This document provides a history of anesthesia, alkaloids, antibiotics, and cardiovascular drugs. It discusses key discoveries and scientists such as:
- Discovery of nitrous oxide, ether, and other inhaled anesthetics for pain relief during surgery in the 18th-19th centuries.
- Isolation of important alkaloids from plants including quinine, atropine, pilocarpine, and curare.
- Milestones in antibiotic discovery including prontosil, penicillin, and streptomycin and their impact on treating bacterial infections.
- Key events in insulin discovery and treatment of diabetes, as well as isolation of corticosteroids and thyroxine hormones.
It was my first pg seminar.I have added notes on which speaker can speak.A few slides that were added after the thank u slide were just for reference and not fit for presenting to audience.
This document provides a history of pharmacology from ancient civilizations to modern times. It discusses:
1) Early use of herbal remedies and natural substances in ancient India, China, Egypt, and Greece with no scientific basis.
2) Developments in the 17th-19th centuries including the establishment of pharmacology as a science based on experimentation and observation.
3) Pioneers in pharmacology like Magendie, Bernard, and Abel who established the field through experimental studies of drugs like curare, strychnine, and epinephrine.
The study of history has sometimes been classified as part of humanities and other time as part of the social sciences. It can also be seen as bridge between these two broad areas, incorporating methodologies from both. Coming back to our world Pharmacology, which has rich history and enduring heritage. It is formed by lot of passionate personalities with grit to serve the mankind.
“It takes an endless amount of history to make even a little tradition”.
-Henry James
There are many stories of both success and failures which shaped our today’s world. Starting from the 18th century Aspirin to the current generation monoclonal antibodies each drug has their own version of stories. In this review I will introduce you to few prominent personalities like the indefatigable Domagk, a person who fought maladies with magic bullets, the Fleming’s story of serendipity, the interesting story of a struggling young orthopaedician’s quest towards invisible treasure and few other stories. we are lucky to have these great discoveries in our past which help the current generation of researchers to make conceptual advances.
Dr. Ranjan, Junior resident, JIPMER
Expt 12 Anticonvulsant effect of drugs by MES and PTZ methodMirza Anwar Baig
This document summarizes a study on the anticonvulsant effect of drugs using the maximum electroshock (MES) and pentylene tetrazole (PTZ) methods. It describes using albino rats or mice and pretreating them for 60 minutes with either a test drug like diphenyl hydantoin-Na or a saline control. The MES method uses electrodes to induce seizures resembling grand mal epilepsy, while PTZ induces seizures resembling petit mal epilepsy. The study procedure involves dividing pre-screened mice into groups, administering the test drug or saline, applying a shock after 1 hour, and recording the timing of seizure phases.
Pharmacology (introduction and handling of experimental animals)Osama Al-Zahrani
1) The document discusses pharmacology practical experiments involving handling experimental animals.
2) It introduces different levels of pharmacological testing from pre-clinical to clinical trials in humans.
3) The main focus is on how to properly handle experimental animals like rats, mice, and rabbits used in studies, including how to house them, provide water, and restrain them safely during experiments.
Pharmacology is the study of drugs and their interaction with living systems. It involves understanding how drugs are administered, how they work in the body on a molecular level by binding to receptors, and their therapeutic and toxic effects. Some key developments in the history of pharmacology include Paracelsus' concept of dosage in the 16th century, the establishment of the first pharmacology laboratory and chair by Rudolf Buchheim and Oswald Schmiedeberg in the 19th century, and the founding of clinical pharmacology as a discipline by Louis Lasagna in the 20th century. Pharmacology continues to advance through subdisciplines focusing on various body systems and aspects of drug discovery, development, and clinical use.
This document summarizes various animal models used to screen analgesics for acute and chronic pain. It describes models using thermal, electrical, chemical, and mechanical stimuli to induce nociception. For acute pain, it details hot plate, tail flick, and formalin tests. For chronic pain, it outlines neuropathic pain models like sciatic nerve injury and vincristine-induced neuropathy. Cancer and diabetic neuropathy models are also summarized. The document provides details of procedures, pain behaviors measured, and usefulness of each model in evaluating different classes of analgesics.
It was my first pg seminar.I have added notes on which speaker can speak.A few slides that were added after the thank u slide were just for reference and not fit for presenting to audience.
This document provides a history of pharmacology from ancient civilizations to modern times. It discusses:
1) Early use of herbal remedies and natural substances in ancient India, China, Egypt, and Greece with no scientific basis.
2) Developments in the 17th-19th centuries including the establishment of pharmacology as a science based on experimentation and observation.
3) Pioneers in pharmacology like Magendie, Bernard, and Abel who established the field through experimental studies of drugs like curare, strychnine, and epinephrine.
The study of history has sometimes been classified as part of humanities and other time as part of the social sciences. It can also be seen as bridge between these two broad areas, incorporating methodologies from both. Coming back to our world Pharmacology, which has rich history and enduring heritage. It is formed by lot of passionate personalities with grit to serve the mankind.
“It takes an endless amount of history to make even a little tradition”.
-Henry James
There are many stories of both success and failures which shaped our today’s world. Starting from the 18th century Aspirin to the current generation monoclonal antibodies each drug has their own version of stories. In this review I will introduce you to few prominent personalities like the indefatigable Domagk, a person who fought maladies with magic bullets, the Fleming’s story of serendipity, the interesting story of a struggling young orthopaedician’s quest towards invisible treasure and few other stories. we are lucky to have these great discoveries in our past which help the current generation of researchers to make conceptual advances.
Dr. Ranjan, Junior resident, JIPMER
Expt 12 Anticonvulsant effect of drugs by MES and PTZ methodMirza Anwar Baig
This document summarizes a study on the anticonvulsant effect of drugs using the maximum electroshock (MES) and pentylene tetrazole (PTZ) methods. It describes using albino rats or mice and pretreating them for 60 minutes with either a test drug like diphenyl hydantoin-Na or a saline control. The MES method uses electrodes to induce seizures resembling grand mal epilepsy, while PTZ induces seizures resembling petit mal epilepsy. The study procedure involves dividing pre-screened mice into groups, administering the test drug or saline, applying a shock after 1 hour, and recording the timing of seizure phases.
Pharmacology (introduction and handling of experimental animals)Osama Al-Zahrani
1) The document discusses pharmacology practical experiments involving handling experimental animals.
2) It introduces different levels of pharmacological testing from pre-clinical to clinical trials in humans.
3) The main focus is on how to properly handle experimental animals like rats, mice, and rabbits used in studies, including how to house them, provide water, and restrain them safely during experiments.
Pharmacology is the study of drugs and their interaction with living systems. It involves understanding how drugs are administered, how they work in the body on a molecular level by binding to receptors, and their therapeutic and toxic effects. Some key developments in the history of pharmacology include Paracelsus' concept of dosage in the 16th century, the establishment of the first pharmacology laboratory and chair by Rudolf Buchheim and Oswald Schmiedeberg in the 19th century, and the founding of clinical pharmacology as a discipline by Louis Lasagna in the 20th century. Pharmacology continues to advance through subdisciplines focusing on various body systems and aspects of drug discovery, development, and clinical use.
This document summarizes various animal models used to screen analgesics for acute and chronic pain. It describes models using thermal, electrical, chemical, and mechanical stimuli to induce nociception. For acute pain, it details hot plate, tail flick, and formalin tests. For chronic pain, it outlines neuropathic pain models like sciatic nerve injury and vincristine-induced neuropathy. Cancer and diabetic neuropathy models are also summarized. The document provides details of procedures, pain behaviors measured, and usefulness of each model in evaluating different classes of analgesics.
This document provides an overview of antibiotics, including their historical background, classification, mechanisms of action, and examples. It focuses on penicillins and their discovery by Alexander Fleming in 1928. Penicillins are beta-lactam antibiotics that work by inhibiting bacterial cell wall synthesis. They have broad applications for treating bacterial infections. The document also discusses cephalosporins, another class of beta-lactam antibiotics derived from the fungus Cephalosporium.
For all YouTube Live video practical series of experimental Pharmacology click:
https://youtube.com/playlist?list=PLBVbJ9HCa1Ba6WSJjeBaK0HMF79hdad3g
For More Such Learning You Can Subscribe to
My YouTube Channel:
https://www.youtube.com/channel/UC5o-WkzmDJaF7udyAP2jtgw/featured?sub_confirmation=1
Facebook Page: https://www.facebook.com/asacademylearningforever
Website Blog: https://itasacademy.blogspot.com/
This document provides an overview of bioassay procedures. It defines bioassay as the comparative assessment of the potency of a test compound to a standard compound using a living biological system. The basic bioassay procedure involves preparing tissues, attaching them to an organ bath, constructing dose-response curves for standard and test compounds, and calculating the potency of the test compound based on its curve's position relative to the standard. Sources of error include biological variation between tissues and methodological errors in experimental design or implementation.
This document discusses peptic ulcers, including their causes, symptoms, and treatments. It notes that peptic ulcers are open sores in the upper digestive tract that can form in the stomach (gastric ulcer) or small intestine (duodenal ulcer). Common causes include H. pylori infection, NSAIDs, and stress. Symptoms may include abdominal pain, nausea, black stools, or weight loss. Treatments discussed include antibiotics to kill H. pylori, antacids to neutralize stomach acid, drugs that decrease acid secretion, ulcer protective drugs to coat the ulcer, and ulcer healing drugs.
1. basics of experimental pharmacologyMBBS IMS MSU
Experimental pharmacology involves studying the effects of pharmacological agents on different animal species. The aims are to identify suitable therapeutic agents for human use, study drug toxicity and mechanisms of action. Common laboratory animals used include mice, rats, guinea pigs and rabbits. Rats are commonly used due to their small size and low drug requirements. Wistar rats are a commonly used strain. Mice are also used for toxicology and drug screening studies due to their small size. Guinea pigs are sensitive to histamine and antibiotics, making them useful for studies in these areas. Rabbits are docile and used for pyrogen testing and studies of drugs affecting capillary permeability. Frogs are commonly used for isolated tissue studies and studies of drugs acting on
Oswald Schmiedeberg was a German pharmacologist considered the Father of Modern Pharmacology. He studied under Rudolf Buchheim, who established the first institute of Experimental Pharmacology in 1847. Schmiedeberg succeeded Buchheim and established his own renowned pharmacological institute at Strassburg in 1872. Over his career, he published over 200 works establishing fundamental concepts in pharmacology. He studied the relationship between chemical structure and drug effects, and investigated important drugs like digitalis and toxic heavy metals. Through his work, he helped establish pharmacology as a distinct scientific discipline.
Expt 11 Effect of drugs on locomotor activity using actophotometerMirza Anwar Baig
This document describes an experiment to evaluate the effects of drugs on locomotor activity using an actophotometer. Rats or mice are injected with either a saline control, the antipsychotic drug chlorpromazine at 3 mg/kg, or caffeine at 3 mg/kg. Their movement is then measured in the actophotometer before and after drug administration. Chlorpromazine is expected to reduce locomotor activity as a CNS depressant, while caffeine may increase it as a CNS stimulant. The results are presented as locomotor activity scores showing that chlorpromazine decreased activity and caffeine increased it, demonstrating their respective CNS effects.
This instrument is designed to measure animal activity levels. It contains a clear Perspex chamber with a grid of brass rods spaced 3/16 inches apart. A shock of variable strength up to 100v and 0.2mA can be delivered through the grid to stimulate movement. A digital counter displays the number of movements detected. The front panel allows independent control of power and shock strength, and displays the shock voltage and movement count.
Anti-inflammatory activity of drugs using carrageenan induced paw-edema modelDr. Sameer H. Sawant
This document describes a study to evaluate the anti-inflammatory activity of drugs using a carrageenan-induced paw edema model in rats. The study involves injecting carrageenan into the paws of rats to cause inflammation and edema, which are measured over time using a plethysmometer. Rats are divided into control and test groups, with the test group receiving indomethacin prior to carrageenan injection. Paw volumes are measured and compared between groups to determine the ability of indomethacin to reduce edema caused by carrageenan. The results show that indomethacin demonstrated anti-inflammatory effects by inhibiting the paw edema induced by carrageenan.
Expt. 4 DRC of acetylcholine using frog rectus abdominis muscleVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of ACh stock and standard solutions
Preparation of frog ringer solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation of magnification value (Mf)
Graphical presentation of CRC/ DRC
Result and interpretation
Expt. 6 Bioassay of histamine using guinea pig ileum by matching methodVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of histamine standard solution
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation
Result and interpretation
The document describes an experiment evaluating the diuretic activity of three drugs - furosemide, torsemide, and metolazone - in rats. Rats were divided into groups and administered one of the drugs along with saline. Urine output was measured over 3 hours. Torsemide showed the highest diuretic activity, followed by furosemide, with metolazone showing the lowest activity. Statistical analysis confirmed torsemide, furosemide, and metolazone all significantly increased urine output compared to the control group.
This document summarizes screening models for diuretic agents. It discusses various in vitro and in vivo models including isolated tubule preparation, carbonic anhydrase inhibition assay, patch clamp technique, Lipschitz test, saluretic activity in rats, stop flow technique, clearance method, and micropuncture technique. It provides details on the principles, procedures, and evaluations of these models for studying mechanisms and effects of diuretic agents. The models allow localization of sites of action and analysis of renal transport processes to evaluate diuretics and their carbonic anhydrase inhibiting or potassium sparing effects.
Pre-clinical trials involve testing new drugs, procedures, or medical treatments in animals before beginning clinical trials in humans. They aim to determine safety and efficacy. The document outlines the stages of pre-clinical trials including in vitro and in vivo testing, pharmacokinetic studies, toxicity tests, and FDA review requirements. The goals are to identify safe starting doses in humans, target organs for toxicity, and safety parameters for clinical monitoring before human trials.
Expt. 10 effect of spasmogens and spasmolytics using rabbit jejunumVISHALJADHAV100
Overview of Discussion
Objective
Principle
Requirements
Experimental specifications (conditions)
Drugs and solutions used in rabbit intestine experiment
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Result and interpretation
Lecture includes definition of bioassay, Types of Assay and Bioassay , Indications, principles, advantages of bioassay. Example of a Bioassay with calculations. This lecture will be of help for postgraduate pharmacology students as well as undergraduates
This document describes different types of bioassays including direct end point assays, quantal assays, and graded assays. It provides details on graded response assays, specifically bracketing assays, matching assays, interpolation assays, and multiple point assays (3-point, 4-point, 6-point, and 8-point assays). Graded response assays involve comparing the response of a test drug to a standard drug response curve to determine the potency of the test drug. Multiple point assays take responses at different doses of both the standard and test drugs to improve accuracy over other graded response assay methods.
This document provides an overview of the scope of pharmacology. It discusses the history and evolution of pharmacology from materia medica and early pharmacy to its modern academic, industrial and research applications. Key areas of pharmacology discussed include drug development process, clinical pharmacology, special domains like pharmacovigilance, pharmacoeconomics and emerging areas like pharmacogenomics. The document outlines the past, present and future scope of pharmacology and how it aims to advance human health through rational and safe use of medicines.
This document summarizes the contributions of various scientists to the field of pharmacology. It discusses early pioneers like Hippocrates, Dhanvantari, and Paracelsus, as well as later scientists who made important discoveries, such as Rudolf Buchheim establishing the first pharmacology chair, Oswald Schmiedeberg founding modern pharmacology, John Jacob Abel giving pharmacology its name, and Otto Loewi proving chemical transmission of nerve impulses. It also discusses scientists like Alexander Fleming discovering penicillin, and Frederick Banting and Charles Best discovering insulin. Overall, the document provides a brief history of pharmacology and highlights some of the key figures and discoveries that advanced the field.
This document provides an overview of antibiotics, including their historical background, classification, mechanisms of action, and examples. It focuses on penicillins and their discovery by Alexander Fleming in 1928. Penicillins are beta-lactam antibiotics that work by inhibiting bacterial cell wall synthesis. They have broad applications for treating bacterial infections. The document also discusses cephalosporins, another class of beta-lactam antibiotics derived from the fungus Cephalosporium.
For all YouTube Live video practical series of experimental Pharmacology click:
https://youtube.com/playlist?list=PLBVbJ9HCa1Ba6WSJjeBaK0HMF79hdad3g
For More Such Learning You Can Subscribe to
My YouTube Channel:
https://www.youtube.com/channel/UC5o-WkzmDJaF7udyAP2jtgw/featured?sub_confirmation=1
Facebook Page: https://www.facebook.com/asacademylearningforever
Website Blog: https://itasacademy.blogspot.com/
This document provides an overview of bioassay procedures. It defines bioassay as the comparative assessment of the potency of a test compound to a standard compound using a living biological system. The basic bioassay procedure involves preparing tissues, attaching them to an organ bath, constructing dose-response curves for standard and test compounds, and calculating the potency of the test compound based on its curve's position relative to the standard. Sources of error include biological variation between tissues and methodological errors in experimental design or implementation.
This document discusses peptic ulcers, including their causes, symptoms, and treatments. It notes that peptic ulcers are open sores in the upper digestive tract that can form in the stomach (gastric ulcer) or small intestine (duodenal ulcer). Common causes include H. pylori infection, NSAIDs, and stress. Symptoms may include abdominal pain, nausea, black stools, or weight loss. Treatments discussed include antibiotics to kill H. pylori, antacids to neutralize stomach acid, drugs that decrease acid secretion, ulcer protective drugs to coat the ulcer, and ulcer healing drugs.
1. basics of experimental pharmacologyMBBS IMS MSU
Experimental pharmacology involves studying the effects of pharmacological agents on different animal species. The aims are to identify suitable therapeutic agents for human use, study drug toxicity and mechanisms of action. Common laboratory animals used include mice, rats, guinea pigs and rabbits. Rats are commonly used due to their small size and low drug requirements. Wistar rats are a commonly used strain. Mice are also used for toxicology and drug screening studies due to their small size. Guinea pigs are sensitive to histamine and antibiotics, making them useful for studies in these areas. Rabbits are docile and used for pyrogen testing and studies of drugs affecting capillary permeability. Frogs are commonly used for isolated tissue studies and studies of drugs acting on
Oswald Schmiedeberg was a German pharmacologist considered the Father of Modern Pharmacology. He studied under Rudolf Buchheim, who established the first institute of Experimental Pharmacology in 1847. Schmiedeberg succeeded Buchheim and established his own renowned pharmacological institute at Strassburg in 1872. Over his career, he published over 200 works establishing fundamental concepts in pharmacology. He studied the relationship between chemical structure and drug effects, and investigated important drugs like digitalis and toxic heavy metals. Through his work, he helped establish pharmacology as a distinct scientific discipline.
Expt 11 Effect of drugs on locomotor activity using actophotometerMirza Anwar Baig
This document describes an experiment to evaluate the effects of drugs on locomotor activity using an actophotometer. Rats or mice are injected with either a saline control, the antipsychotic drug chlorpromazine at 3 mg/kg, or caffeine at 3 mg/kg. Their movement is then measured in the actophotometer before and after drug administration. Chlorpromazine is expected to reduce locomotor activity as a CNS depressant, while caffeine may increase it as a CNS stimulant. The results are presented as locomotor activity scores showing that chlorpromazine decreased activity and caffeine increased it, demonstrating their respective CNS effects.
This instrument is designed to measure animal activity levels. It contains a clear Perspex chamber with a grid of brass rods spaced 3/16 inches apart. A shock of variable strength up to 100v and 0.2mA can be delivered through the grid to stimulate movement. A digital counter displays the number of movements detected. The front panel allows independent control of power and shock strength, and displays the shock voltage and movement count.
Anti-inflammatory activity of drugs using carrageenan induced paw-edema modelDr. Sameer H. Sawant
This document describes a study to evaluate the anti-inflammatory activity of drugs using a carrageenan-induced paw edema model in rats. The study involves injecting carrageenan into the paws of rats to cause inflammation and edema, which are measured over time using a plethysmometer. Rats are divided into control and test groups, with the test group receiving indomethacin prior to carrageenan injection. Paw volumes are measured and compared between groups to determine the ability of indomethacin to reduce edema caused by carrageenan. The results show that indomethacin demonstrated anti-inflammatory effects by inhibiting the paw edema induced by carrageenan.
Expt. 4 DRC of acetylcholine using frog rectus abdominis muscleVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of ACh stock and standard solutions
Preparation of frog ringer solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation of magnification value (Mf)
Graphical presentation of CRC/ DRC
Result and interpretation
Expt. 6 Bioassay of histamine using guinea pig ileum by matching methodVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of histamine standard solution
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation
Result and interpretation
The document describes an experiment evaluating the diuretic activity of three drugs - furosemide, torsemide, and metolazone - in rats. Rats were divided into groups and administered one of the drugs along with saline. Urine output was measured over 3 hours. Torsemide showed the highest diuretic activity, followed by furosemide, with metolazone showing the lowest activity. Statistical analysis confirmed torsemide, furosemide, and metolazone all significantly increased urine output compared to the control group.
This document summarizes screening models for diuretic agents. It discusses various in vitro and in vivo models including isolated tubule preparation, carbonic anhydrase inhibition assay, patch clamp technique, Lipschitz test, saluretic activity in rats, stop flow technique, clearance method, and micropuncture technique. It provides details on the principles, procedures, and evaluations of these models for studying mechanisms and effects of diuretic agents. The models allow localization of sites of action and analysis of renal transport processes to evaluate diuretics and their carbonic anhydrase inhibiting or potassium sparing effects.
Pre-clinical trials involve testing new drugs, procedures, or medical treatments in animals before beginning clinical trials in humans. They aim to determine safety and efficacy. The document outlines the stages of pre-clinical trials including in vitro and in vivo testing, pharmacokinetic studies, toxicity tests, and FDA review requirements. The goals are to identify safe starting doses in humans, target organs for toxicity, and safety parameters for clinical monitoring before human trials.
Expt. 10 effect of spasmogens and spasmolytics using rabbit jejunumVISHALJADHAV100
Overview of Discussion
Objective
Principle
Requirements
Experimental specifications (conditions)
Drugs and solutions used in rabbit intestine experiment
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Result and interpretation
Lecture includes definition of bioassay, Types of Assay and Bioassay , Indications, principles, advantages of bioassay. Example of a Bioassay with calculations. This lecture will be of help for postgraduate pharmacology students as well as undergraduates
This document describes different types of bioassays including direct end point assays, quantal assays, and graded assays. It provides details on graded response assays, specifically bracketing assays, matching assays, interpolation assays, and multiple point assays (3-point, 4-point, 6-point, and 8-point assays). Graded response assays involve comparing the response of a test drug to a standard drug response curve to determine the potency of the test drug. Multiple point assays take responses at different doses of both the standard and test drugs to improve accuracy over other graded response assay methods.
This document provides an overview of the scope of pharmacology. It discusses the history and evolution of pharmacology from materia medica and early pharmacy to its modern academic, industrial and research applications. Key areas of pharmacology discussed include drug development process, clinical pharmacology, special domains like pharmacovigilance, pharmacoeconomics and emerging areas like pharmacogenomics. The document outlines the past, present and future scope of pharmacology and how it aims to advance human health through rational and safe use of medicines.
This document summarizes the contributions of various scientists to the field of pharmacology. It discusses early pioneers like Hippocrates, Dhanvantari, and Paracelsus, as well as later scientists who made important discoveries, such as Rudolf Buchheim establishing the first pharmacology chair, Oswald Schmiedeberg founding modern pharmacology, John Jacob Abel giving pharmacology its name, and Otto Loewi proving chemical transmission of nerve impulses. It also discusses scientists like Alexander Fleming discovering penicillin, and Frederick Banting and Charles Best discovering insulin. Overall, the document provides a brief history of pharmacology and highlights some of the key figures and discoveries that advanced the field.
This document provides information on different classes of medications used to treat hypertension and high cholesterol. It lists specific drugs within statins, fibrates, bile acid resins, niacin, ACE inhibitors, ARBs, calcium channel blockers, aldosterone receptor antagonists, alpha blockers, and direct renin inhibitors. For each drug, it provides the brand name, dosing, and key monitoring parameters and side effects. The document serves as a reference for pharmacists or prescribers on the appropriate use of various antihypertensive and lipid-lowering drug classes.
This document summarizes evidence-based guidelines on hormone replacement therapy. It discusses that HRT can effectively treat hot flashes and vaginal atrophy but may increase risks of breast cancer, heart disease, and blood clots if used long-term. Larger studies like the Women's Health Initiative found these health risks outweighed benefits for chronic disease prevention. Recommendations are that HRT only be used at lowest effective doses for shortest time to treat menopausal symptoms.
Bio Identical or Natural Hormone Replacement Therapymiddela
The document discusses bioidentical hormone restoration as a means to replace hormones lost due to aging. It argues that losing hormones is not adaptive and leads to various health issues. Restoring youthful hormone levels through bioidentical replacements can improve health, prevent disease, and enhance quality of life by treating symptoms caused by hormone deficiencies. Common hormones that decline with age include testosterone, growth hormone, DHEA, progesterone, and estrogen.
The document discusses the benefits of exercise for both physical and mental health. Regular exercise can help reduce the risk of diseases like heart disease and diabetes, and it can also improve mood and reduce stress and anxiety levels. Exercising for at least 30 minutes per day several times a week is recommended to gain these health benefits.
Experimental pharmacology deals with studying the reactions of living organisms to drugs. It involves pre-clinical and clinical studies as well as various types of research like behavioral, developmental, and functional research. Some techniques used in experimental pharmacology include cell culture, immunostaining, computational genomics, transfection, stem cell culture, DNA sequencing, gene knockdown, polymerase chain reaction, and more. Pharmacological research is important for developing life-saving treatments and better understanding traditional medicines like Ayurveda.
Blue cheese in a roquefort style (two methods)Kimetha Loidolt
This document provides instructions for making blue cheese in the style of Roquefort using two different methods. The first method uses a re-culture of blue mold, while the second uses a modern Penicillium Roqueforti culture. The process involves warming milk, adding cultures and rennet to curdle the milk, cutting and heating the curds, draining the curds, pressing the curds into a mold, and aging the cheese to develop the blue mold over several months. Observations are provided on the first day of making cheese using each method.
Introduction to essential Pharmacology for Advanced EMT and Paramedic Students. A bit long but a good lecture. Does not goo into individual drugs, that is later. This is JUST the introduction.
The document discusses various types of alkaloids found in plants, including their chemical properties, biological functions, and medicinal uses. It describes that alkaloids often have nitrogen in a heterocyclic ring and are bitter tasting. Over 10,000 alkaloids have been identified from a wide range of plants. Examples of important medicinal alkaloids mentioned include morphine, caffeine, reserpine, and quinine. The document also summarizes key alkaloid groups such as isoquinolines, purines, and indoles, and specific alkaloids such as berberine, cocaine, and yohimbine.
The document summarizes the evolution of artificial limbs from ancient Egypt to modern times. It discusses some of the earliest known prosthetics from ancient Egypt dating back to 2750-2625 BC. It then outlines key developments in prosthetics throughout history from ancient Greece and Rome to modern innovations like the Jaipur Foot, microprocessor knees, myoelectric arms, and cutting edge research into areas like osseointegration and mind-controlled prosthetics.
Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
This study assessed the potential antifungal activity of extracts from four species of Himalayan lichens. Lichen samples were extracted using acetone, methanol, and chloroform solvents. The extracts were tested for antifungal activity against seven pathogenic fungi using a disc diffusion assay. Acetone and methanol extracts showed differential inhibitory effects against the fungi compared to chloroform extracts and a synthetic antifungal. Principal component analysis revealed acetone and methanol extracts were more effective against some Fusarium species than the positive control. The results suggest lichen extracts may have potential as natural fungicides.
Metastatic bone disease: An old dogma and a new insightMohamed Abdulla
Metastatic bone disease is a challenging condition that places a heavy burden on patients. New insights into the cellular and molecular mechanisms have led to improved treatments. Cancer cells interact with the bone microenvironment through factors like RANKL, RANK, and osteoprotegerin, inducing a "vicious cycle" of bone destruction. Emerging therapies target these interactions by inhibiting RANKL with drugs like denosumab. Radiopharmaceuticals like radium-223 also show promise by targeting areas of new bone growth in metastases. While radiation remains important for pain relief, combination therapies offer the potential for improved outcomes in metastatic bone disease.
Post-harvest diseases can destroy 10-30% of total crop yields and over 30% in some perishable crops. They develop during harvesting, grading, packing, transportation, storage, and consumption. Major losses occur in fresh fruits and vegetables and grains/legumes. Common post-harvest pathogens include Aspergillus, Penicillium, Erwinia, Monilinia, zygomycetes, and Sclerotinia. They cause diseases such as ear rot, soft rot, purple stain, and white mold. Proper post-harvest handling and storage is important to reduce losses from these diseases.
This document discusses menopause and the options for hormone replacement therapy (HRT). It covers the physiology of menopause, effects of declining estrogen levels, and risks like hot flashes, bone loss, and cardiovascular disease. It presents both benefits and risks of HRT, as well as non-hormonal options and lifestyle interventions like diet, exercise and supplements that can help manage menopause symptoms and health risks. The key decision is choosing treatments that improve quality of life based on each woman's individual symptoms, risk factors and medical history.
This document discusses deep fungal infections including subcutaneous and systemic mycoses. It provides details on various subcutaneous mycoses such as sporotrichosis, chromoblastomycosis, and mycetoma. Sporotrichosis is caused by Sporothrix schenckii and can present as lymphangitic or fixed cutaneous lesions. Chromoblastomycosis is caused by several fungi and presents as slow-growing exophytic lesions on the feet and legs. Both infections are diagnosed through microscopic identification of fungal elements and both typically require lengthy antifungal treatment.
Pharmacology - Principles of Antimicrobial therapyAreej Abu Hanieh
This document is a list of references for a Phar 538 pharmacology course taught by Dr. Abdullah Rabba. The references are to chapters 1 through 41 of the 5th edition of Lippincott's Illustrated Reviews: Pharmacology textbook.
This document summarizes the treatment of hypertension. It discusses various classes of antihypertensive drugs including those acting on the renin-angiotensin-aldosterone system like ACE inhibitors, ARBs, and aldosterone antagonists. It also discusses calcium channel blockers, diuretics, beta blockers, and other miscellaneous drugs. Combination drug therapy and treatment of resistant hypertension is also covered. Lifestyle modifications including diet, exercise, weight loss, and limiting alcohol are recommended as first-line treatment.
- Pharmacology is the study of drugs and their interactions with living systems. Rudolf Buchheim established the first pharmacology chair in 1847, marking the emergence of pharmacology as a distinct science. Oswald Schmiedeberg is considered the founder of modern pharmacology due to his pioneering experimental work and textbook on the subject. Important contributors include John Jacob Abel, considered the father of American pharmacology, and Otto Loewi, who provided the first evidence of chemical transmission in synapses.
Hippocrates was an ancient Greek physician who studied people to develop medical ideas and believed illness was caused by imbalances in the body's four humours rather than gods. Galen built on Hippocrates' theories and wrote extensively, though his ideas were disproven over 1000 years later. Vesalius used dissection to prove many of Galen's anatomical theories wrong. Harvey discovered the circulation of blood. Jenner developed the smallpox vaccine. Simpson introduced ether and chloroform for surgery. Pasteur and Koch established germ theory and developed vaccines.
1. The document traces the evolution of anaesthesia practice from the first successful public demonstration of ether anaesthesia in 1846 to the modern anaesthesia workstation. [2] It discusses the development of various inhalational and intravenous agents as well as advances in airway management, monitoring, and regional anaesthesia techniques. [3] The timeline highlights milestones such as the introduction of muscle relaxants, pulse oximetry, and ultrasound guidance for regional blocks that have transformed anaesthesia into a complex medical specialty focused on patient safety.
The document provides a history of hygiene practices from ancient times to modern day. It discusses the following key points in 3 sentences:
The earliest hygiene rules date back to around 1500 BC in Hindu texts, with religious rules around hygiene developing in Judaism and Islam. In ancient Greece, people would clean themselves by rubbing oils and sand on their skin before scraping it off, while Romans enjoyed elaborate public baths that became a pastime. Major developments in personal, food, and home hygiene increased in the 19th century during the Industrial Revolution, including advances in food preservation methods like pasteurization and refrigeration as well as the emergence of public baths and private bathrooms.
The document provides a historical overview of parathyroid surgery worldwide and in Puerto Rico. It discusses:
- Early descriptions and cases of parathyroid disease from the 1850s onwards.
- The first parathyroid operations in the 1920s that resulted in successful treatments.
- Famous early cases of hyperparathyroidism including Albert Gahne and Captain Charles Martell.
- The establishment of parathyroid surgery as the standard treatment for hyperparathyroidism by Felix Mandl in the 1920s.
- The history of parathyroid surgery and endocrinology in Puerto Rico from the 1950s onwards, including the first published case series and operations by Drs. Paniagua,
This document summarizes the history of health science from primitive times through the 21st century. It describes early beliefs that illness was caused by spirits and the use of plants as medicine. It then outlines advances made by ancient Egyptians in record keeping and identifying diseases, ancient Chinese in developing acupuncture, and ancient Greeks like Hippocrates and Aristotle who studied anatomy and the causes of disease. The document continues by discussing developments during the Renaissance like the study of anatomy through dissection, the printing press making information more widely available, and inventions in subsequent centuries like the stethoscope, antibiotics, vaccines, x-rays, and modern approaches to medical care being discovered today.
This document provides a historical overview of the development of research ethics. It discusses early expressions like the Hippocratic Oath. Unethical experiments on humans without consent like those by Dr. Neisser and the Little Albert experiment highlighted the need for standards. The atrocious Nazi human experiments led to the Nuremberg Code. The Declaration of Helsinki addressed clinical research. The unethical Tuskegee Syphilis Study resulted in guidelines like the Belmont Report to protect subjects. Over time, various declarations and guidelines like the Universal Declaration of Bioethics and Human Rights established international standards for ethical research involving human subjects.
A detailed history of plant pathology is mentioned, covered various important contributions with diagrammatic representations of scientists and depth include of subject matter has been updated
Teaching by stories, anecdotes and historical facts sept 25 2018Bhaswat Chakraborty
Many difficult principles in science and humanities can be taught best by a story (of its discovery), by an anecdote or some historical facts about them.
Carl Koller discovered the local anesthetic properties of cocaine in 1884, allowing for the first procedures using regional anesthesia. Throughout the 19th century, various substances like ether, nitrous oxide, and chloroform were discovered and used to relieve the pain of surgery. John Snow made important advances in anesthetic equipment and monitoring in the 1840s-50s. By the mid-20th century, newer nonflammable inhaled agents replaced ether and cyclopropane.
The document provides a history of anesthesia from ancient times up until the present. It discusses early methods of pain management before the discovery of modern anesthesia in 1846, including compression of nerves, application of cold, hypnosis, and bloodletting. It then outlines the development of various inhalational, intravenous, local, and regional anesthetic agents from the 19th century onward. These include nitrous oxide, ether, chloroform, cocaine, barbiturates, and newer inhalational and intravenous drugs. The document also discusses the evolution of airway management tools and early anesthesia machines. It concludes with a brief overview of the history of anesthesia development in Nepal from the early 20th century to the present day
Early medicinal practices involved identifying herbal and other natural remedies to treat diseases, as described in ancient texts like the Ebers Papyrus from 1550 BC listing over 800 remedies. In the 18th-19th centuries, scientists began isolating active compounds from plants like morphine, quinine and salicylates, marking the beginning of the pharmaceutical industry. Modern drug discovery involves screening plant and microbial extracts for biological activity, isolating and characterizing active compounds, and developing them into drug candidates through clinical trials. Natural products and their derivatives still account for over a third of the global medicine market and have potential for new therapeutic discoveries.
When and where the history of volatile anesthesia started and what was the story ?
Whom was the triggering for discovering the effect of volatile anesthesia on human being ?
How the volatile anesthesia developed year by year till reach the best and the most safe volatile anesthetic ?
What were the complications of old volatile anesthetics ?
The document summarizes the historical evolution of clinical trial guidelines from ancient times to the present. Some key events include the first recorded clinical trial by King Nebuchadnezzar in 562 BC, James Lind's 1757 controlled trial of treatments for scurvy, the introduction of the placebo concept in the 1800s, the first double-blind randomized controlled trial in 1943 investigating treatment for the common cold, and major milestones in the development of ethical guidelines and regulations for clinical trials over the 20th century including the Nuremberg Code, Declaration of Helsinki, and establishment of regulatory bodies like the ICMR in India.
History of Pharmacy | L 4|Empiric, Industrialization, Patient Care Era| Pharm...Tayyeb Mehmood
key points:
Ancient Era (Beginning of time to 1600 AD)
Non-Muslim (Babylon, China, Egypt, Greek, Turkey)
Muslim Era or Golden Era
Empiric Era (1600 to 1940 AD)
Industrialization Era (1940 to 1970AD)
Patient Care Era (1970AD to present)
Biotechnology and genetic engineering
This document provides an overview of notable contributors to public health and medicine throughout history, beginning with the establishment of the Nobel Prize and ending in the modern era. It discusses early contributors from ancient civilizations like China, India, Greece, and Rome. It then covers the evolution of scientific medicine between 1500-1900 AD, highlighting figures like Pasteur, Koch, and Lister who established the germ theory of disease. The document also summarizes key developments during the 1800s that established public health as a field, such as the work of Chadwick, Snow, and Budd. It concludes with modern laureates like Ehrlich, Bordet, and Einthoven who advanced medicine in the 20th century.
This document provides a history of plant bacteriology and summarizes important figures and discoveries. Some key points:
- Heinrich Anton De Bary is considered the "Father of Plant Pathology" for his work in the 1860s demonstrating that fungi and bacteria cause plant diseases.
- In the 1880s, Louis Pasteur and others provided evidence that fungi and bacteria are transmitted externally and can be controlled through prevention of infection.
- In the 1940s-1950s, the concepts of gene-for-gene resistance and horizontal resistance were developed to describe plant-pathogen interactions.
- Important discoveries include penicillin by Alexander Fleming in 1928, green revolution wheat varieties by Norman Borlaug in the
Lecture 2 history of drug designing and developmentRAJAN ROLTA
The document summarizes the history of drug design, beginning with drugs originating from natural sources like plants, animals, and microorganisms. It then discusses early milestones in drug development in the 19th century with the isolation of plant extracts and discovery of synthetic drug substances. Major developments are outlined for pain killers, cardiac drugs, antibiotics, anticancer agents, and endocrine therapies. Key events include the isolation of morphine, digitalis, penicillin, and insulin, as well as the discovery of major drug classes like aspirin, nitroglycerin, chloroquine, and statins. The history shows a progression from crude natural product drugs to purified and synthetic small molecule drugs targeted at specific biological pathways and receptors.
This document provides an overview of the history of medicine in America, covering topics such as medicalization vs demedicalization, the heroic narrative of medicine, the development of medical ethics in ancient China, the Hippocratic Oath, homeopathic and irregular practitioners in the 19th century including Samuel Hahnemann and Mary Baker Eddy, the development of psychology and brain research, the history of antisepsis pioneered by figures like Joseph Lister and Oliver Wendell Holmes Sr., and the early history of anesthesia. It examines the development of the medical profession and treatments over time through historical figures, practices, and documents.
The document provides a history of drug design and development. It discusses how drugs were originally derived from natural sources like plants and animals. In the 19th century, drugs began to be isolated from natural sources and synthesized. Major developments included the isolation of morphine, aspirin, penicillin, and statins. The document also outlines the history of developments in pain killers, antibiotics, anticancer drugs, and treatments for cardiac issues and endocrine disorders. It notes drug design aims to find new medications based on biological targets and can involve developing analogs of lead compounds.
Gene therapy involves introducing genetic material into cells to treat or prevent disease. It has the potential to cure genetic disorders by correcting the underlying genetic defect. There are two main types - somatic gene therapy, which affects only targeted cells and is safer, and germline gene therapy which can permanently alter the genes and be passed to offspring. Recent advances include FDA-approved CAR-T immunotherapies for cancer and the first gene therapy approved for an inherited retinal disease. Challenges remain regarding delivery methods, safety, and ethical issues.
This document discusses stereoisomers in pharmacology. It begins with an introduction to stereochemistry and the three types of isomers - constitutional, configurational, and conformational. It then discusses the history of isomerism, chirality, enantiomers, and nomenclature systems. The document outlines important differences between single enantiomers and racemic mixtures in terms of pharmacokinetic and pharmacodynamic properties. It provides several examples to illustrate these differences. Finally, the document concludes that increasing availability of single-enantiomer drugs can provide safer, better tolerated, and more efficacious treatments compared to racemic mixtures.
Recent advances in the treatment of diabetes mellituschandiniyrao
Recent advances in the treatment of diabetes mellitus include newer drug classes and delivery methods. Newer drug classes target the incretin system through GLP-1 agonists and DPP-4 inhibitors, sodium-glucose transporters with SGLT2 inhibitors, and amylin signaling with pramlintide. Improved insulin formulations include long-acting insulins glargine and degludec. Novel delivery methods involve insulin pumps for continuous subcutaneous delivery and inhaled formulations. Emerging therapies aim to preserve beta cell function through stem cell technology, anti-CD3 antibodies, and gene therapies.
- GABA is the major inhibitory neurotransmitter in the mammalian brain. It acts through GABAA, GABAB, and GABAC receptors.
- GABAA receptors are ligand-gated chloride channels modulated by drugs like benzodiazepines, barbiturates, and general anesthetics. GABAB receptors are G-protein coupled receptors that inhibit neurotransmitter release and hyperpolarize neurons.
- Drugs that enhance GABAergic transmission through GABAA receptors like benzodiazepines are used as sedatives, anxiolytics, and anticonvulsants. The GABAB agonist baclofen is used as a muscle relaxant for spastic
- Biosimilars are biologic medical products that are similar but not identical copies of original biologic drugs. They are developed when the patent expires on the original product.
- Regulatory agencies have stringent approval criteria for biosimilars to demonstrate similar quality, safety and efficacy as the reference product. Clinical trials must show comparable pharmacokinetics, pharmacodynamics and immunogenicity.
- While biosimilars increase access and lower costs, they are not generic copies and have unique safety profiles. Automatic substitution is not appropriate and unique nonproprietary names and labeling is required to facilitate pharmacovigilance.
Nitric oxide (NO) is an important signalling molecule in the body that regulates many physiological processes. It is synthesized by nitric oxide synthase enzymes from L-arginine and oxygen. NO signals through activation of soluble guanylate cyclase and production of cyclic GMP. It has diverse effects in the cardiovascular, immune, and nervous systems and is involved in processes like vasodilation, neurotransmission, and inflammation. Both insufficient and excessive NO production can contribute to disease.
This document discusses newer drug delivery systems that provide targeted and sustained drug release. It begins by introducing drug delivery systems and their basic parameters of route of entry and dosage form. It then discusses the need for multidisciplinary approaches to drug delivery due to slow progress treating severe diseases. Newer systems aim for targeted delivery and sustained release formulations. These systems increase efficacy, provide site-specific delivery, decrease toxicity and side effects, and improve convenience and patient compliance. The document goes on to describe various drug delivery systems including carrier-based, transdermal, mucoadhesive, and osmotically-controlled systems. It provides examples of specific drug delivery carriers, formulations, and medical devices. In general, these newer systems provide improvements
This document discusses neuroactive steroids, which are steroids synthesized in the brain or other endocrine glands that rapidly alter neuronal excitability through interaction with receptors. They can have inhibitory or excitatory effects and are involved in many neurological and psychiatric conditions. Neuroactive steroids are also implicated in sex differences in brain disorder susceptibility. While their roles are increasingly understood, key questions remain regarding their regulatory mechanisms and impact on specific brain conditions and gender differences. Further research is needed to clarify their molecular mechanisms of action and therapeutic potential.
The document discusses the transmitters and receptors of the autonomic nervous system (ANS). It covers the main transmitters - acetylcholine (ACh) and norepinephrine (NE). It describes the synthesis, storage, and release of ACh at cholinergic synapses and its transmission via nicotinic and muscarinic receptors. It also discusses the synthesis and metabolism of NE, its transmission via alpha and beta adrenergic receptors, and the mechanisms of cholinergic and adrenergic receptor signal transduction. Additionally, it covers neuromodulation via pre-synaptic and post-synaptic mechanisms and examples such as autoinhibition of noradrenergic nerve terminals.
Cytotoxic agents like alkylating agents and antimetabolites are commonly used in dermatology for cancer treatment and severe dermatologic diseases. Alkylating agents like cyclophosphamide and chlorambucil directly damage DNA through alkylation and crosslinking, inhibiting cell replication. Common side effects include bone marrow suppression, carcinogenesis, and gastrointestinal issues. Antimetabolites like methotrexate, azathioprine, and mycophenolate mofetil interfere with DNA synthesis during the S phase of the cell cycle. They are used as immunosuppressants and for inflammatory conditions. Side effects include bone marrow suppression, infections due to immunosuppression, and hepatotoxicity or neph
Review on various families of drug transporters in our body, their functions & drugs acting through them & drug interactions involving these transporters
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
3. 3
Part 2
• History of
Anaesthesia
Alkaloids
Antimicrobials/Antibiotics
Drugs used in Endocrinology
Cardiovascular drugs
Prostaglandins
OCPs
• Few scientists & their contributions
• History of Human experiments
5. Humphrey Davy
• 1799 – Nitrous oxide
‘Laughing gas’ –
relieved toothache
• To relieve pain of surgery.
• Euphoria
Analgesia
Loss of consciousness
• Henry Hickman –
mixture of CO2 & NO in surgery.
5
7. Ether
• 1815: Michael Faraday – similar effect to nitrous oxide.
• Crawford Long
- ‘Ether frolics’
- studied the anaesthetic properties
of ether.
- 1842 – Was given before cyst excision.
- published his discovery in 1849.
7
9. Horace Wells
• Pioneered the use of anaesthesia in dentistry
• Nitrous oxide – painless tooth extraction
• Experimented on himself
(“A new era of tooth-pulling!”)
9
10. William Thomas Morton
• American dentist
• 1846 – 1st publicly demonstrated
the use of inhaled ether as a
surgical anaesthetic .
10
11. James Young Simpson
• Chloroform
• Used it to relieve pain of childbirth.
• 1853 – Queen Victoria permitted
it’s use by John Snow.
• NO & air machines, pethidine &
‘natural’ childbirth.
11
12. Local anaesthesia
(Cocaine)
• Coca leaves – South America
• Friedrich Gaedcke (1859 ) –
Cocaine alkaloid
‘Erythroxyline’
• For morphine addiction & in soft drinks
(Coca cola – coca leaves & kola nuts)
• Sigmund Freud (1883) –
medical use of cocaine
‘tongue-numbing’ capacity.
12
13. • Carl Koller (‘Coca Koller’)
– ophthalmic use
• William Halstead
– Father of American Surgery
- Nerve block anaesthesia
13
17. Quinine
• Crystalline alkaloid
• antipyretic, antimalarial,
analgesic, anti-
inflammatory
properties
• bark of the Cinchona tree
• Quechua Indians
of Peru and Bolivia
17
19. Discovery of Artemisinin (Qinghaosu)
• Malaria – global burden
• Countless treatments tested –
most of them failed
• Ancient China – leaves of sweet worm wood
• Han dynasty (earliest record)
– treatment for haemorrhoids
Ming dynasty – remedy for fever
• For 1500 yrs; not scientifically tested
Artemisia annua
19
20. China: 1960-1970
• Soldiers died from malaria
• 23 May 1967: ‘Project 523’ – massive,
multi-institute search
for a novel antimalarial drug
• Screening of traditional Chinese pharmacopoeias
Yingzhao (Artabotrys hexapetalus) &
Qinghao (Artemisia annua)
• Early 1970s:
Active ingredient of qinghao – Artemisinin (Qinghaosu)
Artemether & Artesunate 20
22. Pilocarpine
• Chewing of leaves salivation
• 1874 – 1st experiments by Coutinhou T.
• 1875 – alkaloid was isolated
• Weber – action on pupils &
sweat & salivary glands
South American shrub:
Pilocarpus
22
23. Physostigmine
• Calabar or ordeal bean; dried ripe
seed of Physostigma venenosum
• Native tribes of West Africa –
“ordeal poison” (trials of witchcraft)
• 1864 – pure alkaloid isolated by Jobst & Hesse
• 1877 – 1st therapeutic use by Lagueur for glaucoma
23
24. Curare
• South American arrow poisons
• Paralysis of skeletal muscles
• Strychnos species (Eastern Amazonia)
• Griffith & Johnson –
1st trial of curare for
promoting muscle relaxation
in GA (1942)
• King – structure of tubocurarine (1935)
24
25. Ergot alkaloids
• Claviceps purpurea – rye & other grains
• Rhine valley (857AD) – 1st outbreak of
gangrenous ergotism-
feet, legs, hands, and arms
• Extremities - dry, black
and mummified
25
26. • Limbs – ‘Holy Fire’ (burning sensation)
• Early 20th century – active principle isolated
26
27. Vinca Alkaloids
• Madagascar periwinkle plant,
Catharanthus roseus (Vinca rosea)
• Periwinkle extracts – hypoglycemic effects in diabetics
• Vincristine & Vinblastine –
regression of ALL in mice
- leukemias, lymphomas
& testicular cancer.
27
34. Discovery of Penicillin
• Alexander Fleming (1881-1955) –
Penicillium notatum
• 1928 – culture dish contaminated
by mould spores
• ‘Penicillin’ –seeped out from
the mould killed bacteria
near the mould
34
35. • 1935: Howard Florey & Ernst Chain –
investigated the anti-bacterial properties of Penicillin.
• Norman Heatley – isolated penicillin from the mould.
• Experimented with mice inoculated with streptococci
• Used it successfully to treat war wounds
• 1945: Fleming, Florey & Chain received Nobel prize
35
36. Discovery of Streptomycin
• 1946:
Waksman – Streptomyces griseus
(chicken’s throat)
Streptomycin
(cocci, spirochaetes, tb bacilli)
• 1st recorded cure of tb meningitis
• 1952 – Nobel prize
36
37. • Side effects – Ototoxicity & Nephrotoxicity
• 1953: Swedish researchers –
Vitamin A + Streptomycin
• German researchers –
Pantothenic acid + Streptomycin
• side effects (without diminishing antibiotic properties)
37
38. Discovery of Anti-TB drugs
• Streptomycin – promising cure
prolonged treatment with high doses
Severe side effects & Resistance
• 1949 – Combination therapy:
Streptomycin + PAS
• 1951 – Isoniazid (INH) – hydrazide salt of isonicotinic acid
combined with streptomycin dramatic results
• Early 1970s – 5 more antibiotics & 3 synthesized chemicals.
38
40. Discovery of Insulin
• 1st description of diabetes –
mid 17th century.
• Richard Bright –
Involvement of pancreas
• Early 19th century:
Paul Langerhans –
‘Islets of Langerhans’
• Hormone deficiency
disease – ‘Insulin’
(insula = island)
40
41. Banting & Best
• 1921: Frederick Banting – effective &
safe extract of insulin helped by
Charles Herbert Best
• Extracted insulin from a dog’s
degenerated pancreas.
• Saved the lives of diabetic dogs
• Published their findings in American Journal of
Physiology.
41
42. • 11th Jan 1922 – successfully injected
insulin to their 1st human patient
(14 yrs old Leonard Thompson)
• Toxic reactions minimised by
James B. Collip – Purified insulin
• 1923 – Only Banting received Nobel prize.
• 1926: John Jacob Abel –
prepared pure crystalline
Insulin
42
43. Discovery of Corticosteroids
• Began with Anti-TB campaign (1940s)
• Reichstein and Kendall
- 1st isolated & identified adrenal steroids
- effects on carbohydrate metabolism (glucocorticoids)
• World war II: Lewis Sarrett – Cortisone (from bile of cattle)
• Hench & Kendall – treatment of rheumatoid arthritis
• 1950s – skin grafts & kidney transplants
43
50. Nitrates
• 1846: 1st synthesized by Sobrero
• Alfred Nobel – stabilised nitroglycerine
- patented a detonator
• 1857: Lauder Brunton – found that
amyl nitrite relieved angina pain
in 30-60 sec
• William Murrell – established the use of
sublingual NTG in acute angina & for
prophylaxis of exertional angina
50
Alfred Nobel
51. Statins
• 1976: Endo & colleagues –
Penicillium citrinum (mould)
- inhibitors of cholesterol biosynthesis.
• Brown & Goldstein – act by inhibiting
HMG-CoA reductase.
• Compactin (Mevastatin) – 1st statin studied in humans
• Lovastatin - 1st statin approved for use in humans
- Aspergillus terreus
51
52. Discovery of Prostaglandins
• 1935 : Von Euler
– protein in human semen
uterine smooth contraction
Prostaglandin (‘prostate’)
• 1965: synthetic form – used to induce
labour for the 1st time
• Inserted into vagina or cervix as
pessaries or creams –
preferred method of induction.
52
53. History of OCPs
• Early 20th century: Ludwig Haberlandt – 1st experiments.
• Early 1940s: Russel Marker –
extracted ‘diosgenin’ from yam
Progesterone
Norethisterone/Norethindrone (1951)
• Norethynodrel – menstrual regulator & OCP
• Purified progesterone Failure
53
54. • Original compound – traces of Estrogen
Estrogen-Progesterone combined contraceptive pill
• Initial concern of unwanted pregnancies
Over-dosing women with estrogen
thrombo-embolism
fatal heart attacks & strokes
• Dec’1969: UK Committee on the Safety of Medicines
- Estrogen content not > 50 micrograms
54
55. • John Rock – Roman Catholic
Supported research on ‘the pill’
• Faced outrage from the Catholic Church
- natural means (‘safe method’ or ‘rhythm method’)
- forbade the use of unnatural contraception
• 1973 – 50 million women were using OCPs (12 drug
companies) – Era of Birth Control
55
56. Thalidomide Scandal
• 1950: Wilhelm Kunz – invented Thalidomide
• Sedative; but with no obvious toxic effects
• Approved as 1st safe sleeping pill
• Reports of side effects
56
57. • 1961: Dr. William McBride – Teratogenic effect
(babies with deformed limbs)
• 1962 – 7400 ‘thalidomide children’ worldwide
withdrawal of drug
• 1968 – Committee on Safety of Medicines
57
59. William Withering (1741-1799)
• Dropsy – edema that often
accompanies heart & kidney failure
• Fox glove tea
• Active ingredient – Digitalis
(fox glove leaves)
• 1785: An account of the fox glove
– Study of Digitalis
59
60. Otto Loewi
• 1921 – proved the chemical transmission
of nerve impulses
• Prototype experiment - existence of
chemical transmission in a synapse
• 1st chemical neurotransmitter
identified – Ach
• 1936 – Nobel prize, along
with Henry Dale
60
61. Sir Henry Hallet Dale
• 1914 - distinguished muscarinic & nicotininc receptors
- 1st identified Ach as a possible neurotransmitter
(shared the nobel prize with Loewi in 1936)
• Dale’s principle (Dale’s Law) –
Each neuron releases only 1 type of neurotransmitter
• Dale’s Vasomotor Reversal Phenomenon
61
62. James Black
• Developed propranolol –
best-selling drug
• 1975: 2nd major drug –
Cimetidine (Tagamet)
world’s 1st billion dollar drug
62
63. Daniel Bovet
• 1937: synthesized the 1st antihistaminic
Thymoxidiethylamine
• Discovered Pyrilamine (Mepyramine)
• 1947: Discovered Gallamine
• Isolated Succinylcholine
• 1957: Nobel prize in
Physiology/Medicine
63
64. Rudolf Buchheim
• World’s 1st pharmacology lab –
basement of his house
• Remembered for his pioneer work in
Experimental Pharmacology.
• He introduced the bio assay to pharmacology,
• Taken over by his student,
Oswald Schmiedeberg
64
65. Alfred Goodman Gilman
• American pharmacologist and
biochemist
• 1994 – Nobel prize in Physiology or
Medicine along with
Martin Rodbell for their discovery
of G proteins & their role in signal
transduction.
65
66. Historyofhumanexperiments
• During WWII (1940) : Nazis (Germany)
– series of medical experiments on
prisoners, including children. (Jews)
• No consent taken
• Death, trauma & permanent
disability, even execution
• Malaria, immunization,
mustard gas
& Sulphonamide experiments
66
67. • 1946: Doctors’ trial –
Nuremberg (Germany) led by US
Nuremberg Code of medical ethics
• Declaration of Helsinki (DoH)
Human experimentation
World Medical Association (WMA)
1st significant effort to regulate research itself
Basis of most subsequent documents
67
69. References :
1) A History of Medicine - Nancy Duin & Dr Jenny Sutcliffe
2) The Pharmacological Basis of Therepeutics -Goodman & Gilman, 12th
edition
3) Basic and clinical pharmacology : Katzung, Masters and Trevor, 11th
edition
4) Medical Pharmacology – Dr Padmaja Udaykumar, revised 4th edition
5) Rang & Dayle’s pharmacology, 7th edition
6) Pharmacognosy – Dr C.K Kokate, A.P Purohit, S. B Gokhale
7) Pictures & video from the internet
“History, if it has taught us anything at all, has taught us that the strange ideas
we derive today will one day be our celebrated truths.”
― Dan Brown, The Lost Symbol
69
Editor's Notes
From very early times, attempts were being made to find drugs to relieve pain – to relieve
Suggested the use of NITROUS OXIDE to relieve the pain of surgery.
Noted that it caused – euphoria
- analgesia
- loss of consciousness
Pic - Humphry Davy testing the effects of laughing gas on the rich aristocrats of London at a laughing gas party
Administration of ether (pic)
Horace wells - was an American dentist who pioneered the use of anesthesia in dentistry, specifically nitrous oxide (or laughing gas). wanted to find out if nitrous oxide could be used for painless tooth extraction and decided to experiment on himself.one of his friends Dr . John Wells pulled out one of the molars of wells who after regaining consciousness exclaimed – “A new era of tooth-pulling !” However, the gas was improperly administered and the patient cried out in pain. The audience of students in the surgical theatre jeered "humbug“(fraud). Because of this embarrassment, Wells was discredited in the medical community
American dentist
First publicly demonstrated the use of inhaled ether as a surgical anaesthetic in 1846 – before removing a tumor from the neck of a young man (pic)
Professor of midwifery @ Edinburgh, was dissatisfied with ether in obstetrics. He decided to try chloroform (which had been virtually discovered simultaneously in the US, france n Germany)
….
However he faced an uproar as some physicians claimed that pain in labor was a biological necessity.
Although he continued to use chloroform, the outcry did not die down until 1853 when Q. Victoria consented for the use of this volatile liquid for the birth of prince leopold, which was administered by john snow, britian’s 1st specialist anaesthetist who later went on to contribute majorly in the field of public health. After this chloroform’s position in obstetric anaesthesia was secure for more than a century until…
The cocaine alkaloid was first isolated by the German chemist Friedrich Gaedcke in 1855. Gaedcke named the alkaloid "erythroxyline“
For the next 25 years it was used as a treatment for morphine addiction and as an ingredient in soft drinks. Coca-Cola was named back in 1885 for its two "medicinal" ingredients: extract of coca leaves and kola nuts
Cocaine was also used as toothache drops", 1885 advertisement of cocaine for dental pain in children
Crystalline alkaloid having antipyretic, antimalarial, analgesic, anti-inflammatory properties and a bitter taste.
obtained from the bark of the Cinchona tree
Long used by Quechua Indians of Peru and Bolivia , to halt shivering due to low temperatures
thus quinine became one of the most valuable commodities shipped from Peru to Europe.
When King Charles II was cured of malaria at the end of the 17th Century with quinine, it became popular in London.It remained the antimalarial drug of choice until the 1940s, when other drugs took over
MALARIA HAS BEEN A DEVASTATING PARASITE DISEASE THAT HAS LIKELY KILLED ONE HALF OF ALL THE HUMAN BEINGS EVER LIVED ON THE EARTH
Descriptions of such malaria-specific symptoms are found in ancient Chinese literatures compiled thousands of years ago. Although countless ways of treatments were tested over the thousands of years, success was occasional and failure was common. Historically, the epidemic of malaria has been considered as the likely cause for the fall of many major powers (including the Roman Empire) and defeat in wars.
In the midst of time, the Quechuas “doctors” from Peru and Bolivia used the bark of the cinchona tree to produce a medicine to treat some fevers, whereas their counterparts on the other side of the world, in China, used the leaves of sweet wormwood (Artemisia annua) for the same effect.
There are interesting stories on how qinghaosu (artemisinin) was extracted from Artemisia plants, used by Chinese herbalists for thousands of years as a remedy for many illnesses. The earliest record, written on a piece of silk unearthed from the Mawangdui Han Dynasty tombs (168 BC), described it as a treatment for hemorrhoids.
during the Ming Dynasty, qinghao was specifically described as a remedy for fever.
Although Qinghao has been recorded in Chinese medical books compiled about 1500 years ago for its effectiveness in treating malaria, those early practices were based on experiences instead of strict scientific tests
Because soldiers were dying from malaria, effective antimalarial drugs were also needed in the battlefield immediately
Since the late 1960s, The Chinese government started a massive effort to search for new drugs that are effective in treating the malaria resistant to such conventional drugs as chloroquine
23 May 1967 (thus named ‘Project 523’) a large-scale, multi-institute search for novel antimalarial drugs
Screening of the traditional Chinese pharmacopoeia soon led to the identification of more than ten plants with good antimalarial activities, including yingzhao (Artabotrys hexapetalus) and qinghao (Artemisia annua).
In the early 1970’s, the active ingredient of sweet wormwood was identified as artemisinin (qinghaosu) a powerful, though unstable in vitro antimalarial. Further studies lead to the development of more stable derivatives, a methyl-ether derivative, artemether and a water-soluble one, artesunate.
Atropine -
Belladonna’ (beautiful women)
deadly nightshade, to dilate pupils by Italian women & also by Cleopatra
Used by ancient Hindus to treat asthma.
Bezold and Bloebaum (1867) showed that atropine blocked the cardiac effects of vagal stimulation,
and Heidenhain (1872) found that it prevented salivary secretion produced by stimulation of the chorda tympani.
Opium
Purified opium – diarrhoea & dysentery in ayurveda
Paracelsus – ‘stone of immortality’
- ‘Laudanum’
Cholera, dysentery, toothache, flatulence, insanity
and menopause
Opium wars
Hypodermic syringe
Pilocarpine is the chief alkaloid obtained from the leaflets of South American shrubs of the genus Pilocarpus.
Although it was long known by the natives that the chewing of leaves of Pilocarpus plants caused salivation,
the first experiments were apparently performed in 1874 by the Brazilian physician Coutinhou. T
the alkaloid was isolated in 1875, and shortly thereafter
the actions of pilocarpine on the pupil and on the sweat and salivary glands were described by Weber
Physostigmine, also called eserine, is an alkaloid obtained from the Calabar or ordeal bean, the dried, ripe seed of Physostigma venenosum, a perennial plant found in tropical West Africa.
The Calabar bean once was used by native tribes of West Africa as an "ordeal poison" in trials for witchcraft, in which guilt was judged by death from the poison, innocence by survival after ingestion of a bean.
A pure alkaloid was isolated by Jobst and Hesse in 1864 and named physostigmine.
The first therapeutic use of the drug was in 1877 by Laqueur, in the treatment of glaucoma, one of its clinical uses today.
Curare is a generic term for various South American arrow poisons
paralyzing wild animals used for food; death results from paralysis of skeletal muscles.
Following the pioneering work of the scientist/explorer von Humboldt in 1805, the botanical sources of curare became the object of much field research.
The curares from eastern Amazonia come from Strychnos species
Griffith and Johnson reported the first trial of curare for promoting muscular relaxation in general anesthesia in 1942
King established the essential structure of tubocurarine in 1935
Ergot is the product of a fungus (Claviceps purpurea) that grows on rye and other grains
It was in the Rhine Valley, in 857 A.D., that the first major outbreak of gangrenous ergotism was documented
Middle Ages, describing strange epidemics in which the characteristic symptom was l separated off without loss of blood.
Limbs were said to be consumed by the holy fire, blackened like charcoal with agonizing burning sensations, "Holy" because of the belief that this was a punishment from God.
the disease was called holy fire or St. Anthony's fire in honor of the saint at whose shrine relief was said to be obtained
. The relief that followed migration to the shrine of St. Anthony was probably real,
for the sufferers received a diet free of contaminated grain during their sojourn at the shrine.
dramatic abortive effect of ergot ingested during pregnancy.
The active principles of ergot were isolated and chemically identified in the early 20th century
Limbs were said to be consumed by the holy fire, blackened like charcoal with agonizing burning sensations, "Holy" because of the belief that this was a punishment from God.
the disease was called holy fire or St. Anthony's fire in honor of the saint at whose shrine relief was said to be obtained
. The relief that followed migration to the shrine of St. Anthony was probably real,
for the sufferers received a diet free of contaminated grain during their sojourn at the shrine.
dramatic abortive effect of ergot ingested during pregnancy.
The active principles of ergot were isolated and chemically identified in the early 20th century
The beneficial properties of the Madagascar periwinkle plant, Catharanthus roseus (formerly called Vinca rosea),
Periwinkle extracts attracted interest because of their hypoglycemic effects in diabetes.
Purified alkaloids, including vinblastine and vincristine, caused regression of an acute lymphocytic leukemia in mice and
were among the earliest clinical agents for treatment of leukemias, lymphomas, and testicular cancer.
A closely related derivative, vinorelbine, has important activity against lung and breast cancer
3 distinct periods
1.Great antiquity;only substances capable of curing infection were natural plant products
2.Era of synthesis
3.Return to natural plant products,plants of lower order i.e bacteria nd moulds forming antibiotics
drug invention became more allied with synthetic organic chemistry
Study of dye interactions stimulated Paul Ehrlich to postulate the existence of chemical receptors in tissues that interacted with and "fixed" the dyes.
Ehrlich thought that unique receptors on microorganisms or parasites might react specifically with certain dyes and that such selectivity could spare normal tissue.
Ehrlich's work culminated in the invention of arsphenamine in 1907, which was patented as "salvarsan," suggestive of the hope that the chemical would be the salvation of humankind.
This arsenic-containing compound and other organic arsenicals were invaluable for the chemotherapy of syphilis until the discovery of penicillin
Following ehrlich’s spectacular success with salvarsan, researchers began to test virtually every substance that might be effective against infectious diseases
Gerhard Johannes Paul Domagk (1895– 1964)
During that period and thanks to the work of Gerhard Domagk, an azo dye, prontosil (the first clinically useful sulfonamide) was shown to be dramatically effective in treating streptococcal infections which fetched him a nobel prize.
It was found that prontosil would only work when the compound split into 2 parts, & that 1 of the 2 parts – later called sulphanilamide – was largely responsible for pronotsil’s bacteriostatic action (did not kill the bacteria like an antibiotic, only prevented them from multiplying)
However neither prontosil no sulphanilamide proved very effective against pneumococcal infections & scientists began to look for other drugs.
In 1938 a british firm May & Baker developed ‘M&B 693’ later called sulphapyridine – not only worked well against pneumococcal infections but even better than sulphanilamide against strep. (Thus the family of sulphonamide drugs was born) however it was known to cause serious nausea & sometimes kidney & bladder stones. So the search began for a less toxic analogue – sulphadiazine in 1940, but this still produced kidney stones in a few patients taking large doses, so a much more soluble drug was developed – sulphasoxazole which was then almost exclusively used for treatment (while sulphadiazine continued to be used in small doses)
By 1941, 1700 tonnes of these sulpha drugs were given to atleast 10 million americans, for conditions like – puerperal fever, pneumonia, meningitis, rheumatic fever etc..also proved to be the 1st successful treatment for gonorrhoea.
Howvever eventually strains of sulpha-resistant streptococci appeared & spread widely. & soon they were overshadowed by the rising popularity of the 1st true antibiotic
ELIXIR SULFONILAMIDE DISASTER
Elixir sulfanilamide was an improperly prepared sulfanilamide medicine that caused mass poisoning in the United States in 1937. It caused the deaths of more than 100 people.
In 1937, S. E. Massengill Company, a pharmaceutical manufacturer, created a preparation of sulfanilamide using diethylene glycol (DEG) as a solvent, and called the preparation "Elixir Sulfanilamide".[3] DEG is poisonous to humans and other mammals, but Harold Watkins, the company's chief pharmacist and chemist, was not aware of The company started selling and distributing the medication in September 1937. Animal testing was not required by law, and Massengill performed none. By October 11, the American Medical Association received a report of several deaths caused by the medication. The Food and Drug Administration was notified, and an extensive search. verified that the excipient DEG was responsible for the fatal adverse effects. At least 100 deaths were blamed on the medication.
passing the 1938 Food, Drug, and Cosmetic Act, which required companies to perform animal safety tests on their proposed new drugs and submit the data to the FDA before being allowed to market their products.
A 3-year-old boy before, and several weeks after receiving insulin in 1922. (pic)
Shortly after synthetic cortisone became available, Hench and colleagues demonstrated its dramatic effect in the treatment of rheumatoid arthritis
Hench, Kendall and Reichstein received Nobel Prize in 1950
It was originally isolated from canine liver cells, hence its name (hepar or "ήπαρ" is Greek for "liver"). Heparin's discovery can be attributed to the research activities of Jay McLean and William Henry Howell.
In 1916, McLean, a second-year medical student at Johns Hopkins University, was working under the guidance of Howell investigating procoagulant preparations, when he isolated a fat-soluble phosphatide anticoagulant in canine liver tissue.
In 1918, Howell coined the term 'heparin' for this type of fat-soluble anticoagulant.
.
A posthumous attempt to nominate McLean for a Nobel Prize failed.[citation needed]
hemorrhagic disorder in cattle ingestion of spoiled sweet clover silage,
Campbell and Link, in 1939, identified the hemorrhagic agent as bishydroxycoumarin (dicoumarol).
In 1948, a more potent synthetic congener was introduced as an extremely effective rodenticide; the compound was named warfarin as an acronym derived from the name of the patent holder, Wisconsin Alumni Research Foundation (WARF).
Warfarin's potential as a therapeutic anticoagulant was recognized but not widely accepted, partly due to fear of unacceptable toxicity.
1951, an army inductee uneventfully survived an attempted suicide with massive doses of a preparation of warfarin intended for rodent control. Since then, these anticoagulants have become a mainstay for prevention of thromboembolic disease
Story of aspirin
Nitroglycerin was first synthesized in 1846 by Sobrero, who observed that a small quantity placed on the tongue elicited a severe headache
until Alfred Nobel devised a process to stabilize the nitroglycerin and patented a specialized detonator in 1863
In 1857, T. Lauder Brunton of Edinburgh administered amyl nitrite, a known vasodepressor, by inhalation and noted that anginal pain was relieved within 30- 60 seconds
, William Murrell surmised that the action of nitroglycerin mimicked that of amyl nitrite and
established the use of sublingual nitroglycerin for relief of the acute anginal attack and as a prophylactic agent to be taken prior to exertion.
Alfred Nobel himself was prescribed nitroglycerin by his physicians when he developed angina in 1890
Statins were isolated from a mold, Penicillium citrinum, and identified as inhibitors of cholesterol biosynthesis in 1976 by Endo and colleagues
Brown and Goldstein established that statins act by inhibiting HMG-CoA reductase
. The first statin studied in humans was compactin, renamed mevastatin, which demonstrated the therapeutic potential of this class of drugs.
Alberts and colleagues at Merck developed the first statin approved for use in humans, lovastatin (formerly known as mevinolin), which was isolated from Aspergillus terreus.
History of pharmacology would be incomplete without mentioning this infamous event
Recognized dropsy as the edema that often accompanies heart & kidney failure
Otto loewi
A German Pharmacologist
1921 He proved, the chemical transmission of the nerve impulses& in 1936 He received the Nobel price, with Henri Dale.
He designed his most famous experiment, which provided the first evidence for the existence of chemical transmission in a synapse - became a prototype for all investigations of chemical factors in the nervous system
The first chemical neurotransmitter that he identified - ACETYLCHOLINE
SIR HENRY HALLET DALE
Distinguished Muscarinic &Nicotinic receptors in 1914
First identified acetylcholine in 1914 as a possible neurotransmitter, Loewi showed its importance in the nervous system. (shared the 1936
Dale's principle ( Dale's Law). This principle states that each neuron releases only one type of neurotransmitter.
Dale’s Vasomotor Reversal Phenomenon
Sir James Black
A Scottish Pharmacologist
He developed Propranolol while working for ICI , which later became the world's best-selling drug.
Black developed his second major drug, cimetidine (brand name Tagamet ) in 1975 and soon outsold propranolol to become the world's 1st billion dollar drug.
Sir James Black with a molecular model of propranolol (pic)
Daniel bovet
Italian pharmacologist
In 1937 Bovet and his research student Anne Marie Staub succeeded in synthesizing the first antihistaminic
was too toxic to be used so he continued with hundreds of experiments to find a more human body friendly antihistamine.
After years of research he succeeded in discovering Pyrilamine (mepyramine) a very important antihistamine.
In 1947 he discovered gallamine when he was looking for a synthetic substitute for curare
Isolated succinylcholine, a muscle relaxant now used in conjunction with anesthesia during certain surgical procedures.
In 1957 he was awarded the Nobel Prize in Physiology or medicine for his discoveries.
Rudolf Buchheim (a German pharmacologist)
Lacking outside funding, Buchheim built the world’s 1st pharmacology laboratory at his own expense in the basement of his home
Buchheim is remembered for his pioneer work in experimental pharmacology.
He introduced the bioassay to pharmacology,
His reputation is overshadowed by that of his student, Oswald Schmiedeberg
Alfred goodman gilman
American pharmacologist and biochemist
1994 – Nobel prize in Physiology or Medicine along with
Martin Rodbell for their discoveries regarding G-proteins.
Nazi human experimentation was a series of medical experiments on large numbers of prisoners, including children, by Nazi Germany in its concentration camps in the early to mid 1940s, during World War II and the Holocaust. Chief target populations included Romani, Sinti, ethnic Poles, Soviet POWs, disabled Germans, and most prominently of all, Jews from across Europe.
Nazi Physicians and their assistants forced prisoners into participating; they did not willingly volunteer and no consent was given for the procedures. Typically, the experiments resulted in death, trauma, disfigurement or permanent disability, while many others were executed after the tests were completed to study the effects post mortem.and as such are considered examples of medical torture.
1.5Malaria experiments
1.6Immunization experiments
1.7Mustard gas experiments
1.8Sulfonamide experiments
On 19 August 1947, the doctors captured by Allied forces were put on trial in USA vs. Karl Brandt et al., commonly known as the Doctors' Trial. But this defense, which was in any case rejected by the Tribunal, The trials began on December 9, 1946 in Nuremberg, Germany and were led exclusively by the United States.
led to the development of the Nuremberg Code of medical ethics.
The Declaration of Helsinki (DoH) is a set of ethical principles regarding human experimentation developed for the medical community by the World Medical Association (WMA).
The Declaration is an important document in the history of research ethics as it is the first significant effort of the medical community to regulate research itself, and forms the basis of most subsequent documents.
"Even though the Declaration of Helsinki is the responsibility of the World Medical Association, the document should be considered the property of all humanity".
the Nuremberg Code and the related[4] Declaration of Helsinki are the basis for the Code of Federal Regulations ,governing federally funded human subjects research in the United States.
* The Nuremberg code includes such principles as informed consent and absence of coercion; properly formulated scientific experimentation; and beneficence towards experiment participants.