This document provides an overview of general research methodology. It defines key terms like research methods and methodology. It discusses the objectives, types, and requirements of research like developing a problem statement, reviewing literature, and study design. It describes different types of studies like descriptive, analytical, and applied. The document emphasizes that research must be systematic, logical, empirical, and replicable to be considered good. It provides examples of various parts of the research process and criteria for evaluating research.
Cross over design, Placebo and blinding techniques Dinesh Gangoda
A crossover design is a modified randomized block design in which each block receives more than one treatment at different dosing periods.
A block can be a patient or a group of patients.
Patients in each block receive different sequences of treatments.
A crossover design is called a complete crossover design if each sequence contains all treatments under investigation.
A placebo is a dummy medicine containing no active substance.
This substance has no therapeutic effect, used as a control in testing new drugs.
Latin- ‘ I shall please’
Medical Research: conflicts between autonomy and beneficence/non maleficence, euthanasia, informed consent, confidentiality, criticisms of orthodox medical ethics
General Research Methodology: Research, objective, requirements,
practical difficulties, review of literature, study design, types of studies,
strategies to eliminate errors/bias, controls, randomization, crossover design,
placebo, blinding techniques.
Cross over design, Placebo and blinding techniques Dinesh Gangoda
A crossover design is a modified randomized block design in which each block receives more than one treatment at different dosing periods.
A block can be a patient or a group of patients.
Patients in each block receive different sequences of treatments.
A crossover design is called a complete crossover design if each sequence contains all treatments under investigation.
A placebo is a dummy medicine containing no active substance.
This substance has no therapeutic effect, used as a control in testing new drugs.
Latin- ‘ I shall please’
Medical Research: conflicts between autonomy and beneficence/non maleficence, euthanasia, informed consent, confidentiality, criticisms of orthodox medical ethics
General Research Methodology: Research, objective, requirements,
practical difficulties, review of literature, study design, types of studies,
strategies to eliminate errors/bias, controls, randomization, crossover design,
placebo, blinding techniques.
Research Methodology_UNIT_I_General Research Methodology M. Pharm (IIIrd Sem.)Prachi Pandey
General Research Methodology: Research, objective, requirements, practical
difficulties, review of literature, study design, types of studies, strategies to eliminate
errors/bias, controls, randomization, crossover design, placebo, blinding techniques.
Criticisms of orthodox medical ethics, importance ofsupriyawable1
ethics is a very large and complex field of study with many branches .medical ethics is the branch of ethics that deals moral issues in medical practice. principles of medical ethics - autonomy ,beneficence ,confidentiality,do not harm,equity .importance of communication .
(I) MEDICAL RESEARCH_ UNIT_III_RESEARCH METHODOLOGY & BIOSTATISTICS.pptxRAHUL PAL
Research Methodology and Biostatistics syllabus:
Medical Research: History, values in medical ethics, autonomy, beneficence, non-maleficence, double effect, conflicts between autonomy.
Medical research has a long and varied history. It has evolved from rudimentary practices to sophisticated, evidence-based methodologies. Some key milestones include the development of the scientific method, the use of randomized controlled trials, the discovery of antibiotics, and the mapping of the human genome. Ethical concerns have also played a significant role in shaping the history of medical research, especially in response to various ethical violations, such as the Tuskegee Syphilis Study and the Nuremberg Trials.
Resolving conflicts between these principles often requires careful consideration, ethical analysis, and, in some cases, consultation with ethics committees or boards. The specific course of action may vary based on the individual circumstances and ethical frameworks employed by healthcare professionals and researchers. Ethical guidelines and regulations also play a significant role in addressing and preventing these conflicts in medical research.
CROSSOVER STUDY DESIGN, DESIGN OF PHARMACOKINETIC STUDIES, FACTORS INFLUENCING BIOAVAILABILITY STUDIES, STUDY DESIGN, PARALLEL DESIGN, CROSS-OVER STUDIES, LATIN SQUARE DESIN, TWO-PERIOD CROSSOVER STUDY DESIGN, BALANCED INCOMPLETE BLOCK DESIGN (BIBD), REPLICATE CROSSOVER STUDY DESIGN , DIFFERENCE BETWEEN PARALLEL AND CROSSOVER STUDY DESIGN.
Introduction to Research - Biostatistics and Research methodology 8th Sem Uni...Himanshu Sharma
This slide contains B.Pharm Biostatistics and Research methodology 8th Sem. Unit-3 L2 topic- "Introduction to Research"
It contains topics:
1. Introduction to Research
2. Need for Research
3. Need for Design Experiments
4. Experimental Design Techniques
5. Plagiarism
What are the applications of Biostatistics in Pharmacy?pharmacampus
Biostatistics broadly deals with statistical applications in the context of biological problems, including medicine, pharmacy, and public health. Government organizations, research institutes and industry have been extensively using statistics and biostatistics
MEDICAL RESEARCH: UNIT_III_ EUTHANASIA, COI, CONFIDENTIALITY RESEARCH METHODO...RAHUL PAL
Medical research in clinical settings is the study of human health and disease in people. It is the primary way that researchers determine if a new form of treatment or prevention, such as a new drug, diet, or medical device, is safe and effective in people.
A clinical trial is designed to learn if a new treatment is more effective or has less harmful side effects than existing treatments.
Clinical trail is basically have 4 phases: Phase I, Phase II, Phase III, Phase IV
Research Methodology_UNIT_I_General Research Methodology M. Pharm (IIIrd Sem.)Prachi Pandey
General Research Methodology: Research, objective, requirements, practical
difficulties, review of literature, study design, types of studies, strategies to eliminate
errors/bias, controls, randomization, crossover design, placebo, blinding techniques.
Criticisms of orthodox medical ethics, importance ofsupriyawable1
ethics is a very large and complex field of study with many branches .medical ethics is the branch of ethics that deals moral issues in medical practice. principles of medical ethics - autonomy ,beneficence ,confidentiality,do not harm,equity .importance of communication .
(I) MEDICAL RESEARCH_ UNIT_III_RESEARCH METHODOLOGY & BIOSTATISTICS.pptxRAHUL PAL
Research Methodology and Biostatistics syllabus:
Medical Research: History, values in medical ethics, autonomy, beneficence, non-maleficence, double effect, conflicts between autonomy.
Medical research has a long and varied history. It has evolved from rudimentary practices to sophisticated, evidence-based methodologies. Some key milestones include the development of the scientific method, the use of randomized controlled trials, the discovery of antibiotics, and the mapping of the human genome. Ethical concerns have also played a significant role in shaping the history of medical research, especially in response to various ethical violations, such as the Tuskegee Syphilis Study and the Nuremberg Trials.
Resolving conflicts between these principles often requires careful consideration, ethical analysis, and, in some cases, consultation with ethics committees or boards. The specific course of action may vary based on the individual circumstances and ethical frameworks employed by healthcare professionals and researchers. Ethical guidelines and regulations also play a significant role in addressing and preventing these conflicts in medical research.
CROSSOVER STUDY DESIGN, DESIGN OF PHARMACOKINETIC STUDIES, FACTORS INFLUENCING BIOAVAILABILITY STUDIES, STUDY DESIGN, PARALLEL DESIGN, CROSS-OVER STUDIES, LATIN SQUARE DESIN, TWO-PERIOD CROSSOVER STUDY DESIGN, BALANCED INCOMPLETE BLOCK DESIGN (BIBD), REPLICATE CROSSOVER STUDY DESIGN , DIFFERENCE BETWEEN PARALLEL AND CROSSOVER STUDY DESIGN.
Introduction to Research - Biostatistics and Research methodology 8th Sem Uni...Himanshu Sharma
This slide contains B.Pharm Biostatistics and Research methodology 8th Sem. Unit-3 L2 topic- "Introduction to Research"
It contains topics:
1. Introduction to Research
2. Need for Research
3. Need for Design Experiments
4. Experimental Design Techniques
5. Plagiarism
What are the applications of Biostatistics in Pharmacy?pharmacampus
Biostatistics broadly deals with statistical applications in the context of biological problems, including medicine, pharmacy, and public health. Government organizations, research institutes and industry have been extensively using statistics and biostatistics
MEDICAL RESEARCH: UNIT_III_ EUTHANASIA, COI, CONFIDENTIALITY RESEARCH METHODO...RAHUL PAL
Medical research in clinical settings is the study of human health and disease in people. It is the primary way that researchers determine if a new form of treatment or prevention, such as a new drug, diet, or medical device, is safe and effective in people.
A clinical trial is designed to learn if a new treatment is more effective or has less harmful side effects than existing treatments.
Clinical trail is basically have 4 phases: Phase I, Phase II, Phase III, Phase IV
Research Methodology of different data analysis slides.pptxtalhachemist222
General. All solvents were reagent grade or HPLC grade. Unless otherwise noted, all materials
were obtained from commercial suppliers and used without further purification. Melting points
were obtained on a Mel-Temp apparatus and are uncorrected. 1
H NMR spectra were recorded at
400 MHz. 13C NMR spectra were recorded at 100 MHz. Flash column chromatography was carried
out by Biotage Isolera One using ISCO RediSep silica gel cartridges. Analytical HPLC was
performed on an Agilent 1200 series HPLC system equipped with an Agilent G1315D DAD
detector (detection at 220 nm) and an Agilent 6120 quadrupole MS detector using an Agilent
Eclipse Plus C18 column (2.1 mm × 50 mm, 3.5 μm) at a flow rate of 1.25 mL/min. The HPLC
solvent system consisted of deionized water and acetonitrile, both containing 0.1% formic acid.
The mobile phase in HPLC consisted of 5% acetonitrile/95% water for 0.25 min followed by a
gradient to 40% acetonitrile/60% water over 1.5 min and then a gradient to 85% acetonitrile/15%
water over 2.25 min. Unless otherwise noted, all final compounds biologically tested were
confirmed to be of ≥95% purity by the HPLC methods described above. No unexpected or
unusually high safety hazards were encountered during the course of the experiments described
below.
To a solution of 6-aminonicotinic acid 3 (100 mg, 0.72
mmol) and K2CO3 (150 mg, 1.09 mmol) in DMF (5 mL) was added chloromethyl acetate (79 mg,
0.72 mmol). After stirring at 50 °C for 5 h, DMF was removed in vacuo and the residue was
purified using a Biotage Isolera One flash purification system with a silica gel cartridge
(30→100% EtOAc in Hexanes) to give 99.7 mg (66% yield) of compound 5 d as a white solid.
To a solution of 6-aminonicotinic acid 3 (100
mg, 0.72 mmol) and K2CO3 (150 mg, 1.09 mmol) in DMF (5 mL) was added chloromethyl
isobutyrate (99 mg, 0.72 mmol). After stirring at 50 °C for 5 h, DMF was removed in vacuo and
the residue was purified using a Biotage Isolera One flash purification system with a silica gel
cartridge (30→100% EtOAc in Hexanes) to give 136.9 mg (79% yield) of compound 5e as a white
To a solution of 6-aminonicotinic acid 3 (100 mg,
0.72 mmol) and K2CO3 (150 mg, 1.09 mmol) in DMF (5 mL) was added chloromethyl butyrate
(99 mg, 0.72 mmol). After stirring at 50 o
C for 5 h, DMF was removed in vacuo and the residue
was purified using a Biotage Isolera One flash purification system with a silica gel cartridge
(30→100% EtOAc in Hexanes) to give 152.9 mg (89% yield) of compound 5f as a white solid.
To a solution of 6-aminonicotinic acid 3 (100 mg,
0.72 mmol) and K2CO3 (150 mg, 1.09 mmol) in DMF (5 mL) was added chloromethyl butyrate
(99 mg, 0.72 mmol). After stirring at 50 o
C for 5 h, DMF was removed in vacuo and the residue
was purified using a Biotage Isolera One flash purification system with a silica gel cartridge
(30→100% EtOAc in Hexanes) to give 152.9 mg (89% yield) of compound 5f as a white solid.
To a solution of 6-aminonicotine
Quantitative Methods of Research-Intro to research
Once a researcher has written the research question, the next step is to determine the appropriate research methodology necessary to study the question. The three main types of research design methods are qualitative, quantitative and mixed methods.
Quantitative research involves the systematic collection and analysis of data.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
2. Table of contents
Introduction
Definition
Objective
Requirements of research
Practical difficulties
Review of literature
Study design
Types of studies
3. Introduction
The term ‘RESEARCH’ consists of two words:
RESEARCH= RE+SEARCH
‘RE’ means again and again ‘SEARCH’ means to find out something
Following in the process
observes collection of data
again and again analysis of data
Person phenomena conclusions
4. Definitions
Research methods:
All those methods/techniques that are used for conduction of
research. Research methods or techniques, thus, refer to the
methods the researchers use in performing research operations.
Research methodology:
It is a way to systematically solve the research problem. It may be
understood as a science of studying how research is done
scientifically.
5. Definition of research
Research refers to a search for knowledge. A scientific and
systematic search for pertinent information on a specific topic. In
fact, research is an art of scientific investigation. “A careful
investigation or inquiry especially through search for new facts in
any branch of knowledge.” The Advanced Learner’s Dictionary
of Current English “Systematized effort to gain new knowledge”
Redman and Mory.
Research is a process of manipulation of things, concepts or
symbols for the purpose of generalizing to extend, correct or
verify knowledge, whether that knowledge aids in the
construction of theory or in the practice of an art” Slesinger and
Stephenson in Encyclopaedia of Social Sciences. The search for
knowledge through objective and systematic method of finding
solution to a problem is “research
6. Type of Research
Descriptive
Analytical
Applied
Fundamental
Quantitative
Qualitative
Conceptual
Empirical
7. Objectives of Research:
To gain familiarity with a phenomenon or to achieve new insights
into it (studies with this object in view are termed as exploratory
or formulative research studies).
To portray accurately the characteristics of a particular individual,
situation or a group (studies with this object in view are known
as descriptive research studies).
To determine the frequency with which something occurs or with
which it is associated with something else (studies with this object
in view are known as diagnostic research studies)
To test a hypothesis of a causal relationship between variables
(such studies are known as hypothesis testing research studies)
8. Research process
Formulation the
research
problem
Extensive
literature survey
Development of
a working
hypothesis
Preparing the
research design
Determining the
sample design
Collection of
data
Execution of
project
Analysis of data Hypothesis
testing
Generalization
and
interpretation of
data
Preperation of
research report
9. Criteria of Good Research
Purpose should be clearly defined.
Research Process (source of data etc.) should be described in
sufficient detail (except when secrecy is required).
There is a clear statement of research aims, which defines the
research question.
Design (Sampling, questionnaire, observation etc) should be
thoroughly planned so as to yield objective results.
High ethical standards.
Limitations should be frankly revealed (e.g. flaws in design) so
that the decision maker is made aware.
Analysis of data should be adequate and methods of analysis
appropriate. Should check for reliabilityand validity, and
probability of error
Unambiguous presentation
Conclusions should be confined to those justified by the data of
the research.
11. Significance of research
To those students who are to write a master’s or ph. D
thesis research may mean a careerism or a way to attain a
high position in the social structure.
To professional in research methodology, research may
mea a source of livelihood.
To philosophers and thinker research may mean the
outlet for new ideas and insights.
To literary man and women ,research may mean the
development of new styles and creative work.
To analysts and intellectuals, research may mean the
generalisations of new theories.
12. Requirement
Sources of problems
Review of Literature
Formulation of hypothesis
Research design
13. Source of Problems
Reading
Academic Experience
Daily Experience
Exposure to Field Situations
Consultations
Brainstorming
Research
Intuition
14. Process involved in defining the problem
The selection of one appropriate researchable problem out of the
identified problems requires evaluation of those alternatives
against certain criteria.
Internal / Personal criteria – Researcher’s Interest, Researcher’s
Competence, Researcher’s own Resource: finance and time.
External Criteria or Factors – Research ability of the problem,
Importance and Urgency, Novelty of the Problem, Feasibility,
Facilities, Usefulness and Social Relevance, Research Personnel.
15. Cont.
Problem definition or Problem statement is a clear, precise
and succinct statement of the question or issue that is to be
investigated with the goal of finding an answer or solution.
There are two ways of stating a problem:
1) Posting question / questions
2) Making declarative statement.
16. Understanding the nature of problem
Surveying the available literature
Understanding the nature of problem
Surveying the available literature
Developing ideas through discussions
Rephrasing the research problem
17. Review of Literature
Literature Review is the documentation of a
comprehensive review of the published and
unpublished work from secondary sources of data in
the areas of specific interest to the researcher.
The main aim is to find out problems that are already
investigated and those that need further investigation. It
is an extensive survey of all available past studies
relevant to the field of investigation. It gives us
knowledge about what others have found out in the
related field of study and how they have done so.
18. Purpose of Review
To gain a background
knowledge of the research
topic.
To identify the concepts relating
to it, potential relationships
between them and to formulate
researchable hypothesis.
To identify appropriate
methodology, research design,
methods of measuring concepts
and techniques of analysis.
To identify data sources used by
other.
19. Sources of literature
Books and Journals
Electronic Databases
Bibliographic Databases
Abstract Databases
Full-Text Databases
Govt. and Industry Reports
Internet
Research Dissertations / Thesis
20. How to write the review?
There are several ways of presenting the ideas of others within
the body of the paper.
For Example; If you are referring the major influencing
factors in the Sheth’s model of Industrial Buying Behaviour, it
can be written as,
Sheth (1973, p-50) has suggested that, there are a number of
influencing factors
According to Sheth (1973) model of industrial buying
behaviour.
1) In some models of industrial buying behaviour, there are a
number of influencing factors (Sheth, 1973).
2) In some models of industrial buying behaviour, there are a
number of influencing factors1. 1. Sheth J.N (1973), A
Model of Industrial Buying Behaviour, Journal of
Marketing, 37(4), 50-56.
21. Points to be kept in mind while reviewing
literature
Read relevant literature.
Refer original works.
Read with comprehension.
Read in time.
Index the literature.
22. Study design
The study design should be appropriately selected prior to
initiation of any research investigation.
Selecting an inappropriate study design may potentially
undermine the validity of a study in its entirety.
Investigators are encouraged to critically think about the possible
study designs to ensure that the research question is adequately
addressed and should be able to adequately justify their choice.
These study designs have been variously classified and one
common classification system is quantitative vs. qualitative study
designs.
Study designs play a major role in determining the scientific
value of research studies.
.
23. Type of study
Research design Exploratory of
formulative
Descriptive /diagnostic
Overall design Flexible design (design must
provide opportunity for
considering different aspects
of the problem )
Rigid design (design must
make enough provision for
protection against bias and
must maximise reliability)
1. Sampling design
2. Statistical design
3. Observational
design
4. Operational
design
Non-probability sampling
design .
No pre-planned design for
analysis.
Unstructured instruments
for collection of data.
No fixed decisions about the
operational procedures
Probability sampling
design .
Pre-planned design for
analysis.
Structured or well thought
out instrument for
collection of data.
Advanced decisions about
operational procedures.
24. Reference
1. C.R. Kothari, Research Methodology- Methods and
techniques, 2nd revised edition, New age international
publishers, page no.1-54.
2. John W. Best, James V. Kahn, Research in Education,
7th edition ,1995, Prentice hall of India, Page no. 1-61.
Sandra Poncet, Research Methodology 2: Writing a
good research paper, Semester 1, Academic year, 2012-
2013.
3. Getu DeguTegbar Yigzaw, Research Methodology, In
collaboration with the Ethiopia Public Health Training
Initiative, The Carter Center, the Ethiopia Ministry of
Health, and the Ethiopia Ministry of Education, 2006.
4. Principles of good research and research proposal
guide, Prepared by the Policy, Performance and
Quality Assurance Unit (Adults) Tamsin White, March
2006.
