Genetic factors can cause inherited bleeding disorders through mutations in single genes, variants in genes, or chromosomal imbalances. The document discusses two main inherited bleeding disorders: von Willebrand disease and hemophilia. Von Willebrand disease is caused by mutations in the von Willebrand factor gene and is characterized by a decreased von Willebrand factor level. Hemophilia A is caused by factor VIII deficiency due to mutations on the X chromosome, while hemophilia B is caused by factor IX deficiency. The severity of hemophilia depends on the factor level.