This document provides guidelines from the European Society of Gastrointestinal Endoscopy (ESGE) for prophylaxis of post-ERCP pancreatitis. It defines post-ERCP pancreatitis and notes an incidence of 4.4% with mild, moderate, and severe types occurring in 69%, 23%, and 8% of cases, respectively. The main recommendations are to administer rectal NSAIDs before or after ERCP, consider prophylactic pancreatic stenting for high-risk patients, minimize cannulation attempts, and use needle-knife fistulotomy as the preferred precut technique.