Punit Virk Transforming Pathology: Biotechnology as a positive feedback loop ...Kim Solez ,
Punit Virk presents Transforming Pathology: Biotechnology as a positive feedback loop for the evolution of anatomical pathology at Pathology-2015 in New Orleans, July 15, 2015
Punit Virk Transforming Pathology: Biotechnology as a positive feedback loop ...Kim Solez ,
Punit Virk presents Transforming Pathology: Biotechnology as a positive feedback loop for the evolution of anatomical pathology at Pathology-2015 in New Orleans, July 15, 2015
Biology Molecular
University of Haifa. (2015, August 13). Big data and the social character of genes. ScienceDaily. Retrieved September 12, 2015 from www.sciencedaily.com/releases/2015/08/150813084035.htm
Lawrence Berkeley National Laboratory. (2015, August 4). Keeping algae from stressing out. ScienceDaily. Retrieved September 12, 2015 from www.sciencedaily.com/releases/2015/08/150804144013.htm
Martínez Sánchez, Lina María. Biología Molecular. 8.ed. Medellín. UPB. Facultad de Medicina.
Application of Whole Genome Sequencing in the infectious disease’ in vitro di...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Applications of WGS in industry. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
CRISPR gene editing is widely used by biologists as the DNA programming tool of choice - cells, organisms and populations can be altered with it. We’ve made faster progress than you'd imagine. CRISPR programs can now be written online and printed in labs with ease. Teams are attempting human embryo reprogramming for research purposes in China and the UK, and “gene drives” – DNA programs that bias inheritance in populations – are almost ready to modify organisms in the wild. Will we see the eradication of Alzheimer’s and mosquitoes? Or ecological disaster and designer super-babies for the rich?
This deck is from a SXSW Interactive 2016 panel session where inventors and leaders of the CRISPR field discussed what is - and what should be- possible with genome editing.
Specialty pathology endpoints for all clients, including complex immunohistochemistry, in situ hybridization, image analysis, artificial intelligence, stereology, tissue cross-reactivity, and electron microscopy.
Biology Molecular
University of Haifa. (2015, August 13). Big data and the social character of genes. ScienceDaily. Retrieved September 12, 2015 from www.sciencedaily.com/releases/2015/08/150813084035.htm
Lawrence Berkeley National Laboratory. (2015, August 4). Keeping algae from stressing out. ScienceDaily. Retrieved September 12, 2015 from www.sciencedaily.com/releases/2015/08/150804144013.htm
Martínez Sánchez, Lina María. Biología Molecular. 8.ed. Medellín. UPB. Facultad de Medicina.
Application of Whole Genome Sequencing in the infectious disease’ in vitro di...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Applications of WGS in industry. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
CRISPR gene editing is widely used by biologists as the DNA programming tool of choice - cells, organisms and populations can be altered with it. We’ve made faster progress than you'd imagine. CRISPR programs can now be written online and printed in labs with ease. Teams are attempting human embryo reprogramming for research purposes in China and the UK, and “gene drives” – DNA programs that bias inheritance in populations – are almost ready to modify organisms in the wild. Will we see the eradication of Alzheimer’s and mosquitoes? Or ecological disaster and designer super-babies for the rich?
This deck is from a SXSW Interactive 2016 panel session where inventors and leaders of the CRISPR field discussed what is - and what should be- possible with genome editing.
Specialty pathology endpoints for all clients, including complex immunohistochemistry, in situ hybridization, image analysis, artificial intelligence, stereology, tissue cross-reactivity, and electron microscopy.
2023-11-09 HealthRI Biobanking day_Amsterdam_Alain van Gool.pdfAlain van Gool
Examples of lessons learned in Omics-based biomarker studies from myself and colleagues in X-omics and EATRIS, for an audience of biobankers, researchers and diagnostic/clinical chemistry experts.
An overview of genomic epidemiology, Canada's IRIDA project for genome-based outbreak investigation, and a breathless romp through the awesome potential of the MinION
Talk from OHBM education day 2018, an overview of data sharing and other resources for neuroimaging research. Also a brief discussion of the impact that openly shared data has had on publications.
Dr. Leroy Hood lectured to a group of Ohio State University College of Medicine students and faculty on May 13, 2010 in advance of an announcement of a partnership between the Ohio State University Medical Center and the Institute for Systems Biology. The partnership will be known as
Beating Bugs with Big Data: Harnessing HPC to Realize the Potential of Genomi...Tom Connor
Introducing the HPC challenges associated with developing a set of clinical microbial genomics services in the NHS in Wales. Demonstrating the potential of these technologies, and the impact it is already having for the patients of the Welsh NHS.
Cell centered database for immunology and cancer research feb252016Ann-Marie Roche
Determining the cellular mechanisms of diseases is a crucial requirement for understanding the causes and progression of diseases, predicting outcomes, and developing new treatments. Often relevant information, e.g. what cells are involved in a disease or what effects does a drug have on cells, is scattered across many papers and journals, which makes it difficult for researchers to be sure they have a complete picture. Using Elsevier’s automated text mining technology, we have created a new cell-centered database consisting of 850 000 facts captured from more than 24 million PubMed abstracts and 3.5 million full text articles for use in Pathway Studio. This database focused primarily on cellular aspects of immunology and immuno-oncology can be used to summarize and visualize published research, and to analyze experimental data.
Integrative Everything, Deep Learning and Streaming DataJoel Saltz
Workshop on Clusters, Clouds, and Data for Scientific Computing, September 6, 2018
The need to create to label information and segment regions in individual sensor data sources and to create synthesizes from multiple disparate data sources span many areas of science, biomedicine and technology. The rapid evolution in sensor technologies – from digital microscopes to UAVs drive requirements in this area. I will describe a variety of use cases, describe technical challenges as well as tools, algorithms and techniques developed by our group and collaborators.
Lecture given for the Data Mining course at Uppsala university in October 2013. The presentation talks about data analysis in the context of genomics, next-generation sequencing, metagenomics etc.
Filière Médicale Francophone Nancy-Wuhan. Présentation à la réunion annuelle de Chongqing par le Pr ZHAO Yan. Echanges franco-chinois sous l'impulsion du Professeur Jean François STOLTZ.
Cours d'initiation à l'information scientifique et technique de l'UE ISSM7.309 et du DIU Nancy Wuhan Méthodologies de la recherche médicale et chirurgicale
Filières Médicales Francophones Nancy-Wuhan et Kunming. Etudiants et Enseignants. Outils et Ressources. Des dictionnaires à l'IA. 20 ans d'expériences pédagogiques en Chine analysées avec l'évolution des outils, et bouleversées par la crise Covid. Challenges et Opportunités.
Curation of Scientific, Technical and Societal contents on Street and Public Lighting.
presented on the occasion of IDL2022,
actualized from previous analysis of this Content Hub.
Coopération France Chine Nancy-Wuhan depuis 25 ans. Enseignement de la Médecine et du Français. Le temps des dictionnaires. Le temps des blogs. Le temps des diplômes. Le temps des PhDs. Le temps de la curation. Le temps des smartphones. Le temps de Zoom.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
ANAMOLOUS SECONDARY GROWTH IN DICOT ROOTS.pptxRASHMI M G
Abnormal or anomalous secondary growth in plants. It defines secondary growth as an increase in plant girth due to vascular cambium or cork cambium. Anomalous secondary growth does not follow the normal pattern of a single vascular cambium producing xylem internally and phloem externally.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Nucleophilic Addition of carbonyl compounds.pptxSSR02
Nucleophilic addition is the most important reaction of carbonyls. Not just aldehydes and ketones, but also carboxylic acid derivatives in general.
Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
Neutral nucleophiles can also add to carbonyls, although their additions are generally slower and more reversible. Acid catalysis is sometimes employed to increase the rate of addition.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
GFII 2014 Big Data
1. Les Données de la recherche
dans l'écosystème des publications
scientifiques
• Le 12 février 2014
• Institut Pasteur
• Les besoins des chercheurs en
Sciences de la Vie et de la Santé:
exemple de l'Immunologie
• GC Faure, MD, PhD, PUPH
• Faculté de Médecine, Univ Lorraine
• UMR CRAN/CNRS 7039
2. Qui suis-je?
• Un utilisateur final, « enduser » de
l'IST depuis longtemps
– SCICOM Nancy
– Ex-Chargé de Mission à la
documentation UHP Nancy
– ASSIM, SFI, IUIS, ICSU
• Website, Scientific Curation
– Un Immunologiste clinicien engagé
en cytomique
• Des Workshops HLDA
• aux CTCs et CECs
3. Quelles données ? « Big Data »
• Mathématiques, Physique,
Astronomie...
– Des chiffres et des images
(numérisées!)
• En SBS?
– Sciences de la Vie: Gènes, Molécules,
Cellules, Tissus... Données sans
risque mais pas sans impact
– Sciences de la Santé: Données à
risque?!
4. On faisait déjà du big data sans
le savoir
• En France et à l'international, depuis
1981
• CDs, Workshops HLDA
– Data shared
– Molécules nombreuses, >363!
– mais non diverses
5. En Europe
• IMGT/Montpellier
IMGT®, the international ImMunoGeneTics information system®
http://www.imgt.org, is the global reference in immunogenetics and
immunoinformatics, created in 1989 by Marie-Paule Lefranc (
Université Montpellier 2 and CNRS). IMGT® is a high-quality integrated
knowledge resource specialized in the immunoglobulins (IG) or antibodies, T
cell receptors (TR), major histocompatibility (MH) of human and other
vertebrate species, and in the immunoglobulin superfamily (IgSF), MH
superfamily (MhSF) and related proteins of the immune system (RPI) of
vertebrates and invertebrates.
Estimated size of immune repertoire: 10 10
6. Genes, aux USA
• ENCODE
– 75% and not 3% of genome can be
transcribed
• Immunological GENOME project
Curr Opinion Immunol 2013;25:593-7
Trends immunol 2013;34:602-9
Microarray-based transcriptomes for
most of the well-defined leukocyte
subsets of the C57BL/6 mouse
7. Immunité innée et cellules NK
IPD-KIR
• Molécules:
The database provides a centralised repository for human KIR sequences. Killer-cell
Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at
the allelic and haplotypic level. KIRs are members of the immunoglobulin
superfamily (IgSF) formerly called Killer-cell Inhibitory Receptors.
9. Cellules
Projets internationaux
• Immport: Bioinformatics for the
future of Immunology
The Immunology Database and Analysis Portal (ImmPort) system was developed under the Bioinformatics Integration
Support Contract (BISC) Phase II by the Northrop Grumman Information Technology Health Solutions team
for the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID),
Division of Allergy, Immunology, and Transplantation (DAIT)
MHC + Cytometry...FLOCK: Flow
cytometry clustering without K; +
CyTOF Analysis of human T cells
10. Cellules et Tissus
EPIC Sciences (San Diego)
A new kind of cytology detecting rare cells (CTCs and CECs) on blood
slides, allowing to introduce the concept of fluid biopsy.
• Immunome (tumeurs):
– Immunity, Volume 39, Issue 4, 631-632, Oct 2013
– Tumors are complex masses containing not just neoplastic
cells but also stromal cells, neovasculature, and a gamut of
immune cells.
12. Sciences de la Santé:
Recherche clinique et big data
• Du papier aux e-CRFs
• GEIL, EGIL, ELN...
• GOELAMs
– e-CRFs
– ARCs, TECs
• A risque! Médical, données patients
– Secret, confidentialité
• Impact
– Évaluation de protocoles cliniques,
données pharmacoéconomiques
13. Big Data and HIV Research
AIDS 2013;27:835-8
• HIVsystemsbiology.org
– Gene Overlapper
• 39 lists of genes.. 500billion subsets
• 3 genome wide siRNA screens
• CDNA overexpression screen
• Crowd sourcing for Mason-Pfizer monkey
virus proteases
– HIV replication Cycle Site
– AIDSVu project (géographie de la
maladie #GoogleMap)
• Publication 15091 papers in
2011:>40/day
14. UK/(USA): Clinical research
• General Practice Research Database
– 15 years..
• CPRD / NHS
– Asthma
– Cardiovascular disorders
• Patientslikeme!
• SAGE/Bionetworks.. Parkinson
15. Recherche clinique
Médecine personnalisée
• Myélome: MMRF Multiple Myeloma
Research Foundation
– Sept 2013... first and only open
access data platform in myeloma
The groundbreaking MMRF CoMMpass study is now enrolling NEWLY
DIAGNOSED multiple myeloma patients.
Landmark 10-year study,1000 patients, Molecular analysis of every patient
• Personalized or Precision medicine
16. « Open... »
• Data
• Sources
• Software: CrowdSource Coders
• Nature Biotechnology Feb 2013
• TopCoder.com
– « Big Data in biomedicine » FF Costa
– Drugdiscovery Today 2014, in press
• Opportunity for future personalized
medicine programs
17. Les Besoins des chercheurs
• Outils informatiques!?
E-BIOTHON: cloud dédié à la
bioinformatique CNRS, IBM, Inria, the Institut Français de
Bioinformatique and the innovative start-up SysFera are rolling out E-Biothon, an experimental
Cloud platform (1) to help speed up and advance research in biology, health and the environment.
• Maîtrise des logiciels
• Accès aux données publiques et
privées (Dossier Médical)
• Maîtrise des concepts de
l'information scientifique
• Maîtrise de l'évolution des concepts