GNPs final (1).pptx
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- Gold nanoparticles (AuNPs) show potential for cancer therapy by targeting and efficiently treating cancer cells when used as drug carriers. - AuNPs are synthesized using gold and exhibit unique chemical and structural properties compared to bulk gold. They are stable, biocompatible and accumulate in cancerous cells. - Various methods can be used to synthesize AuNPs including physical, chemical and biological methods. Common chemical methods include the Turkevich and Burst-Schiffrin methods, while seeding growth and electrochemical methods are also discussed.
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1. Gold nanoparticles show potential for use in cancer diagnosis and treatment due to their optical and photothermal properties.
2. Gold nanoparticles can be engineered to absorb near-infrared light and convert it to heat, killing nearby cancer cells through localized hyperthermia while sparing healthy cells.
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Thank You.
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This document presents research on using gold nanoparticles for the detection of the biomolecule heparin. It describes synthesizing positively-charged gold nanoparticles by coating them with a lipoic acid derivative. The nanoparticles were shown through SEM, UV-VIS spectroscopy, and other analysis to coagulate and change color when exposed to the negatively-charged heparin molecule. This provides a simple, visual method to detect heparin concentration and has potential applications for controlling heparin dosage during surgeries in Qatar. The research was conducted by two Qatari students at Mosab bin Omair secondary independent school under the supervision of two doctors.Gold Nano Particles Of Cancer Treatment: A Review
Gold nanoparticles are emerging as promising agents for cancer
therapy and are being investigated as drug carriers, photothermal
agents, contrast agents and radiosensitisers. Cancer is the disease
caused by an uncontrolled division of abnormal cells in a part of the
body.In this review some various nanotechnology is found the 10 new
technique and treated with all the cancer treatment is beneficial
compare to other cancer therapy.Will the synthesis of various gold
nano particles and find out the gold nano shells, gold nano cages, gold
colloidal nano spheres. Then Nanoparticles can be used to target bio markers or antigens that
are highly specific to Cancer cells.This gold nano particles using the therapy Rheumatoid
arthritis, Alzheimer's disease, Cancer detection. The introduces to the cancer diseases,nano
particles techniques, cancer therapy, then various types of the gold nano particles, propertices
of cancer cells, future scope of cancer treatment, applications, background of cancer
treatment will be discussed.
KEYWORDS: Gold nano particles techniques, cancer treatment, clinical trials.
Nanoparticle of plant extract: A Novel approach for cancer therap
Nanotechnology deals regulating matter at dimension of 1-100 nanometers. its use in fundamental physics, biology, chemistry, technology of nanometer scale objects. It also includes how such objects can be used in the areas of computation, sensors, nanostructure materials, biolabeling, biomedical, agricultural, biolabeling , cancer, biotechnology. There are 3 methods for preparation of nanoparticles Physical, chemical &biological. Cancer is as an abnormal growth of cells. It is due to lack of proper regulation in cell cycle. Cancer develops through an accumulation of genetic changes or mutations which could emerge due to different factors like physical, chemical, biological. Currently available cancer chemotherapeutic agents insidiously affect the host cells especially bone marrow, epithelial tissues, reticule-endothelial system and gonads Because of high death rate associated with cancer and the serious side effects of chemotherapy & radiation therapy. Silver NanoParticles as an anticancer agent and they have all turned up positive. Many plant-derived products have been reported to exhibit potent antitumour activity against several rodent and human cancer cell lines. Plants history about use in the treatment of cancer. It is significant that over 60% of currently used anticancer agents are derived, in one way or another, from natural sources (plants, marine organism, and microorganisms)
Herbal drug and herbal mediated silver nanoparticles by akshay kakde
1) The document discusses herbal drugs and herbal-mediated silver nanoparticles as potential treatments for diabetes.
2) It describes the green synthesis method used to create herbal-mediated silver nanoparticles (HMSNPs) and various characterization techniques.
3) The synthesized HMSNPs are proposed to be biodegradable, biocompatible and non-toxic with potential for treating diabetes due to an ability to enter biological cell membranes.
American Journal of Current & Applied Research in Microbiology
American Journal of Current & Applied Research in MicrobiologySciRes Literature LLC. | Open Access Journals
Background/Purpose: The reduction solution was aqueous extracted from Acanthus ilicifolius for biosynthesis of silver nanoparticles. as green approach. It is less harmful and more economical as compared to physical and chemical methods.
Methods: Ratio of 1: 10 mixtures of 100 mg/ mL of aqueous extract and 5 mM of silver nitrate were incubated for 24 hours at 40°C with 150 rpm in incubator shaker. The formation of silver nanoparticles were monitored by colour changes and were characterized by UV-Vis spectrometry followed by zeta (potential) sizer analyses.Similar to GNPs final (1).pptx (20)
Current Methods for Synthesis of Gold Nanoparticles
Current Methods for Synthesis of Gold Nanoparticles
Nanotechnology and its Application in Cancer Treatment
Nanotechnology and its Application in Cancer Treatment
Gold Nanoparticle as novel Agent for Drug targeting (1).pptx
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In-vitro evaluation techniques of anticancer, anti oxidant, anti microbial
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Utilization of cationic gold nanoparticles for detection of biomolecules,IR9
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Nanoparticle of plant extract: A Novel approach for cancer therap
Nanoparticle of plant extract: A Novel approach for cancer therap
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American Journal of Current & Applied Research in Microbiology
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- 1. A Review on Gold Nanoparticles in Cancer Therapy Presented by, Anusha Dev M.Pharmacy- Pharmaceutics Geethanjali College of Pharmacy Under the Supervision of , Dr. Y Shivakumar, P Naga Chandrika
- 2. TABLE OF CONTENTS Introduction 01 03 02 05 06 Mechanism of AuNPs on tumor cells Synthesis of Gold nanoparticles Significance of AuNPs Characteristics of Gold nanoparticles 04 Types of Gold nanoparticles
- 3. ― Cancer is difficult to treat because it’s a disease caused by your own cells getting your own body to kill itself can be quite a challenge. By using nanoparticles as drug carriers we can target the cancerous cells and treat them efficiently. ― Nanoparticles synthesized using gold(Au) are called as gold nanoparticles (GNPs/ AuNPs), they are also called as colloidal gold. ― Nanoparticles of gold, exhibit a combination chemical and structural properties that makes it novel from conventional bulk solids. ― Nano-sized gold particles exhibit various shades from red to blue.
- 4. ― Gold has optical properties like plasmon resonance are fluorescence and chemiluminescence. ― These properties have the ability to detect biomolecules, for induction of tumor cell apoptosis through hyperthermia. ― The AuNPs cytotoxic effect on cancer cells is primarily due to their easy permeability to cellular barriers. ― Photothermal therapy using gold NPs may assist with this challenge due to its photon absorbing capability, ultimately transforming NPs into heat, thereby destroying cancer cells. Why Gold?
- 6. Characteristics of Gold Nanoparticles ― Gold nanoparticles have greater biological compatibility and are chemically inert. ― They are highly stable due to gold-sulphur bonds. ― GNPs facilitate as microscopic probes for medical studies. ― Gold nanoparticles accumulate in the cancerous cell and show the cytotoxic effect i.e apoptosis or necrosis of the specific cell and its receptor. ― GNPs are emerging as promising agents for cancer therapy.
- 7. Types of Gold Nanoparticles
- 8. Synthesis of Gold Nanoparticles Chemical Method Physical Method Biological Method
- 9. Physical Method ― The γ- IR radiation technique is one approach is where , the synthesis of GNPs in uniform size ranging from 5-40nm along with high purity is possible. Polysaccharide alginate is used as stabilizer. ― By the action of heat or photochemical reduction or reduction of HAuCl4 (chloroauric acid) by citrate, tartrate and malate.
- 10. Chemical Methods 1.Turkevich Method 2.Burst- Schiffrin method Small amounts of hot chloroauric acid is reacted with sodium citrate solution. The citrate ions act as both as reducing agent and capping agent. Chloroauric acid(AuCl4) reacts with tetraoctylammonium bromide (TOAB) solution in toluene and reduced by sodium borohydride(NaBH4).
- 11. 4.Electrochemical method 3.Seeding growth method AuNPs are prepared electrochemically using a simple two-electrode cell, with oxidation of the anode and reduction of the cathode. Using tetra alkyl ammonium salts as stabilizers. Initially gold nanoparticles with an average diameter of 9 nm were synthesized in toluene by using oleylamine both as a reducing and stabilizing agent. These GNPs act as seeds for a subsequent growth reaction .During the reaction, the gold nanoparticles start to agglomerate which are separated later.
- 12. Biological Methods ― In recent years, the biosynthesis of AuNPs using plants such as Cinnamomum camphora, Aloe vera, lemongrass have been reported. ― Microorganisms like pseudomonas, actinomycetes etc. are used in preparation of AuNPs.
- 14. References 1. https://www.tandfonline.com/doi/full/10.3109/21691401.2014.971807 2. https://www.mdpi.com/2079-4983/12/4/70 3. http://www.slideshare.net/shrenibandi/gold-nano-p?from_m_app=android 4. https://chemistry- europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.201402467#:~:text=A%20see ded%2Dgrowth%20method%20has,morphology%20of%20the%20resulting%20nano particles.
- 15. Thank you