Glucose reabsorption in the renal tubules normally ensures that all 180g of glucose filtered by the kidneys each day is reabsorbed back into circulation. This occurs via a two-step process - sodium-glucose cotransporters in the tubule's apical membrane use active transport to bring glucose into tubule cells, followed by facilitated diffusion and active sodium extrusion to return glucose to the bloodstream. Two sodium-coupled carriers have been identified for this process, one with high capacity but low affinity and one with low capacity but high affinity.

1. Glucose reabsorption in renal
tubules
Department Of Physiology
SMSR, Sharda University
10.01.2019
Sanjog Bam
HUMAN BIOLOGIST
MSc. Medical physiology

2. Glucose reabsorption
• Kidney filter 180gm/day of
glucose
• Normally all glucose gets
reabsorbed from renal tubules.
• Occurs in two step
 Carrier mediated, Na+/glucose
cotransport (apical membrane)
 Followed by glucose transport
by facililated diffusion and
active sodium extrusion.
• Two specific sodium coupled
carrier have been identified in
the apical membrane

3. High capacity
Low affinity
Low capacity
High affinity

4. - In adult human, the transport maximum for glucose(TmG) average
about 375mg/min
- filtered at a rate of approx. 100mg/min (80mg/dl x 125ml/min)
- actual renal threshold is about 200mg/dl of arterial plasma and180
mg/dl of venous plasma

5. THANK YOU