The document discusses DNA replication and repair. It explains that DNA polymerase can only synthesize DNA in the 5' to 3' direction, so the leading strand is replicated continuously while the lagging strand is replicated discontinuously in fragments called Okazaki fragments. It also mentions that DNA replication involves enzymes like DNA polymerase, DNA ligase, primase, and helicase. The document further discusses DNA repair mechanisms like nucleotide excision repair and mismatch repair that fix errors during replication. It introduces telomeres, which protect chromosome ends from shortening due to the incomplete replication of linear DNA.

1. 14: Incorporation of a new nucleotide Energy from triphosphates

6. T16.1: Proteins of DNA replication Joins 5’ to 3’ ends DNA ligase Replaces primer for DNA DNA pol I Makes new DNA DNA pol III Relieves overwinding Topoisomerase Makes RNA primer Primase Stabilizes ssDNA Ssbp: single strand binding protein Unwinds parental DNA Helicase Function Protein

7. 17: Summary of DNA replication

8. 17: Summary of DNA replication

15. Summary chapter 16