This document summarizes the results of a clinical study that tested the Alocado line of products for treating psoriasis. 209 volunteers with stable psoriasis for at least 12 months used various Alocado products daily for 3 weeks under the supervision of 55 dermatologists. Patients' Psoriasis Area and Severity Index (PASI) scores were recorded weekly to evaluate the treatment's effectiveness. The study found that the Alocado products, which contain natural oils, aloe vera extract, and Dead Sea salts without steroids or tar, significantly reduced patients' PASI scores over the 3-week period with no reported side effects.
Certain medications are light-sensitive and can cause photosensitivity reactions when exposed to light, especially sunlight. These reactions include photoallergy and phototoxicity. Photoallergy is an allergic reaction that occurs 0-72 hours after light exposure and causes itchy rashes. Phototoxicity causes skin inflammation and resembles sunburn within minutes to hours of light exposure. Many medications can cause these reactions, including antibiotics, antihistamines, cancer drugs, and heart medications. To prevent photosensitivity reactions, light-sensitive medications are stored in amber-colored packaging such as vials, bottles, ampules, and strips to filter out triggering wavelengths of light.
A Clinical Study to Evaluate the Efficacy of Rajpravartini Vati & Hingvashtak...iosrphr_editor
The women face a lot of physical & psychological problem both at the time of menarche as well as menopause. Kashtartava is a disease where in a female during her reproductive age experiences difficult & painful menstruation. Pathologically its tridoshas having vata predominance .A total 60 patients were randomly divided in these group. An assessment was done on the basis of subjective as well as objective parameters with the help of vas.The study revealed the good report.
Turacoz Healthcare Solutions provides clinical research and regulatory writing services for pharmaceutical companies. We tell you about the different components of a clinical study protocol, the document which is prepared before beginning of any clinical trial. To know more info, visit- goo.gl/C1ec0L or write to us at hello@turacoz.in and call us 011-40584280.
The document outlines the mission, marketing strategies, and product lines of a skin care company that uses natural ingredients from the Dead Sea. The company's mission is to create high-quality skin care products using plant extracts, Dead Sea minerals, and natural mud and salts. Its differentiation strategy is to use 100% natural active ingredients fortified with Dead Sea minerals. The company produces a wide range of body care, skin care, and spa products, including lines for anti-aging, acne treatment, cellulite reduction, and mud treatments.
This document summarizes a 12-month distance learning program in pharmaceutical regulatory affairs. The program provides students with fundamentals in regulatory affairs and quality operations to prepare them for careers in those fields. Graduates will be qualified for jobs like regulatory affairs associates and quality assurance investigators. Completing the certification can increase earnings by 20-30% and is desirable to many employers. The program offers course materials, books, and multimedia to guide students through the curriculum.
CLINICAL STUDY REPORT - IN-TEXT TABLES, TABLES FIGURES AND GRAPHS, PATIENT AN...Angelo Tinazzi
This document discusses technical requirements and solutions for producing statistical outputs for clinical study reports according to ICH E3 guidelines. It provides an overview of key points in ICH E3 related to in-text tables, post-text tables and figures, narratives, and patient data listings. It also discusses considerations for formatting outputs, including paper size and style guidelines. Potential solutions for automating output generation using SAS are presented.
The document discusses the Common Technical Document (CTD), which provides a standardized format for new drug applications across Europe, Japan, and the US. The CTD is organized into 5 modules: Module 1 contains region-specific information; Modules 2-5 are common across regions. Module 2 provides overviews and summaries of quality, non-clinical, and clinical data in Modules 3-5. The CTD format aims to streamline drug approvals across major markets.
“CSR is a detailed regulatory document which gives the information about the methods and results (related to efficacy and safety) of a clinical trial. CSRs are created as a part of the process of submitting applications to the Regulatory Authorities for new medical treatments and for its approval. CSRs can be full, abbreviated, synopsis, supplementary, observational etc as per the results and requirements”.
Certain medications are light-sensitive and can cause photosensitivity reactions when exposed to light, especially sunlight. These reactions include photoallergy and phototoxicity. Photoallergy is an allergic reaction that occurs 0-72 hours after light exposure and causes itchy rashes. Phototoxicity causes skin inflammation and resembles sunburn within minutes to hours of light exposure. Many medications can cause these reactions, including antibiotics, antihistamines, cancer drugs, and heart medications. To prevent photosensitivity reactions, light-sensitive medications are stored in amber-colored packaging such as vials, bottles, ampules, and strips to filter out triggering wavelengths of light.
A Clinical Study to Evaluate the Efficacy of Rajpravartini Vati & Hingvashtak...iosrphr_editor
The women face a lot of physical & psychological problem both at the time of menarche as well as menopause. Kashtartava is a disease where in a female during her reproductive age experiences difficult & painful menstruation. Pathologically its tridoshas having vata predominance .A total 60 patients were randomly divided in these group. An assessment was done on the basis of subjective as well as objective parameters with the help of vas.The study revealed the good report.
Turacoz Healthcare Solutions provides clinical research and regulatory writing services for pharmaceutical companies. We tell you about the different components of a clinical study protocol, the document which is prepared before beginning of any clinical trial. To know more info, visit- goo.gl/C1ec0L or write to us at hello@turacoz.in and call us 011-40584280.
The document outlines the mission, marketing strategies, and product lines of a skin care company that uses natural ingredients from the Dead Sea. The company's mission is to create high-quality skin care products using plant extracts, Dead Sea minerals, and natural mud and salts. Its differentiation strategy is to use 100% natural active ingredients fortified with Dead Sea minerals. The company produces a wide range of body care, skin care, and spa products, including lines for anti-aging, acne treatment, cellulite reduction, and mud treatments.
This document summarizes a 12-month distance learning program in pharmaceutical regulatory affairs. The program provides students with fundamentals in regulatory affairs and quality operations to prepare them for careers in those fields. Graduates will be qualified for jobs like regulatory affairs associates and quality assurance investigators. Completing the certification can increase earnings by 20-30% and is desirable to many employers. The program offers course materials, books, and multimedia to guide students through the curriculum.
CLINICAL STUDY REPORT - IN-TEXT TABLES, TABLES FIGURES AND GRAPHS, PATIENT AN...Angelo Tinazzi
This document discusses technical requirements and solutions for producing statistical outputs for clinical study reports according to ICH E3 guidelines. It provides an overview of key points in ICH E3 related to in-text tables, post-text tables and figures, narratives, and patient data listings. It also discusses considerations for formatting outputs, including paper size and style guidelines. Potential solutions for automating output generation using SAS are presented.
The document discusses the Common Technical Document (CTD), which provides a standardized format for new drug applications across Europe, Japan, and the US. The CTD is organized into 5 modules: Module 1 contains region-specific information; Modules 2-5 are common across regions. Module 2 provides overviews and summaries of quality, non-clinical, and clinical data in Modules 3-5. The CTD format aims to streamline drug approvals across major markets.
“CSR is a detailed regulatory document which gives the information about the methods and results (related to efficacy and safety) of a clinical trial. CSRs are created as a part of the process of submitting applications to the Regulatory Authorities for new medical treatments and for its approval. CSRs can be full, abbreviated, synopsis, supplementary, observational etc as per the results and requirements”.
The document discusses various topics related to international drug regulatory authorities and processes:
- It describes how an increasing number of Indian pharmaceutical companies are obtaining international regulatory approvals from agencies in countries like the US, UK, Australia, and others. India has the largest number of USFDA-approved plants for generic drug manufacturing.
- It provides an overview of the International Conference of Drug Regulatory Authorities (ICDRA), which provides a forum for drug authorities to meet, discuss collaboration, and determine priorities for strengthening regulation.
- It also briefly mentions the International Conference on Harmonisation (ICH), which discusses scientific and technical aspects of product registration to reduce redundant testing between regions.
Clinical Trial Requirements U.S. vs. EU Similarities and DifferencesRETIRE
The document provides an overview of the key similarities and differences between clinical trial requirements in the United States and European Union. Some of the main differences include: in the US, IND approval is not required to begin a trial but the EU requires CTA approval; the US allows protocol waivers under certain conditions while the EU considers waivers a breach of GCP; and adverse event reporting timelines are generally shorter in the EU. Record keeping requirements for documents and investigational products also differ between the regions.
Top 10 regulatory affairs manager interview questions and answersjombenri
This document provides information and advice about common interview questions for a regulatory affairs manager position. It lists 10 typical interview questions, such as "Why do you want this job?", "What challenges are you looking for?", and "What do you know about our company?". For each question, it provides a sample answer and tips on how to effectively respond. The document also includes additional links to online resources about interview preparation.
Regulatory affairs is the bridge between pharmaceutical companies and government regulatory agencies. It involves all activities related to drugs, including research, clinical trials, manufacturing, registration, distribution, pricing, advertising, and post-marketing surveillance. Regulatory dossiers contain all required technical data and documentation needed to obtain approval to market a drug in a given country or region. Common formats include the Common Technical Document for Europe, US, and other markets and Form 44 for India. Compliance with good practices and local regulations is essential for regulatory approval.
USFDA Approval Process For Drug Products & Biological Product i.e NDA Vs. BLA
Comparison of NDA and BLA application process in USA. IND, NDA, ANDA & BLA dossier submission procedure.
The document discusses the Common Technical Document (CTD), which provides a standardized format for submitting documentation to regulatory authorities for approval of pharmaceutical products. It describes the evolution and adoption of the CTD internationally and in India. The CTD aims to streamline the drug approval process and facilitate simultaneous reviews by different regulators. It is organized into five modules covering administrative information, summaries, quality, nonclinical data, and clinical data. Widespread use of the CTD format has allowed for greater harmonization and efficiency in global pharmaceutical development and regulation.
This document discusses the clinical trials process from protocol development through study completion. It covers developing the protocol, regulatory documents, patient recruitment, safety reporting, interim reports, and end of study activities. Key aspects include writing an approvable protocol, establishing an investigator site file, screening and enrolling suitable patients, maintaining safety oversight, and conducting closeout procedures. The goal is to provide guidance on managing all stages of a clinical trial.
The document provides information about regulatory affairs and the registration process for pharmaceutical products. It defines key terms like dossier, DMF, CTD/eCTD, and regulatory filing types. It describes the modules of a common technical document for a product registration, including the administrative, summary, quality, non-clinical and clinical sections. Electronic submission using eCTD format is also discussed. Country-specific regulatory agency websites are listed.
In order to learn how to write effective sentences, paragraphs, essays, and research papers, student must be able to master the basic of all grammar concepts: The 8 Parts of Speech.
The document compares the regulatory processes for drug product submissions in the US and EU. In the US, applications are submitted to the FDA's Center for Drug Evaluation and Research and can be New Drug Applications or Abbreviated New Drug Applications. In the EU, applications are submitted through national regulatory authorities or through the centralized European Medicines Agency process. The key differences between the US and EU processes include differences in application types, approval timelines, post-approval change requirements, manufacturing standards, quality testing standards, and facility inspection processes.
English parts of speech is a challenge to many Indonesian teachers. The content of these slides are purely taken from a book (unfortunately I have completely forgotten the title ad author). By grouping the parts of speech and providing some examples, the book tries to 'elucidate' the seemingly perplexing topic.
Here are some naturopathic treatments for diabetes:
- Diet therapy: Prescribing a diet low in refined carbs and sugar to improve blood sugar regulation. Foods like vegetables, healthy fats and proteins.
- Herbal medicine: Herbs like cinnamon, fenugreek and bitter melon can help lower blood sugar levels.
- Supplements: Chromium, magnesium, alpha-lipoic acid and vitamin D supplements support blood sugar control.
- Lifestyle counseling: Advice on exercise, stress management and sleep hygiene to control risk factors.
- Hydrotherapy: Therapies like sauna or contrast baths to help circulation and stress response.
- Acupuncture:
1. The document provides instructions for a training on the Green World condensed multi-purpose cleaner. Attendees are asked to arrive on time, turn off phones, avoid moving around, and take notes.
2. The cleaner has unique features like being green, powerful for removing dirt yet safe on hands and skin, economical as a concentrated formula, and multipurpose for different cleaning tasks.
3. A demo is proposed to show the cleaner's effectiveness in removing marks from skin and saving water compared to a market brand. The training aims to provide a clean life.
Endocrine disruptors are substances that interfere with hormones and can lead to adverse health effects by mimicking, blocking, or indirectly affecting natural hormones. They are found in many products and sources and may cause disorders like cancer, developmental issues, and neurological problems. While evidence suggests certain chemicals can disrupt hormones, fully proving the link between exposure and human health impacts remains challenging. Regulation aims to limit endocrine disruptor use and remove them from waste and drinking water to reduce risks to human and environmental health. Insurers may face increasing liability claims related to endocrine disruptors if causal relationships with diseases can be established.
This document discusses poisoning and its management. It begins by defining what a poison is and the different types of poisoning, including deliberate, accidental, environmental, and industrial exposures. It then describes common symptoms of poisoning and considerations for managing poisoned patients, including resuscitation, toxicological diagnosis, and therapeutic interventions like decontamination and antidotes. The diagnostic process involves obtaining a thorough history, conducting a physical exam looking for clues, and ordering targeted toxicology investigations to determine the poison involved and properly manage the patient.
Methods of life extension currently availabelavturchin
This document provides an overview of currently available methods for life extension organized into the following categories: lifestyle changes, social life, ecology, motivation, country of residence, risk reduction, health checks, nutrition, mobility, supplements, sleep, controlling health parameters, hormone therapy, hormesis, medications, medical insurance, brain health, regeneration, cryonics, and maintaining motivation. The document outlines specific actions individuals can take within each category to potentially extend their lifespan based on current scientific research and understanding.
This document discusses the benefits of Kangen water and the Kangen water machine. It claims the machine produces micro-clustered water through electrolysis with various health benefits like fighting oxidative stress, acidic stress, and hydrating stress. It also lists various types of water produced - strong Kangen water for emulsifying chemicals in food, clean water for babies, strong acidic water for disinfecting, beauty water as a toner, and various pH Kangen waters for drinking and cooking. Case studies show benefits for conditions like eczema. The machine is said to be used in Japanese hospitals for over 42 years and approved as a medical device in Japan.
This document provides an overview of atopic dermatitis (AD), including its epidemiology, pathogenesis, and current treatment approaches. It discusses that AD is a chronic inflammatory skin disease characterized by eczematous lesions and itching. The document then summarizes the role of phosphodiesterase 4 (PDE4) in the pathogenesis of AD by hydrolyzing cyclic adenosine monophosphate (cAMP) and increasing inflammatory signaling. Current therapies aim to suppress AD symptoms through moisturizing and avoiding triggers, but do not cure the underlying disease. The document proposes developing a PDE4 inhibitor to decrease cAMP hydrolysis and inflammation as a potential new therapeutic approach for AD.
This document provides an overview of pharmacovigilance and the Pharmacovigilance Program of India (PvPI). It defines pharmacovigilance as the science of detecting, assessing, understanding, and preventing adverse effects of medicines. The document outlines the historical events that led to the development of pharmacovigilance, including the sulfanilamide and thalidomide disasters. It describes the vision, mission, aims, and objectives of PvPI in India to improve patient safety related to medicine use. Key aspects of PvPI covered include adverse drug reaction reporting processes and the expansion of PvPI to include additional medical areas over time.
This document provides an overview of endocrine disrupting chemicals (EDCs) and discusses their potential impacts and regulation. It notes that EDCs can interfere with hormone systems and cause adverse health effects. Sources of EDCs include agricultural and industrial chemicals, pharmaceuticals, consumer goods and food/beverage packaging. Regulation of EDCs differs globally. The insurance industry may face increased liability exposures from bodily injury claims related to chronic low-dose EDC exposure given evidence of their environmental persistence and ability to cause long-term health impacts even at low levels. Overall the paper aims to increase awareness of EDCs as an emerging risk that requires monitoring and risk mitigation strategies across industries.
It will be an appropriate source for you to understand about the food toxicology. Further, the impacts of genetically modified are discussed in detail. the effects of toxicity in human and other living organisms are included in this document with examples.
The document discusses various topics related to international drug regulatory authorities and processes:
- It describes how an increasing number of Indian pharmaceutical companies are obtaining international regulatory approvals from agencies in countries like the US, UK, Australia, and others. India has the largest number of USFDA-approved plants for generic drug manufacturing.
- It provides an overview of the International Conference of Drug Regulatory Authorities (ICDRA), which provides a forum for drug authorities to meet, discuss collaboration, and determine priorities for strengthening regulation.
- It also briefly mentions the International Conference on Harmonisation (ICH), which discusses scientific and technical aspects of product registration to reduce redundant testing between regions.
Clinical Trial Requirements U.S. vs. EU Similarities and DifferencesRETIRE
The document provides an overview of the key similarities and differences between clinical trial requirements in the United States and European Union. Some of the main differences include: in the US, IND approval is not required to begin a trial but the EU requires CTA approval; the US allows protocol waivers under certain conditions while the EU considers waivers a breach of GCP; and adverse event reporting timelines are generally shorter in the EU. Record keeping requirements for documents and investigational products also differ between the regions.
Top 10 regulatory affairs manager interview questions and answersjombenri
This document provides information and advice about common interview questions for a regulatory affairs manager position. It lists 10 typical interview questions, such as "Why do you want this job?", "What challenges are you looking for?", and "What do you know about our company?". For each question, it provides a sample answer and tips on how to effectively respond. The document also includes additional links to online resources about interview preparation.
Regulatory affairs is the bridge between pharmaceutical companies and government regulatory agencies. It involves all activities related to drugs, including research, clinical trials, manufacturing, registration, distribution, pricing, advertising, and post-marketing surveillance. Regulatory dossiers contain all required technical data and documentation needed to obtain approval to market a drug in a given country or region. Common formats include the Common Technical Document for Europe, US, and other markets and Form 44 for India. Compliance with good practices and local regulations is essential for regulatory approval.
USFDA Approval Process For Drug Products & Biological Product i.e NDA Vs. BLA
Comparison of NDA and BLA application process in USA. IND, NDA, ANDA & BLA dossier submission procedure.
The document discusses the Common Technical Document (CTD), which provides a standardized format for submitting documentation to regulatory authorities for approval of pharmaceutical products. It describes the evolution and adoption of the CTD internationally and in India. The CTD aims to streamline the drug approval process and facilitate simultaneous reviews by different regulators. It is organized into five modules covering administrative information, summaries, quality, nonclinical data, and clinical data. Widespread use of the CTD format has allowed for greater harmonization and efficiency in global pharmaceutical development and regulation.
This document discusses the clinical trials process from protocol development through study completion. It covers developing the protocol, regulatory documents, patient recruitment, safety reporting, interim reports, and end of study activities. Key aspects include writing an approvable protocol, establishing an investigator site file, screening and enrolling suitable patients, maintaining safety oversight, and conducting closeout procedures. The goal is to provide guidance on managing all stages of a clinical trial.
The document provides information about regulatory affairs and the registration process for pharmaceutical products. It defines key terms like dossier, DMF, CTD/eCTD, and regulatory filing types. It describes the modules of a common technical document for a product registration, including the administrative, summary, quality, non-clinical and clinical sections. Electronic submission using eCTD format is also discussed. Country-specific regulatory agency websites are listed.
In order to learn how to write effective sentences, paragraphs, essays, and research papers, student must be able to master the basic of all grammar concepts: The 8 Parts of Speech.
The document compares the regulatory processes for drug product submissions in the US and EU. In the US, applications are submitted to the FDA's Center for Drug Evaluation and Research and can be New Drug Applications or Abbreviated New Drug Applications. In the EU, applications are submitted through national regulatory authorities or through the centralized European Medicines Agency process. The key differences between the US and EU processes include differences in application types, approval timelines, post-approval change requirements, manufacturing standards, quality testing standards, and facility inspection processes.
English parts of speech is a challenge to many Indonesian teachers. The content of these slides are purely taken from a book (unfortunately I have completely forgotten the title ad author). By grouping the parts of speech and providing some examples, the book tries to 'elucidate' the seemingly perplexing topic.
Here are some naturopathic treatments for diabetes:
- Diet therapy: Prescribing a diet low in refined carbs and sugar to improve blood sugar regulation. Foods like vegetables, healthy fats and proteins.
- Herbal medicine: Herbs like cinnamon, fenugreek and bitter melon can help lower blood sugar levels.
- Supplements: Chromium, magnesium, alpha-lipoic acid and vitamin D supplements support blood sugar control.
- Lifestyle counseling: Advice on exercise, stress management and sleep hygiene to control risk factors.
- Hydrotherapy: Therapies like sauna or contrast baths to help circulation and stress response.
- Acupuncture:
1. The document provides instructions for a training on the Green World condensed multi-purpose cleaner. Attendees are asked to arrive on time, turn off phones, avoid moving around, and take notes.
2. The cleaner has unique features like being green, powerful for removing dirt yet safe on hands and skin, economical as a concentrated formula, and multipurpose for different cleaning tasks.
3. A demo is proposed to show the cleaner's effectiveness in removing marks from skin and saving water compared to a market brand. The training aims to provide a clean life.
Endocrine disruptors are substances that interfere with hormones and can lead to adverse health effects by mimicking, blocking, or indirectly affecting natural hormones. They are found in many products and sources and may cause disorders like cancer, developmental issues, and neurological problems. While evidence suggests certain chemicals can disrupt hormones, fully proving the link between exposure and human health impacts remains challenging. Regulation aims to limit endocrine disruptor use and remove them from waste and drinking water to reduce risks to human and environmental health. Insurers may face increasing liability claims related to endocrine disruptors if causal relationships with diseases can be established.
This document discusses poisoning and its management. It begins by defining what a poison is and the different types of poisoning, including deliberate, accidental, environmental, and industrial exposures. It then describes common symptoms of poisoning and considerations for managing poisoned patients, including resuscitation, toxicological diagnosis, and therapeutic interventions like decontamination and antidotes. The diagnostic process involves obtaining a thorough history, conducting a physical exam looking for clues, and ordering targeted toxicology investigations to determine the poison involved and properly manage the patient.
Methods of life extension currently availabelavturchin
This document provides an overview of currently available methods for life extension organized into the following categories: lifestyle changes, social life, ecology, motivation, country of residence, risk reduction, health checks, nutrition, mobility, supplements, sleep, controlling health parameters, hormone therapy, hormesis, medications, medical insurance, brain health, regeneration, cryonics, and maintaining motivation. The document outlines specific actions individuals can take within each category to potentially extend their lifespan based on current scientific research and understanding.
This document discusses the benefits of Kangen water and the Kangen water machine. It claims the machine produces micro-clustered water through electrolysis with various health benefits like fighting oxidative stress, acidic stress, and hydrating stress. It also lists various types of water produced - strong Kangen water for emulsifying chemicals in food, clean water for babies, strong acidic water for disinfecting, beauty water as a toner, and various pH Kangen waters for drinking and cooking. Case studies show benefits for conditions like eczema. The machine is said to be used in Japanese hospitals for over 42 years and approved as a medical device in Japan.
This document provides an overview of atopic dermatitis (AD), including its epidemiology, pathogenesis, and current treatment approaches. It discusses that AD is a chronic inflammatory skin disease characterized by eczematous lesions and itching. The document then summarizes the role of phosphodiesterase 4 (PDE4) in the pathogenesis of AD by hydrolyzing cyclic adenosine monophosphate (cAMP) and increasing inflammatory signaling. Current therapies aim to suppress AD symptoms through moisturizing and avoiding triggers, but do not cure the underlying disease. The document proposes developing a PDE4 inhibitor to decrease cAMP hydrolysis and inflammation as a potential new therapeutic approach for AD.
This document provides an overview of pharmacovigilance and the Pharmacovigilance Program of India (PvPI). It defines pharmacovigilance as the science of detecting, assessing, understanding, and preventing adverse effects of medicines. The document outlines the historical events that led to the development of pharmacovigilance, including the sulfanilamide and thalidomide disasters. It describes the vision, mission, aims, and objectives of PvPI in India to improve patient safety related to medicine use. Key aspects of PvPI covered include adverse drug reaction reporting processes and the expansion of PvPI to include additional medical areas over time.
This document provides an overview of endocrine disrupting chemicals (EDCs) and discusses their potential impacts and regulation. It notes that EDCs can interfere with hormone systems and cause adverse health effects. Sources of EDCs include agricultural and industrial chemicals, pharmaceuticals, consumer goods and food/beverage packaging. Regulation of EDCs differs globally. The insurance industry may face increased liability exposures from bodily injury claims related to chronic low-dose EDC exposure given evidence of their environmental persistence and ability to cause long-term health impacts even at low levels. Overall the paper aims to increase awareness of EDCs as an emerging risk that requires monitoring and risk mitigation strategies across industries.
It will be an appropriate source for you to understand about the food toxicology. Further, the impacts of genetically modified are discussed in detail. the effects of toxicity in human and other living organisms are included in this document with examples.
This document introduces key concepts in pharmacology. It defines drugs, pharmacology, clinical pharmacology, and therapeutics. An ideal drug is effective, safe, and selective, but in reality no drug is ideal as all can cause harm and have side effects. The objective of drug therapy is to provide maximum benefit with minimum harm by considering factors like administration, pharmacokinetics, pharmacodynamics, and individual patient variations.
This document introduces key concepts in pharmacology. It defines drug, pharmacology, clinical pharmacology, and therapeutics. An ideal drug is effective, safe, and selective, but no drug is truly ideal. The objective of drug therapy is to provide maximum benefit with minimum harm. How individuals respond depends on administration, pharmacokinetics, pharmacodynamics, and individual variations.
This document provides an overview of medical therapy in dermatology, including general aspects of treatment, topical therapy, and commonly used topical treatments. It discusses key considerations for topical therapy like drug concentration, vehicle choice, application frequency and quantity. Topical corticosteroids are highlighted as a major treatment that revolutionized dermatology, though they require proper use to avoid side effects. The document also reviews systemic therapy, phototherapy, radiotherapy, physical therapies and laser therapies.
This document provides an overview of pharmacovigilance and phytoresearch. It discusses the process of pharmacovigilance including adverse drug reaction reporting and its history and purpose. Key terms in pharmacovigilance like causation and stakeholders are defined. The document also covers the identification, extraction, and detection methods used in phytoresearch like chromatography, spectroscopy, and endophyte evaluation. Skills gained in pharmacovigilance like risk management and report writing and those in phytoresearch like instrumentation use and formulation development are summarized. The conclusion emphasizes the goals of ensuring drug safety and discovering bioactive plant compounds.
Name Your Poison - A Guide to the Most Common Toxins v2zq
Name Your Poison - A Guide to the Most Common Toxins - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ purezing.com
Guide to the Most Common Toxins in Food, Cosmetics & Cleaners v2zq
Guide to the Most Common Toxins in Food, Cosmetics & Cleaners - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Pharmacovigilance involves monitoring adverse drug reactions (ADRs) that are detected after drugs receive marketing approval. ADRs are defined as harmful effects from normal drug dosages. Several types of ADRs exist and can be serious or severe. Possible causes include drug interactions and underlying medical conditions. Reporting and monitoring ADRs through pharmacovigilance aims to improve patient safety and reduce risks from drug use.
Resveratrol is a compound found in plants that protects against pathogens and UV light. It has many health benefits including potential assistance with tumors, inflammation, cancer, heart disease, diabetes, and skin repair. Studies show resveratrol supplementation improves skin health by reducing oxidative stress and brown spots while increasing antioxidant levels, elasticity, and moisture. Resveratrol may also help reduce acne and support collagen production. Reserve is a product containing resveratrol and other antioxidants that has been shown scientifically to penetrate cells and protect against oxidative damage.
Do you suffer from a skin disorder? Whether it's acne, eczema, or even gangrene, homeopathy can help treat it and get you back to living a normal life.
This document discusses vitiligo, a skin condition that causes loss of skin pigmentation and the appearance of white patches on the skin. It provides details on what causes vitiligo, the different types, symptoms, who is affected, inheritance, homeopathic treatment using constitutional remedies like samarium, and supporting pranayama practices. Vitiligo is a fairly common condition impacting quality of life, but homeopathy treats it at the constitutional level to restore normal pigmentation over time.
Similar to Alocado™ clinical study report dr angela ruban (20)
This document promotes a new acne treatment product called Kianomer Young Sebu cream. It claims that the $2.5 billion acne market is in need of a natural, non-drying solution without side effects like benzoyl peroxide treatments. Kianomer uses goat's milk and Dead Sea minerals as active ingredients to combat acne without drying skin. Clinical trials showed over 50% improvement in acne for most users within 2 weeks and over 90% improvement within a month, with many users reporting it is the only effective acne product that does not dry their skin.
A large bite wound measuring 40x15cm on an Irish Wolfhound's flank and abdomen was treated with delayed primary closure and VetGold. Initial closure of the large skin flap was unsuccessful due to infection and necrosis. The wound was then managed as an open wound with daily irrigation and antibiotics until the infection cleared and granulation tissue formed. A second delayed closure was planned but deemed unnecessary as the wound contracted rapidly and epithelized well with continued use of VetGold, allowing it to heal openly. The dog made a full recovery after two weeks.
A dog was hit by a car and had an open wound on its right back leg that would not heal with bandages over two months. The vet removed the bandage and treated the open wound with twice daily applications of VetGold cream for five weeks. After one week and five weeks of VetGold treatment, the wound had significantly healed.
Spider Pharm Industries produces a line of natural skincare products called VetGold for veterinary use. The line includes creams, sprays, shampoos, and other products to treat skin conditions in animals. The products contain minerals from the Dead Sea and natural oils and extracts. Spider Pharm is looking to expand distribution of the VetGold line internationally and is inviting companies to become distributors in their countries.
Diabetic feet are prone to damage due to loss of feeling and natural oils. This can cause sores to develop. The CleaDerma DermoSilk Foot Cream and CleaDerma DCB provide necessary nutrients to moisturize, nourish and rejuvenate skin, enhancing its ability to heal itself. They contain natural oils, vitamins, minerals and plant extracts to lubricate skin and boost collagen production. This creates a nourishing system to treat and prevent breakdown of diabetic foot skin.
DermoSilk is a hand and foot cream made from natural active ingredients including plants that are enriched with minerals from the Dead Sea. It contains extracts from the Lesser Elecampane, Common myrtle, and White poplar plants which are combined to restore dry, cracked skin to a healthy, moisturized condition. Regular use of DermoSilk nourishes the skin and strengthens it to prevent further drying and cracking without using harsh chemicals.
The document discusses the Alocado line of products for treating psoriasis. It describes several products in the line including creams, ointments, and lotions that provide moisturization and relief from dry, irritated skin. The products contain ingredients like avocado oil, aloe vera, and Dead Sea salt that nourish the skin and help repair damaged skin cells. Test results from a dermatologist found the Alocado line to be an effective alternative treatment for psoriasis.
Cellulite is caused by poor blood circulation and toxin drainage in fat cells, causing collagen fibers to deform and push against the skin's surface, creating an orange peel-like appearance. Spider Pharm believes consistent treatment with natural active ingredients can significantly reduce the appearance of cellulite. Their Cellu-Treat line includes a daily coffee cream containing caffeine, a weekly deep massage cream with cinnamon oil, and a cleansing soap bar containing Dead Sea salts to eliminate fluid retention and stimulate circulation.
1. 1
AlocadoTM
Effect of AlocadoTM
complex treatment on PASI scores
on psoriasis patients
Prospective Clinical Study
Final report
2008
Prepared for:
Spider pharm Industry Ltd.
Arad Israel
Prepared by:
Teva Pharmaceuticals Ltd.
Hungary
Analyzed, Summarized and Written by:
Dr. Angela Ruben, PhD in Clinical Pharmacology
3. 3
Introduction
Kedo Eurocosmetics Ltd. and Spider Pharm Industries Ltd. entered an agreement in September
2006, to test the Alocado™ product line on volunteers suffering from psoriasis as requested by
Teva Pharmaceuticals Ltd. Hungary. This document contains the test results, which are available
for anyone wishing to be informed about the products. Our aim is to address physicians,
specialists (dermatologists), pharmacists and patients all at the same time.
1. About Psoriasis:
Psoriasis is a classic and common dermatological condition. It is defined as follows: an
“inflammatory skin condition with increased epithelial proliferation, characterized by infiltrated
plaques and silvery scaling”. According to international statistics 2-3% of the overall populations
are affected by this condition in varying degrees.
In Hungary, the estimated number of patients lies between 200,000 and 300,000, although much
fewer visit their physicians, because part of them has already lost faith in receiving effective
treatment; the other reason for not seeing a physician is that they are in remission and do not see
its importance. The causes of psoriasis are still unclear, but research has significantly advanced
our understanding concerning the inflammatory process and the immunological background of
the illness.
The cause of this condition is believed to be genetic in nature. The condition is characterized by
an increased sensitivity of the skin, reacting to external and internal stimuli. These stimuli are the
so-called “provoking factors." The most important provoking factors are mechanical (injury or
irritation of the skin), immunological, metabolic stimuli, and provocation by medicine and stress.
A characteristic feature of the illness is the deterioration of quality of life. This is not a life-
threatening illness, and its gravity is determined not by the physician, but the patient. This
condition influences the patient’s everyday life as well as their social and working activities.
Deterioration of the quality of life due to psoriasis can be as serious as that caused by heart
disease or depression.
Clinically speaking, it is the most versatile skin disease. The most often affected parts of the
body are: the scalp, the knees, the elbow, the buttocks, the genitalia, the navel, the flexures and
the nails. Its most frequent forms: thick, silvery plaque, extensive, inflammatory plaque, tiny,
punctiform lesions and incidental small blisters. From a medical point of view, the degrees of
illness can range from an asymptomatic state through mild symptoms, with isolated plaques to
persistent, thick plaques; from a gradual spread, to a degree, when joints are also affected and the
complete surface of the skin is covered by erythroderma.
According to Prof. Christopher Griffith, the gravity of the illness depends on the degree of
deterioration of quality of life, the resistance to therapy and the degree lesion spreading.
Seeing as psoriasis is an illness that influences the quality of life and its gravity is determined by
the patient, the physician compares his or her own findings with the evaluation of the patient and
offers the patient all available therapeutic alternatives. Finally, they will be able to mutually
choose the best one. The therapy can be either local or system ic.
Local treatment consists of two phases: the first is stopping acute symptoms, and the second is
maintaining therapy with the aim of avoiding a relapse. As for the medication used in
4. 4
maintenance therapy it is of utmost importance that they be well tolerated by the patient, without
any side effects.
There are very few preparations used so far, that comply with the above requirements.
Traditional treatment possibilities for the acute phase are: coal tar, local corticosteroids, vitamin
D analogues, local retinoids, and keratolytic agents (compounds containing salicylic acid, for
external application). Besides these, Photo-therapy (PUVA, UVB) and bath therapy may also be
applied.
1.The above therapies are effective, but they have several side effects:
2.Corticosteroids can cause atrophy of the skin; vasodilation may occur fungal or bacterial
infections may emerge.
3. Vitamin D may be irritating and expensive.
4.The application of coal tar and some of the photo-therapies in large doses are carcinogenic.
5.Salicylic acid in high concentrations is irritating.
From the list of above-mentioned therapies only vitamin D is suitable for maintenance therapy.
So the need for a phase-specific, non-aggressive (non-irritating) maintenance therapy is justified.
2. About Alocado™
treatment
The Alocado™
product line was developed in 1988 based on formulas developed by physicians
and pharmacists working in clinics near the Dead Sea. At that time, it was recognized that the
surroundings, the water and the mud of the Dead Sea had a healing effect on the patients
suffering from skin diseases. This was also the time when some publications on side effects and
disadvantageous features of steroids appeared. Sea minerals are Nature’s ultimate supplement for
maintaining healthy skin. The minerals essential to well-functioning skin – magnesium, calcium,
potassium and sodium – naturally attract and retain water and are known as Natural Moisturizing
Factors (NMF). As a person matures, the NMF levels of the body gradually become depleted,
lessening the body’s ability to retain the proper moisture levels needed to prevent skin aging.
Urban pollution, the ongoing exposure to the elements and the fast-paced lifestyles we live, all
take their toll. Dead Sea mineral formulae help to reactivate the skin’s natural ability to hydrate
and replenish itself and restore its natural suppleness. Realizing these facts, the inventors were
inspired to develop a range of products solving all varying problems using a phase specific range
of products that was a revolutionary departure from the “all in one” existing medicines. During
their work, they could make use of some publications analyzing therapeutic effects of some
vegetable oils like Avocado oil, and the Aloe Vera extract. Besides this, patients wished to enjoy
remission not only for a week for as long as their treatment at the Dead Sea lasted, but for a
longer period of time. This was made possible by being able to take these natural remedies back
home.
Advantages of the Alocado™
product line are as follows:
1.It does not contain steroids.
2.It does not contain tar.
3.It does not contain synthetic vitamin D.
4.The acid content never exceeds 2%.
5.The active ingredients are combined with very strong emollients.
5. 5
6. A unique composition of natural oils (mainly Avocado), Aloe Vera extract and salt from
the Dead Sea (not reaching salt concentration levels that could irritate skin).
7.There are special products to treat different symptoms, including open wounds.
8.We offer products for maintenance therapy to be used in state of remission to contribute to
palliate symptoms of the next relapse.
9.These products don’t have side effects neither after short- nor after long-term treatment..
Study design:
1. Psoriasis study group:
1.Gender: 209 volunteers’ women and men as equal.
2.Age: 18-75 years old
3.Health conditions: stable psoriasis at least last 12 months, PASI >2, body or/and head are
affected.
4.Background: varied
5.Duration:
September 2006-September 2007
6.Termination:
After 3 weeks of the treatment.
7.Report:
Each doctor was follow-up his patient weekly and giving the PASI score that was
documented in personal file of each patient. The mean PASI score was calculated for each
patient and presented in the final report.
8.Treatment:
The follow Alocado™
products were used in the current clinical study:
Product name
Alocado ™
Cream
Alocado ™
Ointment
Alocado ™
Pasta
Alocado ™
Gold
Alocado ™
Skin Softener
Alocado ™
Silver
Alocado ™
Bath Oil
Alocado ™
Body Oil
Alocado ™
Lotion
Alocado ™
Scalp Oil
Alocado ™
Zi-Con
Alocado ™
Zal-Con
Alocado ™
Shampoo
Alocado ™
Hair Conditioner
6. 6
We began testing Alocado™
products in September 2006. It was an open clinical prospective
study over a period of one year. 208 volunteers were recruited to take part in the test, which was
not launched at the most favorable period, because psoriasis generally relapses when cold
weather is to be expected. Baseline data were collected along with the dermatological
examination, i.e. personal data, medical history, and all medications taken before and at the time
of this examination were recorded. The state of the skin was photographed. The exclusion
criteria were unstable psoriasis, children, pregnancy, lactation, history of any thyroid disorder
and severe systemic illnesses. The patients were assessed at the end of 2 and 3 weeks by 55
Dermatologists; each doctor treated and follow-up five volunteers. The volunteers were self-
treated by different combination of the Alocado™
products daily and according to the instruction
of the Dermatologist. Once a week, the volunteers were checked by the same doctor and the
effect of the treatment was evaluated using PASI index. The PASI index widely accepted in
specialist literature to establish condition changes.
We established values on the basis of PASI index from the starting state of illness, and during the
repeated follow-ups.
A short summary on PASI:
The objective skin condition of the patient is expressed by the so called PASI index. This is an
internationally accepted index to demonstrate the state of the skin and to establish efficacy of the
therapy. The index evaluates the main symptoms of psoriasis: erythema, induration, and scaling,
and the size of the affected area are taken into consideration as well. All these factors are taken
into account in the regions of the head, the upper limbs, the torso and the lower limbs. Using
different multipliers a relative number is achieved from the sum of these values. This relative
number is not quite perfect; e.g. changing from PASI 20 to PASI 10 is much easier than to
change from 10 to 5. There is a version of this index where the patients analyze the values
themselves. (This happened in our case, when we had weekly or bi-weekly phone consultations
with the patients.)
Since psoriasis is an illness influencing the quality of life, it is the patient who evaluates the
illness most precisely; his or her opinion is crucial. The results are expressed as mean ± SD.
Student's unpaired t-test was used for statistical analysis of the data. Level of significance was
P<0.005.
The objective
The objective of our study was to assess the clinical efficacy of Alocado™
complex treatment in
psoriasis.
Administering Alocado™
products, our aim was to give emollient, nourishing and calming
preparations to the patient. These products are phase-specific, meaning that they always exert
their effect against the most irritating symptom, and they support maintenance therapy in
conjunction with drug therapy or without. The products prolong the period between relapses and
make the patients feel more comfortable with their skin.
7. 7
Results
When starting the Alocado™
treatment, we tried to choose patients who had not been treated with
any steroids or other medicines within a given period before the test. However, taking these
preparations was not a criterion for exclusion, since it is necessary to have some emollient
treatment for those who took the aforementioned medication.
In any cases, improvement could be observed based on the regular application of the Alocado™
products. When stopping it, the skin’s condition could deteriorate in some cases the conditions as
it was before the treatment. We observed that the efficacy of the products, and the response to
them could be increased by applying the appropriate Alocado™
product several times a day. It
has been observed that application 4 times daily (this dosage proved to be necessary to achieve
maximum efficacy) resulted in the fastest improvement.
Throughout the treatment, we had to change products with many patients, because Alocado™
products are phase-specific, and a different product is recommended depending on the
predominant symptom (scaling, inflammation, infiltration). In patients showing improvement,
the use of the compound called Gold should be emphasized, having a soothing effect on the
itching, excoriated parts of the skin, which quickly epithelized and the patient soon became
asymptomatic.
1. Three weeks after the treatment with Alocado™
complex all 208 patients showed
significant improvement in their symptoms. The positive effect of the treatment was
observed already after the first week of the treatment. The Table 1 summarized PASI
index scores as per follow-up. As it can be seen in the table the positive effect of the
treatment was achieved independently on the severity of the disease or on the affected
area percent.
Patients PASI
Number 1st
week 2nd
week 3nd week
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
4
3
4.6
7.4
6.8
11.3
7.1
2.7
19.1
8.7
5.4
1.8
2.6
2.2
7.2
2.8
4.1
4.4
4.9
12.6
3.2
2.4
3.6
4.2
6
9.8
4.8
1.2
13.8
5.8
4.4
1.4
1
1.8
5.6
2.3
3.1
0.9
3
11.9
2.8
1.5
2.1
2.9
3.2
7.6
4.7
1
9.2
2.6
3
1
0.7
1.2
3
1.6
1.3
0.9
2.5
6.6
12. 12
index before the treatment) and by 65% in the end of the 3 weeks of the treatment (35%
compare to the PASI index before the treatment) (unpaired t- test p<0.001).
The most important was the fact that no side effects were reported during the period of the
treatment and within half year later as well.
2. Besides the significant improving in the symptoms, in 107 patients was observed
significant reducing in the percent of the affected area of the body, as can be seen in the
Figure 3. After 1st
week of the treatment with Alocado™
complex the percent of the
affected area of the body was reduced by 8% as compare to the beginning of the
treatment (32% versus 40%) and by 23% in the end of the 3 weeks of the treatment (17%
versus 40%) (unpaired t- test p<0.001).
Figure 1.
14. 14
Discussion
Psoriasis is a chronic inflammatory skin disease with a high social and psychological impact on
the quality of life of patients. Literature reports that psoriasis can cause a physical and mental
disability similar to other medical diseases, like hypertension and diabetes, and psychological
distress can influence the rate of withdrawal during standard therapy, because patients who feel
worse spend less time caring for their psoriasis.
The Dead Sea region is recognized worldwide for its efficacy in the treatment of dermatological
diseases, particularly Psoriasis, Atopic Dermatitis, Vitiligo, and Mycosis Fungoides. Sea
minerals are Nature’s ultimate supplement for maintaining healthy skin. The minerals essential
to well-functioning skin – magnesium, calcium, potassium and sodium – naturally attract and
retain water and are known as Natural Moisturizing Factors (NMF). As a person matures, the
NMF levels of the body gradually become depleted, lessening the body’s ability to retain the
proper moisture levels needed to prevent skin aging.
We conducted a prospective clinical trial on 208 patients affected by mild to severe psoriasis
undergoing Alocado™
complex therapy. We recorded a significant reduction of the mean
Psoriasis Area and Severity Index (PASI) index in all 208 patients who completed the three-
week course and an improvement of the ‘quality of life’ of patients. In addition, the recurrence of
the symptoms 6 months later without treatment that was observed in few cases was usually less
severe than the previous attack. It should be mentioned that no side effects were observed. The
good efficacy obtained by this treatment, and the psychological impact on the quality of life of
patients, demonstrated that Alocado™
complex therapy could be a very good option for the
treatment of a chronic disease associated with psychological distress, like psoriasis, particularly
when the patient is affected by other diseases, and we cannot use any systemic psoriasis drug.
What is not less important that this treatment is more cost-effective than many other treatments.
Conclusion
Based on these results, it may be concluded that the phase-specific, emollient, palliative natural
compounds of the ALOCADO™
product line offer a highly effective, very fast and safe
alternative for the treatment of psoriasis.
15. 15
References:
1. O. Braun - Falco. G. Plewig, H.H .Wolff, W.H.C Burgdorf: Dermatology Second,
Completely Revised Edition, Springer
2. Prof. Louis Dubertret: Psoriasis from clinic to therapy Edition Med'com,2005
3. A lokális antipsoriatikus kezelés uj irányvonalai dr Hoffer Gábor II.Budapesti
Bfirgyógyászati Továbbképzfi Tanfolyam Faragó, Katalin MD, Dermatologist
4. Rapp SR, Feldman SR, Exum ML, Fleischer AB Jr, Reboussin DM. Psoriasis
causes as much disability as other major medical diseases. J Am Acad Dermatol
1999; 41: 401–407.
5. Levi-Schaffer F, Shani J, Politi Y, Rubinchik E, Brenner S. Inhibition of
proliferation of psoriatic and healthy fibroblasts in cell culture by selected Dead-
sea salts. Pharmacology 1996; 52: 321–328.
16. 16
Appendix 1
I. ATOPIC DERMATITIS
Clinical test for ALOCADO™
• A woman of 29 years of age
• Suffering from Atopic Dermatitis for 12 years.
• Treated with all kinds of medicine, including injections and steroids.
• Past two years, no changes.
• Start of treatment 8.11.06 – before photo.
• Last check 31.12.06 – after photo.
• Treated with Alocado™ Cream and Alocado ™ Skin Softener, to be applied three times a
day, first Alocado™ Skin Softener and when absorbed, Alocado™ Cream. When itchy,
Alocado™ Cream can be applied as much as needed.
• In 31.12.06 Alocado™ Gold was added to treat open wounds left on the body,
• 10.01.07 wounds are closed; most of the skin is clear, continue maintenance treatment
with the Alocado™ Cream.
17. 17
II. PSORIASIS
Clinical test for ALOCADO™
• 75 years old
• PASI index at start 39.2 for the past 15 years no improvement whatever medicine taken.
• Very swollen, red and inflamed skin, sometimes very itchy, others not
• Some areas are covered with thin plaque.
• At current situation, using medicine with steroids, help minor.
• Started Alocado™ treatment at the 28/9/06 received Alocado™ Gold for treating
inflammation and Alocado™ Pasta for treating red swollen skin.
• The moment stop taking medicines within one week situation worsen to 55 in PASI index
(steroid effect).
• After 1 month when inflammation reduced, Alocado™ Body oil and Alocado™ Cream
for itching and dry skin were added. So treatment included Alocado™ Gold, Alocado™
Body oil, Alocado™ Pasta and Alocado™ Cream, when inflammation was reduced to
zero Alocado™ Gold was stopped. After 1 more month at the 3rd of December 2006 the
PASI index dropped to 13.2.
• No Itching, No scaling, No inflammation, No swelling, No redness (small red dots are the
only thing left, typical to old peoples skin), fingernails grew back better than before (were
treated with Alocado™ Skin Softener).
• Over all, pretty satisfying results.
• Ongoing treatment – Alocado™ Cream, Alocado™ Body oil and Alocado™ Skin
Softener for maintenance.
18. 18
III. PSORIASIS
Clinical test for ALOCADO™
• 68 years old lady
• PASI index at start 26, for the past 10 years no improvement whatever medicine taken.
• Very swollen, very red and extremely inflamed skin, amazingly no itching.
• At current situation, gave up on treatment for several years.
• Started Alocado™ treatment at the 28/9/06 received Alocado™ Gold for treating
inflammation and Alocado™ Pasta for treating red swollen skin and Alocado™ Cream
for dry skin.
• After 1 month of treatment, PASI index dropped to 13, inflammation reduced and at one
area only pinkish coloration left. (Patient refuse to stop taking the Alocado™ Gold
although inflammation was reduced, we let it stay).
• After two months PASI index 5 and less, No Itching, No scaling, No inflammation, No
swelling, No redness but very light almost unnoticeable pink.
• Over all, pretty satisfying results.
• Ongoing treatment – Alocado™ Cream, Alocado™ Body oil and Alocado™ Bath oil for
maintenance.