Hypopituitarism occurs when the pituitary gland loses its ability to produce hormones, resulting in multiple hormone deficiencies. It can be congenital or acquired. Congenital causes include genetic disorders and developmental brain defects. Acquired causes include tumors, infections, and injuries to the pituitary or hypothalamus. Symptoms depend on which hormones are deficient but may include growth failure, hypoglycemia, delayed puberty, and diabetes insipidus. Diagnosis involves blood tests of hormone levels and imaging of the pituitary. Treatment consists of hormone replacement therapies and monitoring for hormone deficiencies.