HEV is a single-stranded RNA virus that causes hepatitis E and can also affect other organs beyond the liver. It is transmitted via the fecal-oral route from contaminated water or undercooked meat. While HEV primarily affects the liver, it has also been associated with neurological, renal, hematological, musculoskeletal and cardiac effects. The most common extrahepatic manifestation is neurological disorders such as Guillain-Barré syndrome. Treatment of extrahepatic manifestations involves antiviral medication like ribavirin as well as steroids. Preventive measures include avoiding raw meat and untreated water from areas where HEV is prevalent.