1. The patient presented with intermittent right upper abdominal pain for 2 years with associated low grade fever. Imaging showed multiple hydatid cysts in the liver.
2. Hydatid cyst disease is caused by the larval stage of Echinococcus granulosus. Humans can become infected by contact with definitive hosts like dogs or ingesting contaminated food or water.
3. Treatment options include albendazole medication, puncturing and draining cysts using PAIR technique, or surgery to remove cysts depending on number and location.
Hydatid cyst disease of the liver الدكتور طارق المنيزل Tariq Al munaizel
A comprehensive lecture about the hydatid cyst disease of the liver including the parasite life cycle, infection, clinical presentation, complications, diagnosis , medical and surgical treatment.
Hydatid cyst disease of the liver الدكتور طارق المنيزل Tariq Al munaizel
A comprehensive lecture about the hydatid cyst disease of the liver including the parasite life cycle, infection, clinical presentation, complications, diagnosis , medical and surgical treatment.
Hydatid cyst of the liver is very rare problem in the urban population of INDIA. However, we must know the disease its presentation, the review of literature for the same and its management with current updates.
Presentation of a case of liver Hydatid Cyst (HC) treated in Al Hammadi Hospital, Suwaidi, Riyadh, Kingdom of Saudi Arabia in 2017. Includes US and CT images findings and operative technique. Followed by a review of HC including epidemiology, presentation, diagnosis, treatment and prevention in an illustrated presentation.
This presentation is hoped to be of help to medical students, junior doctors, trainees in surgery as well as senior surgeons.
Dr. Mohamad Al-Gailani FRCS
Consultant Surgeon
Medical Education & Training Director
Al Hammadi Hospital, Suwaidi
Riyadh
KSA
2017
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
Testicular tumors are rare.
1 – 2 % of all malignant tumors.
Most common malignancy in men in the 15 to 35 year age group.
Benign lesions represent a greater percentage of cases in children than in adults.
Most curable solid neoplasm
Intestinal fistulas pose the greatest challenge to the General Surgeon. The presentation provides abrief guideline for management of this complex problem.
Echinococcus granulosus, also called hydatid worm belongs to class Cestoda
It causes cystic echinococcosis in livestock and humans being intermediate hosts and parasitize the small intestines of adult canids
It is a zoonotic disease
Definitive hosts are carnivorous predators like dogs, wolves, foxes and lions. While sheep, goat, cattle, pigs and rodents are intermediate hosts. Birds and arthropods act as mechanical vectors
Hydatid cyst of the liver is very rare problem in the urban population of INDIA. However, we must know the disease its presentation, the review of literature for the same and its management with current updates.
Presentation of a case of liver Hydatid Cyst (HC) treated in Al Hammadi Hospital, Suwaidi, Riyadh, Kingdom of Saudi Arabia in 2017. Includes US and CT images findings and operative technique. Followed by a review of HC including epidemiology, presentation, diagnosis, treatment and prevention in an illustrated presentation.
This presentation is hoped to be of help to medical students, junior doctors, trainees in surgery as well as senior surgeons.
Dr. Mohamad Al-Gailani FRCS
Consultant Surgeon
Medical Education & Training Director
Al Hammadi Hospital, Suwaidi
Riyadh
KSA
2017
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
Testicular tumors are rare.
1 – 2 % of all malignant tumors.
Most common malignancy in men in the 15 to 35 year age group.
Benign lesions represent a greater percentage of cases in children than in adults.
Most curable solid neoplasm
Intestinal fistulas pose the greatest challenge to the General Surgeon. The presentation provides abrief guideline for management of this complex problem.
Echinococcus granulosus, also called hydatid worm belongs to class Cestoda
It causes cystic echinococcosis in livestock and humans being intermediate hosts and parasitize the small intestines of adult canids
It is a zoonotic disease
Definitive hosts are carnivorous predators like dogs, wolves, foxes and lions. While sheep, goat, cattle, pigs and rodents are intermediate hosts. Birds and arthropods act as mechanical vectors
Hydatid cysts are most commonly found in the liver and lungs, although they may also occur in other organs, bones and muscles. The cysts can increase in size to 5 – 10 cm or more and may survive for decades. Non-specific signs include loss of appetite, weight loss and weakness
Echinococcus granulosus sensu lato occurs practically worldwide, and more frequently in rural, grazing areas where dogs ingest organs from
diagnosis
epidemiology
managment
Surgical management of hepatic hydatid diseaseKETAN VAGHOLKAR
Hydatidosis is strictly a zoonosis. Humans are an accidental host. The disease is endemic in rural agricultural areas. However if acquired by humans, it can cause extensive spread affecting a wide range of organs with predilection for the liver. Managing such cases requires a sound fundamental knowledge of the parasite and its pathogenicity. It is essential that surgeons who deal with such cases have a good working knowledge of the disease. The approaches to hepatic hydatids with respect to the principles of surgical treatment are presented in this article.
varicose veins are elongated,b dilated tortuous veins which may occur due to perforator incompetence or due to congenital reasons. various tests are performed before going for surgery. the presentation gives an idea of what is to be done pre-operatively.
starts with history taking, pathophysiology of burns, inhalation injury, early burn wound excision via tangential and fascial excision, antimicrobials in burns,nutrition support, skin substitutes,newer drugs,flaps
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. CASE PRESENTATION
A lady aged 30 years presented with intermittent pain in the right
upper abdomen for past 2 years.
She had associated low grade fever
The pain was dull aching, persistent in nature, insidious in onset and
was not related to food intake or vomiting. The was no aggravating or
relieving factor
No h/o weight loss or loss of appetite
No h/o jaundice, hematemesis , melena
No h/o cough , haemoptysis , bone pain
3. PHYSICAL EXAMINATION
On general survey, patient’s nutrition was normal, not associated with
pallor, icterus or lymphadenopathy, pulse 80 per minute. No evidence
of dehydration.
On inspection , the shape of the abdomen was normal, umbilicus was
inverted, normal in position. The skin over the abdomen was normal.
No visible pulsations or scar mark.
On superficial palpation, the temperature of all quadrants were equal
and normal. Abdomen was soft and non tender.
On deep palpation liver was palpable , at about 4 fingers below the
costal margin. There was no lump in the abdomen. All other systemic
examinations were normal.
4. INVESTIGATIONS
USG – liver shows one echogenic SOL in the posterior segment of
right lobe of the liver. Huge cystic SOL with internal septations in
right sub hepatic region.
CECT – thin walled cystic lesion measuring 50x49 mm with wall
calcification is seen in segment 8. Another large lesion measuring
89x80mm involving right lobe of liver with an exophytic component.
The lesion shows mural calcification. Both lesion shows intrinsic
daughter cysts. Rest of hepatic parenchyma is normal. IHBR not
dilated. Intra-hepatic vascular structures appear normal. Cysts show
no post contrast enhancement.
IGG ECHINOCOCCUS – 6.0 mg/dl (HIGH)
5.
6.
7.
8.
9.
10. HYDATID LIVER CYST
Echinococcosis (hydatid disease) is a zoonosis caused by the larval
stage of Echinococcus granulosus
Humans are accidental intermediate hosts, whereas animals can be
both intermediate and definitive hosts
The two main types of hydatid disease are caused by E. granulosus
and E. multilocularis
11. ETIOLOGY
The definitive host is usually a dog or some other carnivore
The adult worm of the parasite lives in the proximal small bowel of
the definitive host attached by hooklets to the mucosa.
Eggs are released into the host’s intestine and excreted in the feces
Sheep are the most common intermediate host, and these animals
ingest the ovum while grazing
The ovum loses the protective chitinous layer and is digested in the
duodenum. The released hexacanth embryo (oncosphere) passes
through the intestinal wall into the portal circulation and develops
into cysts within the liver. The definitive host eats the viscera of the
intermediate host to complete the cycle
12. Humans may become intermediate hosts through contact with the
definitive host (usually a dog) or by ingestion of contaminated water
or vegetables
Once in the liver, cysts grow to 1 cm in the first 6 months and 2–3
cm annually thereafter
13.
14. PATHOLOGY
Majority are single cysts which occur in the right lobe of the liver and
half of them has daughter cysts and are multiloculated.
The typical hydatid cyst has a three-layer wall surrounding a fluid
cavity
Pericyst is the outer layer. It is thin ,indistinct fibrous tissue which is
adventitial reaction to the parasite infection. As the cyst grows the
blood vessels and bile ducts get incorporated in the structure leading
to hemorrhagic and biliary complications.over tym the pericyst
calcifies. It is the mechanical support and metabolic interface
between the host and parasite.
15. Ectocyst it is the outer layer , the laminated membrane made up of
cuticular chitinous structure without nuclei.0.5cm in thickness and
forms a barrier to bacteria and an ultrafilter for protein molecules
Endocyst it is the germinal membrane. responsible for the production
of clear hydatid fluid, the ectocyst, brood capsules, scoleces, and
daughter cysts.This germinal layer forms small cellular masses that
give rise to brood capsules, in which future worm heads develop.
They enlarge and develop into invaginated protoscoleces with four
suckers and a double row of hooks—a protoscolex
16. Hydatid sand = protoscoleces + brood capsudes + fluid +
calcareous bodies.
Hydatid sand is made up of around 400,000 scoleces per milliliter of
fluid. The protoscolex can differentiate in two directions. In the
definitive host, the scolex becomes an adult tapeworm. In the
intermediate host, including humans, each of the released
protoscoleces is capable of differentiating into a new hydatid cyst
17. Endogenic vesiculation = it is the formation of daughter cysts which a
defense reaction to the injury.
Ectogenic vesiculation = it is the crack in the germinal membrane
which leads to formation of satellite cysts, characteristic of
E.multilocularis.
18. DIAGNOSIS
Pain in the RUQ,hepatomegaly,fever, fatigue,nausea,dyspepsia.
Some may present with eosinophilia
Specific IgE antibodies are demonstrated with ELISA and
radioallergosorbent test (RAST) if active disease is present
Arc 5 antibody test is also there
20. CT and MRI gives detailed images of the cysts
Endoscopic retrograde cholangiopancreatography (ERCP) may show
communication between the cysts and bile ducts and can be used to
drain the biliary tree before surgery. It is done by some routinely to
find out any silent communication between biliary ducts and cysts.
21. TREATMENT
DOC is albendazole which is given for atleast 1 month
PAIR technique stands for puncture of the cyst wall, aspiration of cyst
content, injection, and re-aspiration of a scolecoidal agent
modified PAIR technique was created to introduce concomitant
evacuation of cyst contents while infusing scolicidal agent via a
specially designed coaxial catheter system
22. Indications of PAIR is type 1 and type 2 cysts,and type 3,type 4 cysts
with drainable material,inoperable,pregnantor infected hydatid cysts.
C/I is in chillren less than 3 years of age, and ruptured cysts into
biliary tree or peritoneum
Type 5 cysts are meant for simple followup
Surgery remains the treatment of choice for uncomplicated hydatid
disease of the liver