This is the NCERT CBSE syllabus ppt on the topic Gravitation. It will be helpful for students studying in that class and will enable them to understand better.
It is always amazing to see the interaction of planets, Sun, Stars, and other celestial objects in space which leads to astronomical events. In this chapter we will learn certain laws of physics which explains gravitation between celestial objects, free fall of body, mass and weight of the objects.
It is always amazing to see the interaction of planets, Sun, Stars, and other celestial objects in space which leads to astronomical events. In this chapter we will learn certain laws of physics which explains gravitation between celestial objects, free fall of body, mass and weight of the objects.
Gravitation has been the most common phenomenon in our lives but somewhere down the line we don't know musch about it. So here is a presentation whic will help you out to know what it is !! I'll be makin it available for download once i submit it in school :P :P ! Coz last one of the brats showed the same presentation that i uploade and unfortunatele his roll number fell before mine ! I was damned..:D :D :P
Gravity Gravitation English Presentation
Tugas Fisika
Tugas Bahasa Inggris
oleh :
Kelas 12 IPA 6 SMA Negeri 1 Yogyakarta tahun 2014
Semangat!!!!!!! SUKSES
Gravitation has been the most common phenomenon in our lives but somewhere down the line we don't know musch about it. So here is a presentation whic will help you out to know what it is !! I'll be makin it available for download once i submit it in school :P :P ! Coz last one of the brats showed the same presentation that i uploade and unfortunatele his roll number fell before mine ! I was damned..:D :D :P
Gravity Gravitation English Presentation
Tugas Fisika
Tugas Bahasa Inggris
oleh :
Kelas 12 IPA 6 SMA Negeri 1 Yogyakarta tahun 2014
Semangat!!!!!!! SUKSES
Remember it's just a start for class 20 students. Just a way to declare hot to teach students of class by using the scope of ICT . It declares the scope of ICT in the field of education.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
2. Introduction
• Force is required to change the speed or direction of
motion of an object.
• We observe that a
Object dropped from a height falls towards the earth
All the planets go around the Sun
The moon goes around the earth
In all these cases there must be some force acting on the
objects, the planets and the moon.
Isaac Newton explained this as gravitational force.
2GRAVITATION
3. Newton’s theory
• It is said that when Newton was sitting under a tree, an
apple fell on him. The fall of the apple made Newton start
thinking. He thought that: if the earth can attract an apple,
can it not attract the moon? Is the force the same in both
cases? He conjectured that the same type of force is
responsible in both the cases. He argued that at each
point of its orbit, the moon falls towards the earth, instead
of going off in a straight line. So, it must be attracted by
the earth. But we do not really see the moon falling
towards the earth.
3GRAVITATION
4. Activity to understand moon’s motion
• Take a piece of thread. Tie a small stone at one end. Hold
the other end of the thread and whirl it round, as shown.
Note the motion of the stone. Release the thread. Again,
note the direction of motion of the stone.
4GRAVITATION
5. • Before the thread is released, the stone moves in a
circular path with a certain speed and changes direction
at every point. The change in direction involves change in
velocity or acceleration. The force that causes this
acceleration and keeps the body moving along the
circular path is acting towards the centre. This force is
called the centripetal (meaning ‘centre-seeking’) force.
• In the absence of this force force, the stone flies off along
a straight line. This straight line will be a tangent to the
circular path.
5GRAVITATION
6. • The motion of the moon around the earth is due to the
centripetal force. The centripetal force is provided by the
force of attraction of the earth. If there were no such force,
the moon would pursue a uniform straight line motion.
6GRAVITATION
7. Why earth does not move towards apple
• According to the third law of motion, the apple does
attract the earth. But according to the second law of
motion, for a given force, acceleration is inversely
proportional to the mass of an object. The mass of an
apple is negligibly small compared to that of the earth. So,
we do not see the earth moving towards the apple.
• Newton concluded that not only does the earth attract an
apple and the moon, but all objects in the universe attract
each other. This force of attraction between objects is
called the gravitational force.
7GRAVITATION
8. UNIVERSAL LAW OF GRAVITATION
• Every object in the universe attracts every other object
with a force which is proportional to the product of their
masses and inversely proportional to the square of the
distance between them. The force is along the line joining
the centres of two objects.
8GRAVITATION
9. • Let two objects A and B of masses M and m lie at a
distance d from each other. Let the force of attraction
between two objects be F. According to the universal law
of gravitation, the force between two objects is directly
proportional to the product of their masses.
• And the force between two objects is inversely
proportional to the square of the distance between them.
---- Combine 1 and 2. Here G is the constant of proportionality
and is called the universal gravitation constant.
---- 2
----1
9GRAVITATION
10. Value of “G”
• The SI unit of G can be obtained by substituting the units
of force, distance and mass in the above as N m2 kg–2.
The value of G was found out by Henry Cavendish by
using a sensitive balance. The accepted value of G is
6.673 × 10–11 N m2 kg–2.
10GRAVITATION
11. IMPORTANCE OF THE UNIVERSAL
LAW OF GRAVITATION
• The universal law of gravitation successfully explained
several phenomena:
the force that binds us to the earth
the motion of the moon around the earth
the motion of planets around the Sun; and
the tides due to the moon and the Sun.
11GRAVITATION
12. Free Fall
• Take a stone. Throw it upwards. It reaches a
certain height and then it starts falling down.
• Whenever objects fall towards the earth under
the gravitational force alone, we say that the
objects are in free fall.
• Any change in velocity involves acceleration.
• This acceleration is called the acceleration due
to the gravitational force of the earth (or
acceleration due to gravity). It is denoted by g.
The unit of g is the same as that of acceleration,
that is, m s–2.
12GRAVITATION
13. • Let the mass of the stone in the above activity be m. And
let acceleration due to gravity be g.
• From the second law of motion that force is the product of
mass and acceleration. Therefore F=mg
• M is the mass of the earth, and d is the distance between
the object and the earth.
13GRAVITATION
14. • When the object is on or near the surface of the earth.
The distance d will be equal to R, the radius of the earth.
Thus, for objects on or near the surface of the earth,
14GRAVITATION
15. Activity
• Take a sheet of paper and a stone.
Drop them simultaneously from the first
floor of a building. Observe whether
both of them reach the ground
simultaneously. We see that paper
reaches the ground little later than the
stone. This happens because of air
resistance. The air offers resistance due
to friction to the motion of the falling
objects. The resistance offered by air to
the paper is more than the resistance
offered to the stone. If we do the
experiment in a glass jar from which air
has been sucked out, the paper and the
stone would fall at the same rate.
15GRAVITATION
16. • Acceleration experienced by an object is independent of
its mass. This means that all objects hollow or solid, big or
small, should fall at the same rate.
• As g is constant near the earth, all the equations for the
uniformly accelerated motion of objects become valid with
acceleration a replaced by g.
16GRAVITATION
17. Mass
• Mass of an object is the measure of its inertia.
• The mass of an object is constant and does not change
from place to place.
17GRAVITATION
18. Weight
• The weight of an object is the force with which it is
attracted towards the earth.
• The SI unit of weight is the same as that of force, that is,
newton (N). The weight is a force acting vertically
downwards; it has both magnitude and direction.
• Weight of the object on the moon = (1/6) × its weight on
the earth.
18GRAVITATION
19. Activity
• Take an empty plastic bottle. Close the mouth of the bottle
with an airtight stopper. Put it in a bucket filled with water.
You see that the bottle floats. Push the bottle into the
water. You feel an upward push. This indicates that water
exerts a force on the bottle in the upward direction. The
upward force exerted by the water goes on increasing as
the bottle is pushed deeper till it is completely immersed.
Now, release the bottle. It bounces back to the surface.
• When the bottle is immersed, the upward force exerted by
the water on the bottle > than its weight. Therefore it rises
up when released.
19GRAVITATION
20. BUOYANCY
• The upward force exerted by the
water on the bottle is known as
upthrust or buoyant force. In
fact, all objects experience a
force of buoyancy when they are
immersed in a fluid.
• The magnitude of this buoyant
force depends on the density of
the fluid.
20GRAVITATION
21. Activity
• Take a beaker filled with water. Take a piece of cork and
an iron nail of equal mass. Place them on the surface of
water. Observe what happens.
21GRAVITATION
22. • The cork floats, nail sinks. This happens because of the
difference in their densities. The density of cork is less
than the density of water. This means that the upthrust of
water on the cork > weight of the cork. So it floats.
• The density of an iron nail is more than the density of
water. This means that the upthrust of water on the iron
nail < the weight of the nail. So it sinks.
• Therefore objects of density less than that of a liquid float
on the liquid. The objects of density greater than that of a
liquid sink in the liquid.
22GRAVITATION
23. Archimedes’ Principle
• When a body is immersed fully or partially in a fluid, it
experiences an upward force that is equal to the weight of
the fluid displaced by it.
• Archimedes’ principle has many applications. It is used in
designing ships and submarines. Lactometers, which are
used to determine the purity of a sample of milk and
hydrometers used for determining density of liquids, are
based on this principle.
23GRAVITATION
25. Relative density
• The density of a substance is defined as mass of a unit
volume. The unit of density is kilogram per metre cube
(kgm–3). The density of a given substance, under
specified conditions, remains the same.
• It is often convenient to express density of a substance in
comparison with that of water. The relative density of a
substance is the ratio of its density to that of water:
• Since the relative density is a ratio of similar quantities, it
has no unit.
25GRAVITATION