1. MADE TO MEASURE
FROM YOUR PATIENT’S DNA
iDDNA®
Anti-aging programs
personalized on DNA
designed and developed in Switzerland
2. WE ARE ALL DIFFERENT
THIS IS MAINLY DUE TO OUR GENES
SNP’s
With the exception of identical twins, all people have small
differences in the information that their DNA contains and it’s
these differences that make each of us unique. Gene variations
are slight changes in the genetic code that are present in at least
one percent of the population.
This variation is called a Single Nucleotide Polymorphism, or SNP.
It is the collection of these small differences that affect who we
are and define our individuality – but genes are not all, they don’t
work alone and they don’t determine everything about us.
PHENOTYPE
A phenotype results from the expression of an organism’s
genes as well as the influence of environmental factors and the
interactions between the two.
GENOTYPE
Genomes contain all of the information needed to determine the
functions of an organism and maintain homeostasis, a state of
equilibrium within an organism’s internal environment.
All the members of our species share around 99.8% of our
genome.
There are approximately 20,500 genes in human beings, the
same range as in mice.
The human genome has approximately 3.3 billion base-pairs.
Among these, there are between 3 to 10 million single
nucleotide polymorphism (SNPs).
SCIENTIFIC REFERENCES
About the Human Genome Project: What is the Human Genome Project,
The Human Genome Management Information System (HGMIS). 2011
The Human Genome Project: a new reality.
Wellcome Trust Sanger Institute
A genetic variant is said to have clinical validity if its
impact on human health is well understood, so that
detecting the variant supplies useful information about
the patient’s health or predispositions to disease.
Clin Interv Aging. 2006 Sep; 1(3): 201–203.
3. NOBEL PRIZE WINNING RESEARCH
To this day, the field of genetics remains an active area of
ongoing research, but several landmarks are the foundation of
iDDNA®
:
• Nobel Prize in Physiology or Medicine 1962
• Nobel Prize in Physiology or Medicine 1968
• Human Genome Project 2003
• Nobel Prize in Physiology or Medicine 1986
• Nobel Prize in Physiology or Medicine 2009
TARGETING AGING AT THE SOURCE
The polymorphic nature of aging indicates that
any anti-aging strategy has to start with a better
understanding of genes that affect tissue viability.
If we are to widen the gap between chronological and biological
age, we must better understand the role of the individual genetic
make-up and gene-expression in aging and how topicals and
dietary ingredients can interact in a positive way.
Aging is not an episodic process; rather, it is the
consequence of cumulative damage occurring at the molecular,
cellular and tissue levels.
Attenuation of aging is entirely dependent on
mitigating such molecular damage by augmenting
protection and compensatory repair mechanisms,
therefore slowing the degenerative processes.
Many people believe that American biologist
James Watson and English physicist Francis Crick
discovered DNA in the 1950s. In reality, this is not
the case. Rather, DNA was first identified in the late
1860s by Swiss chemist Friedrich Miescher.
4. DNA-DAMAGE AND AGING
DNA damages that are naturally occurring, due to normal cellular
processes that produce reactive oxygen species, the hydrolytic
activities of cellular water, etc., also occur frequently (in estimates
made for mice, on average approximately 1,500 to 7,000 DNA
lesions occur per hour in each mouse cell, or about 36,000 to
160,000 per cell per day). In any cell some DNA damage may
remain despite the action of repair processes. These remaining
DNA damages accumulate with age in mammalian postmitotic
tissues.
Several inherited genetic defects in ability to repair DNA
damage give rise to premature aging suggesting a causal
relationship between DNA damage and aging.
Studies comparing DNA repair capacity in different mammalian
species have shown that repair capacity correlates with lifespan.
The initial study of this type, by Hart and Setlow, showed that
the ability of skin fibroblasts of seven mammalian species to
perform DNA repair after exposure to a DNA damaging agent
correlated with lifespan of the species.
DNA-DAMAGE
Research shows that there are 2 different types of aging:
• INTRINSIC (INTERNAL) AGING, caused by the genes we inherit.
• EXTRINSIC (EXTERNAL) AGING, caused by environmental
factors, such as exposure to the sun’s rays.
INTRINSIC AGING, the natural aging process, is a continuous
process that normally begins in our mid-20s.
The DNA damage theory of aging proposes that aging is a
consequence of unrepaired accumulation of naturally occurring
DNA damages. Nuclear DNA damage can contribute to aging
either indirectly (by increasing apoptosis or cellular senescence)
or directly (by increasing cell dysfunction).
SCIENTIFIC REFERENCES
Bernstein H, Payne CM, Bernstein C, Garewal H, Dvorak K (2008).
Cancer and aging as consequences of un-repaired DNA damage.
New Research on DNA Damages (Editors: Honoka Kimura and Aoi Suzuki) Nova Science Publishers, Inc., New York, Chapter 1, pp. 1–47.
Hoeijmakers JH (October 2009).
“DNA damage, aging, and cancer”.
N. Engl. J. Med. 361 (15): 1475–85.
Freitas AA, de Magalhães JP (2011).
“A review and appraisal of the DNA damage theory of aging”.
Mutat. Res. 728 (1–2): 12–22.
Vilenchik, MM; Knudson, AG (May 2000).
“Inverse radiation dose-rate effects on somatic and germ-line mutations and DNA damage rates”.
Proc Natl Acad Sci U S A. 97 (10): 5381–6.
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.”
Proceedings of the National Academy of Sciences 71 (6): 2169–73. Jun 1974.
Bürkle A, Brabeck C, Diefenbach J, Beneke S.
“The emerging role of poly(ADP-ribose) polymerase-1 in longevity.
Int J Biochem Cell Biol. 2005 May;37(5):1043-53. Review.
SCIENTIFIC REFERENCES
Best,BP (2009).
"Nuclear DNA damage as a direct cause of aging" (PDF)
Rejuvenation Research 12 (3): 199–208.
Freitas AA, de Magalhães JP (2011).
"A review and appraisal of the DNA damage theory of aging".
Mutation Research (journal) 728 (1-2): 12–22.
5. iDDNA®
services:
• SKIN AGING
• ANTI-AGING NUTRIGENETICS (available November, 2015)
• FITNESS/SPORT PERFORMANCE (available February, 2016)
• HAIRLOSS TREATMENT (available February, 2016).
GENETIC APPROACH
TO ANTI-AGING SCIENCE
iDDNA®
is a suite of personalized anti-aging
treatments based on the patient’s DNA.
Designed and developed in Switzerland.
iDDNA®
is the first DNA-PERSONALIZED anti-aging solution to address
the root causes of aging.
Suisse Life Science’s breakthrough scientific research and 8+ years of
clinical practice in cutting-edge regenerative and cellular therapies offers
a deeper understanding of the aging process at a genetic and molecular
level.
Integrating iDDNA®
solutions in your practice:
• Suisse Life Science analyzes your patients’ genetic code, lifestyle and
environmental interactions to build a comprehensive targeted profile,
providing easy, clinically relevant recommendations you can use
directly while making medical decisions.
• Suisse Life Science delivers a customized preventative anti-aging
program that addresses the unique challenges of every patient.
CUTTING-EDGE. iDDNA®
maps your patients’ genes to
recommend the ultimate anti-aging treatment. We calibrate the correct
dosage, frequency and highest quality active ingredients to target each
patient’s particular needs.
INNOVATIVE. Suisse Life Science has searched the world for the
most effective ingredients to trigger cell rejuvenation.
DISTINCTIVE. iDDNA®
treatment programs are a turnkey
solution, designed and developed with precise ingredients, based on
scientific evidence, clinically tested to positively affect your patients’
genes expression to create the most personalized solution.
An innovative functional and integrative medical approach that can help
you to:
• Redefine your therapeutic outcomes
• Incorporate scientific progress into your practice
• Diversify your revenue generation
An open business model that supports physician practices in many ways:
• Experience sharing on a global worldwide basis
• Ongoing education and training
• Superior in technology, scientific foundation and formulation
• Zero tolerance policy of product diversion (no internet sales)
6. DNA AGE: A WINDOW ON THE
PATIENT’S CELLULAR AGING
WITH JUST A SALIVA SAMPLE, WE CAN ACCURATELY PREDICT A PERSON’S
AGE WITHOUT KNOWING ANYTHING ELSE ABOUT THEM.
UCLA scientists looked at a process called methylation, a chemical
modification of one of the four building blocks that make up our DNA.
While genes partly shape how our body ages, environmental influences
can also change our DNA as we age. Methylation patterns shift as
we grow older and contribute to aging-related disease. Methylation's
relationship with age is so strong that we can identify how old someone
is by examining just 2 of the 3 billion building blocks that make up our
genome. Methylated cytosine, also known as “the fifth base of DNA” has
attracted a lot of attention lately as a predictor of biological age due to
its importance in controlling gene expression.
AGING AT A GENETIC LEVEL:
OUR BIOLOGICAL CLOCK
Telomeres shorten with each round of replication. Therefore TELOMERES
HAVE BEEN CALLED THE BIOLOGICAL CLOCK: they tell a cell how old
it is and if it’s time to enter senescence or die. Research has shown that
any DNA-damaging agent that injures cells creates damage throughout the
genome, but you get far more damage in the telomere.
Today, cellular age is estimated statistically through statistical comparison
of individual median telomere length to population.
DNA AS THE REAL AGE-PREDICTOR
The epigenetic clock was developed by Steve Horvath, a professor of
human genetics at the David Geffen School of Medicine at UCLA and of
biostatistics at the UCLA Fielding School of Public Health. The epigenetic
clock leads to an age prediction that has a Pearson correlation
coefficient of r=0.96 with chronological age. Thus the age correlation
is close to its maximum possible correlation value of 1. Other biological
clocks are based on telomere length: correlation between chronological
age and telomere length is r=-0.51 in women and r=-0.55 in men. By
contrasting DNA methylation age (predicted age) with chronological age,
one can define measures of age acceleration. Age acceleration, defined as
difference between DNA methylation age and chronological age, is highly
heritable.
SCIENTIFIC REFERENCES
Bocklandt S et al.
Epigenetic predictor of age.
PLoS One. 6(6):e14821 (2011).
Horvath S (2013)
DNA methylation age of human tissues and cell types.
Genome Biology.2013, 14:R115.
7. Age disparity results from the interaction between
NEGATIVE GENETICS, LIFESTYLE, ENVIRONMENT &
BEHAVIOR.
In this example, the genetically-guided treatment is designed
to address a +10-year difference (50 vs. 40) between the
patient’s (biological) DNA age and her birth-certificate age.
YOUR PATIENT'S iDDNA®
IS A PERSONALIZED ANTI-AGING PROGRAM BASED ON HIS OR
HER REAL BIOLOGICAL AGE (NOT THEIR CHRONOLOGICAL AGE), THAT STIMULATES YOUR
PATIENT'S BODY’S NATURAL ANTI-AGING POWERS, DELIVERING AGE MANAGEMENT AT A
CELLULAR AND MOLECULAR LEVEL.
DNA Age > Age
iDDNA®
TARGET > iDDNA®
INDEX
DNA Age = Age
iDDNA®
TARGET = iDDNA®
INDEX
AGE-MANAGEMENT AT A GENETIC LEVEL
Intrinsic aging, the natural course of aging, is a continuous and irreversible progression that begins
in our mid-20s. Appearing and feeling older is a consequence of the accumulation of naturally
occurring cellular DNA damage.
The truest measure of our aging is our biological age: our “actual” age measured through our
genetics.
Our DNA is like a “fluid material that interconnects us and our environment”. The “diseases of
civilization” are believed to result from a gene-environment mismatch, meaning that we are not
genetically adapted to the modern environment (Western diet and lifestyle). Many studies have
shown that modern lifestyle affects our DNA.
Because of the compelling connection between the environment and our DNA,
genetics is the key that can offer the true answer of how to change the way your
patients live and optimize their body’s aptitude for staying younger.
Your patient may be 28 years old chronologically, but due to his or her lifestyle and environment, he
or she may present a biological age of 40.
Many treatments are unsuccessful due to this age disparity.
iDDNA®
USES YOUR PATIENT’S DNA AS AN AGE-PREDICTOR.
AGE - the patient’s chronological age, the actual time he or she has been alive.
DNA AGE - the biological age, how old he or she seems.
8. WHAT IS INCLUDED IN THE SERVICE?
• 60 days GENETICALLY-PERSONALIZED TREATMENT REGIMEN, made of Swiss proprietary
formulations cosmeceuticals and nutraceuticals.
• 80+ pages [iD] GENETIC REPORT
• ONLINE ACCOUNT and MOBILE APP, to manage your patient’s personalized treatment calendars.
• [iD] CHALLENGE, a second human genetics service at the end of the program to track the
progress, consult the patient and promote a new personalized follow-up program.
The patient’s [iD] GENETIC REPORT includes:
• GENETIC (SNPs/SNPs cross-talks) RESULTS
• PHENOTIPIC (environment/gene-environment interactions) RECOMMENDATIONS
• LIFESTYLE RECOMMENDATIONS
• NUTRITIONAL RECOMMENDATIONS
• ACTIVE INGREDIENTS (clinically tested to affect DNA repair or genes’ expression) suggestions.
Easy to understand recommendations to use while making medical decisions without a need
for a genetics background.
A selection of the most advanced and effective ingredients in the world, tested to act on the
patient’s DNA and SNPs’ affected metabolic systems at a cellular and molecular level.
HOW ARE THE RESULTS
REPORTED?
Aging is recorded in our genes.
Our Science of [DNA] f(x)™ Swiss bioinformatics
technology measures each patient’s individual anti-
aging potential from the relationship between their
genes and lifestyle.
The results are a numerical classification based on a
graduated scale of 100% to 0 to visually represent the
patient’s combined genetic and lifestyle risk factors
portrayed across his or her individual aging processes:
the iDDNA®
index.
Continued evaluation of this composite index
is a relative indicator of how rapidly the patient
is aging, building on current population-based
recommendations and multi-disciplinary peer
reviewed studies, published in the top scientific and
medical journals. iDDNA®
index above the population
baseline are desirable.
WHAT DO THE RESULTS MEAN TO
THE PATIENT AND THE DOCTOR?
Suisse Life Science’s technology is very targeted: a real
measure of the biological age has to be referenced to
specific metabolic processes and to specific genetic
variations. It’s very possible that the same patient could
have different DNA Age, depending on the different services
being provided (e.g. a DNA Age of 39 for iDDNA®
anti-aging
and a DNA Age of 36 for iDDNA®
nutrigenetics, because the
specific genes heritage, phenotype and lifestyle of the same
patient have completely different implications to slow down
aging).
Aging is specifically approached from:
• GENETICS
• PHENOTYPE (ENVIRONMENT)
• LIFESTYLE
Age-management programs and clear, actionable findings
are provided on specific patient basis, from:
• ANTI-AGING SCIENCE
• NUTRITIONAL SCIENCE
• LIFESTYLE MEDICINE
A retesting of phenotypic and lifestyle interaction ([iD] Challenge) is included in each protocol. It is
suggested to evaluate the patient’s aging at least once a year (after age 35) and make adjustments to
nutrition, nutritional supplements, cosmeceuticals, weight management and other lifestyle modifications
to know how to positively affect the aging process.
10. WHY iDDNA®
?
By making iDDNA®
available only through a healthcare professional, it
ensures that the individual’s results are private and protected, just like
any other health information. Most importantly, it enables the healthcare
practitioner to further customize the nutritional plan by taking into
account phenotype, environmental and lifestyle factors, preferences and
aversions, which can all help the patient set realistic targets and goals.
You are building on the DNA revolution, becoming a promoter of
prospective medicine; a new proactive, personalized model of healthcare
delivery. This involves the “interplay of genetics and environment over
time,” so that we can quantify an individual’s risk for disease, deploy
preventative measures and track progression or regression over time.
You broaden your age-management options and make the difference
empowered through simplified genomics.
Clinically relevant, medically actionable support. You receive clear
recommendations for suggested dosing and combination therapies to
integrate with your current practice.
No more trial and error. iDDNA®
helps you fine-tune anti-aging
combination therapies, provides you with distinctive options for non-
medical new patients and simplifies the complex issues of personalized
programs when the patient’s aging is affected by genetic variations.
iDDNA®
does not require an EMR system.
You can simply use your idna.works secure web portal interface. Your
patients’ privacy is strictly protected. Every service is identified by an
unique [iD] Code, so personal details are visible only to the clinician. Our
technology will help you collect and store important patient information,
a valuable contribution to your practice.
iDDNA®
, NEXT GEN ANTI-AGING
A Swiss technology that simplifies your anti-aging prescriptions with
the power of genetics.
EXCLUSIVE PERSONALIZED MEDICINE THAT WORKS -
Be among the first to offer distinctive, solid science and molecular-based
protocols that are receiving worldwide acceptance.
HELP YOUR PATIENTS LEAD HEALTHIER, MORE
PRODUCTIVE LIVES - With DNA-based, preventative, lifestyle
medicine, you help patients look better, feel better and live healthier.
INCREASE YOUR INCOME - Add cash components to your
practice with an exclusive cutting-edge Swiss technology, giving you
distinction and competitive advantage over the competition.
SEAMLESSLY INTEGRATE INTO YOUR PRACTICE -
iDDNA®
can be incorporated immediately into your existing practice,
training your patient coordinator or assistant to manage the service for
you.
ENJOY YOUR PRACTICE AGAIN - Build prestige around your
practice by attracting high-spending patients. Guide them to a new
dimension of health through next generation genetic personalization.
11. PLoS one
Cell
J Cell Physiol
Exp. Cell. Res
Nat. Rev. Mol. Cell. Biol.
Nature Cell Biol.,
J Biol Chem
Biochem J.
Int J Biochem Cell Biol
Int J Biol Sci
Nature
Nature Reviews Genetics
Nature Genetics
Sci. Amer.
Proc Natl Acad Sci USA
Int J Mol Med
Science
N. Engl. J. Med
Genome Biology
Ame J Hum Gen
Gene
Curr Pharm Biotechnol.
Aging Cell
Matrix Biol.
J Gen Microbiol.
J Am Chem Soc.
Glycobiology
Int J Biochem Cell Biol
Curr Opin Cell Biol.
J Theor Biol.
J Appl Toxicol
American Society for Microbiology
N. Engl. J. Med
J Clin Invest
J Intern Med
J Dermatol Sci.
ABOUT iDDNA®
• Quick, simple and non-invasive
• State-of-the-art lab
genotyping (MALDI-TOF mass
spectrometry, 99.7% accuracy)
• Designed and developed in
Switzerland for each and every
client
• Reports and treatments
delivered in 2-4 weeks
• Ingredients clinically tested
to positively affect genes
expressions or protect the DNA
• Once in a lifetime DNA test, for
genetically-guided programs
throughout your patients’
lifespan
OUR SERVICE
• Comprehensive training
• Ongoing support
• Oral cells collection kits
• Genetic profiling
• Customized reports
• Exclusive ultra-custom
treatment programs made with
proprietary cosmeceuticals and
nutraceuticals, delivered to your
door
• Private area and mobile app for
patients
• Marketing support
• Customer service
SWISS TECHNOLOGY
8 years of international research
and development, in the field of
biomedical genetical and cellular
age-management therapies.
SCIENCE &
PUBLICATIONS
MORE THAN 5,000,000
PUBLISHED STUDIES ON DNA.
1 ANTI-AGING PROGRAM
THAT PUTS SCIENCE
TO WORK FOR YOU.
Genetics and the functional approach
to aging remain an active area of
ongoing research. This is the reason why
iDDNA®
is based only on robust and
not controversial peer-reviewed studies
published in the top scientific and
medical journals.
J Invest Dermatol
Int. J. Dermatol.
Br. J. Dermatol.
Eur J Dermatol.
Exp Dermatol
Clin Cosmet Investig Dermatol
Cosmet Dermatol.
Arch Dermatol Res
Dermatoendocrinol
Am J Contact Dermat
Clin Dermat.
J Am Acad Dermatol.
J Drugs Dermatol.
J Eur Acad Dermatol Venereol
Int J Cosmet Sci
Aging
Rejuvenation research
British Jrnl of Nutrition
J Am Coll Nutr
Am J Clin Nutr
Nutrition
Obesity
J Nutr Biochem
Nutrition Research
Physiology & Behaviour
JAMA
FASEB J
The Journal of the American
Nutraceutical Association
J Agric Food Chem.
Nutrition journal
Nutr Res.
Free Radic. Biol. Med.
Eur J Clin Nutr.
Gastroenterology
designed and developed in Switzerland
