This document describes a study to evaluate the anti-inflammatory activity of drugs using a carrageenan-induced paw edema model in rats. The study involves injecting carrageenan into the paws of rats to cause inflammation and edema, which are measured over time using a plethysmometer. Rats are divided into control and test groups, with the test group receiving indomethacin prior to carrageenan injection. Paw volumes are measured and compared between groups to determine the ability of indomethacin to reduce edema caused by carrageenan. The results show that indomethacin demonstrated anti-inflammatory effects by inhibiting the paw edema induced by carrageenan.