It is a fugal disease.

1. 1

2. 2

3. CONTENTS
1. INTRODUCTION.
2. CLINICAL FEATURES.
3. ORAL MANIFESTATIONS.
4. HISTOLOGIC FEATURES.
5. LABORATORY DIAGNOSIS.
6. TREATMENT.
3

4. HISTOPLASMOSIS
4

5. INTRODUCTION.
 Histoplasmosis is generalized fungal infection caused by
organism Histoplasma capsulatum.
Fig: Histoplasma capsulatum
 It is also known as Darling’s Disease.
5

6.  It is usually acquired by inhalation of dust containing spores
of fungus, also contamination occur from excreta of birds
containing spores such as pigeons , starlings
.
6

7. Clinical Features
 Chronic low grade fever, productive cough, splenomegaly ,
hepatomegaly &Lymphadenopathy.
 Anemia and leukopenia may be present.
 The infection may manifest as local lesions such as
subcutaneous nodules or suppurative arthritis.
 May Show positive histoplasmin skin reaction or calcified
pulmonary nodules as seen in TB.
7

8. Type equation here.
8

9. 9

10. Lymphadenopathy 10

11. Fig : Calcified pulmonary nodules.
11

12. Oral Manifestation.
 They appear as nodular , ulcerated , or vegetative
lesions on buccal mucosa, gingiva , tongue , palate or
lips.
 The ulcerated areas are usually covered by non-specific
gray membrane which is indurated with raised and rolled
out borders resembling carcinoma.
 Granulomatous lesion often cause alveolar bone
destruction.
12

13. Fig : Ulcerative lesion showing destruction of gingival papilla.
13

14. 14

15. Histologic Features.
 Histoplasmosis is a granulomatous infection that affect
Reticuloendothelial system.
 The organism can be found in phagocytic cells and
appear as tiny intracellular structures.
15

16. Histoplasma capsulatum within Macrophage
16

17. LABORATORY
DIAGNOSIS
1. Complete blood count : Mild anemia may be present
in chronic pulmonary histoplasmosis.
2. Alkaline phosphatase and lactate
dehydrogenase:Alkaline phosphatase levels are elevated in
histoplasmosis.
3. Detection of Immunoprecipitating antibodies: Both Anti M
& Anti H antibody are detected in histoplasmosis. Anti-H
antibody is more specific for active histoplasmosis.
17

18. Treatment.
 Pulmonary Histoplasmosis usually resolves
spontaneously , while severe forms of the disease
treated by Amphotericin B.
18

19. THANK
YOU .
19