AnnaLaura Brown is a health coach who specializes in helping people manage allergies, asthma, and autism through nutrition and essential oils. She struggled with these conditions herself as a child but found relief through a gluten-free/dairy-free diet, essential oils, chiropractic care, and eliminating food sensitivities. As a health coach, she offers wellness discovery sessions and multi-month coaching programs to help others adopt a lifestyle of healthy eating and natural remedies.
Obesity, Weight Loss Surgery and AddictionJulie Dostal
Obesity, Weight Loss Surgery and Addiction: What every bariatric patient should know about their risk for addiction post operatively. Why are bariatric patients at risk? What can one do to prevent addiction after surgery? What is "addiction transfer?"
This document provides dos and don'ts for living well with lupus based on advice from doctors. The dos include following medication instructions, attending doctor visits and lab work, learning about lupus, being open with your doctor, and getting the right amount of exercise. The don'ts include smoking, allowing yourself to become overtired, planning a pregnancy without talking to your doctor, allowing stress to take over your life, and forgetting to use sunscreen. The key is working jointly with your doctor to control the disease.
This document provides information on building a strong social support network for those living with lupus or caring for someone with lupus. It discusses the importance of social support for well-being and outlines seven steps to build a network: 1) understand the dangers of isolation, 2) reach out to potential support sources, 3) set up different types of support for emotional, physical, and task-related needs, 4) learn to ask for help from your network, 5) connect with others through shared activities and online communities, 6) share different aspects of your experience with different supporters, and 7) find purpose and validation by volunteering to help others with lupus. Maintaining social connections helps ensure lupus is
Depression (major depressive disorder) is a common and serious medical illness that negatively affects how you feel, the way you think and how you act. Fortunately, it is also treatable.
So here is my answer. Diabetes Choose Life is for all types of diabetics and prediabetics.
It has been designed to be useful to anyone who reads it, even those
without diabetes. Indeed, the type of diet and lifestyle that I describe there seem
appropriate and beneficial for the majority of people in the majority of situations.
And the life of type 1 diabetics could be made easier by my approach
AnnaLaura Brown is a health coach who specializes in helping people manage allergies, asthma, and autism through nutrition and essential oils. She struggled with these conditions herself as a child but found relief through a gluten-free/dairy-free diet, essential oils, chiropractic care, and eliminating food sensitivities. As a health coach, she offers wellness discovery sessions and multi-month coaching programs to help others adopt a lifestyle of healthy eating and natural remedies.
Obesity, Weight Loss Surgery and AddictionJulie Dostal
Obesity, Weight Loss Surgery and Addiction: What every bariatric patient should know about their risk for addiction post operatively. Why are bariatric patients at risk? What can one do to prevent addiction after surgery? What is "addiction transfer?"
This document provides dos and don'ts for living well with lupus based on advice from doctors. The dos include following medication instructions, attending doctor visits and lab work, learning about lupus, being open with your doctor, and getting the right amount of exercise. The don'ts include smoking, allowing yourself to become overtired, planning a pregnancy without talking to your doctor, allowing stress to take over your life, and forgetting to use sunscreen. The key is working jointly with your doctor to control the disease.
This document provides information on building a strong social support network for those living with lupus or caring for someone with lupus. It discusses the importance of social support for well-being and outlines seven steps to build a network: 1) understand the dangers of isolation, 2) reach out to potential support sources, 3) set up different types of support for emotional, physical, and task-related needs, 4) learn to ask for help from your network, 5) connect with others through shared activities and online communities, 6) share different aspects of your experience with different supporters, and 7) find purpose and validation by volunteering to help others with lupus. Maintaining social connections helps ensure lupus is
Depression (major depressive disorder) is a common and serious medical illness that negatively affects how you feel, the way you think and how you act. Fortunately, it is also treatable.
So here is my answer. Diabetes Choose Life is for all types of diabetics and prediabetics.
It has been designed to be useful to anyone who reads it, even those
without diabetes. Indeed, the type of diet and lifestyle that I describe there seem
appropriate and beneficial for the majority of people in the majority of situations.
And the life of type 1 diabetics could be made easier by my approach
Your parents and doctors make a lot of the important decisions about your health, but you have a big role to play, too. When you’re at school, it’s important that you manage your lupus as well as you can. This means making smart decisions and thinking about how you feel. Having lupus may make you feel different from classmates, but you can help them understand why you have to do certain things and be mindful of your health. Here are some things to do so you can make sure school is as productive and fun as possible.
overwhelming at times, especially when attempting to navigate a maze-like healthcare system. It is important to know how to self-advocate by knowing your rights and responsibilities, speaking up for your rights, and making choices and decisions that affect your health
This document provides information about a DVD and guidebook produced by GlaxoSmithKline called "Give Your Health A Shot: A Guide to Vaccines and Adult Wellness." The DVD features Olympic soccer star Mia Hamm, who discusses the importance of staying healthy as an individual and parent by keeping up-to-date with medical checkups and vaccinations. The guidebook that accompanies the DVD provides information on which vaccines adults may need and the diseases they help prevent.
This document discusses the dangers of prescription medication abuse and provides tips to avoid addiction. It warns that using medications more frequently or at higher dosages than prescribed can lead to dependency and potential legal and health problems. It encourages taking medications only as directed by a doctor, being honest about any side effects, and dealing with life stresses in healthy ways rather than turning to drugs. If addiction develops, it recommends admitting oneself to rehab for help.
Communication and Empathy in Mental IllnessChandra Knabel
Improve your relationships by improving communication
Communicating with friends and family who are struggling with mental illness can be challenging. Learn some small changes you can implement that will make a big difference.
Food allergy is an abnormal response to a food triggered by your body's immune system. In adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. Problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat
Teen depression. Global Health 2012. TASISOlymar Marco
This document discusses teen depression, providing information on causes, signs and symptoms, and treatment options. It notes that depression can have various physical and emotional manifestations, and can be caused by genetic and environmental factors like stressful life events. Signs may include feelings of sadness, changes in sleep or appetite, and declining academic performance. Treatment involves counseling, lifestyle changes like exercise, and medication in some cases. Resources for further information are also provided.
Food intolerance is a detrimental reaction, often delayed, to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems, but generally refers to reactions other than food allergy
#MyGPandMe is a campaign run by Dimensions to help make GP surgeries more accessible for people with learning disabilities and autism. John's story shows how chemical restraint isn't always the best options.
www.dimensions-uk.org/mygpandme
A 28-year-old pregnant woman in her second pregnancy presents with a history of hypertension, headache, and one prior convulsive episode during this pregnancy. The headache is intense, throbbing, and worsens in the morning, improving in the evening. It is relieved by holding her head tightly and vomiting. She was previously given Belladonna with no relief. Based on her symptoms, Glonoine is prescribed along with continuing her antihypertensive medication. Her symptoms improve over subsequent follow ups.
Postpartum depression is a severe form of depression that can develop within the first six months after giving birth. Symptoms include sadness, anxiety, restlessness and in rare cases, postpartum psychosis. It is caused by hormonal changes after childbirth and other contributing factors like stress, lack of sleep, and feelings of loss. About 10-15% of new mothers are affected. Left untreated, it can interfere with mother-child bonding and cause family distress, and increase the risk of behavioral problems in children. Treatment options include counseling, antidepressants, and lifestyle changes.
This document provides information about managing migraines, including what causes them, common triggers, and strategies for prevention and treatment. It begins by defining migraines and explaining that they are severe headaches that often have accompanying symptoms like nausea and sensitivity to light and sound. It then discusses common migraine triggers such as stress, hormonal changes, certain foods and medications, as well as environmental factors. The document provides tips for lifestyle changes to help manage migraines and prevent attacks, such as getting sufficient sleep, eating regularly, and avoiding known triggers. It also discusses medication options for both preventative treatment and pain relief during attacks.
This document provides information on finding balance, harmony, and passion in life. It discusses that passion is the genesis of genius, and fear is the passion of slaves. Happiness can come from experiences, accomplishments, sensual pleasure, material possessions, physical appearance, financial success, and solitude. Being successful involves self-development, achievement, recognition, material possessions, popularity, personal freedom, and creativity. The highest values are inspired while the lowest values are motivated. Balance is supported through challenges. Inspiration comes from within while motivation minimizes pain and maximizes pleasure. Priorities and values include how one spends time and money and what energizes and disciplines them. Perception of a partner will equal reality, and treating a partner
Generalized anxiety disorder (GAD) is characterized by excessive, uncontrollable worry that interferes with daily life. While the exact causes are unknown, genetics and abnormal brain chemistry may play a role. Common symptoms include restlessness, difficulty concentrating, muscle tension, and feeling easily startled. Approximately 9 million Americans have GAD, with about half experiencing symptoms their whole life and half seeing symptoms dissipate after 12 months. Treatment focuses on cognitive behavioral therapy and lifestyle changes to manage symptoms, as medications alone are usually not effective long-term.
This document provides information to help people better manage rheumatoid arthritis. It discusses the condition and treatments, including medications like DMARDs, steroids, and anti-inflammatory drugs. It emphasizes the importance of taking medications as prescribed and offers tips for making everyday activities easier, such as using assistive devices. The document also provides dietary recommendations, suggesting a heart-healthy diet high in omega-3s, calcium, and vitamins. Overall, the guide aims to help people understand rheumatoid arthritis and learn self-care strategies to feel better.
This is my book about women and depression, in this book we are going to discover about women and depression, cause, symptoms, effects, treatment and much more.
Cartoon Introduction to Evidence in Medicinesynchro85
An anecdote is a personal story that does not provide strong evidence on its own due to small sample sizes, reporting bias, and lack of a control group. Larger controlled studies are needed to establish if a treatment is truly effective. Placebos can still provide relief from expectations even without active ingredients, so anecdotal reports do not prove the underlying cause of improvement. Herbal remedies contain active chemical compounds that can impact the body like pharmaceutical drugs, but their effects and safe dosages are often less clearly defined.
A presentation by Ellen O’Donnell, PhD, Staff Psychologist, Massachusetts General Hospital, at JDRF New England chapter's 2nd Annual “Living Well with T1D” Symposium on March 3, 2013.
This document provides information about diabetes, including the three main types, pre-diabetes, lifestyle factors that can increase risk, and tips for management and treatment. Type 1 diabetes requires insulin therapy and usually occurs in people under 30, while type 2 is the most common type and occurs in people over 40 who are overweight. Pre-diabetes signals the need to make lifestyle changes to potentially reverse the condition or prevent progression to type 2 diabetes. Physical inactivity, processed foods, stress, and excess weight can increase diabetes risk, so the document recommends increasing activity, eating whole foods, managing stress, and weight control. Medications and self-monitoring of blood sugar are usually part of diabetes treatment plans aimed at controlling blood pressure and cholesterol
Your parents and doctors make a lot of the important decisions about your health, but you have a big role to play, too. When you’re at school, it’s important that you manage your lupus as well as you can. This means making smart decisions and thinking about how you feel. Having lupus may make you feel different from classmates, but you can help them understand why you have to do certain things and be mindful of your health. Here are some things to do so you can make sure school is as productive and fun as possible.
overwhelming at times, especially when attempting to navigate a maze-like healthcare system. It is important to know how to self-advocate by knowing your rights and responsibilities, speaking up for your rights, and making choices and decisions that affect your health
This document provides information about a DVD and guidebook produced by GlaxoSmithKline called "Give Your Health A Shot: A Guide to Vaccines and Adult Wellness." The DVD features Olympic soccer star Mia Hamm, who discusses the importance of staying healthy as an individual and parent by keeping up-to-date with medical checkups and vaccinations. The guidebook that accompanies the DVD provides information on which vaccines adults may need and the diseases they help prevent.
This document discusses the dangers of prescription medication abuse and provides tips to avoid addiction. It warns that using medications more frequently or at higher dosages than prescribed can lead to dependency and potential legal and health problems. It encourages taking medications only as directed by a doctor, being honest about any side effects, and dealing with life stresses in healthy ways rather than turning to drugs. If addiction develops, it recommends admitting oneself to rehab for help.
Communication and Empathy in Mental IllnessChandra Knabel
Improve your relationships by improving communication
Communicating with friends and family who are struggling with mental illness can be challenging. Learn some small changes you can implement that will make a big difference.
Food allergy is an abnormal response to a food triggered by your body's immune system. In adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. Problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat
Teen depression. Global Health 2012. TASISOlymar Marco
This document discusses teen depression, providing information on causes, signs and symptoms, and treatment options. It notes that depression can have various physical and emotional manifestations, and can be caused by genetic and environmental factors like stressful life events. Signs may include feelings of sadness, changes in sleep or appetite, and declining academic performance. Treatment involves counseling, lifestyle changes like exercise, and medication in some cases. Resources for further information are also provided.
Food intolerance is a detrimental reaction, often delayed, to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems, but generally refers to reactions other than food allergy
#MyGPandMe is a campaign run by Dimensions to help make GP surgeries more accessible for people with learning disabilities and autism. John's story shows how chemical restraint isn't always the best options.
www.dimensions-uk.org/mygpandme
A 28-year-old pregnant woman in her second pregnancy presents with a history of hypertension, headache, and one prior convulsive episode during this pregnancy. The headache is intense, throbbing, and worsens in the morning, improving in the evening. It is relieved by holding her head tightly and vomiting. She was previously given Belladonna with no relief. Based on her symptoms, Glonoine is prescribed along with continuing her antihypertensive medication. Her symptoms improve over subsequent follow ups.
Postpartum depression is a severe form of depression that can develop within the first six months after giving birth. Symptoms include sadness, anxiety, restlessness and in rare cases, postpartum psychosis. It is caused by hormonal changes after childbirth and other contributing factors like stress, lack of sleep, and feelings of loss. About 10-15% of new mothers are affected. Left untreated, it can interfere with mother-child bonding and cause family distress, and increase the risk of behavioral problems in children. Treatment options include counseling, antidepressants, and lifestyle changes.
This document provides information about managing migraines, including what causes them, common triggers, and strategies for prevention and treatment. It begins by defining migraines and explaining that they are severe headaches that often have accompanying symptoms like nausea and sensitivity to light and sound. It then discusses common migraine triggers such as stress, hormonal changes, certain foods and medications, as well as environmental factors. The document provides tips for lifestyle changes to help manage migraines and prevent attacks, such as getting sufficient sleep, eating regularly, and avoiding known triggers. It also discusses medication options for both preventative treatment and pain relief during attacks.
This document provides information on finding balance, harmony, and passion in life. It discusses that passion is the genesis of genius, and fear is the passion of slaves. Happiness can come from experiences, accomplishments, sensual pleasure, material possessions, physical appearance, financial success, and solitude. Being successful involves self-development, achievement, recognition, material possessions, popularity, personal freedom, and creativity. The highest values are inspired while the lowest values are motivated. Balance is supported through challenges. Inspiration comes from within while motivation minimizes pain and maximizes pleasure. Priorities and values include how one spends time and money and what energizes and disciplines them. Perception of a partner will equal reality, and treating a partner
Generalized anxiety disorder (GAD) is characterized by excessive, uncontrollable worry that interferes with daily life. While the exact causes are unknown, genetics and abnormal brain chemistry may play a role. Common symptoms include restlessness, difficulty concentrating, muscle tension, and feeling easily startled. Approximately 9 million Americans have GAD, with about half experiencing symptoms their whole life and half seeing symptoms dissipate after 12 months. Treatment focuses on cognitive behavioral therapy and lifestyle changes to manage symptoms, as medications alone are usually not effective long-term.
This document provides information to help people better manage rheumatoid arthritis. It discusses the condition and treatments, including medications like DMARDs, steroids, and anti-inflammatory drugs. It emphasizes the importance of taking medications as prescribed and offers tips for making everyday activities easier, such as using assistive devices. The document also provides dietary recommendations, suggesting a heart-healthy diet high in omega-3s, calcium, and vitamins. Overall, the guide aims to help people understand rheumatoid arthritis and learn self-care strategies to feel better.
This is my book about women and depression, in this book we are going to discover about women and depression, cause, symptoms, effects, treatment and much more.
Cartoon Introduction to Evidence in Medicinesynchro85
An anecdote is a personal story that does not provide strong evidence on its own due to small sample sizes, reporting bias, and lack of a control group. Larger controlled studies are needed to establish if a treatment is truly effective. Placebos can still provide relief from expectations even without active ingredients, so anecdotal reports do not prove the underlying cause of improvement. Herbal remedies contain active chemical compounds that can impact the body like pharmaceutical drugs, but their effects and safe dosages are often less clearly defined.
A presentation by Ellen O’Donnell, PhD, Staff Psychologist, Massachusetts General Hospital, at JDRF New England chapter's 2nd Annual “Living Well with T1D” Symposium on March 3, 2013.
This document provides information about diabetes, including the three main types, pre-diabetes, lifestyle factors that can increase risk, and tips for management and treatment. Type 1 diabetes requires insulin therapy and usually occurs in people under 30, while type 2 is the most common type and occurs in people over 40 who are overweight. Pre-diabetes signals the need to make lifestyle changes to potentially reverse the condition or prevent progression to type 2 diabetes. Physical inactivity, processed foods, stress, and excess weight can increase diabetes risk, so the document recommends increasing activity, eating whole foods, managing stress, and weight control. Medications and self-monitoring of blood sugar are usually part of diabetes treatment plans aimed at controlling blood pressure and cholesterol
One of the main things for Diabetic diet in diabetes treatment is Glycemic index of food. If the Glycemic index of the food is higher it gives more strain on insulin receptors. So that sharply rises in blood sugar. If the glycemic index of the food is lowerit gives less strain on insulin receptors as a result blood sugar in control.
We at Diet kundali provide proper diet plan with diabetes treatment.
For more details click here :http://www.dietkundali.com/diabetes-treatment.html
Wellness involves preventing illness and disease rather than just treating it after the fact. Regular physical activity like walking can help people lose weight gradually and reduce health risks. The document advocates for workplaces to make small changes like offering walking breaks and healthier food options to encourage employees to adopt a more active lifestyle and improved diet. It provides examples of how one company saw positive results from a wellness program including weight loss, increased physical activity and lower health risks among participating employees.
The document provides biographical information about the author, Beverleigh Piepers, a registered nurse with 25 years of experience. It describes how she was diagnosed with pre-diabetes after routine blood tests showed elevated blood sugar levels. She was given little information and guidance about type 2 diabetes. This motivated her to conduct extensive research to better understand the condition. The document aims to provide clear and accessible information to help others manage type 2 diabetes.
This document discusses lifestyle diseases and provides strategies for maintaining health. It notes that non-communicable diseases like diabetes, obesity, and heart disease are on the rise globally due to risk factors like poor diet, physical inactivity, tobacco and alcohol use. Adopting a mainly whole-food, plant-based diet with limited processed foods and adequate exercise can help reverse these conditions and reduce medication needs. The author shares their personal experience improving health conditions like diabetes and cholesterol through lifestyle changes based on nutritional guidance from doctors and organizations.
This document discusses maintaining a healthy weight and lifestyle. It explains that energy balance is important, which means balancing the calories consumed with calories expended through physical activity and exercise. It provides tips for becoming more active, such as starting slow, aiming for 30 minutes per day of exercise, strength training, mixing up activities, and stretching. Losing weight can improve health conditions like heart disease, diabetes and cancer. Treatment options for obesity include diet changes, physical activity, medication, and possibly surgery.
The diabetes cure (the 5 step plan to eliminate hunger, lose weight, and rev...Aqileditz
This document discusses the real cause of diabetes as chronic inflammation in the body. It explains that diabetes results from fat and waste buildup in and around cells that damages mitochondria and hinders insulin production. Several lifestyle factors can increase inflammation like poor diet, lack of exercise, and sedentary behavior. While genetics play a role, epigenetics or how lifestyle influences gene expression, may be more important. The document distinguishes between acute and chronic inflammation, noting that chronic, hidden inflammation in organs is what leads to diabetes and other diseases over time if left unaddressed.
CBIZ Wellbeing Insights Newlsetter - November 2014CBIZ, Inc.
This document is a newsletter that provides information on diabetes awareness month and prediabetes. It discusses who is at risk for prediabetes, how it is diagnosed, and lifestyle changes one can make to prevent or delay diabetes if prediabetes is detected. It also profiles actress Halle Berry's experience of being diagnosed with type 1 diabetes at age 22 and how she manages her condition through diet and exercise.
If you want a chance to possibly add decades to your life, lose weight and avoid some life-threatening illnesses, I want you to pay close attention as I explain exactly why the modern food industry is designed to keep you unhealthy AND addicted as long as possible.
https://foodhealthandyou.com/written.php?hop=samldol
The document discusses how to manage diabetes through reversing and eliminating diabetic peripheral neuropathy by focusing on nutrition, detoxification, exercise, and properly functioning nerve flow as part of a four pillar approach. It outlines the diabetes health curriculum at Campbell Medical Clinic which involves a consultation, wellness evaluation, and personalized plan of action to treat the whole body and reverse diabetes through lifestyle changes. The summary dispels common diabetes myths and details the complications that can arise from uncontrolled diabetes.
This document discusses eating disorders, including their causes, symptoms, and treatments. It covers three main types of eating disorders - anorexia, bulimia, and eating disorder not otherwise specified (EDNOS). Causes include social pressures, low self-esteem, stress, and unhealthy dieting patterns. Signs and symptoms vary but can include weight loss, binge eating, purging, and obsessive food thoughts. Treatments involve group therapy, family support, counseling, medication, and addressing underlying psychological issues through therapy. Admitting the problem and seeking help from mental health professionals is important for recovery.
UNDERSTANDING AND DEFEATING THE SILENT KILLERErnest Fonjie
Diabetes is a chronic condition that affects millions of people worldwide. Understanding and managing diabetes is crucial to prevent its negative impacts on your health. With the right information and strategy in place, you can successfully control your blood sugar levels and lead a healthy and fulfilling life. In this blog, we will explore the causes, symptoms, and consequences of diabetes, along with preventive measures and management techniques to tackle this silent killer head-on. So, let's dive right in and learn how to keep diabetes at bay.
Intermittent Fasting Weight Loss and Health.pptxdrgunasingh
Intermittent fasting is a method of time-restricted eating where one only eats during a specific window each day. It focuses on when a person eats rather than what they eat. Some benefits of intermittent fasting include easier weight loss and control of appetite compared to calorie-restricted diets. Intermittent fasting helps regulate hunger hormones and reduces belly fat. It also improves sleep, energy levels, and cognitive functions. Precautions need to be taken for certain groups and plateaus can be addressed by increasing fasting duration or making dietary changes.
The document discusses the emotional aspects of managing diabetes. It emphasizes that diabetes involves not just medical treatment but also emotional challenges. Living well with diabetes requires emotional strength to manage stress and keep blood sugar, blood pressure, and cholesterol at healthy levels. The document provides advice on overcoming common emotional obstacles like depression, denial, guilt, and feeling discouraged. It suggests seeking social support, setting reasonable expectations, and focusing on long-term health goals rather than daily fluctuations to help manage the emotional side of diabetes.
For many, weight loss seems like a difficult thing. Maybe you’ve tried things in the
past…diets, workouts, pills, creams, ANYTHING to help get the weight off, but it
seems like no matter how hard you tr y, it either doesn’t come off at all, or it comes
right back on.
There is a very simple answer. Start learning the foods your body understands. The foods your metabolism and digestive systems were created to handle. Reignite your natural connection to your body and discover intuitive eating.bit.ly/1tM6Lmy
The document discusses how type 2 diabetes can be reversed through lifestyle changes by targeting the root cause of inflammation, rather than just treating symptoms with drugs. It claims that countless studies show diabetics can normalize blood sugar and insulin sensitivity by addressing inflammation through diet and lifestyle interventions. The document promotes a guide called "The 7 Steps to Health and the Big Diabetes Lie" that has helped tens of thousands of diabetics reverse their condition without medications. It argues that conventional diabetes treatment with drugs does not cure diabetes and only manages symptoms, putting patients at risk of serious health complications.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
Debunking Nutrition Myths: Separating Fact from Fiction"AlexandraDiaz101
In a world overflowing with diet trends and conflicting nutrition advice, it’s easy to get lost in misinformation. This article cuts through the noise to debunk common nutrition myths that may be sabotaging your health goals. From the truth about carbohydrates and fats to the real effects of sugar and artificial sweeteners, we break down what science actually says. Equip yourself with knowledge to make informed decisions about your diet, and learn how to navigate the complexities of modern nutrition with confidence. Say goodbye to food confusion and hello to a healthier you!
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Ignite health 2_v08
1. The Light Bulb Moment
How I'm Beating Diabetes and
How YOU Can (and Should)
Attack Any Chronic Disease
Charlie Levenson
@CharlieLevenson | CharlieLevenson.com | #IgniteHealth
2. “Chronic Diseases” are
conditions that can't be
“cured” but only managed
and controlled.
Diabetes
COPD
Asthma
Heart Disease
Cancer
Osteoporosis
Smoking
Alcoholism
RSD
…and many others
3. I have a chronic disease:
High fat, high carb,
high sugar diet
High Stress
I am a diabetic.
Diagnosed in 1999
with A1c of 13.5
Weight of 230 lbs.
Sedentary lifestyle
4. My responses went
through cycles
for me, for 14 years, it went like this...
A1c usually around 7.5 to 9.5
Weight high, between 235 and 245+
Attitude between mildly positive and depressed
Dealing with it a bit then ignoring it
5. Responses to a Diagnosis
Immediate and
Ongoing Action, or
Minimal Response, or
Intermittent Response
or
a very common
option…
6. Providers try to present
“The Facts” to patients
Usually in isolation
from each other.
And from their individual
medical perspective.
Usually it's...
If you don't do THIS
then THIS WILL HAPPEN.
7. Diagnosis often comes
as a surprise to the patient.
If patient is
in shock,
it's not
a good time
to educate them.
13. When the patient is ENGAGED
the whole team is stronger.
Before engagement,
everything was a series
of unrelated encounters
with relevant but random
information.
When engaged, every
new fact and every
potential strategy has
traction and value.
14. What can the provider do to
prepare the patient for the
light bulb moment?
Make information available.
Provide non-judgemental suggestions.
Show the possibility of success.
15. And most importantly...
Show them that
it's incremental.
Remind the patient
that the battle is
never lost
…or won.
Image used with permission of Emily Steffen.
16. The healthcare team is
flipping the circuit breaker
to prepare the patient for
the light bulb to go on.
17. What the patient can do
to prepare themselves
for the light bulb moment.
Know what's important to them
Know what they want out of life
Take an inventory of their support network
18. My light bulb moment...
October 7, 2013, 7:30am
A1c of 8.7
Weight of 245 lbs
Bad diet
No exercise
Low energy
Sedentary
19. One Year Later
A1c of 6.5 and trending down.
Below 200 lbs (loss of 45+ lbs).
Exercising 10+ times a week.
Eating well.
Misbehaving only occasionally.
Planning to live and work to 90.
With the support of Melissa Ho, M.A., R.N.,
C.D.E., a Diabetes Nutritionist at Providence,
and many others...
20. Thank You.
Charlie Levenson
Writer & Media Strategy
CharlieLevenson.com
@CharlieLevenson
CLL2001 @ gmail . com
503.449.3376
All images used with creator's permission or under Creative Commons
Attribution 4.0 International (CC BY 4.0).