- Dr. Kilmer McCully discovered in the 1960s that high levels of the amino acid homocysteine were linked to atherosclerosis and other diseases, but his work was rejected in favor of the cholesterol hypothesis.
- Homocysteine was "rediscovered" as a risk factor for heart disease and other illnesses in the 1980s and 1990s through large studies finding associations with cardiovascular and other diseases.
- Maintaining homocysteine levels below 9 μmol/L through diet and supplements can significantly reduce risks of heart disease, stroke, cancers, Alzheimer's, and early death.
This is a presentation that I gave to my graduate level Vitamins and Minerals class depicting how the amino acid homocysteine effects cardiovascular disease.
Identifying women with GDM is important because appropriate therapy can decrease maternal and fetal morbidity .
Can prevent two generations from developing diabetes in the future.
This is a presentation that I gave to my graduate level Vitamins and Minerals class depicting how the amino acid homocysteine effects cardiovascular disease.
Identifying women with GDM is important because appropriate therapy can decrease maternal and fetal morbidity .
Can prevent two generations from developing diabetes in the future.
Dr Abdullah Ansari
MBBS, MD Medicine
Aligarh Muslim University
Clinical case
Hemolytic Anemia
Intravascular vs extravascular hemolysis
Classification of hemolytic anemia
Approach to hemolysis
Patient history
Clinical features
Peripheral blood smear
Investigation
Treatment
Author Profile - http://baligadiagnostics.com/dr-vivek-baliga/
In this presentation, Dr Vivek Baliga discusses some of the common cardiac conditions that are seen in post menopausal women.
Presentation by DR. MISHAL on the topic of NON CIRRHOTIC PORTAL HYPERTENSION. Its a grey area but very important topic particularly for FCPS residents .
Homocysteine as a risk factor in strokeSudhir Kumar
Elevated Homocysteine levels in serum are an important risk factor for ischemic stroke and is associated with higher mortality. Lowering homocysteine lowers the risk of stroke recurrence.
Dr Abdullah Ansari
MBBS, MD Medicine
Aligarh Muslim University
Clinical case
Hemolytic Anemia
Intravascular vs extravascular hemolysis
Classification of hemolytic anemia
Approach to hemolysis
Patient history
Clinical features
Peripheral blood smear
Investigation
Treatment
Author Profile - http://baligadiagnostics.com/dr-vivek-baliga/
In this presentation, Dr Vivek Baliga discusses some of the common cardiac conditions that are seen in post menopausal women.
Presentation by DR. MISHAL on the topic of NON CIRRHOTIC PORTAL HYPERTENSION. Its a grey area but very important topic particularly for FCPS residents .
Homocysteine as a risk factor in strokeSudhir Kumar
Elevated Homocysteine levels in serum are an important risk factor for ischemic stroke and is associated with higher mortality. Lowering homocysteine lowers the risk of stroke recurrence.
Alzheimer's disease is a neurological disorder ,It's never too late to come out of Alzheimer's disease.Here are some easy interesting Tips and solutions that could help you in reducing your Alzheimer.
Preventing back injuries can be as simple as taking a few minutes to warm up, evaluating and properly performing job tasks and strengthening your back at home.
For more information, visit http://apnacare.in
This presentation gives a few tips on keeping the brain razor sharp. The presentation was originally given at the 2013 Cleary University Entrepreneurs Forum.
Brain Food: How to Eat Right to Think RightGaia Clinic
Your brain runs your life and is the greatest asset you possess. Yet many people spend more time and money considering whether they are nourishing their skin and hair properly than nourishing their brain. In this lecture, Medical Doctor, Tracy Thomson explains why learning to feed your brain can effectively increase your productivity, enhance your relationships (including your sex life) and generally make you happier on a daily basis!
http://www.lotusholisticmedicine.com - Integrated holistic approach to treat body, mind and soul. We adopt goodness of modern conventional medicine, ancient herbal medicine (SIDDHA), to activate innate healing potential by naturopathy and yoga therapy and energize the mind and soul with positive promotion of mental well being and by incorporating spirituality for self healing.
10Obesity and hypertension.Obesity and hypertension in.docxpaynetawnya
10
Obesity and hypertension.
Obesity and hypertension introduction
Introduction
Today, obesity has become among the highest ranked causes of disease in the world, in fact, obesity has been ranked 6th most disease risk in globally [2]. This research found that over 1 billion grownups and 10% of youngsters are now classified as weighty and obese [2]. Also, obesity was said to have the leading cause of premature deaths and many chronic illnesses which can be prevented after it was seen to surpass smoking in the USA [3]. Hypertension and obesity are increasingly becoming a challenge all over the world today, making it a significant public health challenge that is unable to be ignored. When we look at the case in the year 2000 and compare it with now, the total of grown-ups with hypertension is predicted to surge by 60% making it a total tally of 1.56 billion by the time we get to the year 2025 [1]. The rising numbers of obesity cases translate to a considerable probability of these people getting hypertension. This means that if instances of obesity are reduced then most probably the trials of hypertension will decrease significantly. Also, this condition not only increases the risk of hypertension but is also associated with other medical conditions such as chronic kidney diseases and diabetes. Central obesity excessive belly fat around the digestive system and abdomen has been a significant cause of diseases such as hypertension and cardiovascular disease. Population studies have shown that at least two-thirds of the commonness of hypertension can directly be as a result of obesity [4]. Belly fat, also, has also been associated with the development of sleep apnoea, stroke, coronary artery disease, and blocking of the heart causing heart failure [2].
Studies have shown that leptin represents the most significant invention in the reviews about obesity as it has been of much help in the energy and appetite studies. Leptin is an adipocyte resultant hormone that is used in the regulation of appetite and energy use. Leptin has also been seen to decrease the decreases action of hypothalamic AMPK. It has also been observed to help in the instigation of the trail that reduces the eating and even the other weight cut actions associated with leptin.
Obesity combined with hypertension is what is causes the increased risk of cardiovascular disease. Overweight and obese people have been found to not have cardiovascular risk increase significantly without the presence of hypertension [5]. This makes it clear that hypertension is a central player in the determining the risk of obese people having cardiovascular disease. Although people with the fat condition are at significant risk of hypertension, the vice versa has also been found to be true. People with hypertension have a high probability of becoming obese is very high. According to Tecumseh and Framingham studies, it has been seen that weight gain in days to come is expected to have a higher perc ...
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
![The Story of Hyperhomocysteinemia “ A Discovery from Rediscovery” [email_address]](https://image.slidesharecdn.com/hyperhomocysteinemia1270/85/Hyperhomocy-steinemia-1-320.jpg)
![The 'homocysteine story' ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[email_address]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)