- Headaches can have many causes, both ocular and systemic. A thorough medical history is important to determine the nature and cause of a patient's headache. - The history should explore symptoms like site, onset, characteristics, radiation, associated symptoms, timing, exacerbating/relieving factors, and severity. - A comprehensive examination of vision, ocular motility, the anterior segment, fundus, refraction and visual fields can help identify potential ocular causes, while neurological and other system examinations may reveal underlying systemic disorders. - Further investigations should be guided by the history and examination findings to arrive at a diagnosis and appropriate management.