Hpmc ppt
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The document describes the processes for making several fruit-based food products including squashes, RTS beverages, pickles, jams, plum pulp, fruit juice concentrates, and fruit juice. For each product, the key steps in the production process are outlined, including preparation of the fruit, addition of other ingredients like sugar and acid, boiling, cooling, packaging, and storage. Quality control tests are also listed including tests for pectin, starch, acidity, total soluble solids, and SO2 levels. In the presentation, it is noted that the fruit processing plant produces various products on a daily basis and that all the fruit beverages produced are highly nutritious and thirst-quenching.
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DEVELOPMENT OF ITRACONAZOLE IMMEDIATE RELEASE PELLETS BY USING HPMC LOADED IN...
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“The Novel approach of drug delivery system in which drug can Instilled on the cull de sac cavity of eye is known has Ocular drug delivery system”.
Friability test ppt
Friable: “ A friable substance is any substance that can be reduced to finer particles by the action of a small pressure or friction, such as rubbing or inadvertently brushing up against the substance”.
Friability test: Defined as the % of weight loss by tablets due to mechanical action during the test. Tablets are weighing before & after testing & friability is expressed as a percentage loss on pre-test tablet weight. & Friability test is done to check the ability of the compressed tablet to avoid fracture & breaking during the transport.
This testing involves repeatedly dropping a sample of tablets over a fixed time, using a rotating wheel with a baffle. The result is inspected for broken tablets, and the percentage of tablet mass lost through chipping.
If the average weight of the tablet is 0.65gm or less. Take 10 times of the whole weight i.e., 6.5 gm
2. Carefully deducts the tablets & weight required numbers of tablets.
Initial weight = 6.536gm
3. Set the Time duration for 4min
4. Set number of counts to 100
5. Make sure the drum is cleaned with no contaminates ,
add the initial weighted tables carefully & close the lid
6. Click Start button
Drum diameter : 283 -291mm
Depth: 36-40mm
Inner radius of the curve projection : 75.5mm – 85.5mm
Outer diameter of the central ring : 24.5mm – 25.5mm
Rotation Speed : 25 +/_ 1 cycle
Time Set: 4 min
After 4min automatically it stops ,
7. Take out the tablets & take out the dust from the tablets using brush /crumps
8. Take the After weight of the tablets
Total weight of after rotation= 6.443gm
Interpretation :
Value of friability should not be more than 1% for most of tablets.
If the value of friability for the first is greater than 1%, then repeat the test twice & mean of three values is taken.
If the mean value of three tests is less than 1% tablets passes the friability test,
otherwise tablet fails the test.
If the tablets are broken , chipped or cracked during the test, the tablets fails the friability test.
By ArcImBioCLinica (AIBC)
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It is an route of administration other than the oral route, this route of administration bypasses the alimentary canal.
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This document discusses nanoemulsions and their use as drug delivery systems. It begins with an introduction that defines nanoemulsions as thermodynamically stable mixtures of oil, water and surfactant with droplet sizes between 50-500nm. It then covers the classification, advantages, limitations and methods of preparing nanoemulsions. The document discusses characterizing techniques and various applications of nanoemulsions for drug delivery, including parenteral, intranasal, ocular, tumor targeting, pulmonary and oral routes. In conclusion, nanoemulsions can increase drug solubility, bioavailability and targeting potential for various therapeutic applications.
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This document provides information about intrauterine drug delivery systems (IUDs). It discusses the anatomy and physiology of the female reproductive system. It describes the types of IUDs including non-hormonal copper IUDs and hormonal IUDs like Progestasert that release progesterone. The advantages of IUDs include avoiding first-pass metabolism and providing localized drug delivery. Applications of IUDs include emergency contraception, treatment for heavy menstrual bleeding and menopausal hormone therapy.
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This document discusses large volume parenterals (LVPs), which are sterile solutions intended for intravenous use that come in containers holding more than 100 mL. It describes the key characteristics of LVPs, including that they must be sterile, nonpyrogenic, isotonic, and free of preservatives. The document then outlines different types of LVPs, such as electrolyte solutions, carbohydrate solutions, nutritional solutions, fat emulsions, total parenteral nutrition, and intravenous admixtures. It also discusses some specialized LVPs like hyperalimentation solutions, cardioplegia solutions, peritoneal dialysis fluids, and irrigation solutions.
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This document provides a synopsis for a Master's thesis project titled "Formulation and Evaluation of Fast Dissolving Films of Lisinopril". The project aims to develop fast dissolving films of the hypertension drug Lisinopril to improve patient compliance. Literature on fast dissolving drug delivery systems and films has been reviewed. The planned work involves preparing Lisinopril films using natural and synthetic polymers through various techniques and evaluating the films for properties like drug content, dissolution, and pharmacodynamics. If successful, the fast dissolving Lisinopril films could provide quick action and ease of administration benefits for hypertension patients.
DEVELOPMENT OF ITRACONAZOLE IMMEDIATE RELEASE PELLETS BY USING HPMC LOADED IN...
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ABSTRACT The purpose of this study was to prepare and evaluate immediate release itraconazole pellets and comprehensive studies of the same. The itraconazole pellets is prepared using fluid bed processer with different concentration of HPMC (Hydroxy Propyl Methyl Cellulose). The physicochemical compatibility of the drug and the excipient studied by differential scanning calorimetry. The prepared pellets were physically evaluated with size, shape, bulk density, tapped density, compressibility index, hausners ratio, angle of repose, sieve analysis, surface roughness, density, moisture content, assay and drug release etc. The in vitro drug release profile from pellets shows that all the formulation release more than 75% drug within 90min. Optimized formulations were found to have HPMC concentration 2-5% of total weight of pellets to maximize high-quality surface, desired release, and size distribution within the range. These results indicate that pellets containing 10 % HPMC of total weight of pellets give better quality of itraconazole pellets for immediate release. Key Words: Itraconazole, Hydroxyl propyl methyl cellulose and Immediate release.Ocular drug delivery system (ODDS)
“The Novel approach of drug delivery system in which drug can Instilled on the cull de sac cavity of eye is known has Ocular drug delivery system”.
Friability test ppt
Friable: “ A friable substance is any substance that can be reduced to finer particles by the action of a small pressure or friction, such as rubbing or inadvertently brushing up against the substance”.
Friability test: Defined as the % of weight loss by tablets due to mechanical action during the test. Tablets are weighing before & after testing & friability is expressed as a percentage loss on pre-test tablet weight. & Friability test is done to check the ability of the compressed tablet to avoid fracture & breaking during the transport.
This testing involves repeatedly dropping a sample of tablets over a fixed time, using a rotating wheel with a baffle. The result is inspected for broken tablets, and the percentage of tablet mass lost through chipping.
If the average weight of the tablet is 0.65gm or less. Take 10 times of the whole weight i.e., 6.5 gm
2. Carefully deducts the tablets & weight required numbers of tablets.
Initial weight = 6.536gm
3. Set the Time duration for 4min
4. Set number of counts to 100
5. Make sure the drum is cleaned with no contaminates ,
add the initial weighted tables carefully & close the lid
6. Click Start button
Drum diameter : 283 -291mm
Depth: 36-40mm
Inner radius of the curve projection : 75.5mm – 85.5mm
Outer diameter of the central ring : 24.5mm – 25.5mm
Rotation Speed : 25 +/_ 1 cycle
Time Set: 4 min
After 4min automatically it stops ,
7. Take out the tablets & take out the dust from the tablets using brush /crumps
8. Take the After weight of the tablets
Total weight of after rotation= 6.443gm
Interpretation :
Value of friability should not be more than 1% for most of tablets.
If the value of friability for the first is greater than 1%, then repeat the test twice & mean of three values is taken.
If the mean value of three tests is less than 1% tablets passes the friability test,
otherwise tablet fails the test.
If the tablets are broken , chipped or cracked during the test, the tablets fails the friability test.
By ArcImBioCLinica (AIBC)
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solventless coating techniques can avoid the use of solvents used for coating of dosage form and reduce the cost and time associated with it.
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This document provides an overview of osmotic drug delivery systems. It discusses the basic components and principles of osmosis that osmotic drug delivery systems utilize. The key components discussed include the drug, osmogen, semipermeable membrane, and factors that affect drug release such as solubility, osmotic pressure, delivery orifice size, and membrane type. A variety of osmotic pump designs are also briefly mentioned.
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This document discusses fortifying rice with micronutrients like folic acid and vitamin B12. There are different fortification techniques including dusting, coating, and extrusion. Dusting involves dusting rice grains with micronutrient powder while coating sprays a fortification mix onto rice kernels. Extrusion uses rice flour, fortificants, and water to make dough that is extruded and cut before drying. Ensuring the fortified rice has proper qualities like appearance, taste and nutrient retention is important. Fortifying rice can help address deficiencies but also faces challenges with costs and reaching all people.
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Hpmc ppt
- 1. Presented by: - AAKRITI GFT/115201
- 2. # SQUASHES ( Litchi, Rhodo, Lemon, Ginger, Orange, Kiwi) # RTS ( Litchi, Lemon, Kiwi, Orange, Mango, Plum, Pineapple, Mixed Fruit ) # PICKLES ( Mango, Mushroom, Mixed) # JAMS ( Apple, Mixed Fruit) # PLUM PULP # FRUIT JUICE CONCENTRATES ( Apple, Litchi, Pineapple, Orange, Mango)
- 3. SUGAR+WATER+ACID FILTER CLEAR SYRUP CLEAR SYRUP MIXING TANK (COLOR, ESSENCE,OIL,JUICE) MIX THOROUGHLY BOTTLING (PET bottles for squash and glass bottles for RTS) PASTEURIZATION (85ºC, 5 MINUTES, ONLY FOR RTS) LABELING PACKAGING AND STORAGE
- 4. PREPARATION OF FRUIT (CUT IN TO SMALL PIECES) CURING ADDITION OF SPICES IN HEATED OIL ADDITION OF BRINE AND LEMON JUICE BOILING PUT CUT PIECES IN IT STIR WELL HEATING COOLING PACKAGING, LABELING AND STORAGE
- 5. RIPE FIRM FRUITS WASHING PEELING PULPING ( REMOVAL OF SEED AND CORE) ADDITION OF SUGAR (ADD WATER IF NECESSARY) BOILING ( WITH CONTINUOUS STIRRING) ADDITION OF CITRIC ACID JUDGING OF END POINT (BY FURTHUR COOKING UP TO 105ºC OR 68-70 % TSS OR BY SHEET TEST) FILLING HOT INTO STERILIZED BOTTLES COOLING WAXING, CAPPING AND STORAGE
- 6. FLOWSHEET FOR PLUM PULP EXTRACTION:- RIPE FRUITS WASHING ADDITION OF WATER (1 KG FRUIT: 0.5 LIT WATER) HEATING UP TO 80ºC SEED REMOVAL PASSING THROUGH PULPER PULP STORAGE FLOWSHEET FOR LITCHI (PINEAPPLE, ORANGE & MANGO) CONCENTRATE:- LITCHI ( PINEAPPLE, ORANGE, MANGO) JUICE (STRAINED, 150 KG) MIXING WITH STRAINED SYRUP SOLUTION (SUGAR (300 KG)+ WATER(200 ML) + ACID (5 KG), HEATING JUST TO DISSOLVE) FILLING IN PLASTIC CANS ( 2 LIT CAPACITY) CAPPING STORAGE
- 7. FRUIT WASHING CRUSHING ( WITH GRATER) PULPING ADDITION OF ENZYMES (PECTINASE& AMYLASE) CLARIFICATION (GELATIN AND BENTONITE) FILTRATION (PLATE AND FRAME FILTER PRESS) PASTEURIZATION (190ºF FOR 30 SEC) COOLING 1st STAGE PROCESSING(AROMA RECOVERY ) 2nd STAGE PROCESSING (100º C FOR 40 -45º B) 3rd STAGE PROCESSING(45º C FOR 50-60ºB) FINAL HEATING(45º C FOR 72º B) CONCENTRATE ( TOTALLY NATURAL, NO ADDED PRESERVATIVE) COOLING, PACKING AND STORAGE
- 8. # ALCOHOL TEST ON PECTIN IN FRUIT JUICES- DEFINE THE DOSAGE OF PECLYVE CP # IODINE TEST ON STARCH IN APPLE JUICE- DEFINE THE DOSAGE OF AMYLYVE TC # DETERMINATION OF ACIDITY # DETERMINATION OF TOTAL SOLUBLE SOLIDS (TSS)- BY USING REFRACTOMETER # DETERMINATION OF SO2 ( IN PPM)
- 9. # HPMC, FRUIT PROCESSING PLANT WAS A MARKETTING AND PROCESSING PLANT. # THE DIFFERENT PRODUCTS WERE PRODUCED ON DAILY BASIS. # ALL THE FRUIT BEVERAGES PRODUCED WERE HIGHLY NUTRITIOUS AND THIRST QUENCHING.