Huntington's Disease
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Huntington's disease is a genetic neurodegenerative disorder characterized by defects in behavior, cognition and movement that begin in middle age. It is caused by an expanded CAG repeat in the Huntingtin gene, which is inherited in an autosomal dominant pattern. Symptoms include jerky, involuntary movements as well as mood and personality changes. Pathologically, it involves the degeneration of the caudate nucleus and putamen in the brain. There is currently no cure for Huntington's disease, though medications can help manage symptoms.
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Huntington’S Disease
Huntington's disease is a genetic disorder caused by a defective gene on chromosome 4 that results in abnormal repetitions of a CAG sequence in DNA. It is inherited from a parent and causes progressive breakdown of nerve cells in the brain. Symptoms include involuntary movements, cognitive decline, and psychiatric problems. There is no cure, but medications can help manage symptoms.
Huntington disease
Huntington's disease is an inherited, progressive disorder that causes chorea and dementia. It results from an expanded CAG repeat in the huntingtin gene on chromosome 4. Symptoms typically begin in adulthood and include chorea as well as cognitive and psychiatric problems. Chorea results from overactivity in dopaminergic pathways in the basal ganglia. Treatment involves dopamine-depleting drugs like reserpine or tetrabenazine or dopamine receptor blockers like haloperidol to reduce chorea.
Huntington’s disease
Huntington's disease is a genetic disorder where nerve cells in the brain deteriorate, typically causing death within 10 to 30 years of symptoms appearing. It is caused by a defective gene on chromosome 4 that causes abnormal repetition of the CAG sequence. Anyone can develop the disease if they inherit the defective gene from a parent. While there are no cures, treatments can help manage symptoms, and in vitro fertilization with pre-implantation screening allows selection of embryos without the gene to prevent passing it to children.
Huntington disease
Huntington disease is a rare genetic disorder that is characterized by uncontrolled movements, emotional problems, and loss of thinking ability
Huntingtons disease
Huntington's disease is a genetic disorder that causes the progressive breakdown of nerve cells in the brain. It is inherited in an autosomal dominant pattern, meaning only one copy of the defective gene is needed to develop the disease. Common signs and symptoms include uncontrolled movements, cognitive decline, and psychiatric issues like depression. While there is no cure, medications can help reduce motor symptoms, and lifestyle interventions focused on diet, exercise, and social support can help improve quality of life for those living with Huntington's disease.
What is HUNTINGTON'S DISEASE?
Huntington's disease is an inherited disorder that results in the degeneration of brain cells. It causes movement, cognitive, and psychiatric disorders. Symptoms usually appear between ages 30-40 and include involuntary movements, impaired voluntary movement, cognitive decline, and psychiatric issues like depression. Huntington's disease is caused by a mutated HTT gene that results in an elongated huntingtin protein. This protein forms toxic fragments in neurons that lead to their dysfunction and death. The disorder is inherited in an autosomal dominant pattern, so only one copy of the mutated gene is needed. Larger CAG repeat lengths in the gene cause earlier onset and more severe symptoms.
Huntington's Disease
Huntington's disease is a genetic disorder that causes the degeneration of neurons in the brain. It affects muscle coordination and leads to cognitive and psychiatric decline. The disease is named after George Huntington, the doctor who first described it in 1872. It is inherited in an autosomal dominant pattern, meaning there is a 50% chance of offspring inheriting the mutated gene. Common symptoms include involuntary movements called chorea, as well as issues with memory, speech, coordination and personality. The disease progresses over time and is ultimately fatal, though medication can help manage symptoms. There is currently no cure for Huntington's disease.
Huntington's disease
John, age 45, presented with declining memory and concentration along with involuntary movements in his fingers, toes and face. After extensive evaluation, he was diagnosed with Huntington's disease, which was confirmed by a DNA analysis showing 43 CAG repeats. Huntington's disease is an inherited, degenerative disorder that affects movement, cognition and psychiatric functions. It is caused by a dominant genetic mutation and results in the death of brain cells in the basal ganglia. There is currently no cure for Huntington's disease.
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Huntington’S Disease
Huntington's disease is a genetic disorder caused by a defective gene on chromosome 4 that results in abnormal repetitions of a CAG sequence in DNA. It is inherited from a parent and causes progressive breakdown of nerve cells in the brain. Symptoms include involuntary movements, cognitive decline, and psychiatric problems. There is no cure, but medications can help manage symptoms.
Huntington disease
Huntington's disease is an inherited, progressive disorder that causes chorea and dementia. It results from an expanded CAG repeat in the huntingtin gene on chromosome 4. Symptoms typically begin in adulthood and include chorea as well as cognitive and psychiatric problems. Chorea results from overactivity in dopaminergic pathways in the basal ganglia. Treatment involves dopamine-depleting drugs like reserpine or tetrabenazine or dopamine receptor blockers like haloperidol to reduce chorea.
Huntington’s disease
Huntington's disease is a genetic disorder where nerve cells in the brain deteriorate, typically causing death within 10 to 30 years of symptoms appearing. It is caused by a defective gene on chromosome 4 that causes abnormal repetition of the CAG sequence. Anyone can develop the disease if they inherit the defective gene from a parent. While there are no cures, treatments can help manage symptoms, and in vitro fertilization with pre-implantation screening allows selection of embryos without the gene to prevent passing it to children.
Huntington disease
Huntington disease is a rare genetic disorder that is characterized by uncontrolled movements, emotional problems, and loss of thinking ability
Huntingtons disease
Huntington's disease is a genetic disorder that causes the progressive breakdown of nerve cells in the brain. It is inherited in an autosomal dominant pattern, meaning only one copy of the defective gene is needed to develop the disease. Common signs and symptoms include uncontrolled movements, cognitive decline, and psychiatric issues like depression. While there is no cure, medications can help reduce motor symptoms, and lifestyle interventions focused on diet, exercise, and social support can help improve quality of life for those living with Huntington's disease.
What is HUNTINGTON'S DISEASE?
Huntington's disease is an inherited disorder that results in the degeneration of brain cells. It causes movement, cognitive, and psychiatric disorders. Symptoms usually appear between ages 30-40 and include involuntary movements, impaired voluntary movement, cognitive decline, and psychiatric issues like depression. Huntington's disease is caused by a mutated HTT gene that results in an elongated huntingtin protein. This protein forms toxic fragments in neurons that lead to their dysfunction and death. The disorder is inherited in an autosomal dominant pattern, so only one copy of the mutated gene is needed. Larger CAG repeat lengths in the gene cause earlier onset and more severe symptoms.
Huntington's Disease
Huntington's disease is a genetic disorder that causes the degeneration of neurons in the brain. It affects muscle coordination and leads to cognitive and psychiatric decline. The disease is named after George Huntington, the doctor who first described it in 1872. It is inherited in an autosomal dominant pattern, meaning there is a 50% chance of offspring inheriting the mutated gene. Common symptoms include involuntary movements called chorea, as well as issues with memory, speech, coordination and personality. The disease progresses over time and is ultimately fatal, though medication can help manage symptoms. There is currently no cure for Huntington's disease.
Huntington's disease
John, age 45, presented with declining memory and concentration along with involuntary movements in his fingers, toes and face. After extensive evaluation, he was diagnosed with Huntington's disease, which was confirmed by a DNA analysis showing 43 CAG repeats. Huntington's disease is an inherited, degenerative disorder that affects movement, cognition and psychiatric functions. It is caused by a dominant genetic mutation and results in the death of brain cells in the basal ganglia. There is currently no cure for Huntington's disease.
Huntington's disease
Huntington's disease is a genetic disorder caused by inheriting a defective gene, which results in the gradual destruction of neurons over time. The defective gene can be passed down from parent to child, with the child having a 50% chance of inheriting it if a parent has the gene. Symptoms appear between ages 30-50 and include fidgeting, twitching, clumsiness, memory loss, depression, and problems with movement and coordination. Huntington's affects both the mind and body as the disease progresses. While there is no cure, medications can help control movement and emotional symptoms.
Huntington's Disease
Huntington's disease is a genetic neurological disorder that causes the progressive breakdown of nerve cells in the brain. It typically manifests in a person's 30s or 40s with motor, cognitive, and psychiatric symptoms. The motor symptoms include involuntary writhing movements and problems with voluntary movement. Cognitive symptoms involve difficulties with tasks, flexibility, impulsivity, and processing speed. Common psychiatric issues are depression, OCD, mania, and bipolar disorder. The disease is caused by a loss of GABA and acetylcholine-producing neurons in the brain due to a defective gene. While there is no cure, treatments aim to support patients through diet, exercise, and psychosocial support.
Huntington’s disease
Huntington's disease is a genetic neurodegenerative disorder that typically causes movement, cognitive, and psychiatric problems. It is caused by an expanded CAG repeat in the Huntington gene, which leads to damage and death of nerve cells in the brain over time. The signs and symptoms of Huntington's disease usually appear between ages 30 and 50 and worsen over 10 to 25 years, progressing through distinct stages of mild, moderate, and severe problems with movement, thinking, and behavior. While there is no cure for Huntington's disease currently, medications and therapies can help manage some of the symptoms.
Huntington’s Disease
Huntington's disease is a progressive neurodegenerative disorder caused by a mutation on chromosome 4 that results in an elongated huntingtin protein. It is inherited in an autosomal dominant pattern and usually strikes in middle age, causing movement, cognitive, and behavioral issues. There is no cure, but symptoms can be managed through medications. Future treatments focus on gene therapy to silence the mutated gene or neural transplantation, though mutant huntingtin may spread to transplanted tissue.
Huntingtons disease
Huntington's disease is a genetic disorder that causes brain cells to waste away over time. It is passed down through families and results from a defective gene on chromosome 4 that causes an excess of the protein CAG. The disease has two types - adult onset which occurs in one's 30s-40s and is more common, and childhood onset which happens at a young age in rare cases. Signs and symptoms include involuntary movements, cognitive and psychiatric problems, and eventually death around 15-20 years after diagnosis usually from infection or sometimes suicide.
Huntington's disease & its Treatment
Huntington's disease is slowly progressive, rapidly growing hereditary brain disease that causes abnormal motor coordination, thinking, behavior and ultimately leads to dementia.
Its necessary to diagnosis earlier i.e. onset of movement disorder, particularly
with chorea and impaired voluntary movement.
Autosomal dominant inheritance with 2000 people are diagnosed each year.
No drug therapy is available
The worldwide prevalence of Huntington’s Disease is 5-10 cases per 10000 which affects men and women equally
Huntingtons disease
The document provides information about Huntington's disease (HD), including:
1) HD is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene, and is characterized by motor, cognitive, and psychiatric symptoms.
2) The disease primarily involves degeneration of the basal ganglia, especially the caudate and putamen nuclei.
3) Symptoms typically begin in mid-life and include chorea, dystonia, cognitive impairment, and psychiatric issues. There is currently no cure for HD.
Huntington Disease
Huntington's disease is an autosomal dominant, progressive neurodegenerative disease that affects 5-10 per 100,000 people in the Caucasian population. It is caused by a CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4p16.3, which leads to striatal and cortical atrophy. Symptoms include increasingly severe motor disturbances, cognitive impairment, and psychiatric symptoms. Current pharmacological treatments aim to reduce chorea and include tetrabenazine, dopamine antagonists, anti-glutamatergics, and benzodiazepines.
Huntington's Disease
Huntington's disease is a genetic disorder that causes certain nerve cells in the brain to break down over time. It is inherited in an autosomal dominant pattern, meaning only one parent needs to carry the gene for a child to be at risk. Common symptoms include behavioral changes, abnormal movements, dementia, and difficulty swallowing and speaking. While there is no cure, lifestyle interventions including diet, supplements, exercise and social support can help manage symptoms and potentially delay onset. The disease is caused by destruction of cells in the basal ganglia and approximately 1 in 33,333 people in the US are affected.
Huntigton's disease
Huntington's disease is an inherited, progressive brain disorder that causes uncontrolled movements, emotional issues, and loss of thinking abilities. It is caused by a defective gene that is inherited from a parent. Early symptoms vary but may include mood swings, personality changes, and abnormal body movements. Currently there is no cure, but medications and therapies can help manage symptoms. The condition steadily worsens over time and is ultimately fatal.
Genetic linkage in psychiatric disorders
This document outlines an introduction to genetic linkage analysis in various psychiatric disorders. It discusses the history and basics of genetics as well as evidence of genetic linkage found in studies of schizophrenia, affective disorders, anxiety disorders, substance abuse disorders, attention deficit hyperactivity disorder, autism spectrum disorders, intellectual disabilities, and personality disorders. Specific genes have been implicated in disorders like schizophrenia, bipolar disorder, and Rett Syndrome through linkage analysis studies.
Huntington's Disease
Huntington's disease is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It is caused by a mutated gene on chromosome 4 that results in an abnormal protein damaging brain cells. Symptoms start with mood or movement changes and progress to uncontrolled movements and loss of mental abilities. Currently there is no cure, but medications can help treat symptoms.
Huntington disease final
Huntington disease is a rare, degenerative disease caused by a defective gene on chromosome 4 that results in the expansion of a CAG trinucleotide repeat. It is characterized by movement abnormalities such as chorea, as well as psychiatric and cognitive dysfunction. Onset typically occurs between ages 35-45. There is currently no cure, but symptoms can be managed through medications. The disease progresses over 15-20 years from onset to death.
Topic 7 - Comorbidity in ADHD and Autism 2010
Autism, Asperger's and ADHD.
Topic 7 - Comorbidity on ADHD and Autism.
The views expressed in this presentation are those of the individual Simon Bignell and not University of Derby.
ADHD
The document discusses attention deficit hyperactivity disorder (ADHD), including:
1) ADHD is characterized by diminished sustained attention and high impulsivity compared to others of the same age. It has three main types and affects 5-10% of the US population, predominantly males.
2) ADHD has genetic and neurological causes like central nervous system insults and dysfunction of the noradrenergic and dopamine systems. Stimulant medications are the first-line treatment as they target these systems.
3) Diagnosis involves assessing symptoms, impairment, history, and ruling out other conditions. Treatment includes medication, behavioral modifications, and accommodations at home and school to help manage symptoms.
ADHD presentation By Sajjad Hassan
ADHD is a neurodevelopmental disorder characterized by difficulty paying attention, excessive activity, and difficulty controlling behavior. It affects children and often continues into adulthood. Common symptoms include inattention, hyperactivity, and impulsivity. While the specific causes are unknown, genetics and environmental factors like diet may play a role. Treatment often involves medications, dietary changes, supplements, essential oils, exercise, and organization strategies. Proper diagnosis and management of ADHD is important.
HUNGTINGTON'S CHOREA
Huntington's disease is a progressive neurodegenerative disorder caused by a defective gene that results in the production of an abnormal protein called huntingtin. It affects movement, cognition, and personality. Symptoms include uncontrolled movements, impaired walking and talking, and mood and cognitive changes. There is currently no cure, but treatments can help manage symptoms. The disease is inherited in an autosomal dominant pattern and typically appears in middle adulthood.
Huntington's disease
In this we will study basically what's the huntington's disease is, its cause,symptoms, detection, treatment.
Genetics In Psychiatry
Genetic terms used in psychiatry include:
- Concordance and heritability which measure the genetic influences on traits and diseases
- Mendelian and complex diseases which can be caused by single genes or interactions between genes and environment
- Alleles, haplotypes, loci, genetic maps, and linkage disequilibrium which describe genetic variations and inheritance patterns
Genome-wide association studies typically assay common genetic variants like single nucleotide polymorphisms to identify associations with traits and diseases.
huntington chorea for nursing
Huntington's disease (HD) is a rare inherited neurodegenerative disorder that causes uncontrolled movements, cognitive decline and psychiatric problems. It is caused by a mutated gene on chromosome 4 that produces an abnormal protein which causes the death of brain cells. HD is passed on in an autosomal dominant pattern and typically appears in mid-adult life. There is currently no cure, but treatments can help manage symptoms and nursing care focuses on safety, nutrition, mobility and quality of life.
Huntington's chorea
Huntington's disease is a genetic neurodegenerative disorder that affects movement, thinking, and behavior. It is caused by an expanded CAG repeat in the HTT gene, which produces a defective huntingtin protein. Symptoms typically appear in mid-life and include involuntary movements (chorea), cognitive decline, and psychiatric problems. There is currently no cure, but treatments can help manage symptoms such as chorea, OCD, and irritability. The disease is inherited in an autosomal dominant pattern and testing is available to identify individuals with the expanded HTT gene.
population genetics
Huntington's disease is an autosomal dominant neurological disorder that results from a genetically progressive degeneration of neurons in certain areas of the brain, specifically the basal ganglia. It affects movement coordination. About 30,000 people in the US have been diagnosed, and 200,000 are at risk of inheriting it. The gene responsible is located on chromosome 4 and causes an excess number of glutamine amino acids due to an abnormal expansion of CAG repeats in the DNA coding for the huntingtin protein. There is a 50% chance of inheriting the mutated gene from an affected parent and passing it on to children. While there is no cure, various drugs can help manage symptoms, and new techniques like in vitro fertilization with
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Huntington's disease
Huntington's disease is a genetic disorder caused by inheriting a defective gene, which results in the gradual destruction of neurons over time. The defective gene can be passed down from parent to child, with the child having a 50% chance of inheriting it if a parent has the gene. Symptoms appear between ages 30-50 and include fidgeting, twitching, clumsiness, memory loss, depression, and problems with movement and coordination. Huntington's affects both the mind and body as the disease progresses. While there is no cure, medications can help control movement and emotional symptoms.
Huntington's Disease
Huntington's disease is a genetic neurological disorder that causes the progressive breakdown of nerve cells in the brain. It typically manifests in a person's 30s or 40s with motor, cognitive, and psychiatric symptoms. The motor symptoms include involuntary writhing movements and problems with voluntary movement. Cognitive symptoms involve difficulties with tasks, flexibility, impulsivity, and processing speed. Common psychiatric issues are depression, OCD, mania, and bipolar disorder. The disease is caused by a loss of GABA and acetylcholine-producing neurons in the brain due to a defective gene. While there is no cure, treatments aim to support patients through diet, exercise, and psychosocial support.
Huntington’s disease
Huntington's disease is a genetic neurodegenerative disorder that typically causes movement, cognitive, and psychiatric problems. It is caused by an expanded CAG repeat in the Huntington gene, which leads to damage and death of nerve cells in the brain over time. The signs and symptoms of Huntington's disease usually appear between ages 30 and 50 and worsen over 10 to 25 years, progressing through distinct stages of mild, moderate, and severe problems with movement, thinking, and behavior. While there is no cure for Huntington's disease currently, medications and therapies can help manage some of the symptoms.
Huntington’s Disease
Huntington's disease is a progressive neurodegenerative disorder caused by a mutation on chromosome 4 that results in an elongated huntingtin protein. It is inherited in an autosomal dominant pattern and usually strikes in middle age, causing movement, cognitive, and behavioral issues. There is no cure, but symptoms can be managed through medications. Future treatments focus on gene therapy to silence the mutated gene or neural transplantation, though mutant huntingtin may spread to transplanted tissue.
Huntingtons disease
Huntington's disease is a genetic disorder that causes brain cells to waste away over time. It is passed down through families and results from a defective gene on chromosome 4 that causes an excess of the protein CAG. The disease has two types - adult onset which occurs in one's 30s-40s and is more common, and childhood onset which happens at a young age in rare cases. Signs and symptoms include involuntary movements, cognitive and psychiatric problems, and eventually death around 15-20 years after diagnosis usually from infection or sometimes suicide.
Huntington's disease & its Treatment
Huntington's disease is slowly progressive, rapidly growing hereditary brain disease that causes abnormal motor coordination, thinking, behavior and ultimately leads to dementia.
Its necessary to diagnosis earlier i.e. onset of movement disorder, particularly
with chorea and impaired voluntary movement.
Autosomal dominant inheritance with 2000 people are diagnosed each year.
No drug therapy is available
The worldwide prevalence of Huntington’s Disease is 5-10 cases per 10000 which affects men and women equally
Huntingtons disease
The document provides information about Huntington's disease (HD), including:
1) HD is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene, and is characterized by motor, cognitive, and psychiatric symptoms.
2) The disease primarily involves degeneration of the basal ganglia, especially the caudate and putamen nuclei.
3) Symptoms typically begin in mid-life and include chorea, dystonia, cognitive impairment, and psychiatric issues. There is currently no cure for HD.
Huntington Disease
Huntington's disease is an autosomal dominant, progressive neurodegenerative disease that affects 5-10 per 100,000 people in the Caucasian population. It is caused by a CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4p16.3, which leads to striatal and cortical atrophy. Symptoms include increasingly severe motor disturbances, cognitive impairment, and psychiatric symptoms. Current pharmacological treatments aim to reduce chorea and include tetrabenazine, dopamine antagonists, anti-glutamatergics, and benzodiazepines.
Huntington's Disease
Huntington's disease is a genetic disorder that causes certain nerve cells in the brain to break down over time. It is inherited in an autosomal dominant pattern, meaning only one parent needs to carry the gene for a child to be at risk. Common symptoms include behavioral changes, abnormal movements, dementia, and difficulty swallowing and speaking. While there is no cure, lifestyle interventions including diet, supplements, exercise and social support can help manage symptoms and potentially delay onset. The disease is caused by destruction of cells in the basal ganglia and approximately 1 in 33,333 people in the US are affected.
Huntigton's disease
Huntington's disease is an inherited, progressive brain disorder that causes uncontrolled movements, emotional issues, and loss of thinking abilities. It is caused by a defective gene that is inherited from a parent. Early symptoms vary but may include mood swings, personality changes, and abnormal body movements. Currently there is no cure, but medications and therapies can help manage symptoms. The condition steadily worsens over time and is ultimately fatal.
Genetic linkage in psychiatric disorders
This document outlines an introduction to genetic linkage analysis in various psychiatric disorders. It discusses the history and basics of genetics as well as evidence of genetic linkage found in studies of schizophrenia, affective disorders, anxiety disorders, substance abuse disorders, attention deficit hyperactivity disorder, autism spectrum disorders, intellectual disabilities, and personality disorders. Specific genes have been implicated in disorders like schizophrenia, bipolar disorder, and Rett Syndrome through linkage analysis studies.
Huntington's Disease
Huntington's disease is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It is caused by a mutated gene on chromosome 4 that results in an abnormal protein damaging brain cells. Symptoms start with mood or movement changes and progress to uncontrolled movements and loss of mental abilities. Currently there is no cure, but medications can help treat symptoms.
Huntington disease final
Huntington disease is a rare, degenerative disease caused by a defective gene on chromosome 4 that results in the expansion of a CAG trinucleotide repeat. It is characterized by movement abnormalities such as chorea, as well as psychiatric and cognitive dysfunction. Onset typically occurs between ages 35-45. There is currently no cure, but symptoms can be managed through medications. The disease progresses over 15-20 years from onset to death.
Topic 7 - Comorbidity in ADHD and Autism 2010
Autism, Asperger's and ADHD.
Topic 7 - Comorbidity on ADHD and Autism.
The views expressed in this presentation are those of the individual Simon Bignell and not University of Derby.
ADHD
The document discusses attention deficit hyperactivity disorder (ADHD), including:
1) ADHD is characterized by diminished sustained attention and high impulsivity compared to others of the same age. It has three main types and affects 5-10% of the US population, predominantly males.
2) ADHD has genetic and neurological causes like central nervous system insults and dysfunction of the noradrenergic and dopamine systems. Stimulant medications are the first-line treatment as they target these systems.
3) Diagnosis involves assessing symptoms, impairment, history, and ruling out other conditions. Treatment includes medication, behavioral modifications, and accommodations at home and school to help manage symptoms.
ADHD presentation By Sajjad Hassan
ADHD is a neurodevelopmental disorder characterized by difficulty paying attention, excessive activity, and difficulty controlling behavior. It affects children and often continues into adulthood. Common symptoms include inattention, hyperactivity, and impulsivity. While the specific causes are unknown, genetics and environmental factors like diet may play a role. Treatment often involves medications, dietary changes, supplements, essential oils, exercise, and organization strategies. Proper diagnosis and management of ADHD is important.
HUNGTINGTON'S CHOREA
Huntington's disease is a progressive neurodegenerative disorder caused by a defective gene that results in the production of an abnormal protein called huntingtin. It affects movement, cognition, and personality. Symptoms include uncontrolled movements, impaired walking and talking, and mood and cognitive changes. There is currently no cure, but treatments can help manage symptoms. The disease is inherited in an autosomal dominant pattern and typically appears in middle adulthood.
Huntington's disease
In this we will study basically what's the huntington's disease is, its cause,symptoms, detection, treatment.
Genetics In Psychiatry
Genetic terms used in psychiatry include:
- Concordance and heritability which measure the genetic influences on traits and diseases
- Mendelian and complex diseases which can be caused by single genes or interactions between genes and environment
- Alleles, haplotypes, loci, genetic maps, and linkage disequilibrium which describe genetic variations and inheritance patterns
Genome-wide association studies typically assay common genetic variants like single nucleotide polymorphisms to identify associations with traits and diseases.
huntington chorea for nursing
Huntington's disease (HD) is a rare inherited neurodegenerative disorder that causes uncontrolled movements, cognitive decline and psychiatric problems. It is caused by a mutated gene on chromosome 4 that produces an abnormal protein which causes the death of brain cells. HD is passed on in an autosomal dominant pattern and typically appears in mid-adult life. There is currently no cure, but treatments can help manage symptoms and nursing care focuses on safety, nutrition, mobility and quality of life.
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Huntington's chorea
Huntington's disease is a genetic neurodegenerative disorder that affects movement, thinking, and behavior. It is caused by an expanded CAG repeat in the HTT gene, which produces a defective huntingtin protein. Symptoms typically appear in mid-life and include involuntary movements (chorea), cognitive decline, and psychiatric problems. There is currently no cure, but treatments can help manage symptoms such as chorea, OCD, and irritability. The disease is inherited in an autosomal dominant pattern and testing is available to identify individuals with the expanded HTT gene.
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Huntington's disease is an autosomal dominant neurological disorder that results from a genetically progressive degeneration of neurons in certain areas of the brain, specifically the basal ganglia. It affects movement coordination. About 30,000 people in the US have been diagnosed, and 200,000 are at risk of inheriting it. The gene responsible is located on chromosome 4 and causes an excess number of glutamine amino acids due to an abnormal expansion of CAG repeats in the DNA coding for the huntingtin protein. There is a 50% chance of inheriting the mutated gene from an affected parent and passing it on to children. While there is no cure, various drugs can help manage symptoms, and new techniques like in vitro fertilization with
Huntington's Disease .ppt
Huntington's disease is a condition that stops parts of the brain working properly over time. It's passed on (inherited) from a person's parents. It gets gradually worse over time and is usually fatal after a period of up to 20 years.
Huntington
Huntington's disease is a neurodegenerative genetic disorder that causes progressive breakdown of nerve cells in the brain, especially in the basal ganglia. It affects movement, cognition, and psychiatric functions. Symptoms usually appear between 30-40 years of age and include involuntary movements, cognitive decline, and psychiatric issues like depression. It is caused by a defective gene that is inherited in an autosomal dominant pattern. While there is no cure, treatment aims to reduce symptoms and complications through medications, speech/occupational/physical therapy, and supportive care.
Huntington
Huntington's disease is a neurodegenerative genetic disorder that causes the progressive breakdown of nerve cells in the brain, especially in the basal ganglia. It affects movement, cognition, and psychiatric functions and is caused by a defective gene inherited from a parent. Symptoms typically appear between ages 30-50 and include involuntary movements, cognitive decline, and psychiatric issues like depression. While there is no cure, treatment aims to reduce symptoms and complications through medications, speech/occupational/physical therapy, and supportive care.
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The chapter discusses two neurodegenerative diseases: Alzheimer's disease and Huntington's disease. Alzheimer's disease typically presents with early problems in memory and visuospatial abilities and accounts for about 65% of dementia cases in the United States. The majority of Alzheimer's disease cases are late onset and usually develop after age 65. Huntington's disease is an autosomal dominant disorder characterized by involuntary movements and deterioration of cognitive function. There is no cure for either disease.
Huntington’s disease
Huntington’s disease is an autosomal, dominant, slowly progressive, inherited, incurable, and a
neurodegenerative disease characterized by uncontrolled motor movements, cognitive impairment, behavior
abnormalities which may finally lead to dementia. The main cause of this disease is the mutation in the
huntingtin gene, which is an IT 15 gene. The Occurrence of this disease is more in western countries between
the age group of 35 to 45. Symptoms of this disease depend upon CAG triplet repeat. Main symptoms are
chorea, athetosis, jerks, weight loss, difficulty in speech are seen. Symptomatic treatment may improve the
quality of the life of the individual or may decrease complications.
Huntingtons Disease Melissa Thomas Psy492
Huntington's disease is a hereditary brain disorder caused by a mutated gene on chromosome 4. It is characterized by uncontrolled movements, cognitive decline, and behavioral changes. Symptoms typically appear between the ages of 30-50 and worsen over 10-20 years, ultimately leading to death. While there is no cure, various therapies can help manage symptoms and allow patients to live more comfortably. The disease has devastating emotional and psychological impacts not only on patients, but also their families.
Huntington Disease and Mental illness.pdf
Huntington's disease is a rare, inherited disease that causes the progressive breakdown of nerve cells in the brain. It is caused by a faulty gene that results in parts of the brain becoming gradually damaged over time. The main symptoms are movement disorders, cognitive decline, and psychiatric problems. Mental illness refers to conditions that affect mood, thinking, and behavior, including depression, anxiety, schizophrenia, and addictive behaviors. There are many contributing factors including genetics, brain chemistry, life experiences, and environment. Left untreated, mental illness can cause disability and physical health complications.
huntington disease presentation by archana.pdf
Huntington chorea is chronic, progressive, hereditary, autosomal ,neuro degenerative disease of the nervous system that results in progressive involuntary choreiform movement and dementia.
Huntington's
Huntington's disease is an inherited neurological disorder that damages nerve cells in the brain and affects movement, cognition, and behavior. Symptoms usually appear in adulthood and include personality changes, mood swings, and unusual behavior. There is no cure for Huntington's disease and its progression cannot be slowed, though medication and therapies can help manage some symptoms and support daily living.
Huntington's Disease-.ppt
Huntington's disease is a hereditary neurodegenerative disorder caused by a mutated huntingtin gene. The mutation involves an expanded CAG trinucleotide repeat that results in elongated polyglutamine stretches within the huntingtin protein. This causes the protein to misfold and form intracellular aggregates that interfere with cellular processes and lead to the progressive death of neurons in certain brain regions such as the striatum. Common symptoms include chorea, psychiatric disturbances, and cognitive decline. Onset is typically between ages 30-50 and prognosis is poor, with death occurring within 10-25 years of initial symptoms. No treatments exist to halt or reverse the neurological effects of Huntington's disease.
Tez Powerpoint
Huntington's disease is a genetically programmed degeneration of brain cells that causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. It was first described in 1872 by American doctor George Huntington. HD is diagnosed through genetic and neurological testing, including tests that can determine if someone is carrying the HD gene before symptoms appear. There is no cure for Huntington's disease, and treatment focuses on reducing symptoms, preventing complications, and providing support to patients and their families.
Tez Powerpoint
Huntington's disease is a genetically inherited disorder that causes the degeneration of neurons in the brain, leading to uncontrolled movements, loss of mental abilities, and emotional issues. It was first described in 1872 by American doctor George Huntington. HD is diagnosed through genetic and neurological testing, including tests that can determine if someone carries the HD gene before symptoms appear. While there is no cure for Huntington's disease, treatment focuses on reducing symptoms and complications through support and assistance for patients.
Huntington's disease.pptx
Huntington's disease is a genetic neurodegenerative disorder that causes uncontrolled movements, emotional issues, and loss of cognitive abilities. It is caused by an expanded CAG repeat in the Huntington gene on chromosome 4. Symptoms typically appear in mid-life and include jerking movements, mood swings, and cognitive decline. There is no cure for Huntington's disease and treatment aims to manage symptoms, though the condition steadily worsens over time.
huntingtonsdisease1-210915055835.pptx...
Huntington's disease is an inherited neurodegenerative disorder that causes the progressive breakdown of nerve cells in the brain. It is caused by an expanded CAG repeat in the HTT gene, which results in the production of abnormal huntingtin protein that damages brain cells over time. Symptoms include involuntary movements, cognitive decline, and psychiatric problems. There is currently no cure, but medications and therapies can help manage symptoms.
Huntington's Disease
Huntington's disease is an inherited neurodegenerative disorder that results in uncontrolled movements, emotional problems, and loss of thinking ability. It is caused by an expanded CAG repeat in the HTT gene, which produces a mutant huntingtin protein that leads to the degeneration of neurons in the basal ganglia. Symptoms usually appear between 30-50 years of age and include chorea, psychiatric disorders, and cognitive decline. There is no cure, but medications can help manage symptoms, and genetic testing can determine risk. Nursing care involves education, encouraging activity, managing behaviors, and safety during feeding.
dementias
Vascular (Multi-infarct) dementia (MID) is the second most common cause of dementia, accounting for 30% of cases. It is more common in older adults and may coexist with Alzheimer's disease. MRI scans demonstrate focal strokes (lacunes) in subcortical and cortical brain regions. MID is caused by atherosclerosis reducing blood flow to the brain, resulting in repeated mini-strokes that cause brain cell death (infarcts) in areas and lead to cognitive impairment if they continue accumulating. Risk factors include high cholesterol, triglycerides, homocysteine, C-reactive protein, smoking, and long-term high levels of fibrinogen. Symptom onset is often relatively sudden
Huntingtons chorea- Genetics
Huntington's disease is a genetic disorder that causes the progressive breakdown of nerve cells in the brain. It is caused by a mutated gene that results in elongated repeats of the amino acid glutamine, which leads to the death of neurons in the basal ganglia. The primary symptoms include movement abnormalities such as chorea, cognitive decline, and psychiatric issues like depression. While there is currently no cure, treatment aims to manage symptoms and provide overall support through diet, exercise, and psychosocial interventions to help patients live as positively as possible.
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- 1. Huntington’s Disease For final project of Understanding the Brain: the Neurobiology of Everyday Life Leo Xu July, 2014
- 2. Definition Huntington's disease (HD) is a neurodegenerative genetic disorder characterized by the gradual onset of defects in behavior, cognition, and movement beginning in the fourth and fifth decades of life, with an average life expectancy of about 10-20 years thereafter. The worldwide prevalence of HD is 5–10 cases per 100,000 persons. The hallmark of the disease is a movement disorder consisting of rapid, jerky motions with no clear purpose, which is why the disease used to be called Huntington's chorea; these choreiform movements may be confined to a finger or may involve a whole extremity, the facial musculature, or even the vocal apparatus. HD usually presents as an alternation in mood (especially depression) or a change in personality. Defects of memory and attention may also occur. A profound but selective atrophy of the caudate and putamen is associated with these clinical manifestations. (see the photo on the right)
- 3. Genetic Basis The mutation of Huntingtin is an unstable CAG (cytosine-adenine-guanine) triplet repeat. In normal individuals, Huntingtin contains between 15 and 34 repeats, whereas the gene in HD patients contains from 42 to 66 repeats. Huntington's disease is inherited in an autosomal dominant pattern. If one of your parents has Huntington's disease, you have a 50 percent chance of getting it. Why this dominant disorder endured the evolutionary selection? Because its symptoms usually do not appear until age 35 or later, after the person has passed on the dominant allele to his or her children.
- 4. Neurobiology ① ② ③ ④ ⑤⑥ ⑦ ①Cerebral Cortex ②Putamen ④Globus Pallidus, External ⑤Globus Pallidus, Internal ⑥ Subthalamic Nucleus ⑦Thalamus Frontal cortex for motor activities ③Caudate (2) Inhibition decreases (3) Inhibition increases (3) Inhibition increases (5) Inhibition decreases Normal inhibition Normal excitation (6) Excitation increases (1) HD degenerates Putamen & Caudate Larger arrow: neural activity increases, either inhibitive or excitatory Thinner arrow: neural activity decreases, either inhibitive or excitatory
- 5. Opinion & Treatment A blood test can tell you if have the HD gene and will develop the disease. Genetic counseling can help you weigh the risks and benefits of taking the test. There is no cure. Medicines can help manage some of the symptoms, but cannot slow down or stop the disease
- 6. References Neuroscience 3rd edition, by Dale Purves et al Child Development 8th edition, by Laura E. Berk http://dailydiseasesanddisorders.tumblr.com/post/60401 94582/huntingtons-disease http://www.studyblue.com/notes/note/n/2-3- 13/deck/5374356 http://www.eurostemcell.org/factsheet/huntington%E2% 80%99s-disease-how-could-stem-cells-help http://en.wikipedia.org/wiki/Huntington%27s_disease#R esearch_directions