Huntington's disease is an inherited disorder characterized by the degeneration of nerve cells, affecting cognitive and motor functions, primarily appearing between ages 30-50. It is caused by a genetic mutation on chromosome #4 that leads to increased CAG repeat sequences, and while there is no cure, treatments focus on managing symptoms. Diagnosis is made through genetic, neurological, and blood tests, with common symptoms including twitching, restlessness, and memory loss.

1. HUNTINGTON’S
DISEASE
Presented by: Alisha Moazzam.
B.S (HONS) BIOTECHNOLOGY.
UNIVERSITY OF VETERINARY AND
ANIMALS SCIENCES, LAHORE
PAKISTAN.

2. What is Huntington's disease?
■ Disorder.
■ Inherited.
■ Certain nerve cell degenerate.
■ Affects people’s ability to think,
move or talk.

3. How is it inherited?
■ Occurs on chromosome # 4.
■ Autosomal dominant condition.
■ Only one parent must have this
gene in order for a child to
inherit this.
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4. ■ Makes CAG repeats occur more rapidly
– Normal 10 to 35 times.
– In defect 36 to 120 times (abnormal).
– Greater CAG repeats higher chances
Of receiving disease.
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5. Signs and symptoms
■ Appears between age 30-50.
■ Minor twitching in fingers and toes.
■ Excessive restlessness.
■ Some clumsiness.
■ Periods of depression.
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6. ■ Short term memory loss.
■ Less ability to recognize routines.
■ Difficult to concentrate.
■ Troubling in moving eyes.
■ Speech impairment.
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7. How it is detected?
■ Genetic testing's.
■ Neurological testing's.
■ Blood testing's.
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8. How many people get this?
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9. Treatment or medications
■ No cure for HD as of this time.
■ Doctors prescribe tetra benzene to minimize the
jerky movements.
■ Some tranquilizers have proved helpful, but have
severe side effects.
■ Speech and physical therapies.
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10. References
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