Warner hotel group introduced an alcoholic ice cream van to cater to their adult-only hotel guests. Research showed that a third of men over 45 prefer beer and 15% of women prefer cocktails, so the hotel designed a van serving ice cream mixed with alcohol to appeal to customers' childhood memories and preferred drinks.
A professional services marketplace set up a new "Pokemon Go trainer" category on its website to capitalize on the popularity of the mobile game. The category allowed trainers to offer their services and was quickly added to the site.
Lucasfilm's ILMxLAB virtual reality division unveiled plans for an immersive VR experience featuring Darth Vader from Star Wars. The project will incorporate virtual
This document provides instructions for downloading, building, and flashing kernels for the Dell Venue 7 3740 and Venue 8 3840 tablets. It describes prerequisites, downloading required drivers and tools, flashing stock firmware, rooting the device and unlocking the bootloader using an OTA package, building a custom kernel from source code and flashing it, and an unbricking process for troubleshooting issues.
This document discusses cross-cultural communication and awareness. It defines culture as a shared system of meanings and experiences that influence how people view and interact with the world. Cross-cultural communication focuses on how people from different backgrounds communicate across cultures. Culture can influence what people notice and how they make sense of what they see. Barriers to cross-cultural understanding include ethnocentrism, stereotyping, and cultural blindness. Developing cross-cultural awareness and respecting differences are important for effective communication across cultures.
business development sales plan is an overview of the coaching program for how to generate leads and sales of your products, services and solutions
More info available at http://www.fraserhay.co.uk
sales plan
business development plan
sales strategy
sales pipeline
sales training
sales coaching
business development
pipeline selling
social networking
social selling
online selling
sales management
sales planning
business development strategy
business development checklist
sales training checklist
The document discusses thermoregulation and normal body temperature. It notes that the hypothalamus contains heat- and cold-sensitive neurons that detect core and skin temperatures and trigger various neuronal mechanisms to increase or decrease body heat through processes like vasodilation, sweating, shivering and chemical thermogenesis. These keep the body's core temperature within a normal range of 36.1-37.8°C (97.0-100°F) orally. Fever results when pyrogens raise the hypothalamic set point.
The spinothalamic system transmits somatosensory information about pain, temperature, and crude touch from the skin to the thalamus. It consists of first-order neurons in the dorsal horn that synapse on second-order neurons in the spinal cord. These second-order neurons decussate and ascend contralaterally to the thalamus. They then synapse on third-order neurons that project to the somatosensory cortex. The system includes the lateral and anterior spinothalamic tracts, which are important for localization of painful or thermal stimuli. It also includes smaller tracts that project to the reticular formation and tectum.
An illustration about what happens from the beginning to the end of a septic shock & what are the factors that cause it.
*There are notes provided in some slides.
Warner hotel group introduced an alcoholic ice cream van to cater to their adult-only hotel guests. Research showed that a third of men over 45 prefer beer and 15% of women prefer cocktails, so the hotel designed a van serving ice cream mixed with alcohol to appeal to customers' childhood memories and preferred drinks.
A professional services marketplace set up a new "Pokemon Go trainer" category on its website to capitalize on the popularity of the mobile game. The category allowed trainers to offer their services and was quickly added to the site.
Lucasfilm's ILMxLAB virtual reality division unveiled plans for an immersive VR experience featuring Darth Vader from Star Wars. The project will incorporate virtual
This document provides instructions for downloading, building, and flashing kernels for the Dell Venue 7 3740 and Venue 8 3840 tablets. It describes prerequisites, downloading required drivers and tools, flashing stock firmware, rooting the device and unlocking the bootloader using an OTA package, building a custom kernel from source code and flashing it, and an unbricking process for troubleshooting issues.
This document discusses cross-cultural communication and awareness. It defines culture as a shared system of meanings and experiences that influence how people view and interact with the world. Cross-cultural communication focuses on how people from different backgrounds communicate across cultures. Culture can influence what people notice and how they make sense of what they see. Barriers to cross-cultural understanding include ethnocentrism, stereotyping, and cultural blindness. Developing cross-cultural awareness and respecting differences are important for effective communication across cultures.
business development sales plan is an overview of the coaching program for how to generate leads and sales of your products, services and solutions
More info available at http://www.fraserhay.co.uk
sales plan
business development plan
sales strategy
sales pipeline
sales training
sales coaching
business development
pipeline selling
social networking
social selling
online selling
sales management
sales planning
business development strategy
business development checklist
sales training checklist
The document discusses thermoregulation and normal body temperature. It notes that the hypothalamus contains heat- and cold-sensitive neurons that detect core and skin temperatures and trigger various neuronal mechanisms to increase or decrease body heat through processes like vasodilation, sweating, shivering and chemical thermogenesis. These keep the body's core temperature within a normal range of 36.1-37.8°C (97.0-100°F) orally. Fever results when pyrogens raise the hypothalamic set point.
The spinothalamic system transmits somatosensory information about pain, temperature, and crude touch from the skin to the thalamus. It consists of first-order neurons in the dorsal horn that synapse on second-order neurons in the spinal cord. These second-order neurons decussate and ascend contralaterally to the thalamus. They then synapse on third-order neurons that project to the somatosensory cortex. The system includes the lateral and anterior spinothalamic tracts, which are important for localization of painful or thermal stimuli. It also includes smaller tracts that project to the reticular formation and tectum.
An illustration about what happens from the beginning to the end of a septic shock & what are the factors that cause it.
*There are notes provided in some slides.
The document summarizes the descending motor tracts that transmit signals from the brain to lower motor neurons and muscles. It focuses on the pyramidal tracts, including the corticospinal tract which controls voluntary limb movement, and corticobulbar tract which controls head and neck muscles. The corticospinal tract originates in motor areas of the cortex and projects through the brainstem and spinal cord. The corticobulbar tract projects to motor nuclei controlling cranial nerves.
Genetic factors can cause inherited bleeding disorders through mutations in single genes, variants in genes, or chromosomal imbalances. The document discusses two main inherited bleeding disorders: von Willebrand disease and hemophilia. Von Willebrand disease is caused by mutations in the von Willebrand factor gene and is characterized by a decreased von Willebrand factor level. Hemophilia A is caused by factor VIII deficiency due to mutations on the X chromosome, while hemophilia B is caused by factor IX deficiency. The severity of hemophilia depends on the factor level.
G6PD deficiency is an X-linked genetic condition characterized by low levels of the enzyme glucose-6-phosphate dehydrogenase, which helps maintain red blood cell health. People with G6PD deficiency are prone to hemolytic anemia during times of oxidative stress, such as certain infections, foods like fava beans, drugs, and chemicals. The condition is most common in people from the Mediterranean and Africa and provides some protection against malaria.
Epilepsy is characterized by recurrent seizures caused by abnormal neuronal activity in the brain. Seizures can have various presentations depending on the affected brain region. Epilepsy has genetic and acquired causes such as brain injuries, tumors, or infections. Diagnosis involves tests like EEG, MRI, and bloodwork to identify structural or metabolic abnormalities. Treatment focuses on medications, dietary changes, surgery, or devices like vagus nerve stimulators to reduce or eliminate seizures. Identifying a patient's epilepsy syndrome provides guidance on determining causes and appropriate treatments.
This document discusses different types of ear discharge including wax, pus, mucus, blood, and cerebrospinal fluid. It notes that ear discharge can be caused by conditions like otitis externa, otitis media, otomycosis, and trauma. Signs and symptoms of ear discharge include ear pain, swollen ear, itchy ear, vertigo, and tinnitus. The color and consistency of the discharge provides clues to the underlying cause, with purulent discharge indicating infection, mucoid discharge a perforated eardrum, and bloody or clear fluid potential trauma or skull base surgery.
Hematopoiesis occurs in bone marrow where large numbers of white blood cells and red blood cells are generated each hour. Specifically, 2-5 x 108 white blood cells and 1 x 1010 red blood cells are produced per hour through hematopoiesis in bone marrow. This process is essential for generating new blood cells to replenish and maintain the levels in circulation.
Abstract of depression assessment:
- How to assess
- Differential diagnosis for physiologic causes vs. psychological
- Rating scales
*There are notes provided in some slides
Cranial hematomas can be either extra-axial (outside the brain), occurring between membranes covering the brain, or intra-axial (inside the brain). The most common extra-axial hematomas are epidural, subdural, and subarachnoid hematomas. Epidural hematomas typically result from injuries that rupture the middle meningeal artery. Subdural hematomas are caused by tears in bridging veins, while subarachnoid hematomas usually stem from ruptured cerebral aneurysms. In newborns, common cranial hematomas include caput succedaneum, cephalohematoma, and subgaleal hematoma, which are usually due to difficult childbirth and
Autoimmune thyroiditis is an autoimmune disease where antibodies are produced against thyroid antigens, potentially causing inflammation and destruction of thyroid tissue leading to hypothyroidism. It has genetic and environmental risk factors and a higher prevalence in women. Primary hypothyroidism can be caused by autoimmune thyroiditis (Hashimoto's thyroiditis), which is characterized by lymphocytic infiltration of the thyroid gland and sometimes enlargement. Symptoms include weight gain, fatigue, dry skin and hair, and depression.
Anatomical description & illustration of:
- Ankle joint, it's relation with both leg and foot, movements.
- Foot bones, joints, ligaments, movements, arches and clinical significance in both ankle & foot.
*There are notes provided in some slides
Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow characterized by the rapid growth of abnormal white blood cells that build up in the bone marrow and interfere with normal blood cell production. AML is most common in adults around age 50 and has an overall low survival rate of 15-30%. Risk factors include other blood disorders, genetic conditions like Down syndrome, and exposure to chemicals or radiation. Signs and symptoms include fatigue, fever, bleeding, bone pain, and an enlarged spleen or lymph nodes. Laboratory tests show abnormal blood cell counts and the presence of immature white blood cells in the bone marrow. Immunophenotyping helps distinguish AML from other leukemias. Classification systems organize A
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
The document summarizes the descending motor tracts that transmit signals from the brain to lower motor neurons and muscles. It focuses on the pyramidal tracts, including the corticospinal tract which controls voluntary limb movement, and corticobulbar tract which controls head and neck muscles. The corticospinal tract originates in motor areas of the cortex and projects through the brainstem and spinal cord. The corticobulbar tract projects to motor nuclei controlling cranial nerves.
Genetic factors can cause inherited bleeding disorders through mutations in single genes, variants in genes, or chromosomal imbalances. The document discusses two main inherited bleeding disorders: von Willebrand disease and hemophilia. Von Willebrand disease is caused by mutations in the von Willebrand factor gene and is characterized by a decreased von Willebrand factor level. Hemophilia A is caused by factor VIII deficiency due to mutations on the X chromosome, while hemophilia B is caused by factor IX deficiency. The severity of hemophilia depends on the factor level.
G6PD deficiency is an X-linked genetic condition characterized by low levels of the enzyme glucose-6-phosphate dehydrogenase, which helps maintain red blood cell health. People with G6PD deficiency are prone to hemolytic anemia during times of oxidative stress, such as certain infections, foods like fava beans, drugs, and chemicals. The condition is most common in people from the Mediterranean and Africa and provides some protection against malaria.
Epilepsy is characterized by recurrent seizures caused by abnormal neuronal activity in the brain. Seizures can have various presentations depending on the affected brain region. Epilepsy has genetic and acquired causes such as brain injuries, tumors, or infections. Diagnosis involves tests like EEG, MRI, and bloodwork to identify structural or metabolic abnormalities. Treatment focuses on medications, dietary changes, surgery, or devices like vagus nerve stimulators to reduce or eliminate seizures. Identifying a patient's epilepsy syndrome provides guidance on determining causes and appropriate treatments.
This document discusses different types of ear discharge including wax, pus, mucus, blood, and cerebrospinal fluid. It notes that ear discharge can be caused by conditions like otitis externa, otitis media, otomycosis, and trauma. Signs and symptoms of ear discharge include ear pain, swollen ear, itchy ear, vertigo, and tinnitus. The color and consistency of the discharge provides clues to the underlying cause, with purulent discharge indicating infection, mucoid discharge a perforated eardrum, and bloody or clear fluid potential trauma or skull base surgery.
Hematopoiesis occurs in bone marrow where large numbers of white blood cells and red blood cells are generated each hour. Specifically, 2-5 x 108 white blood cells and 1 x 1010 red blood cells are produced per hour through hematopoiesis in bone marrow. This process is essential for generating new blood cells to replenish and maintain the levels in circulation.
Abstract of depression assessment:
- How to assess
- Differential diagnosis for physiologic causes vs. psychological
- Rating scales
*There are notes provided in some slides
Cranial hematomas can be either extra-axial (outside the brain), occurring between membranes covering the brain, or intra-axial (inside the brain). The most common extra-axial hematomas are epidural, subdural, and subarachnoid hematomas. Epidural hematomas typically result from injuries that rupture the middle meningeal artery. Subdural hematomas are caused by tears in bridging veins, while subarachnoid hematomas usually stem from ruptured cerebral aneurysms. In newborns, common cranial hematomas include caput succedaneum, cephalohematoma, and subgaleal hematoma, which are usually due to difficult childbirth and
Autoimmune thyroiditis is an autoimmune disease where antibodies are produced against thyroid antigens, potentially causing inflammation and destruction of thyroid tissue leading to hypothyroidism. It has genetic and environmental risk factors and a higher prevalence in women. Primary hypothyroidism can be caused by autoimmune thyroiditis (Hashimoto's thyroiditis), which is characterized by lymphocytic infiltration of the thyroid gland and sometimes enlargement. Symptoms include weight gain, fatigue, dry skin and hair, and depression.
Anatomical description & illustration of:
- Ankle joint, it's relation with both leg and foot, movements.
- Foot bones, joints, ligaments, movements, arches and clinical significance in both ankle & foot.
*There are notes provided in some slides
Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow characterized by the rapid growth of abnormal white blood cells that build up in the bone marrow and interfere with normal blood cell production. AML is most common in adults around age 50 and has an overall low survival rate of 15-30%. Risk factors include other blood disorders, genetic conditions like Down syndrome, and exposure to chemicals or radiation. Signs and symptoms include fatigue, fever, bleeding, bone pain, and an enlarged spleen or lymph nodes. Laboratory tests show abnormal blood cell counts and the presence of immature white blood cells in the bone marrow. Immunophenotyping helps distinguish AML from other leukemias. Classification systems organize A
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Cell Therapy Expansion and Challenges in Autoimmune Disease
Editor's Notes
In stroke: initial flaccidity (reduced muscle tone), replaced by spasticity (increased muscle tone).
Chronic kidney disease: due to metabolic acidosis (increased excitability of cardiac and neuronal membranes by the promotion of hyperkalemia due to excess acid).
Amphetamine: is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.
It increases monoamine and excitatory neurotransmitter activity in the brain, with its most pronounced effects targeting the catecholamine neurotransmitters norepinephrine and dopamine.
Cocaine: is a strong stimulant mostly used as a recreational drug. Topical cocaine can be used as a local numbing agent and decreasing bleeding during nasal surgery. After cannabis, cocaine is the most frequently used illegal drug globally.
Caffeine is a central nervous system stimulant and is used to reduce physical fatigue and to prevent or treat drowsiness.
It is the world's most widely consumed psychoactive drug.
SSRI: increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption into the presynaptic cell.