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Prophylaxis of post-ERCP pancreatitis:
ESGE Guideline 2014
Prepared by:
Dr.Mohamed Shekhani
Endoscopy 2014
PEP diagnosis definition:
 Requires two of the three following criteria:
 (i) abdominal pain consistent with acute pancreatitis (acute
onset of a persistent, severe, epigastric pain often
radiating to the back)
 (ii) serum lipase or amylase activity at least three times
>ULN; and
 (iii) characteristic findings of acute pancreatitis on
contrast-enhanced CT &less commonly, MRI or TAUS.
 4 degrees of severity based on the presence or absence of
complications, both local (necrosis of the pancreas&/or
peripancreatic tissue) &systemic (cardiovascular, renal, or
respiratory organ failure).
Incidence:
 4.4 %.
 Mild, moderate, severe type in 69%, 23%& 8%, respectively.
www.themegallery.com
Main recommendations:
 1. ESGE recommends routine rectal administration of
100mg of diclofenac or indomethacin immediately before
or after ERCP in all patients without contraindication.
 In addition to this, in the case of high risk for (PEP), the
placement of a 5-Fr prophylactic pancreatic stent should
be strongly considered.
 Sublingually administered glyceryl trinitrate or 250 μg
somatostatin given in bolus injection might be considered
as an option in high risk cases if (NSAIDs) are
contraindicated&if prophylactic pancreatic stenting is not
possible or successful.
Main recommendations:
 2. ESGE recommends keeping the number of cannulation
attempts as low as possible.
 3. ESGE suggests restricting the use of a pancreatic
guidewire as a backup technique for biliary cannulation to
cases with repeated inadvertent cannulation of the
pancreatic duct; if this method is used, deep biliary
cannulation should be attempted using a guidewire rather
than the contrast-assisted method&a prophylactic
pancreatic stent should be placed.
Main recommendations:
 4. ESGE suggests that needle-knife fistulotomy should be
the preferred precut technique in patients with a bile duct
dilated down to the papilla. Conventional precut &
transpancreatic sphincterotomy present similar success
&complication rates; if conventional precut is selected&
pancreatic cannulation is easily obtained,
 ESGE suggests attempting to place a small-diameter (3-Fr
or 5-Fr) pancreatic stent to guide the cut& leaving the
pancreatic stent in place at the end of ERCP for a minimum
of 12–24 hours.
Main recommendations:
 5. ESGE does not recommend endoscopic papillary
balloon dilation as an alternative to sphincterotomy in
routine ERCP, but it may be advantageous in selected
patients; if this technique is used, the duration of dilation
should be longer than 1 minute.
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GIT Kurdistan Board GEH Journal club: Post ERCP Pancreatitis prophylaxis.

  • 1. LOGO Prophylaxis of post-ERCP pancreatitis: ESGE Guideline 2014 Prepared by: Dr.Mohamed Shekhani Endoscopy 2014
  • 2. PEP diagnosis definition:  Requires two of the three following criteria:  (i) abdominal pain consistent with acute pancreatitis (acute onset of a persistent, severe, epigastric pain often radiating to the back)  (ii) serum lipase or amylase activity at least three times >ULN; and  (iii) characteristic findings of acute pancreatitis on contrast-enhanced CT &less commonly, MRI or TAUS.  4 degrees of severity based on the presence or absence of complications, both local (necrosis of the pancreas&/or peripancreatic tissue) &systemic (cardiovascular, renal, or respiratory organ failure).
  • 3. Incidence:  4.4 %.  Mild, moderate, severe type in 69%, 23%& 8%, respectively.
  • 4.
  • 6. Main recommendations:  1. ESGE recommends routine rectal administration of 100mg of diclofenac or indomethacin immediately before or after ERCP in all patients without contraindication.  In addition to this, in the case of high risk for (PEP), the placement of a 5-Fr prophylactic pancreatic stent should be strongly considered.  Sublingually administered glyceryl trinitrate or 250 μg somatostatin given in bolus injection might be considered as an option in high risk cases if (NSAIDs) are contraindicated&if prophylactic pancreatic stenting is not possible or successful.
  • 7. Main recommendations:  2. ESGE recommends keeping the number of cannulation attempts as low as possible.  3. ESGE suggests restricting the use of a pancreatic guidewire as a backup technique for biliary cannulation to cases with repeated inadvertent cannulation of the pancreatic duct; if this method is used, deep biliary cannulation should be attempted using a guidewire rather than the contrast-assisted method&a prophylactic pancreatic stent should be placed.
  • 8. Main recommendations:  4. ESGE suggests that needle-knife fistulotomy should be the preferred precut technique in patients with a bile duct dilated down to the papilla. Conventional precut & transpancreatic sphincterotomy present similar success &complication rates; if conventional precut is selected& pancreatic cannulation is easily obtained,  ESGE suggests attempting to place a small-diameter (3-Fr or 5-Fr) pancreatic stent to guide the cut& leaving the pancreatic stent in place at the end of ERCP for a minimum of 12–24 hours.
  • 9. Main recommendations:  5. ESGE does not recommend endoscopic papillary balloon dilation as an alternative to sphincterotomy in routine ERCP, but it may be advantageous in selected patients; if this technique is used, the duration of dilation should be longer than 1 minute.
  • 10.
  • 11. LOGO Click to edit subtitle style