The glossopharyngeal nerve, vagus nerve, and cranial portion of the accessory nerve are collectively known as the vagal system. They originate from common brainstem nuclei and exit the skull through the jugular foramen together. The glossopharyngeal nerve innervates parts of the throat and tongue. The vagus nerve is the longest cranial nerve and innervates parts of the heart, lungs and digestive system. The accessory nerve innervates muscles of the neck and shoulder. Injuries to these nerves can cause issues like difficulty swallowing, impaired taste, and muscle weakness.
Infratemporal fossa a systematic approachAugustine raj
infratemporal fossa is a irregular space with numerous neurovascular structures. an attempt has been made by me to decode all the boundaries and structures in a systematic way. sincere thanks to Dr. Viren Karia for his awesome video.
Infratemporal fossa a systematic approachAugustine raj
infratemporal fossa is a irregular space with numerous neurovascular structures. an attempt has been made by me to decode all the boundaries and structures in a systematic way. sincere thanks to Dr. Viren Karia for his awesome video.
Liliequist membrane may be understood as a projection formed by an arachnoid membrane extending from the dorsum sellae to the mammillary bodies coined after Liliequist (1956). It has surgical importance in Endoscopic third ventriculostomy and cisternostomy.
Liliequist membrane may be understood as a projection formed by an arachnoid membrane extending from the dorsum sellae to the mammillary bodies coined after Liliequist (1956). It has surgical importance in Endoscopic third ventriculostomy and cisternostomy.
Obstetrical Surgeries - Operative vaginal deliveries are accomplished by appl...MariaDavis42
Operative vaginal deliveries are accomplished by applying direct traction on the fetal skull with forceps or by applying traction to the fetal scalp by means of a vacuum extractor
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Vagal system
1.
2. • The glossopharyngeal nerve, the vagus nerve, and the
cranial portion of the accessory nerve that these
nerves are together known as a single “vagal system”
• They all are mixed nerves, and some of their
components arise from common brainstem nuclei
(the nucleus ambiguus and nucleus solitarius)
• The glossopharyngeal, vagal, and accessory nerves
exit the skull together through the jugular foramen
3. GLOSSOPHARYNGEAL NERVE
• The glossopharyngeal nerve is the 9th paired mixed cranial nerve.
• ORIGIN- in the medulla oblongata of the brain. It emerges from the
anterior aspect of the medulla, moving laterally in the posterior cranial
fossa.
• EXIT -The nerve leaves the cranium via the jugular foramen
• GANGLIA- Immediately outside the jugular foramen lie two ganglia
(collections of nerve cell bodies).They are known as
the superior and inferior (or petrous) ganglia – they contain the cell
bodies of the sensory fibres in the glossopharyngeal nerve.
• The nerve enters the pharynx by passing between the superior and middle
pharyngeal constrictors. Within the pharynx, it terminates by dividing
into several branches
1. Pharyngeal branch – combines with fibres of the vagus nerve to form the
pharyngeal plexus. It innervates the mucosa of the oropharynx
2. Lingual branch – provides the posterior 1/3 of the tongue with general
and taste sensation
3. Tonsillar branch – forms a network of nerves, known as the tonsillar
plexus, which innervates the palatine tonsils.
4. Function
• It is a mixed nerve:
1. Sensory: Innervates the oropharynx, carotid body and sinus, posterior 1/3 of the
tongue, middle ear cavity and Eustachian tube.
2. Special sensory: Provides taste sensation to the posterior 1/3 of the tongue.
3. Parasympathetic: Provides parasympathetic innervation to the parotid gland.
4. Motor: Innervates the stylopharyngeus muscle that acts to shorten and widen
the pharynx and elevate the larynx during swallowing.
5. Glossopharyngeal nerve lesions
Glossopharyngeal nerve lesions produce:
difficulty swallowing
impairment of taste over the posterior one-third of the tongue and palate;
impaired sensation over the posterior one-third of the tongue, palate, and
pharynx
an absent gag reflex
dysfunction of the parotid gland.
6. Glossopharyngeal Neuralgia
• Characterized by a sharp, jabbing pain deep in the throat, or in the tongue, ear,
and tonsils, lasting a few seconds to a few minutes.
• CAUSE- small blood vessel that presses on the nerves as they exit the brainstem.
This condition is caused by irritation of the ninth cranial nerve by a blood vessel,
and is most commonly seen in people over age 40
• Attacks may be triggered by a particular action, such as chewing, swallowing,
talking, yawning, coughing, or sneezing.
• DIAGNOSIS-
1. For the test, a doctor touches the back of the throat with a cotton-tipped
applicator. If pain results, the doctor applies a local anesthetic to the back of the
throat. If the anesthetic eliminates the pain, glossopharyngeal neuralgia is likely.
2. Magnetic resonance imaging (MRI) is done to check for tumors.
• TREATMENT - anticonvulsant medications, such as carbamazepine, gabapentin
etc.
7. VAGUS NERVE
• The vagus is the 10th cranial nerve and the longest nerve of the
autonomic nervous system in the human body and comprises
sensory and motor fibers.
• ORIGIN- from neurons of the nodose ganglion, whereas the motor
fibers come from neurons of the dorsal motor nucleus of theVagus
and the nucleus ambiguus.
• It is also known asWandering nerve
NUCLEI
• The dorsal nucleus of vagus nerve – which sends parasympathetic
output to the viscera, especially the intestines
• The nucleus ambiguus – which gives rise to the branchial efferent
motor fibers of the vagus nerve and preganglionic parasympathetic
neurons that innervate the heart
• The solitary nucleus – which receives afferent taste information
and primary afferents from visceral organs
• The spinal trigeminal nucleus – which receives information about
deep/crude touch, pain, and temperature of the outer ear, the dura
of the posterior cranial fossa and the mucosa of the larynx
8. Function
• Sensory: Innervates the skin of the external acoustic meatus and the internal
surfaces of the laryngopharynx and larynx. Provides visceral sensation to the heart
and abdominal viscera.
• Special Sensory: Provides taste sensation to the epiglottis and root of the tongue.
• Motor: Provides motor innervation to the majority of the muscles of the pharynx,
soft palate and larynx.
• Parasympathetic: Innervates the smooth muscle of the trachea, bronchi and
gastro-intestinal tract and regulates heart rhythm.
9. Vagus Nerve Lesion
• The soft palate is left hanging down on the side of the lesion
• The gag reflex is diminished, and the patient’s speech is nasal because the nasal
cavity can no longer be closed off from the oral cavity.
• Paresis of the pharyngeal constrictor muscle causes the palatal veil to be pulled
over to the normal side when the patient speakes
• Hoarseness of the voice due to paresis of the vocal folds (lesion of the recurrent
laryngeal nerve with paresis of the internal muscles of the larynx, with the
exception of the cricothyroid muscle).
• Dysphagia and occasionally tachycardia, and cardiac arrhythmia
10. ACCESSORY NERVE
• The accessory nerve is the 11th paired cranial nerve. It has a
purely somatic motor function, innervating the
sternocleidomastoid and trapezius muscles.
• The accessory nerve is divided into spinal and cranial parts
Cranial Component
• The cranial portion arises from the lateral aspect of
the medulla oblongata.
• It leaves the cranium via the jugular foramen, where it briefly
contacts the spinal part of the accessory nerve.
• Immediately after leaving the skull, cranial part combines
with the vagus nerve (CN X) at the inferior ganglion of vagus
nerve (a ganglion is a collection of nerve cell bodies).
• The fibres from the cranial part are then distributed through
the vagus nerve. For this reason, the cranial part of the
accessory nerve is considered as part of the vagus nerve.
11. Function
The spinal accessory nerve innervates two muscles – the sternocleidomastoid and trapezius.
Sternocleidomastoid
• Attachments – Runs from the mastoid process of the temporal bone to the manubrium
(sternal head) and the medial third of the clavicle (clavicular head).
• Actions – Lateral flexion and rotation of the neck when acting unilaterally, and extension
of the neck at the atlanto-occipital joints when acting bilaterally.
Trapezius
• Attachments – Runs from the base of the skull and the spinous processes of the C7-T12
vertebrae to lateral third of the clavicle and the acromion of the scapula.
• Actions – It is made up of upper, middle, and lower fibres.The upper fibres of the trapezius
elevate the scapula and rotate it during abduction of the arm.The middle fibres retract the
scapula and the lower fibres pull the scapula inferiorly.
12. Accessory Nerve Lesion
• Sternocleidomastoid muscle is paralyzed whileTrapezius
muscle is affected only in its upper half, because it also
receives innervation from the spinal nerves of segments C2
through C4.
• Injury to the accessory nerve distal to the
sternocleidomastoid muscle causes weakness of the
trapezius muscle exclusively.
• Patient has difficulty turning the head to the opposite
side.Weakness of the trapezius muscle causes a shoulder
drop.
• Scapula is displaced downward and outward to the side of
lesion.Lateral raising of the arm beyond 90° is impaired.
• Simple visual inspection of a patient with an accessory
nerve palsy reveals atrophy of the sternocleidomastoid
muscle as well as a drooping shoulder.
• Bilateral weakness makes it difficult to hold the head
erect or to raise the head when lying supine.