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LAMBLIA
Prepared by:
1- Jehad Yaqoob
2-Omer Ali
3-Sarkar Sardar
TABLE OF CONTENTS
 Introduction
 Epidemiology
 Pathogenesis
 Life cycle
 Signs & symptoms
 Diagnosis
 Transmission
 Who is at Risk?
 Treatment
 Prevention
INTRODUCTION
 Giardia Lamblia
 Morphology
 History and distribution
INTRODUCTION
EPIDEMIOLOGY
PATHOGENESIS
PATHOGENESIS
SIGNS AND SYMPTOMS
 Watery diarrhea
 Abdominal cramp
 Weight loss
 Vomiting
 Enteropathy in Chronic giardiasis
 Steatorrhea ...etc.
DIAGNOSIS
 Direct or indirect microscopical stool
examination
 Immunofluoroscent for antigens
 ELISA for antigens or antibodies
 PCR
 Histological section for enteropathy
TRANSMISSION
 Ingestion of contaminated food and water
 Person-to-person contact
 homosexually transported
WHO IS AT RISK?
 Children
 People without access to safe
drinking water.
 Homosex
TREATMENT
 Metronidazole
 Tinidazole
 Furuzolidone and nitazoxamide
are preferred in children.
 Parmomycin, for symptomatic pregnant
females.
PREVENTION
 Wash your hands
 Purify wilderness water
 Keep your mouth closed
 Use bottled or boiled water
 Avoid homosex
KEY POINTS
 Giardia is the only protozoan parasite found in the lumen of the
 human small intestine (duodenum and jejunum).
 Trophozoites are pearshaped bilaterally symmetrical
with 2 nuclei, 4 pairs of fl agella, and a ventral concave sucking disc.
They exhibit motility resembling a ‘falling leaf’.
Ellipsoid cysts contain 4 nuclei with remnants of flagella.
 Infective form: Ellipsoid cysts.
 Clinical features: Mostly asymptomatic but in some
 cases may cause diarrhea, dull epigastric pain, and malabsorption.
Stool contains excess mucus but no blood.
 Diagnosis: By microscopic demonstration of trophozoites
 or cysts in stool, enterotest, and serodiagnosis by
ELISA (ProSpec T/Giardia antigen assay).
 Treatment: Metronidazole and tinidazole are the
drugs of choice.

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Giardia lamblia presentation

  • 1. LAMBLIA Prepared by: 1- Jehad Yaqoob 2-Omer Ali 3-Sarkar Sardar
  • 2. TABLE OF CONTENTS  Introduction  Epidemiology  Pathogenesis  Life cycle  Signs & symptoms  Diagnosis  Transmission  Who is at Risk?  Treatment  Prevention
  • 3. INTRODUCTION  Giardia Lamblia  Morphology  History and distribution
  • 8.
  • 9.
  • 10. SIGNS AND SYMPTOMS  Watery diarrhea  Abdominal cramp  Weight loss  Vomiting  Enteropathy in Chronic giardiasis  Steatorrhea ...etc.
  • 11.
  • 12. DIAGNOSIS  Direct or indirect microscopical stool examination  Immunofluoroscent for antigens  ELISA for antigens or antibodies  PCR  Histological section for enteropathy
  • 13.
  • 14. TRANSMISSION  Ingestion of contaminated food and water  Person-to-person contact  homosexually transported
  • 15. WHO IS AT RISK?  Children  People without access to safe drinking water.  Homosex
  • 16.
  • 17. TREATMENT  Metronidazole  Tinidazole  Furuzolidone and nitazoxamide are preferred in children.  Parmomycin, for symptomatic pregnant females.
  • 18.
  • 19. PREVENTION  Wash your hands  Purify wilderness water  Keep your mouth closed  Use bottled or boiled water  Avoid homosex
  • 20. KEY POINTS  Giardia is the only protozoan parasite found in the lumen of the  human small intestine (duodenum and jejunum).  Trophozoites are pearshaped bilaterally symmetrical with 2 nuclei, 4 pairs of fl agella, and a ventral concave sucking disc. They exhibit motility resembling a ‘falling leaf’. Ellipsoid cysts contain 4 nuclei with remnants of flagella.  Infective form: Ellipsoid cysts.  Clinical features: Mostly asymptomatic but in some  cases may cause diarrhea, dull epigastric pain, and malabsorption. Stool contains excess mucus but no blood.  Diagnosis: By microscopic demonstration of trophozoites  or cysts in stool, enterotest, and serodiagnosis by ELISA (ProSpec T/Giardia antigen assay).  Treatment: Metronidazole and tinidazole are the drugs of choice.