2016 dec idat-mbib-do_ehighlight2016
•Download as PPTX, PDF•
0 likes•65 views
Biological systems require intricate protein and DNA assemblies that can only be understood using multiple experimental techniques across different scales. Recent studies have utilized small angle X-ray scattering (SAXS) through the Integrated Diffraction Analysis Technologies facility to inform the design of dynamic protein cages in solution and understand the structure and regulation of epigenetic pathways. Additional work has characterized the molecular architecture of fertilization complexes and components of the non-homologous end joining DNA repair pathway.
Report
Share
Report
Share
Recommended
DNA replication
The document discusses two studies related to DNA replication and cancer. The first study found that certain enzymes in the APOBEC family can cause mutations during DNA replication by deaminating cytosines, potentially leading to cancer. The second study identified a protein pathway that some cancer cells use to replicate their DNA and which could be a target for new cancer therapies. Understanding the processes of DNA replication and how they can be disrupted provides insights into cancer development and new opportunities for diagnosis and treatment.
Folding
The document discusses recent discoveries related to DNA and stem cells that are allowing for new therapeutic approaches to cancer management. Specifically, it discusses how discoveries of the protein MutL, which helps repair DNA errors, and how mutations in genes encoding DNA repair proteins can lead to cancers. It also discusses how researchers have identified a new stem cell signaling pathway that may help lower tumor risks in stem cell therapies by reducing formation of teratomas during stem cell differentiation.
Cell evolution
The document discusses two studies related to cells and medical applications. The first study investigated how bacteria can modify their cell walls to become resistant to antibiotics by changing peptidoglycan structure. The second study discusses the development of programmable RNA vaccines that can be rapidly produced in nanomaterials to provide protection against diseases like Ebola and influenza within days. Both studies demonstrate the importance of continued biological research on cells to develop new treatment methods and address issues like antimicrobial resistance and pandemic outbreaks.
Molecular Biologist Academic CV for Industry or Private Sector Consideration
Molecular Biologist with over thirteen years of hands-on research experience, impactful writer and presenter, dynamic leader and enthusiastic team player with an eye for great ideas and a passion to move science in new directions seeks challenging opportunities beyond the bench.
Genetic Mapping
Genetic mapping is used to determine the specific location of genes on chromosomes. Knowing gene locations can help identify genetic diseases and their underlying causes. One document describes how researchers used genetic techniques to identify a gene (PSR1) in algae that increases lipid production without subjecting the algae to stress. This could allow for lipid extraction and energy production while preserving the algae species. A second document discusses a new method developed by the University of Haifa to reduce the number of possible genetic effects to study from millions to thousands. The method was tested successfully in a plant with over 7,000 genes. This type of research can help identify genetic diseases more easily and determine the best treatments.
GENETIC MAPPING
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
Plegable Proteínas - Biología Molecular
This document discusses several articles about proteins and their roles. It first provides background on proteins and their functions as enzymes, antibodies, channels and receptors. It then summarizes two research articles. The first article finds that the RAB35 protein, which normally regulates protein transport, can also drive cancer formation when mutated. The second article details research that used x-ray crystallography to determine the atomic structure of the HIV capsid protein, which helps HIV replicate and could inform new antiviral drugs. The document concludes by discussing the medical applications of studying protein structures.
Folding
The document discusses two scientific studies:
1) A study that used the CRISPR/Cas9 gene editing system to simultaneously disrupt two target genes in monkey embryos, paving the way for valuable human disease models. Researchers were able to generate mutations in targeted genes without off-target effects.
2) A study showing that activating the tumor suppressor p53 in normal cells causes them to secrete the potent tumor suppressor Par-4, which induces cell death in p53-deficient cancer cells. This suggests a potential approach for preventing therapy resistance in tumors.
Recommended
DNA replication
The document discusses two studies related to DNA replication and cancer. The first study found that certain enzymes in the APOBEC family can cause mutations during DNA replication by deaminating cytosines, potentially leading to cancer. The second study identified a protein pathway that some cancer cells use to replicate their DNA and which could be a target for new cancer therapies. Understanding the processes of DNA replication and how they can be disrupted provides insights into cancer development and new opportunities for diagnosis and treatment.
Folding
The document discusses recent discoveries related to DNA and stem cells that are allowing for new therapeutic approaches to cancer management. Specifically, it discusses how discoveries of the protein MutL, which helps repair DNA errors, and how mutations in genes encoding DNA repair proteins can lead to cancers. It also discusses how researchers have identified a new stem cell signaling pathway that may help lower tumor risks in stem cell therapies by reducing formation of teratomas during stem cell differentiation.
Cell evolution
The document discusses two studies related to cells and medical applications. The first study investigated how bacteria can modify their cell walls to become resistant to antibiotics by changing peptidoglycan structure. The second study discusses the development of programmable RNA vaccines that can be rapidly produced in nanomaterials to provide protection against diseases like Ebola and influenza within days. Both studies demonstrate the importance of continued biological research on cells to develop new treatment methods and address issues like antimicrobial resistance and pandemic outbreaks.
Molecular Biologist Academic CV for Industry or Private Sector Consideration
Molecular Biologist with over thirteen years of hands-on research experience, impactful writer and presenter, dynamic leader and enthusiastic team player with an eye for great ideas and a passion to move science in new directions seeks challenging opportunities beyond the bench.
Genetic Mapping
Genetic mapping is used to determine the specific location of genes on chromosomes. Knowing gene locations can help identify genetic diseases and their underlying causes. One document describes how researchers used genetic techniques to identify a gene (PSR1) in algae that increases lipid production without subjecting the algae to stress. This could allow for lipid extraction and energy production while preserving the algae species. A second document discusses a new method developed by the University of Haifa to reduce the number of possible genetic effects to study from millions to thousands. The method was tested successfully in a plant with over 7,000 genes. This type of research can help identify genetic diseases more easily and determine the best treatments.
GENETIC MAPPING
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
Plegable Proteínas - Biología Molecular
This document discusses several articles about proteins and their roles. It first provides background on proteins and their functions as enzymes, antibodies, channels and receptors. It then summarizes two research articles. The first article finds that the RAB35 protein, which normally regulates protein transport, can also drive cancer formation when mutated. The second article details research that used x-ray crystallography to determine the atomic structure of the HIV capsid protein, which helps HIV replicate and could inform new antiviral drugs. The document concludes by discussing the medical applications of studying protein structures.
Folding
The document discusses two scientific studies:
1) A study that used the CRISPR/Cas9 gene editing system to simultaneously disrupt two target genes in monkey embryos, paving the way for valuable human disease models. Researchers were able to generate mutations in targeted genes without off-target effects.
2) A study showing that activating the tumor suppressor p53 in normal cells causes them to secrete the potent tumor suppressor Par-4, which induces cell death in p53-deficient cancer cells. This suggests a potential approach for preventing therapy resistance in tumors.
Genetic mapping Plegable
This document discusses genetic mapping and its various medical applications. It describes how genetic mapping is used to identify the positions of genes within genomes and locate genes associated with certain traits or diseases. Specifically, it mentions two studies: one that used genetic mapping in mice to identify the pituitary tumor transforming gene's role in liver fibrosis, and another that mapped genes responsible for leaf rust resistance in wheat. The document also outlines some of genetic mapping's utility in medical fields like assessing disease predispositions, genetically engineering crop resistance, and examining fetal genetics during high-risk pregnancies.
Folding molecular biology
The document discusses how identifying mutations in human genes through advances in biotechnology can help prevent and treat cancers and genetic diseases. As more is learned about the human genome and specific gene mutations, new arguments emerge to support gene therapy as a potential treatment method, especially as it becomes better understood and can be implemented safely and ethically. The knowledge of the human genome continues to grow each year through investigations like those mentioned.
The Human Genome Project
The sequencing of the complete human genome has led to three key outcomes:
1) It has allowed for improved forensics like identifying suspects through DNA evidence and exonerating those wrongly convicted.
2) It has enabled advances in molecular medicine such as improving gene therapy and developing earlier detection methods for genetic diseases.
3) It has facilitated better risk assessment including evaluating health risks from radiation exposure and carcinogens.
EGRupdatedCVwithCL052015
Erik Rogers earned his M.S. in Molecular and Cellular Biology and B.S. in Molecular Bioscience and Biotechnology from Arizona State University, where he worked as a teaching assistant for several courses. His research focused on the role of inflammation in muscle repair and regeneration. He has published two papers and presented his work at several conferences. Erik has extensive experience in histology, molecular biology techniques, cell culture, microscopy, and animal research. He is looking to apply his skills in an industrial research setting.
Human genome project by kk sahu
What is bioinformatics?
About human genome
Human genome project
Aim of human genome project
History
Sequencing Strategy
Benefits of Human Genome Project research
Disadvantages of human genome project
Conclusion
References
Plegable- Splicing
The document discusses two news articles about scientific research. The first article talks about a graduate student named Tuttle who studies the spliceosome and wants to share her passion for science with youth. The second article discusses research on using antisense oligonucleotides to treat spinal muscular atrophy by correcting defects in alternative splicing. The student observes that splicing is an important molecular process that is fundamental to understanding and curing diseases.
Molecular Systematics and Biodiversity
Molecular Systematics and Biodiversity
Presented By: Sarwar AD
Research Scholar
Department of Zoology
GC University Lahore Pakistan
Dna replication
The document discusses DNA replication and how it can go awry. It normally faithfully copies DNA but the APOBEC protein, which normally protects against viruses, can instead cause mutations by interfering with replication. This can lead to cancer. Researchers identified that the protein SMARCAL1 is key to alternative lengthening of telomeres (ALT), a pathway cancer cells use to maintain telomere length and bypass growth arrest. Understanding these replication and repair pathways could lead to new targeted cancer therapies.
Dna replication 2
The document discusses DNA replication and the role of the APOBEC protein. It summarizes that DNA replication is the process where one DNA molecule makes two identical copies of itself. It then explains that the APOBEC protein normally protects against viruses but can also cause mutations during DNA replication, potentially leading to cancer. The student notes it is important to understand these mechanisms to research ways to prevent cancer. A second section discusses how cancer cells can maintain telomere length to continue replicating, and researchers have identified the protein SMARCAL1 as playing a key role in this alternative lengthening of telomeres pathway used by some cancer cells. Understanding this pathway could lead to new targeted cancer therapies.
Introducción a la bioinformatica
The document introduces bioinformatics and discusses its goals and applications. Bioinformatics involves using computational tools and databases to analyze and understand biological data like DNA, RNA, and proteins. It has two main subfields - developing computational tools and databases, and applying these tools to generate biological knowledge and insights into living systems. Bioinformatics aims to better understand cells at the molecular level and how they function. It has applications in areas like drug design, forensics, agriculture, and medicine.
Human genome project
The document summarizes the human genome project. It discusses that the goal of the project was to map all the genes in the human DNA and determine the sequence of the 3 billion nucleotide base pairs. It was a large international project started in 1990 involving many universities. Some key milestones were determining the genes and their sequences, improving data analysis tools, and addressing ethical issues. The project provided benefits like understanding disease and developing personalized medicine. However, it also raised social issues regarding privacy of genetic data and potential discrimination. The sequencing revealed there are around 30,000 genes but many functions are still unknown. Future challenges include determining non-coding DNA and gene functions.
Folding.cielo
The document summarizes several research articles on gene transcription and regulation. It discusses a study that described a gene network regulated by the splicing factor NOVA1 during vertebrate brain development. It also outlines research on the mechanisms that generate chromosomal breaks in bacteria like E. coli during collisions between DNA replication and transcription. Understanding these mechanisms is important for treating infectious diseases and explaining some human genetic diseases. The realization of these investigations leads to advances in disease diagnosis, explanation, and prevention.
Human genome project 2007
The human genome project mapped the entire human genetic code and identified approximately 30,000 human genes, providing insights into the genetic basis of diseases and opportunities for new diagnostic tests and treatments. Gene therapy aims to treat diseases by modifying genes, either in vivo by introducing normal genes into patients' cells to replace mutated genes or ex vivo by extracting cells, modifying them genetically, and returning them to patients. While promising, gene therapy faces challenges in safety, delivery methods, and treating complex multi-gene disorders.
THE CELL AND ITS EVOLUTION
This document discusses several studies related to viruses and the immune system. It first summarizes a study that found a patient had a successful immune response to Lassa virus infection characterized by early IFN-α expression and activated CD8 T cells, which correlated with virus clearance. It next summarizes a modeling study that found eliminating HPV16-related cervical cancer requires higher vaccine efficacy than other HPV types due to differences in infection duration and cancer risk. The document concludes by stating these studies help understand life processes important for treatment and many medical technologies are inspired by biological research.
Post human genome project
The document summarizes several genome and brain mapping projects that followed the completion of the Human Genome Project in 2003. It describes the objectives and outcomes of the HapMap Project, ENCODE Project, Human Proteome Project, European Commission's Human Brain Project, and U.S. Brain Mapping Project. All of these projects aimed to further understand the human genome and proteome, characterize gene functions, and map the structure and diseases of the human brain. The research generated vast amounts of freely available data and furthered knowledge in human biology, disease research, and brain-inspired technologies.
Unlocking The Secrets Of DNA And First View Of DNA Damage Within Entire Human...
Neutron scattering can provide information about the correlation between DNA base pairs during denaturation, which is not possible using other techniques. The experiment measured the first stage of the melting transition where DNA strands separate as the bonds between base pairs break. A new technique developed at Cardiff University allows scientists to examine DNA damage across all 28,000 human genes for the first time, providing an unprecedented view of damage that can lead to cancer. This novel technology will have implications for cancer risk assessment, diagnostics, and developing new therapeutics.
Impact of the human genome project on medical advancement in India.
Impact of the human genome project on medical advancement in India.University of Petroleum and Energy studies
This document discusses the impact of the Human Genome Project on medical advancement in India. It provides background on the human genome and the goals and processes of the Human Genome Project. Completing the human genome sequence provides benefits like enabling the diagnosis and treatment of genetic diseases in India. However, challenges remain like determining gene functions and understanding complex genetic traits. Overall, the document argues that further utilizing genome sequencing can help India better understand and manage its burden of genetic diseases.Central dogma of genetic information
The documents discuss new research challenging the idea of the selfish gene, proposing that evolution is instead driven by the selfish ribosome. The ribosome contains the machinery for translating genetic information from DNA into proteins. Research suggests the ribosome was central to the origin of the first cell and its complex structure makes even minor mutations highly lethal for viruses. Studies of the central dogma of genetics and how life began are important for advancing medicine by providing new perspectives to approach genetic problems and find cures for diseases.
Human genome project and elsi
The document discusses the Human Genome Project (HGP), including its goals, key milestones, and findings. It also examines some of the ethical, legal, and social issues raised by the HGP. In 3 sentences:
The HGP was an international scientific research project begun in 1990 that aimed to map and sequence the entire human genome. It was completed in 2003, revealing that the human genome contains over 3 billion DNA base pairs and around 30,000 genes. However, the HGP also raised important ethical questions around issues like privacy, ownership, justice, and the potential for discrimination.
Plegable molecular
The document discusses the importance of DNA studies for improving quality of life and advancing medicine. DNA plays a key role in transporting drugs across cell membranes and can be used in gene therapy by altering intracellular functions with packaged DNA delivered into cells. Studies of DNA cages and sequences help develop new drug delivery methods and genetic experiments for implanting new gene therapies to potentially treat diseases and prevent malformations by correcting transcriptional errors in the genome.
PLEGABLE BIOLOGIA MOLECULAR 2012
1. Researchers have developed a new method for more efficiently labeling proteins that is faster, higher yielding, and less disruptive to protein and cell function than current methods.
2. They engineered mammalian cells to incorporate an artificial chemical handle that allows a small fluorescent molecule to rapidly and stably attach to proteins of interest, enabling new types of cell biological studies.
3. Understanding protein interactions with nanomaterials at the nanoscale is important for controlling their function in applications like biosensing and tissue engineering, and for developing new composite materials.
Diapositivas plegable carolina cardona tobon
This document summarizes genetic mapping techniques and their medical utility. It discusses a new technique that maps phosphohistidine markers on proteins using antibodies, allowing visualization of this previously difficult to see bond. It also describes research finding a genetic marker, Lgr5, that is expressed after damage to supporting cells in the inner ear, causing proliferation and replacement of lost hair cells. Genome mapping is important for medical applications as it allows localization of genes associated with diseases to better understand illness processes and develop improved treatments, helping to advance precision medicine and improve quality of life.
More Related Content
What's hot
Genetic mapping Plegable
This document discusses genetic mapping and its various medical applications. It describes how genetic mapping is used to identify the positions of genes within genomes and locate genes associated with certain traits or diseases. Specifically, it mentions two studies: one that used genetic mapping in mice to identify the pituitary tumor transforming gene's role in liver fibrosis, and another that mapped genes responsible for leaf rust resistance in wheat. The document also outlines some of genetic mapping's utility in medical fields like assessing disease predispositions, genetically engineering crop resistance, and examining fetal genetics during high-risk pregnancies.
Folding molecular biology
The document discusses how identifying mutations in human genes through advances in biotechnology can help prevent and treat cancers and genetic diseases. As more is learned about the human genome and specific gene mutations, new arguments emerge to support gene therapy as a potential treatment method, especially as it becomes better understood and can be implemented safely and ethically. The knowledge of the human genome continues to grow each year through investigations like those mentioned.
The Human Genome Project
The sequencing of the complete human genome has led to three key outcomes:
1) It has allowed for improved forensics like identifying suspects through DNA evidence and exonerating those wrongly convicted.
2) It has enabled advances in molecular medicine such as improving gene therapy and developing earlier detection methods for genetic diseases.
3) It has facilitated better risk assessment including evaluating health risks from radiation exposure and carcinogens.
EGRupdatedCVwithCL052015
Erik Rogers earned his M.S. in Molecular and Cellular Biology and B.S. in Molecular Bioscience and Biotechnology from Arizona State University, where he worked as a teaching assistant for several courses. His research focused on the role of inflammation in muscle repair and regeneration. He has published two papers and presented his work at several conferences. Erik has extensive experience in histology, molecular biology techniques, cell culture, microscopy, and animal research. He is looking to apply his skills in an industrial research setting.
Human genome project by kk sahu
What is bioinformatics?
About human genome
Human genome project
Aim of human genome project
History
Sequencing Strategy
Benefits of Human Genome Project research
Disadvantages of human genome project
Conclusion
References
Plegable- Splicing
The document discusses two news articles about scientific research. The first article talks about a graduate student named Tuttle who studies the spliceosome and wants to share her passion for science with youth. The second article discusses research on using antisense oligonucleotides to treat spinal muscular atrophy by correcting defects in alternative splicing. The student observes that splicing is an important molecular process that is fundamental to understanding and curing diseases.
Molecular Systematics and Biodiversity
Molecular Systematics and Biodiversity
Presented By: Sarwar AD
Research Scholar
Department of Zoology
GC University Lahore Pakistan
Dna replication
The document discusses DNA replication and how it can go awry. It normally faithfully copies DNA but the APOBEC protein, which normally protects against viruses, can instead cause mutations by interfering with replication. This can lead to cancer. Researchers identified that the protein SMARCAL1 is key to alternative lengthening of telomeres (ALT), a pathway cancer cells use to maintain telomere length and bypass growth arrest. Understanding these replication and repair pathways could lead to new targeted cancer therapies.
Dna replication 2
The document discusses DNA replication and the role of the APOBEC protein. It summarizes that DNA replication is the process where one DNA molecule makes two identical copies of itself. It then explains that the APOBEC protein normally protects against viruses but can also cause mutations during DNA replication, potentially leading to cancer. The student notes it is important to understand these mechanisms to research ways to prevent cancer. A second section discusses how cancer cells can maintain telomere length to continue replicating, and researchers have identified the protein SMARCAL1 as playing a key role in this alternative lengthening of telomeres pathway used by some cancer cells. Understanding this pathway could lead to new targeted cancer therapies.
Introducción a la bioinformatica
The document introduces bioinformatics and discusses its goals and applications. Bioinformatics involves using computational tools and databases to analyze and understand biological data like DNA, RNA, and proteins. It has two main subfields - developing computational tools and databases, and applying these tools to generate biological knowledge and insights into living systems. Bioinformatics aims to better understand cells at the molecular level and how they function. It has applications in areas like drug design, forensics, agriculture, and medicine.
Human genome project
The document summarizes the human genome project. It discusses that the goal of the project was to map all the genes in the human DNA and determine the sequence of the 3 billion nucleotide base pairs. It was a large international project started in 1990 involving many universities. Some key milestones were determining the genes and their sequences, improving data analysis tools, and addressing ethical issues. The project provided benefits like understanding disease and developing personalized medicine. However, it also raised social issues regarding privacy of genetic data and potential discrimination. The sequencing revealed there are around 30,000 genes but many functions are still unknown. Future challenges include determining non-coding DNA and gene functions.
Folding.cielo
The document summarizes several research articles on gene transcription and regulation. It discusses a study that described a gene network regulated by the splicing factor NOVA1 during vertebrate brain development. It also outlines research on the mechanisms that generate chromosomal breaks in bacteria like E. coli during collisions between DNA replication and transcription. Understanding these mechanisms is important for treating infectious diseases and explaining some human genetic diseases. The realization of these investigations leads to advances in disease diagnosis, explanation, and prevention.
Human genome project 2007
The human genome project mapped the entire human genetic code and identified approximately 30,000 human genes, providing insights into the genetic basis of diseases and opportunities for new diagnostic tests and treatments. Gene therapy aims to treat diseases by modifying genes, either in vivo by introducing normal genes into patients' cells to replace mutated genes or ex vivo by extracting cells, modifying them genetically, and returning them to patients. While promising, gene therapy faces challenges in safety, delivery methods, and treating complex multi-gene disorders.
THE CELL AND ITS EVOLUTION
This document discusses several studies related to viruses and the immune system. It first summarizes a study that found a patient had a successful immune response to Lassa virus infection characterized by early IFN-α expression and activated CD8 T cells, which correlated with virus clearance. It next summarizes a modeling study that found eliminating HPV16-related cervical cancer requires higher vaccine efficacy than other HPV types due to differences in infection duration and cancer risk. The document concludes by stating these studies help understand life processes important for treatment and many medical technologies are inspired by biological research.
Post human genome project
The document summarizes several genome and brain mapping projects that followed the completion of the Human Genome Project in 2003. It describes the objectives and outcomes of the HapMap Project, ENCODE Project, Human Proteome Project, European Commission's Human Brain Project, and U.S. Brain Mapping Project. All of these projects aimed to further understand the human genome and proteome, characterize gene functions, and map the structure and diseases of the human brain. The research generated vast amounts of freely available data and furthered knowledge in human biology, disease research, and brain-inspired technologies.
Unlocking The Secrets Of DNA And First View Of DNA Damage Within Entire Human...
Neutron scattering can provide information about the correlation between DNA base pairs during denaturation, which is not possible using other techniques. The experiment measured the first stage of the melting transition where DNA strands separate as the bonds between base pairs break. A new technique developed at Cardiff University allows scientists to examine DNA damage across all 28,000 human genes for the first time, providing an unprecedented view of damage that can lead to cancer. This novel technology will have implications for cancer risk assessment, diagnostics, and developing new therapeutics.
Impact of the human genome project on medical advancement in India.
Impact of the human genome project on medical advancement in India.University of Petroleum and Energy studies
This document discusses the impact of the Human Genome Project on medical advancement in India. It provides background on the human genome and the goals and processes of the Human Genome Project. Completing the human genome sequence provides benefits like enabling the diagnosis and treatment of genetic diseases in India. However, challenges remain like determining gene functions and understanding complex genetic traits. Overall, the document argues that further utilizing genome sequencing can help India better understand and manage its burden of genetic diseases.Central dogma of genetic information
The documents discuss new research challenging the idea of the selfish gene, proposing that evolution is instead driven by the selfish ribosome. The ribosome contains the machinery for translating genetic information from DNA into proteins. Research suggests the ribosome was central to the origin of the first cell and its complex structure makes even minor mutations highly lethal for viruses. Studies of the central dogma of genetics and how life began are important for advancing medicine by providing new perspectives to approach genetic problems and find cures for diseases.
Human genome project and elsi
The document discusses the Human Genome Project (HGP), including its goals, key milestones, and findings. It also examines some of the ethical, legal, and social issues raised by the HGP. In 3 sentences:
The HGP was an international scientific research project begun in 1990 that aimed to map and sequence the entire human genome. It was completed in 2003, revealing that the human genome contains over 3 billion DNA base pairs and around 30,000 genes. However, the HGP also raised important ethical questions around issues like privacy, ownership, justice, and the potential for discrimination.
Plegable molecular
The document discusses the importance of DNA studies for improving quality of life and advancing medicine. DNA plays a key role in transporting drugs across cell membranes and can be used in gene therapy by altering intracellular functions with packaged DNA delivered into cells. Studies of DNA cages and sequences help develop new drug delivery methods and genetic experiments for implanting new gene therapies to potentially treat diseases and prevent malformations by correcting transcriptional errors in the genome.
What's hot (20)
Unlocking The Secrets Of DNA And First View Of DNA Damage Within Entire Human...
Unlocking The Secrets Of DNA And First View Of DNA Damage Within Entire Human...
Impact of the human genome project on medical advancement in India.
Impact of the human genome project on medical advancement in India.
Similar to 2016 dec idat-mbib-do_ehighlight2016
PLEGABLE BIOLOGIA MOLECULAR 2012
1. Researchers have developed a new method for more efficiently labeling proteins that is faster, higher yielding, and less disruptive to protein and cell function than current methods.
2. They engineered mammalian cells to incorporate an artificial chemical handle that allows a small fluorescent molecule to rapidly and stably attach to proteins of interest, enabling new types of cell biological studies.
3. Understanding protein interactions with nanomaterials at the nanoscale is important for controlling their function in applications like biosensing and tissue engineering, and for developing new composite materials.
Diapositivas plegable carolina cardona tobon
This document summarizes genetic mapping techniques and their medical utility. It discusses a new technique that maps phosphohistidine markers on proteins using antibodies, allowing visualization of this previously difficult to see bond. It also describes research finding a genetic marker, Lgr5, that is expressed after damage to supporting cells in the inner ear, causing proliferation and replacement of lost hair cells. Genome mapping is important for medical applications as it allows localization of genes associated with diseases to better understand illness processes and develop improved treatments, helping to advance precision medicine and improve quality of life.
CV LaSalleSandra
This document is a resume for Sandra Anderson LaSalle, who has over 20 years of experience in clinical and basic science research. She has worked in a variety of roles including as a research scientist at Merck, Pfizer, and various universities. Her experience includes laboratory management, product development, clinical research, and teaching. She has advanced knowledge in microbiology and experience in fields like oncology, diabetes, and female reproduction.
My presentation2
The document summarizes key points about the human genome project and its impacts over the past 10 years as well as opportunities for the next 10 years. It discusses how the human genome project revealed the blueprint for building a human in 2001 and enabled greater understanding of gene functions and their medical impacts. It then outlines focus areas for genomic medicine in the coming decade like diagnostics, disease biology insights, cancer genome characterization, and clinical informatics. The role of the human microbiome in health and disease is also summarized along with challenges in bioinformatics like data analysis, integration and tools. Ethical and societal issues related to genomics research and medicine are also highlighted.
Lab summariesassignment 2 done
This document contains summaries of three laboratory assignments:
1) The first summary discusses how nanotechnology is used in biomedicine, including using nanoparticles and hydroxyapatite fibers to help regenerate cells and avoid implant corrosion. Electron microscopy is used to study the fibers.
2) The second summary explains how plasminogen activator was isolated from HeLa broth using magnetic affinity nanoparticles, chromatography to measure absorbance, and electrophoresis to analyze protein isolation.
3) The third summary describes an in silico approach to study protein-protein interactions and drug design. The workshop involved identifying a protein target, analyzing interactions, mapping ligand sizes, and analyzing benzene molecule binding and clustering to the target.
Jane Yang_Resume_10-2016
This resume summarizes the qualifications of Jane Yang, a scientist with extensive experience in cancer biology, transcriptional and epigenetic regulation, and cell differentiation. She has over 15 years of research experience, including positions at Genentech and Stanford University where she led projects discovering new mechanisms of action for small molecule inhibitors and identifying protein complexes involved in cell fate decisions. Her publications include high-impact articles in journals such as Cell Death and Differentiation and Genes & Development. She has strong skills in molecular and biochemical techniques and has received competitive NIH funding and honors for her work.
Molecular biology
The document summarizes several studies on DNA replication and the molecular machinery involved. It describes how researchers used tools like molecular biology and biochemistry to slow down and "freeze" the replication process at intermediate steps. This allowed them to observe conformational changes in proteins like the origin recognition complex (ORC) as it recruits the helicase enzyme to unwind DNA. Cryo-electron microscopy was then used to capture 3D structures of the protein components and reveal how they interact during replication initiation. The studies provide new insights into this critical cellular process.
Juan Lab Summary 2
This document contains summaries of three laboratory assignments from a biomedical techniques course at the University of Puerto Rico - Cayey. The first summary describes learning about nanotechnology and observing nano fibers using an electron microscope. The second discusses using nanoparticles and affinity chromatography to isolate specific proteins, then using SDS-Page gel electrophoresis to measure the results. The third summary explains how computer programs help researchers visualize proteins and compare them to databases to understand protein-protein interactions and design new drugs.
2016-07-CV_JaemunChoi04
This document provides a summary of the research experience and qualifications of Jae-Mun Choi, a postdoctoral research associate at Baylor College of Medicine. It outlines his educational background, including a Ph.D. in structural biology from Baylor College of Medicine, as well as his extensive experience in structural biology research on viruses like norovirus and rotavirus. It also details his technical expertise and accomplishments, such as authoring several published research papers.
Gdt 2-126
1) Nanomedicine uses nanotechnology to prevent and treat disease by imparting properties like antibacterial and anti-odor functionality to skin products using nanomaterials.
2) Molecular biomimetics marries materials science and molecular biology to develop functional hybrid systems composed of inorganic and protein materials. It uses protein templates designed through genetics, surface proteins to bind synthetic entities, and the ability of proteins to self-assemble into complex structures.
3) Combinatorial biology techniques like phage display and cell-surface display are used to select protein sequences that strongly bind to inorganic surfaces from large random peptide libraries. This allows obtaining inorganic-binding proteins without an a priori knowledge of their sequence.
Gdt 2-126 (1)
1) The document discusses interfaces between nanoelectronic and biological systems, including applications of nanotechnology in medicine (nanomedicine) and molecular biomimetics.
2) It describes techniques like phage display and cell surface display that use libraries of random peptides to select sequences that bind to inorganic surfaces for constructing hybrid biomaterials.
3) The applications discussed include bio-nanowire devices for ultrasensitive detection, nanowire-based sensors for cancer markers, and interfaces between nanoelectronic devices and cells.
CV_Timothy_Sanchez_Dec2015
This document is a resume for Timothy C. Sanchez. It summarizes his education, research experience, publications, presentations, honors and awards. The key points are:
- He has a PhD in Biomedical Engineering from UNM and previous degrees from Northern New Mexico College and New Mexico Highlands University.
- His research experience includes projects at Los Alamos National Laboratory from 2007-present related to proteomics, metabolomics, and nanotoxicology using various analytical techniques like mass spectrometry.
- He has over 10 peer-reviewed publications and numerous conference presentations and posters.
- Notable honors include distinguished performance awards from LANL and graduate scholarships from UNM.
CV Resume David Moore PRAHS 2015
This document provides biographical and career information about David S. Moore. It includes his education history, with PhD and MS degrees in Pharmacology & Toxicology from the University of Kansas. It lists his appointments including director of microscopy laboratories and various research positions. It also provides details of his patents, teaching experience, and publications.
Listado de proyectos Programa INPhINIT-CSIC
El programa INPhINIT está dirigido a los candidatos de doctorado más motivados y se centra en los campos de investigación en los que España destaca: las ciencias de la salud y de la vida, la tecnología, la física, la ingeniería y las matemáticas https://obrasociallacaixa.org/es/educacion-becas/becas-de-posgrado/inphinit/programme-description
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
Abstract
Pharos (https://pharos.nih.gov/) is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current version of Pharos (as of October 2019) spans 20,244 proteins in the human proteome, 19,880 disease and phenotype associations, and 226,829 ChEMBL compounds. This resource not only collates and analyzes data from over 60 high-quality resources to generate these types, but also uses text indexing to find less apparent connections between targets, and has recently begun to collaborate with institutions that generate data and resources. Proteins are ranked according to a knowledge-based classification system, which can help researchers to identify less studied “dark” targets that could be potentially further illuminated. This is an important process for both drug discovery and target validation, as more knowledge can accelerate target identification, and previously understudied proteins can serve as novel targets in drug discovery. In this webinar, Dr. Tudor Oprea will introduce how to use Pharos to find targets of interest for drug discovery.
The top 3 key questions that Pharos can answer:
1. What are the novel drug targets that may play a role in a specific disease?
2. What are the diseases that are related directly or indirectly to a drug target?
3. Find researchers that are related directly or indirectly to a drug target.
Presenter: Tudor Oprea, MD, PhD, Professor of Medicine, Chief of Translational Informatics Division & Internal Medicine, University of New Mexico
dkNET Webinar Information: https://dknet.org/about/webinar
Urmi Roy, Clarkson University, Potsdam
This document provides a curriculum vitae for Urmi Roy, including her contact information, education history, research interests, publications, presentations, and affiliations. She received her Ph.D. from the Indian Institute of Chemical Biology in 2002 and is currently an Adjunct Research Associate Professor at Clarkson University. Her research focuses on structural biology, protein chemistry, and computational modeling to explore applications in drug discovery. She has over 20 publications and has presented her work at several conferences.
Ijetr021102
ER Publication,
IJETR, IJMCTR,
Journals,
International Journals,
High Impact Journals,
Monthly Journal,
Good quality Journals,
Research,
Research Papers,
Research Article,
Free Journals, Open access Journals,
erpublication.org,
Engineering Journal,
Science Journals,
Ijetr021102
Engineering Research Publication
Best International Journals, High Impact Journals,
International Journal of Engineering & Technical Research
ISSN : 2321-0869 (O) 2454-4698 (P)
www.erpublication.org
PROTEINS (Molecular Biology)
The document discusses two studies related to protein synthesis and cancer. The first study developed a new method to selectively silence genes encoding proteins to determine their function in tumor cells. The second study identified the protein components responsible for inserting membrane proteins, resolving a mechanism that was previously unknown. Understanding protein functions and interactions is important for gaining insights into the origins of cancer and developing prevention and treatment strategies.
Human genome project(ibri)
The document provides an overview of the Human Genome Project (HGP). It describes the HGP's goal of mapping and sequencing the entire human genome. The HGP was an international research effort that worked alongside a private company, Celera Genomics, to complete a rough draft of the human genome by 2000. The completion of the HGP marked a major scientific achievement and has transformed fields like medicine, biotechnology, and genetics by providing a comprehensive map of the human genetic code.
Similar to 2016 dec idat-mbib-do_ehighlight2016 (20)
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
dkNET Webinar: Illuminating The Druggable Genome With Pharos 10/23/2020
Recently uploaded
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
原版制作(carleton毕业证书)卡尔顿大学毕业证硕士文凭原版一模一样
原版纸张【微信：741003700 】【(carleton毕业证书)卡尔顿大学毕业证】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原海外各大学 Bachelor Diploma degree, Master Degree Diploma
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
3D Hybrid PIC simulation of the plasma expansion (ISSS-14)
3D Particle-In-Cell (PIC) algorithm,
Plasma expansion in the dipole magnetic field.
Thornton ESPP slides UK WW Network 4_6_24.pdf
ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
and the revised UWWTD (Urban Waste Water Treatment Directive)”
20240520 Planning a Circuit Simulator in JavaScript.pptx
Evaporation step counter work. I have done a physical experiment.
(Work in progress.)
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterTexas Alliance of Groundwater Districts
Presented at June 6-7 Texas Alliance of Groundwater Districts Business MeetingSAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Shallowest Oil Discovery of Turkiye.pptx
The Petroleum System of the Çukurova Field - the Shallowest Oil Discovery of Türkiye, Adana
Recently uploaded (20)
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
3D Hybrid PIC simulation of the plasma expansion (ISSS-14)
3D Hybrid PIC simulation of the plasma expansion (ISSS-14)
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
Equivariant neural networks and representation theory
Equivariant neural networks and representation theory
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
2016 dec idat-mbib-do_ehighlight2016
- 1. Biological Nanomachine Architecture and Designed Function with SAXS through DOE/BER:IDAT “Designing and defining dynamic protein cage nanoassemblies in solution” Science Advances Dec 14th 2016 IDAT: Greg L. Hura & John A. Tainer collaboration with UCLA-DOE Institute: Yen Ting Lai and Todd O. Yeates Emergent DOE/BER methodologies for using SAXS to inform on protein design
- 2. Structure and Mechanisms of Complex Biological Pathways with Combined X-ray Methods through DOE/BER:IDAT Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance NATURE COMMUNICATIONS Industrial Collaborators: Pfizer FEB 10 2016 Scaling Atomic to Cellular Distances for Microbial Epigenetic Control Cellular X-ray Tomography Mutant 1 Mutant 2 Hammel M, Larabell C. Tainer JA et al Science Advances July 2016 Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex NATURE By: Aydin, Halil; et al. JUN 23 2016 Biology requires complex protein and DNA assemblies that can only be characterized by multiple techniques at multiple scales An Intrinsically Disordered APLF Links Ku, DNA- PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex. JBC By:Hammel M, Tainer JA, et al NOV 14 2016
Editor's Notes
- The DOE/BER funded IDAT (Integrated Diffraction Analysis Technologies) program supports combining two biophysical techniques of SAXS (small angle X-ray scattering) and MX (Macromolecular Crystallography). When IDAT started SAXS was a niche technique but because we made use of significant and wide spread innovation in MX for SAXS, we have made SAXS accessible to hundreds of groups. A recently demonstrated “killer app” of SAXS is in the realm of macromolecular engineering. In Science, Nature and other journals this year SAXS we and IDAT supported users are creating novel structures with profound impact. Many constructs are also being patented with SAXS data. An example is the large (600kDa) self- assembling pyramid that expands, collapses or disassembles in response to solution conditions. We will build off of this structure to carry payloads for a variety of applications.
- The joint application of SAXS, MX and other technologies is at the core of IDAT. It is well recognized that biology spans many scales. By combining MX and SAX we span the atomic to intra-cellular scale as demonstrated in many publications where IDAT collaborated with users. We have gone further and added X-ray Tomography with another synchrotron beamline (BER funded NCXT) to visualize the impact of changes to one protein in bacteria. The protein, HU, is modular in that it can either bind to an identical copy of itself forming an HU or it can bind to a different form making HU. These two forms appear during different stages of bacterial growth, creating different degrees of compaction in its DNA. We can visualize this compaction and atomically identify the mechanism using the combined techniques.