The hypoglossal nerve is the twelfth cranial nerve that innervates all the muscles of the tongue except one. Damage to this nerve can cause unilateral paralysis of the tongue, causing it to curve towards the affected side when protruded. Causes of hypoglossal nerve palsy include strokes, brain tumors, multiple sclerosis, and infections. Affected individuals may have difficulty swallowing and speaking due to misarticulation of several sounds. Treatment involves speech therapy and tongue exercises.