treated as objects that can be bought and sold. Each year over four million victims, mostly women and children from third world countries, are trafficked around the world, including to countries like Canada. While governments acknowledge it is a serious crime, some prioritize the money it generates for local economies over victim protection. Increased awareness campaigns are needed to curb the demand and complicity that enables the abusive human trafficking industry.
Shake (Powerpoint)
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Sam Kim Dragon
The document discusses a snow shoveling robot called S.S. 2010 that is designed to save people time and energy by shoveling snow for them. It notes that many people, especially those working or with busy lifestyles, dislike shoveling snow themselves. S.S. 2010 is presented as a solution that can shovel snow faster than humans, leaving more time for other activities. The document also discusses research finding that as society has advanced, more women are working, contributing to busier lifestyles where people have less time for tasks like shoveling snow. Elderly people who cannot shovel themselves would also benefit from S.S. 2010.
Enterprise
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Dragons Den Project(2)
Sung-Il Kim has created an umbrella surrounded by transparent polyvinyl on the bottom to protect users' clothes from getting wet when it rains. The product is intended for people who don't like getting exposed to rain or don't want to wear a raincoat. The inventor was motivated to create this product because traditional umbrellas only protect the top half of the body from rain and wind, leaving the lower half exposed. The intended market is people in England, where the climate involves significant rainfall throughout the year. The plan is to order the umbrellas from a Chinese manufacturer and ship them to a distributor in England to sell, in various sizes to suit different needs.
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Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
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