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Regenerative Medicine Options
Island House Hotel, The Bahamas
William Faloon
April 20th 2023
The Perpetual Project
Unparalleled Track Record
of Biomedical Innovation
First Established 1977
Decades Ahead of Mainstream Medicine
https://www.lifeextension.com/about/life-extension-story/history
LifeExtension.com
Our Controversial Contention
It may be possible…
www.age-reversal.net
Feb 23 /March 2, 2015
TIME describes
the prospect of
delayed aging.
Early Media
Report Year 2015
May 2017
https://www.pressreader.com/usa/popular-science/20180505/281672550562011
“Bill Faloon has pursued immortality for
decades. Now he’s got lots of company.
What does science have to say?”
“The FOREVER Man” May 5, 2018
https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/
“He stirred controversy with his plans to bring back the woolly mammoth. But first
he’s working on editing sperm – and trying out his aging reversal techniques on dogs.”
“George Church: The maverick
geneticist now wants to reverse aging”
August 25th, 2018
April 27, 2019
https://www.newscientist.com/issue/3227/
According to Juvenescence’s Greg Bailey
“We won’t be aging as fast or
poorly as our parents”
“I think the world is going to be shocked”
Juvenescence has now raised $165 million
to fund longevity projects with the goal of
extending human lifespans to 150 years.
“Science fiction has become science”
‘Extraordinary’ Breakthroughs In Anti-Aging
Research ‘Will Happen Faster Than People Think’
https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
https://www.technologyreview.com/magazine/2019/09 September
2019
“Later this year, at a conference
of longevity enthusiasts called
RAADfest, to be held in Las
Vegas, Faloon plans to take the
strategy one step further with
what he has been calling the
“Perpetual Clinical Trial.”
“OLD AGE IS OVER!”
https:// www.dailymail.co.uk/health/article-7435427/
Oct.22,2019
Turning Back Time!
“Aging is REVERSED in men using a
cocktail of growth hormones and
diabetes drugs in study that saw test
group shed 2.5 biological years.”
“Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019
Human Age Reversal Demonstrated in 2019
1) Human growth hormone
2) DHEA
3) Metformin
Study conducted by Dr. Greg Fahy in collaboration
with researchers from Stanford University and
UCLA used individualized doses of:
Study subjects also provided with daily
vitamin D3 and zinc.
Scientists have identified synergistic cellular pathways for
longevity that amplify lifespan fivefold in C. elegans, a
nematode worm used as a model in aging research.
“The increase in lifespan would be the
equivalent of a human living for 400 or 500
years, according to one of the scientists.”
Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di
Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019;
28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078
“Pathways that extend lifespan
By 500 percent identified” Jan 8, 2020
Dec. 30, 2020
https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
Mainstream Recognition of
The Need to Reverse Human Aging
“Age is the biggest risk factor for cancer,
cardiovasculardisease,andneurodegeneration.
Withouttreatmentsto slowor reverseaspects
of biologicalaging,anagingpopulationmeans
we areinfor ahealthcarecosttsunami.
With such treatments, Americans would
experiencemorehealthy,productiveyearsoflife.”
March 7, 2022
https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
Feb. 20, 2021
“Is There a Cure for Aging?”
“Fueledinpartbyabilliondollarsofinvestor
money, they are attempting to reverse-
engineer your molecular biological clock.
To eliminate not merely diseases that kill
people, but to prevent death itself.”
Their Goal?
March 7, 2022
Scientists
Reverse Aging in Mice
March 11, 2022
“Anti-Aging Breakthrough:
https://scitechdaily.com/anti-aging-breakthrough-cellular-rejuvenation-therapy-safely-reverses-the-aging-process-in-mice/
Cellular rejuvenation therapy safely reverses signs of
aging in mice. Credit: Salk Institute
Cellular Rejuvenation
Therapy Safely Reverses
the Aging Process in Mice”
March 9, 2022
“Newresearchbythe
SalkInstitutehasshown
cellularrejuvenation
therapysafelyreverses
signsofaginginmice.”
https://www.drugtargetreview.com/news/101826/scientists-have-shown-ageing-process-can-be-safely-and-effectively-reversed-in-mice/
“Scientists have shown aging process can
be safely and effectively reversed in mice”
https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html
• Experts injected mice with molecules called the Yamanaka transcription factors
• Treatment period of seven to 10 months was effective for restoring youthfulness
• The 'safe' treatment could one day help humans wind back their biological clock
March 7, 2022
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
Mar. 7, 2022
“Scientistssafelyandeffectivelyreversetheagingprocessinmiddle-aged
andelderlymicebypartiallyresettingtheircellstomoreyouthfulstates.”
• Partial cell reprogramming in live (in vivo) mice
• OSKM (“Yamanaka”) transcription factors used
• Longeradministrationdemonstrateduniquebenefits
• No toxicity or increase in cancer detected
Partial Cell Reprogramming Safe
https://www.nature.com/articles/s43587-022-00183-2
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
Transcription factors
can enable old cells to
be reprogrammed into
embryonic cells capable
of developing into all
tissues of the body.
Transcription factors are proteins that help turn
specific genes "on" or "off" by binding to DNA.
The Nobel Prize in Physiology or Medicine 2012
These transcription factors are called:
“Yamanaka Factors”
Four specific genes encode transcription
factors that can convert somatic cells
into pluripotent stem cells that can
propagate indefinitely.
nobelprize.org/prizes/medicine/2012/yamanaka
https://hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse
“Study in mice implicates changes to
way DNA is organized, regulated rather
than changes to genetic code itself”
“Loss of Epigenetic Information Can
Drive Aging, Restoration Can Reverse it”
Jan.12th,2023
1
“the extensive experiments led the team to conclude that “by manipulating
the epigenome, aging can be driven forwards and backwards”
Jan 12, 2023
https://www.cnn.com/2023/01/12/health/reversing-aging-scn-wellness/index.html
“Old Mice Grow Young Again…
Can People Do The Same?”
 Harvard researchers show aging may
be caused by changes in epigenetic
markers.
 No data on lifespan that we know of.
 Researchers may have induced
aging by damaging DNA in mice.
• Long-termcell reprogrammingresults in “younger”skin age.
• Skin cells divide more rapidly.
• Lower inflammation and reduced senescent-associated
secretory phenotypes in treated animals.
• No data collected on lifespan.
Cell Rejuvenation in Live Mice
https://www.nature.com/articles/s43587-022-00183-2
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
- January 9th, 2023
technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/
This Biotech Startup Says Mice Live
Longer After Genetic Reprogramming
“A small biotech company claims it has used a
technology called reprogramming to rejuvenate old
mice and extend their lives, a result suggesting that
one day older people could have their biological clocks
turned backwithaninjection—literally becomingyounger.”
Scientists at Rejuvenate Bio recently tested
epigenetic reprogramming in elderly mice
Jan. 5th, 2023
They gave 124-week-old mice gene
therapy with three Yamanaka factors: OSK
They reported that remaining lifespan
was more than doubled with treatment
Reference: https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 *Study has not yet been peer reviewed as of 1/24/2023.
Frailty was also reduced in treated mice
Jan.5th,2023
Old mice injected with the Yamanaka factor-encoded virus.
Adeno-associated virus encoded with three Yamanaka factors (OSK)
(Doxycycline used as Yamanaka factor promoter.)
Doxycycline in drinking water (one week on and one
week off) controllably promotes Yamanaka factors.
The start-ups seeking a cure for old age
RESULTS
► Reversal of epigenetic aging markers
► Restored youthful functions
► Extension of remaining lifespan by 109%
Reference: https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 *Study has not yet been peer reviewed as of 1/24/2023.
Typical 77-year-old American expected to live to age 87
If extend remaining lifespan as reported:
98
MissedTimeforAgeReversalTechnologies
87
Averageremaininghumanlifespansgo from 87to98years.
After large animal research, next step may be testing old people.
►Researchers can order Yamanaka factor-encoded
viral vectors from certified biologics suppliers.
What may be studied next….
►Inject into old dogs and old primates.
►Test differing doxycycline dosing schedules to turn
on Yamanaka factors and measure effects on aging.
December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process
https://www.dailymail.co.uk/sciencetech/article-9166007/Chinese-scientists-develop-gene-therapy-delay-ageing.html
CRISPR Extends Lifespan
In Normal Aged Mice
January 21, 2021
A new gene therapy has
been shown to reverse
some of the effects of
aging in mice and extend
their lifespans by up to
25%.
1) 25% extended lifespan in normal aged mice.1
2) Improved overall appearance and grip strength.1
“A genome-wide CRISPR-based screen identifies
KAT7 as a driver of cellular senescence”
January 6, 2021
1. https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
2. https://www.genome.gov/10001345/importance-of-mouse-genome
Mice and humans share virtually the same set of genes though in slightly different forms.2
KAT7 gene is significant driver of cell senescence. Targeting KAT7 using CRISPR enabled:
98-Year Average Lifespan?
25% Lifespan Extension
It May Be Possible for Normal Aged People to
Benefit from these Kinds of Single-Gene CRISPR Edit
If this CRISPR-Treatment Works Similar in Normal Aged Humans
CRISPR-Treated NormalAged Mouse
Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
Female rat ‘Sima’ (pictured right) is the last
surviving rat in a group given young plasma
transfusions at the University of Maryland.
February 8th, 2023 theguardian.com/science/2023/feb/08/anti-ageing-scientists-extend-lifespan-of-oldest-living-lab-rat
“Anti-agingScientistsExtendLifespanOfOldestLivingLabRat”
Researchteaseshopesthat‘rejuvenationofthebodymaybecomecommonplacewithinourlifetimes’
Treated rats also had improved grip strength
Sima is 47 months old, older than
the oldest known rat of 45.5 months.
This was a small study of only 8 rats, but suggests a
significant effect of the young plasma treatment
September 02, 2022 | https://doi.org/10.1111/acel.13696
September 2nd, 2022
• GrimAge®: -0.78yearsyounger(predictorofdeathrisk)
• 30% of 90 biomarkers changed
beneficially, zero negatively
• No significant side effects
• Kidney function: 7% improvement
measured by eGFR (+ 5)
• Phenotypic Age Score biomarkers such as RDW
and MCV improved, reducing predicted age
September 2nd, 2022 https://onlinelibrary.wiley.com/doi/10.1111/acel.13696
“Umbilical cord plasma concentrate has beneficial effects on
DNA methylation GrimAge and human clinical biomarkers”
Human Study
• Each injection equivalent to 100 mL
umbilical cord plasma infusion.
September 02, 2022 | https://doi.org/10.1111/acel.13696
• 18 human participants average age 74 years.
• Safety-efficacy evaluated with blood tests +
GrimAge® epigenetic clock.
• Weekly injection of umbilical cord plasma
concentrate into muscle for 10 weeks.
(Fourumbilicalcordsusedtoproduceeachweeklyinjection.)
 Once-faltering paws gripped objects
with renewed strength.
 Hearts and livers of rats regained
youthful vitality.
 Fuzzy memories sharpened.
 Biological age had been cut in half.
“It was as if someone had turned back time.”
April 30, 2022
“GrowingYounger:RadicalInsights IntoAgingCouldHelpUsReverse It”
April 30,2022|https://www.newscientist.com/issue/3384/
June 7
2022
https://www.technologyreview.com/2022/06/07/1053132/saudi-arabia-slow-aging-metformin/
The oil kingdom fears that its population is aging at an accelerated rate and hopes
to test drugs to reverse the problem. First up might be the diabetes drug metformin.
Saudi Arabia Plans To Spend $1 Billion A
Year Discovering Treatments To Slow Aging
of its oil wealth supportingbasic research on the biology of aging and
findingwaysto extend the number of years people live in good health
$1 BILLION A YEAR
has started a not-for-profit organization
called the Hevolution Foundation that plans to spend up to
“
”
- July 19, 2022
 The field of geroscience aims to find ways to delay onset of age-related diseases.
 Geroscience experts met virtually at a symposium of the New York Academy of Sciences.
 Advances made in understanding the mechanisms underlying biological aging.
“The presentations focused on identifying biomarkers
of aging and the search for interventions to prevent and
treat age-related diseases.”
https://www.medscape.com/viewarticle/985809
“FDA does not recognize aging as an indication for drug approval…”
December19th,2022
https://www.nationalgeographic.com/magazine/article/aging-cure-longevity-science-technology-feature/
Dec. 28, 2022
“A Drug to Treat Aging May Not Be a Pipe Dream”
“By the end of 2023, it’s likely that one of these
ideas will be shown to work in humans.” www.wired.com/story/drugs-aging-medicine-biotech/
►“In 2023, early success of these treatments
could kickstart the greatest revolution in
medicine since the discovery of antibiotics.”
►“Senolytics aren’t the only contenders…but
the success of a drug targeting an aspect of
aging in clinical trials will allow us to consider
this loftier goal in the not-too-distant future.”
Jan. 1st, 2023
New approaches to the biology of senescence can make lives longer and healthier.
The start-ups seeking a cure for old age
 Eric Verdin, chief executive of the Buck Institute, “scientists
have completely changed how they think about ageing”
“Tech billionaires are funding research
to help us live longer and healthier lives”
“Thestart-ups seeking acureforoldage”
January 2, 2023 https://www.ft.com/content/649b0446-698c-4363-82ad-0be5b5faa68f
 Nir Barzilai, Institute for Aging Research at Albert Einstein College of Medicine “the world
is on the cusp…of finding transformational drugs that prevent the effects of ageing…”
 Mehmood Khan, chief executive of Hevolution Foundation (Saudi Arabia),
“its vision is to “extend healthy lifespan for the benefit of all humanity”
“Powerful billionaires are pouring money into life-
extending technology -and they just might succeed.”
“Reverse the aging process
and live decades longer?
March 8, 2023
Transfer your brain onto a database
and achieve digital immortality?
Humansonedaymayhavesuch options.”
https://www.marketwatch.com/story/upload-your-mind-or-alter-genetics-powerful-billionaires-are-pouring-money-into-life-extending-technology-and-they-just-might-succeed-6e1042f4
- March 8th, 2023
technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/
Sam Altman invested $180 million
into a company trying to delay death
“Can anti-aging breakthroughs add 10 healthy years to the
human life span? The CEO of OpenAI is paying to find out.”
The $180 million went to start Retro Biosciences which said
that it would “prize speed” and “tighten feedback loops” as
partofan“aggressive mission”tostall aging, or even reverse it.
| March 12th, 2023
Report on the Science of Aging
The WSJ cited several studies associating
telomerelengthwithhealthoutcomesinolderpeople.
“Smoking,excessivedrinking,pollution,stress,socialisolation
andeatingprocessedfoods…causestelomerestoshortenfaster.”
Shorter telomeres were associated with depression
and cognitive problems in people aged 60-79.
Peopleover60withshortertelomereswere3xmorelikelyto
diefromheartdiseaseand8xmorelikelytodiefrominfections.
Source article: https://www.nationalgeographic.com/magazine/article/longevity-life-death-technology-advances
• National Geographic recently reported on several
developments in tissue regeneration and artificial organs
• Highlights included a Harvard professor working on a
technique to enable the body to repair its own knee
ligament (ACL) rather than using replacements
• Researchers at Cleveland Clinic were said only three years
away from growing a heart and transplanting it to humans if
they had enough funding
• The possibility of artery-scrubbing nanobots also mentioned
Can we delay death with tech? These advances hold
promise.
X-ray image of a knee joint
Image by Dr. Manuel González Reyes
from Pixabay
“Scientists are reverse-
engineering patients’ own
skin or blood cells to behave
similarly to embryonic cells
and using them in tests to
treat incurable diseases.”
| March 23rd, 2023
“The Personalized Stem Cells That Could
One Day Treat Parkinson’s and Heart Failure”
www.wsj.com/articles/stem-cells-parkinsons-disease-heart-failure-60e9e21f?
www.nytimes.com/books/best-sellers/2023/03/12/
Explosion of Interest in Anti-aging
The month prior to “Outlive”
taking the #1 spot on the NY Times
Best Seller List, the #1 spot was
held by Young Forever, a different
book about anti-aging medicine.
March 12th, 2023
The Pro-longevity view of why healthcare delivery
in the U.S. “routinely fails to treat or cure many long-
term conditions” and how “Modern doctors are trained
to solve ‘the problems of an earlier era’—that is, acute
illnesses and injuries with fairly short event horizons.”
www.wsj.com/articles/outlive-review-heaven-can-wait-6a50eb2 www.nytimes.com/books/best-sellers/2023/04/16/
“Medicine3.0,’thenexterainmedicineifDr.Attiahashis
way, will be ‘proactive’ and focus on prevention.
It will also avoid one-size-fits-all treatment
protocols of the sort that are common today.”
WSJ Review of Outlive:
March 29th, 2023
www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer
March 29,2023
“Humans will achieve immortality in EIGHT YEARS, says former
Google engineer who has predicted the future with 86% accuracy”
“We’d like to advance human life
expectancy – my life expectancy,
by more then a year every
year, and I think we can get
there by the end of this decade.”
- Ray Kurzweil, Lex Fridman Podcast #321
April 5th, 2023
only about 1 in 5 interventions end up in routine clinical practice”
https://jamanetwork.com/journals/jama/fullarticle/2803716
“It Takes an Average of 17 Years for Evidence to Change Practice—the
Burgeoning Field of Implementation Science Seeks to Speed Things Up”
“Why aren’t clinicians in the community
using evidence-based practices?”
17 Year Wait For Better Treatments!
“Eventhen…
New term:
“Implementation
Science”
“…why not launch an
Operation Warp Speed
for biological aging?”
CONCLUSION
https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
December 30, 2020
Bridging the Longevity Gap
Urgent Need to Reform Clinical Trial Regulations
“FDA is responsible for advancing the public health by helping to speed
innovations that make medical products more effective, safer, and more
affordable…”1
1. https://www.fda.gov/about-fda/what-we-do
FDA Headquarters, Rockville, Maryland
What FDA says: What FDA does:
2. FDA Holocaust Museum- 1994-2022
“FDA is responsible for
advancing the public
health by helping to
speed innovations that
make medical products
more effective, safer, and
more affordable…”1
“FDA impairs the public
health by delaying
innovations that make
medical products less
effective, less safe, and
less affordable…”2
= Delayed Research
"We stand on the cusp of a revolution in
health care. Advances in molecular medicine
will allow us to develop powerful new
treatments that can cure or even prevent
diseases like Alzheimer's and cancer."1
"What's missing," according to Dr. von Eschenbach:
1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissioner-admits-risk
Former FDA commissioner
Andrew von Eschenbach, M.D.:
FDA Commissioner Margaret
Hamburg’s sworn testimony:
1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissioner-admits-risk
Margaret Hamburg M.D.
https://www.cato.org/commentary/rethinking-fda
“If the FDA delays a good drug, the cost is less obvious
because most of those affected are not aware their illness
could have been treated more effectively. A great deal
of evidence supports this perspective and estimates huge
life‐​saving benefits would be derived from greater speed.”
August 24th, 2022
“Scientists have shown aging process
can be safely and effectively
“Rethinking the FDA”
https://www.bmj.com/content/379/bmj.o2628
“The FDA is “endangering public health” by not being candid about
violations that are uncovered during clinical trial site inspections”
“The lack of full transparency and data sharing does not allow
physicians and other medical scientists to confirm the data
independently and make comprehensive risk-benefit assessments…”
“The FDA has a long history of failing adequately to oversee clinical trial sites.
A report in 2007 by the Department of Health and Human Services’ Office of
the Inspector General found the FDA audited less than 1% of the nation’s
clinical trial sites between 2000 and 2005 and was highly critical of the agency
because it did not have a database of operational clinical trial sites.”
BritishMedicalJournalcitesHistoricFDAFailures
November 16, 2022
BritishMedicalJournal
January 6, 2023
“The reversal of aging could hinge on one huge decision.”
“If the FDA classifies aging as a disease,
drug companies can take a new
approach to curing death.”
https://www.popularmechanics.com/science/health/a42419017/anti-aging-drugs-fda-approval/
“Humans Can Start Living Longer
—Once the FDA Does This”
“Scientists are already targeting proteins
in cells to keep them from degenerating.”
“TheWHOsupportsthegrowingtrendofcallingagingadisease.”
| Jan. 11, 2023
“FDA Increasingly Halting Human Trials…”
Clinical holds by FDA can stifle progress:
2017-2020: 557 clinical holds*
2002-2021: 664 clinical holds
2021-2022: 747 clinical holds
“FDA is also saying that's probably part of the reason it's having to
press pause on more trials because the technology is just so new.”
*average each year
 England approves metformin:1957
 FDA approves metformin: 1994
 37-year delay caused millions of
American deaths.
 66 years later most people don’t
know metformin is anti-aging drug.
Regulatory Barriers Must be Abolished!
Deadly Delays…Urgent Need for Reform
Heart failure kills
https://www.cdc.gov/heartdisease/heart_failure.htm
Epidemic Killer: Heart Failure
About 6.2 million adults in the
United States have heart failure.
Heart failure cost the United
States $30 billion in 2012.
400,000 Americans every year.
“Stem cell therapy may reduce risk of heart attack &
stroke in certain heart failure patients, study shows”
Feb. 27, 2023
https://www.cnn.com/2023/02/27/health/cell-therapy-heart-failure-patients-study
One dose of adult stem cells reduced heart attack
& stroke risk by 58% in people with heart failure.
Riskreducedby75% inthosewithhighinflammation.
Largest study of its kind on 565 patients – treatment
began a mean of 7.5 years after heart failure diagnosis.
The effects lasted for the entire follow up period – 3 years.
But human data 10+ years ago suggested this effect… Dr. Emerson Perin holds up adult stem cells
- The Texas Heart Institute
hopkinsmedicine.org/news/media/releases/stem_cell_therapy_safely_repairs_damaged_heart_muscle_in_chronic_heart_failure_patients_study_shows
Backin ,JohnsHopkinshadaverysimilarstudyresultin31peoplewithheartfailure.
“Stem cell therapy safely repairs damaged
heart muscle in chronic heart failure patients”
November 6th, 2012
The2012studywasreportedintheJournalofAmericanMedicalAssociation(JAMA)
The study reported that the stem cell therapy “reduced heart muscle scar
tissue” and “enhanced heart pumping ability” for many study patients.
Why the Lethal Delay in Using Stem Cells in Common Practice
March 2002
Life Extension Magazine-March 2002
Age Reversal
Interventions
Autophagy Plasma exchange
Remove
senescent cells
Combat
Immune senescence
Lengthen
telomeres
AMPK/
mTOR
NAD+
Exosomes
Experimental Human Age Reversal Interventions
Urgent Need to Rapidly Assess Human Data
While Also Delaying Aging NOW?
Age Reversal Needed Today!
How to Rapidly
Assess Efficacy
Nov 29, 2015
April 24, 2016
https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
February 20, 2021
“If the results are what
they think they will be, the
whole world could go on
metformin and extend life
for everybody.”
- Nir Barzilai, lead researcher on
“Targeting Aging with Metformin”
Clinical Trial
While Also Delaying Aging NOW?
Age Reversal Needed Today!
How to Rapidly
Assess Efficacy
A SOLUTION:
The Perpetual Project
Advances to Remain
Utilize Scientific
Healthy &
Fact: FDR died at age 63 of hypertension – a
condition his doctors thought “normal for his age”.
Reaction: As a result of FDR’s untimely
death, doctors started questioning the
conventional wisdom about hypertension.
Result: FDR’s death was a major reason why the
Framingham Heart Study was proposed and funded.
Learning from History
Dead at
Framingham Heart Study
Educated the World!
Began in 1948 with 5,209 adults
in Framingham, Massachusetts
Prior to Framingham little was
known about cardiovascular risks
Doctors did not know
how to prevent heart attacks
Atherosclerosis was thought to
be unavoidable aspect of aging
Framingham Heart Study
Saved Millions of Lives
Framingham findings revealed role of
diet and other artery-clogging factors
3,000 medical papers published using
Framingham…now in its third generation
Framingham source of
the term “risk factor”
Lyndon Johnson Prematurely
Died Due to Technology Delay
•First heart attack age 46 (1955)
•Suffered chronic angina pain
•Resigned re-election age 59 (1968)
•Dead age 64 years (1973)
(Treatments to reverse coronary blockage lacking)
Alive Because of Biomedical Technology
Bill Clinton
Coronary Bypass Age 58
In 2004
Coronary Stent Age 63
In 2010
George W. Bush
Coronary Stent Age 67
in 2013
Dick Cheney
Coronary Bypass Age 47
In 1988
Coronary Stent Age 59
in 2000
Ventricular Assist Age 69
in 2010
Heart Transplant Age 71
in 2012
Age 76 Today Age 82 Today
Age 76 Today
Enormous Decrease in Cardiovascular Deaths
1. “Trends and Patterns of Geographic Variation of Cardiovascular Mortality 1980-2014”
Journal of the American Medical Association (JAMA); May 16th 2017
Between 1980 and 2014
`
-50%
Decrease in Deaths from
Heart Disease
Identify your individual “risk factors”
Learn about biomarker testing
Share data about regenerative treatments
Measure effects of self-experimentation
APrivateAssociationToDefeatAging!
Accelerate science of human age reversal





Identify your individual “risk factors”
Learn about biomarker testing
Share data about regenerative treatments
Measure effects of self-experimentation
Accelerate science of human age reversal
Open to Everyone…No Exclusion Criteria!
 Individualized treatments
 Not a clinical study
 No termination date
Group Effort to Defeat Biological Aging
The Perpetual Project
Individualized treatments
Not a clinical study
No termination date
OptimizeConventionalRiskFactors
Restore Youthful Biochemistry
Boost cell energizing NAD+
Reverse Aging Biomarkers
SuppressmTOR/BoostAutophagy
Perpetual Project
Individual Treatment Options
Level 1 is essential to
progress to Level 2
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Underlying Risk Factors
Individualized Age
Reversal Interventions
House of
Optimal Health
Correct Your
House of
Optimal Health
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Exosomes
- Mesenchymal Stem Cells - Mitochondria Transfer
- Young Plasma/Blood filtering
Failure to optimize
Level 1, preclude
benefits of Level 2.
Optional Approaches
Healthy Aging
- Perinatal tissues
- Hyperbaric - Gene therapy
Level 2
Level 1
Level 1
Level 2
The House of
Optimal Health
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Death
Level 1
…Essential to sustain life
Harsh Reality!
Failure To Correct
Proven Risk Factors
Age-Reversal.Net
Assess baseline markers of aging/disease risk
Correct your markers of aging/disease risk
Share your data/experiences with the group
Foster strategic alliances
Exchange new scientific information
Seek to reverse disease risk/aging markers
DF
ThePerpetualProject
(or use your favorite diagnostics center…preferably LabCorp.)
Results help identify factors associated with rapid aging,
age-delay, or age-reversal…assist your doctor in decisions.
Blood draws available at LabCorp stations in U.S. (Includes Phenotypic Age measure).
Lower Priced Panels available starting at $77
Commercial Lab: $572
Perpetual Project: $77
+ Phenotypic Age at no cost
Blood Tests
to Calculate Phenotypic Age:
A1C + Lipids + Fasting Insulin
Complete Blood Count-Chemistry
and C-reactive protein
Added tests:
Enroll at age-reversal.net
Use results to adjust your longevity program
Re-test to measure age reversal efficacy
Adjust interventions based on retest results
Upload blood tests/other diagnostic results
HowtoParticipateinThePerpetualProject
1
2
3
4
5
No charge to enroll - Open to Everyone - (Patient-Funded Diagnostics/Treatments)
In the 1980s, HIV activists pushed FDA to think differently about the way
it assessed drug efficacy. AIDS activists wanted FDA to authorize use of:
Surrogate data markers-data points that
https://www.wsj.com/articles/making-medical-science-more-democratic-2f189fd2
Theagencyagreedandin1992initiatedtheAcceleratedApprovalProgram
thatallowedforfasterapprovalofdrugsforHIVandotherconditions.
Theagencyagreedandin1992initiatedtheAcceleratedApprovalProgram
that allowed for faster approval of drugs for HIV and other conditions.
definitive proof they were surviving longer.
indicate patients are benefiting…without
Clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01112-7
Academic.oup.com/biomedgerontology/article/76/5/741/5992253
“DNAm GrimAge is a strong predictor
of mortality independent of genetic
influences among female twin pairs.” 1
“GrimAge Outperforms Other Epigenetic
Clocks in the Prediction of Age-Related
Clinical Phenotypes and All-Cause Mortality.”2
2021 findings corroboratedata published 2019-2020
1.
2.
The Surrogate Biomarkers of Aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111
Levine-Horvath Phenotypic Age Model
►‘Phenotypic Age’ estimate based on
clinical measures of 9,926 adults with
complete biomarker (blood test) data
►Analyzed data from over
23 years of mortality follow-up
►Advanced computational/statistical
methods identified 9 phenotypic blood test
markers that predict morbidity/mortality risk
Beyond formal acceleration of AIDS research, FDA compromised and
allowed AIDS victims to try any intervention that might be effective.
https://www.tampabay.com/archive/1992/10/15/the-fda-s-cruel-indifference/
AIDS Buyers Clubs were allowed to import
unapproveddrugstheybelievedmightbehelpful.
Historic Precedent:
The result was more rapid development of effective
therapies and speedy recognition of worthless ones.
A SOLUTION:
The Perpetual Project
Advances to Remain
Utilize Scientific
Healthy &
We Don’t Have Time for
Delayed Age Reversal
1497: Citrus shown to cure scurvy
1747: James Lind proves citrus cures scurvy
1870: Flawed study discredits “citrus cure”
1911: Dr. Robert Scott loses crew to scurvy
1932:Vitamin C proven to cure scurvy
Thousands of Deaths After Scurvy Cure Discovered
Risk of Delayed Treatment
Chronic Diseases May Preclude Systemic Regeneration
“…mice with progeria that got the
gene-editing treatment lived more than
twice as long as the untreated mice.”
| Jan. 7, 2021
CRISPR Gene-Editing Treatment
CRISPR Gene-Editing Treatment
An untreated progeria mouse at 7.5
months of age, with a thin, grayish
coat, pronounced spinal curvature,
and low activity levels. Untreated
progeria mice have an average
lifespan of 7.1 months.
Three treated progeria mice at 11
months of age, with healthy
coats, no apparent spinal
curvature, and normal activity
levels. The treated progeria mice
had an average lifespan of 17
months.
CRISPR-Edited
Progeroid Mice
Unedited
Progeroid
Mouse
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
Untreated Male
Progeroid Mouse
7.5 months old
https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-020-03086-7/MediaObjects/41586_2020_3086_MOESM9_ESM.mp4
 Thin, grayish coat
 Spinal curvature
 Low activity levels
Male progeroid mice
injected with CRISPR
gene editing virus.
9.75 months old
https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-
020-03086-7/MediaObjects/41586_2020_3086_MOESM10_ESM.mp4
(2.25 months older the unedited mouse)
https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-
020-03086-7/MediaObjects/41586_2020_3086_MOESM12_ESM.mp4
Male progeroid mice
injected with CRISPR
gene editing virus.
11 months old
(3.25 months older the unedited mouse)
Unedited Mice Died around 7.1 months
10
7.5-month-old unedited 9.75-month-old CRISPR-edited male mice
9.75-month-old CRISPR-edited male mice
10
7.5-month-old unedited 9.75-month-old CRISPR-edited female mice
10
7.5-month-old unedited 11.00-month-old CRISPR-edited male mice
Crispr-Treated Progeroid Mouse
17 Months
>160 Years?
7.1 Months
Combination Crispr-Treated Human
Untreated Progeroid Mouse
https://www.nature.com/articles/s41586-020-03086-7 https://doi.org/10.1073/pnas.1910073116
Extrapolation Assuming
Normal Aged People
Can Have Multi-Gene Edits
via Crispr
Perpetual Project Goals
Age-Reversal.Net
Utilize blood & other tests to evaluate safety & potential efficacy.
Robust communications amongst the group members, share test
result data & suggestions on potential ways to improve outcomes.
Accelerate & validate potential rejuvenation technologies to
benefit all of humanity…including Perpetual Project members.
Rapidly convey data to members and the public so that
medical professionals, scientists, and the lay persons are
aware of scientific findings that may save human lives.
Join the Perpetual Project private
association and receive updates
about regenerative medicine initiatives
www.age-reversal.net
How to Enroll
1980-1986: Anti-Aging News
1986-1994: Life Extension Report
1994-2023:Life Extension Magazine
43 Consecutive Years
of Monthly Publication
(> 400,000 copies mailed each month)
Scientific Conference at Atlantis This Week
Focused on Regenerative Medicine Research
Bill W. Faloon
Bill W. Faloon
age-reversal.net
This presentation and info
about aging research available at:
Regenerative Medicine Options
Island House Hotel, The Bahamas
William Faloon
April 20th 2023
The Perpetual Project
Any Questions

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Bill Faloon at HEALinc Summit April 20th 2023 Perpetual Project Presentation

  • 1. Regenerative Medicine Options Island House Hotel, The Bahamas William Faloon April 20th 2023 The Perpetual Project
  • 2. Unparalleled Track Record of Biomedical Innovation First Established 1977
  • 3. Decades Ahead of Mainstream Medicine https://www.lifeextension.com/about/life-extension-story/history
  • 5.
  • 6.
  • 7. Our Controversial Contention It may be possible… www.age-reversal.net
  • 8. Feb 23 /March 2, 2015 TIME describes the prospect of delayed aging. Early Media Report Year 2015
  • 10. https://www.pressreader.com/usa/popular-science/20180505/281672550562011 “Bill Faloon has pursued immortality for decades. Now he’s got lots of company. What does science have to say?” “The FOREVER Man” May 5, 2018
  • 11. https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/ “He stirred controversy with his plans to bring back the woolly mammoth. But first he’s working on editing sperm – and trying out his aging reversal techniques on dogs.” “George Church: The maverick geneticist now wants to reverse aging” August 25th, 2018
  • 13. According to Juvenescence’s Greg Bailey “We won’t be aging as fast or poorly as our parents” “I think the world is going to be shocked” Juvenescence has now raised $165 million to fund longevity projects with the goal of extending human lifespans to 150 years. “Science fiction has become science” ‘Extraordinary’ Breakthroughs In Anti-Aging Research ‘Will Happen Faster Than People Think’ https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
  • 14. https://www.technologyreview.com/magazine/2019/09 September 2019 “Later this year, at a conference of longevity enthusiasts called RAADfest, to be held in Las Vegas, Faloon plans to take the strategy one step further with what he has been calling the “Perpetual Clinical Trial.” “OLD AGE IS OVER!”
  • 15. https:// www.dailymail.co.uk/health/article-7435427/ Oct.22,2019 Turning Back Time! “Aging is REVERSED in men using a cocktail of growth hormones and diabetes drugs in study that saw test group shed 2.5 biological years.”
  • 16. “Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019 Human Age Reversal Demonstrated in 2019 1) Human growth hormone 2) DHEA 3) Metformin Study conducted by Dr. Greg Fahy in collaboration with researchers from Stanford University and UCLA used individualized doses of: Study subjects also provided with daily vitamin D3 and zinc.
  • 17. Scientists have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. “The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.” Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019; 28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078 “Pathways that extend lifespan By 500 percent identified” Jan 8, 2020
  • 18. Dec. 30, 2020 https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/ Mainstream Recognition of The Need to Reverse Human Aging “Age is the biggest risk factor for cancer, cardiovasculardisease,andneurodegeneration. Withouttreatmentsto slowor reverseaspects of biologicalaging,anagingpopulationmeans we areinfor ahealthcarecosttsunami. With such treatments, Americans would experiencemorehealthy,productiveyearsoflife.”
  • 19. March 7, 2022 https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging Feb. 20, 2021 “Is There a Cure for Aging?” “Fueledinpartbyabilliondollarsofinvestor money, they are attempting to reverse- engineer your molecular biological clock. To eliminate not merely diseases that kill people, but to prevent death itself.” Their Goal?
  • 21. March 11, 2022 “Anti-Aging Breakthrough: https://scitechdaily.com/anti-aging-breakthrough-cellular-rejuvenation-therapy-safely-reverses-the-aging-process-in-mice/ Cellular rejuvenation therapy safely reverses signs of aging in mice. Credit: Salk Institute Cellular Rejuvenation Therapy Safely Reverses the Aging Process in Mice”
  • 23. https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html • Experts injected mice with molecules called the Yamanaka transcription factors • Treatment period of seven to 10 months was effective for restoring youthfulness • The 'safe' treatment could one day help humans wind back their biological clock
  • 24.
  • 25. March 7, 2022 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/ Mar. 7, 2022 “Scientistssafelyandeffectivelyreversetheagingprocessinmiddle-aged andelderlymicebypartiallyresettingtheircellstomoreyouthfulstates.”
  • 26. • Partial cell reprogramming in live (in vivo) mice • OSKM (“Yamanaka”) transcription factors used • Longeradministrationdemonstrateduniquebenefits • No toxicity or increase in cancer detected Partial Cell Reprogramming Safe https://www.nature.com/articles/s43587-022-00183-2 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
  • 27. Transcription factors can enable old cells to be reprogrammed into embryonic cells capable of developing into all tissues of the body. Transcription factors are proteins that help turn specific genes "on" or "off" by binding to DNA.
  • 28. The Nobel Prize in Physiology or Medicine 2012 These transcription factors are called: “Yamanaka Factors” Four specific genes encode transcription factors that can convert somatic cells into pluripotent stem cells that can propagate indefinitely. nobelprize.org/prizes/medicine/2012/yamanaka
  • 29. https://hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse “Study in mice implicates changes to way DNA is organized, regulated rather than changes to genetic code itself” “Loss of Epigenetic Information Can Drive Aging, Restoration Can Reverse it” Jan.12th,2023 1 “the extensive experiments led the team to conclude that “by manipulating the epigenome, aging can be driven forwards and backwards”
  • 30. Jan 12, 2023 https://www.cnn.com/2023/01/12/health/reversing-aging-scn-wellness/index.html “Old Mice Grow Young Again… Can People Do The Same?”  Harvard researchers show aging may be caused by changes in epigenetic markers.  No data on lifespan that we know of.  Researchers may have induced aging by damaging DNA in mice.
  • 31. • Long-termcell reprogrammingresults in “younger”skin age. • Skin cells divide more rapidly. • Lower inflammation and reduced senescent-associated secretory phenotypes in treated animals. • No data collected on lifespan. Cell Rejuvenation in Live Mice https://www.nature.com/articles/s43587-022-00183-2 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
  • 32. - January 9th, 2023 technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/ This Biotech Startup Says Mice Live Longer After Genetic Reprogramming “A small biotech company claims it has used a technology called reprogramming to rejuvenate old mice and extend their lives, a result suggesting that one day older people could have their biological clocks turned backwithaninjection—literally becomingyounger.”
  • 33. Scientists at Rejuvenate Bio recently tested epigenetic reprogramming in elderly mice Jan. 5th, 2023 They gave 124-week-old mice gene therapy with three Yamanaka factors: OSK They reported that remaining lifespan was more than doubled with treatment Reference: https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 *Study has not yet been peer reviewed as of 1/24/2023. Frailty was also reduced in treated mice
  • 34. Jan.5th,2023 Old mice injected with the Yamanaka factor-encoded virus. Adeno-associated virus encoded with three Yamanaka factors (OSK) (Doxycycline used as Yamanaka factor promoter.) Doxycycline in drinking water (one week on and one week off) controllably promotes Yamanaka factors. The start-ups seeking a cure for old age RESULTS ► Reversal of epigenetic aging markers ► Restored youthful functions ► Extension of remaining lifespan by 109% Reference: https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 *Study has not yet been peer reviewed as of 1/24/2023.
  • 35. Typical 77-year-old American expected to live to age 87 If extend remaining lifespan as reported: 98 MissedTimeforAgeReversalTechnologies 87 Averageremaininghumanlifespansgo from 87to98years.
  • 36. After large animal research, next step may be testing old people. ►Researchers can order Yamanaka factor-encoded viral vectors from certified biologics suppliers. What may be studied next…. ►Inject into old dogs and old primates. ►Test differing doxycycline dosing schedules to turn on Yamanaka factors and measure effects on aging.
  • 37. December 2, 2015 George Church, Ph.D. A Cure for Aging by Year 2030? https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process
  • 38.
  • 39. https://www.dailymail.co.uk/sciencetech/article-9166007/Chinese-scientists-develop-gene-therapy-delay-ageing.html CRISPR Extends Lifespan In Normal Aged Mice January 21, 2021 A new gene therapy has been shown to reverse some of the effects of aging in mice and extend their lifespans by up to 25%.
  • 40. 1) 25% extended lifespan in normal aged mice.1 2) Improved overall appearance and grip strength.1 “A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence” January 6, 2021 1. https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf 2. https://www.genome.gov/10001345/importance-of-mouse-genome Mice and humans share virtually the same set of genes though in slightly different forms.2 KAT7 gene is significant driver of cell senescence. Targeting KAT7 using CRISPR enabled:
  • 41. 98-Year Average Lifespan? 25% Lifespan Extension It May Be Possible for Normal Aged People to Benefit from these Kinds of Single-Gene CRISPR Edit If this CRISPR-Treatment Works Similar in Normal Aged Humans CRISPR-Treated NormalAged Mouse Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
  • 42. Female rat ‘Sima’ (pictured right) is the last surviving rat in a group given young plasma transfusions at the University of Maryland. February 8th, 2023 theguardian.com/science/2023/feb/08/anti-ageing-scientists-extend-lifespan-of-oldest-living-lab-rat “Anti-agingScientistsExtendLifespanOfOldestLivingLabRat” Researchteaseshopesthat‘rejuvenationofthebodymaybecomecommonplacewithinourlifetimes’ Treated rats also had improved grip strength Sima is 47 months old, older than the oldest known rat of 45.5 months. This was a small study of only 8 rats, but suggests a significant effect of the young plasma treatment
  • 43. September 02, 2022 | https://doi.org/10.1111/acel.13696 September 2nd, 2022
  • 44. • GrimAge®: -0.78yearsyounger(predictorofdeathrisk) • 30% of 90 biomarkers changed beneficially, zero negatively • No significant side effects • Kidney function: 7% improvement measured by eGFR (+ 5) • Phenotypic Age Score biomarkers such as RDW and MCV improved, reducing predicted age September 2nd, 2022 https://onlinelibrary.wiley.com/doi/10.1111/acel.13696
  • 45. “Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers” Human Study • Each injection equivalent to 100 mL umbilical cord plasma infusion. September 02, 2022 | https://doi.org/10.1111/acel.13696 • 18 human participants average age 74 years. • Safety-efficacy evaluated with blood tests + GrimAge® epigenetic clock. • Weekly injection of umbilical cord plasma concentrate into muscle for 10 weeks. (Fourumbilicalcordsusedtoproduceeachweeklyinjection.)
  • 46.  Once-faltering paws gripped objects with renewed strength.  Hearts and livers of rats regained youthful vitality.  Fuzzy memories sharpened.  Biological age had been cut in half. “It was as if someone had turned back time.” April 30, 2022 “GrowingYounger:RadicalInsights IntoAgingCouldHelpUsReverse It” April 30,2022|https://www.newscientist.com/issue/3384/
  • 47. June 7 2022 https://www.technologyreview.com/2022/06/07/1053132/saudi-arabia-slow-aging-metformin/ The oil kingdom fears that its population is aging at an accelerated rate and hopes to test drugs to reverse the problem. First up might be the diabetes drug metformin. Saudi Arabia Plans To Spend $1 Billion A Year Discovering Treatments To Slow Aging of its oil wealth supportingbasic research on the biology of aging and findingwaysto extend the number of years people live in good health $1 BILLION A YEAR has started a not-for-profit organization called the Hevolution Foundation that plans to spend up to “ ”
  • 48. - July 19, 2022
  • 49.  The field of geroscience aims to find ways to delay onset of age-related diseases.  Geroscience experts met virtually at a symposium of the New York Academy of Sciences.  Advances made in understanding the mechanisms underlying biological aging. “The presentations focused on identifying biomarkers of aging and the search for interventions to prevent and treat age-related diseases.” https://www.medscape.com/viewarticle/985809 “FDA does not recognize aging as an indication for drug approval…” December19th,2022
  • 51. “A Drug to Treat Aging May Not Be a Pipe Dream” “By the end of 2023, it’s likely that one of these ideas will be shown to work in humans.” www.wired.com/story/drugs-aging-medicine-biotech/ ►“In 2023, early success of these treatments could kickstart the greatest revolution in medicine since the discovery of antibiotics.” ►“Senolytics aren’t the only contenders…but the success of a drug targeting an aspect of aging in clinical trials will allow us to consider this loftier goal in the not-too-distant future.” Jan. 1st, 2023 New approaches to the biology of senescence can make lives longer and healthier.
  • 52. The start-ups seeking a cure for old age  Eric Verdin, chief executive of the Buck Institute, “scientists have completely changed how they think about ageing” “Tech billionaires are funding research to help us live longer and healthier lives” “Thestart-ups seeking acureforoldage” January 2, 2023 https://www.ft.com/content/649b0446-698c-4363-82ad-0be5b5faa68f  Nir Barzilai, Institute for Aging Research at Albert Einstein College of Medicine “the world is on the cusp…of finding transformational drugs that prevent the effects of ageing…”  Mehmood Khan, chief executive of Hevolution Foundation (Saudi Arabia), “its vision is to “extend healthy lifespan for the benefit of all humanity”
  • 53. “Powerful billionaires are pouring money into life- extending technology -and they just might succeed.” “Reverse the aging process and live decades longer? March 8, 2023 Transfer your brain onto a database and achieve digital immortality? Humansonedaymayhavesuch options.” https://www.marketwatch.com/story/upload-your-mind-or-alter-genetics-powerful-billionaires-are-pouring-money-into-life-extending-technology-and-they-just-might-succeed-6e1042f4
  • 54. - March 8th, 2023 technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/ Sam Altman invested $180 million into a company trying to delay death “Can anti-aging breakthroughs add 10 healthy years to the human life span? The CEO of OpenAI is paying to find out.” The $180 million went to start Retro Biosciences which said that it would “prize speed” and “tighten feedback loops” as partofan“aggressive mission”tostall aging, or even reverse it.
  • 55. | March 12th, 2023 Report on the Science of Aging The WSJ cited several studies associating telomerelengthwithhealthoutcomesinolderpeople. “Smoking,excessivedrinking,pollution,stress,socialisolation andeatingprocessedfoods…causestelomerestoshortenfaster.” Shorter telomeres were associated with depression and cognitive problems in people aged 60-79. Peopleover60withshortertelomereswere3xmorelikelyto diefromheartdiseaseand8xmorelikelytodiefrominfections.
  • 56. Source article: https://www.nationalgeographic.com/magazine/article/longevity-life-death-technology-advances • National Geographic recently reported on several developments in tissue regeneration and artificial organs • Highlights included a Harvard professor working on a technique to enable the body to repair its own knee ligament (ACL) rather than using replacements • Researchers at Cleveland Clinic were said only three years away from growing a heart and transplanting it to humans if they had enough funding • The possibility of artery-scrubbing nanobots also mentioned Can we delay death with tech? These advances hold promise. X-ray image of a knee joint Image by Dr. Manuel González Reyes from Pixabay
  • 57. “Scientists are reverse- engineering patients’ own skin or blood cells to behave similarly to embryonic cells and using them in tests to treat incurable diseases.” | March 23rd, 2023 “The Personalized Stem Cells That Could One Day Treat Parkinson’s and Heart Failure” www.wsj.com/articles/stem-cells-parkinsons-disease-heart-failure-60e9e21f?
  • 58. www.nytimes.com/books/best-sellers/2023/03/12/ Explosion of Interest in Anti-aging The month prior to “Outlive” taking the #1 spot on the NY Times Best Seller List, the #1 spot was held by Young Forever, a different book about anti-aging medicine. March 12th, 2023
  • 59. The Pro-longevity view of why healthcare delivery in the U.S. “routinely fails to treat or cure many long- term conditions” and how “Modern doctors are trained to solve ‘the problems of an earlier era’—that is, acute illnesses and injuries with fairly short event horizons.” www.wsj.com/articles/outlive-review-heaven-can-wait-6a50eb2 www.nytimes.com/books/best-sellers/2023/04/16/ “Medicine3.0,’thenexterainmedicineifDr.Attiahashis way, will be ‘proactive’ and focus on prevention. It will also avoid one-size-fits-all treatment protocols of the sort that are common today.” WSJ Review of Outlive: March 29th, 2023
  • 60. www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer March 29,2023 “Humans will achieve immortality in EIGHT YEARS, says former Google engineer who has predicted the future with 86% accuracy” “We’d like to advance human life expectancy – my life expectancy, by more then a year every year, and I think we can get there by the end of this decade.” - Ray Kurzweil, Lex Fridman Podcast #321
  • 61. April 5th, 2023 only about 1 in 5 interventions end up in routine clinical practice” https://jamanetwork.com/journals/jama/fullarticle/2803716 “It Takes an Average of 17 Years for Evidence to Change Practice—the Burgeoning Field of Implementation Science Seeks to Speed Things Up” “Why aren’t clinicians in the community using evidence-based practices?” 17 Year Wait For Better Treatments! “Eventhen… New term: “Implementation Science”
  • 62. “…why not launch an Operation Warp Speed for biological aging?” CONCLUSION https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/ December 30, 2020
  • 63. Bridging the Longevity Gap Urgent Need to Reform Clinical Trial Regulations
  • 64. “FDA is responsible for advancing the public health by helping to speed innovations that make medical products more effective, safer, and more affordable…”1 1. https://www.fda.gov/about-fda/what-we-do FDA Headquarters, Rockville, Maryland
  • 65. What FDA says: What FDA does: 2. FDA Holocaust Museum- 1994-2022 “FDA is responsible for advancing the public health by helping to speed innovations that make medical products more effective, safer, and more affordable…”1 “FDA impairs the public health by delaying innovations that make medical products less effective, less safe, and less affordable…”2 = Delayed Research
  • 66. "We stand on the cusp of a revolution in health care. Advances in molecular medicine will allow us to develop powerful new treatments that can cure or even prevent diseases like Alzheimer's and cancer."1 "What's missing," according to Dr. von Eschenbach: 1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissioner-admits-risk Former FDA commissioner Andrew von Eschenbach, M.D.:
  • 67. FDA Commissioner Margaret Hamburg’s sworn testimony: 1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissioner-admits-risk Margaret Hamburg M.D.
  • 68. https://www.cato.org/commentary/rethinking-fda “If the FDA delays a good drug, the cost is less obvious because most of those affected are not aware their illness could have been treated more effectively. A great deal of evidence supports this perspective and estimates huge life‐​saving benefits would be derived from greater speed.” August 24th, 2022 “Scientists have shown aging process can be safely and effectively “Rethinking the FDA”
  • 69. https://www.bmj.com/content/379/bmj.o2628 “The FDA is “endangering public health” by not being candid about violations that are uncovered during clinical trial site inspections” “The lack of full transparency and data sharing does not allow physicians and other medical scientists to confirm the data independently and make comprehensive risk-benefit assessments…” “The FDA has a long history of failing adequately to oversee clinical trial sites. A report in 2007 by the Department of Health and Human Services’ Office of the Inspector General found the FDA audited less than 1% of the nation’s clinical trial sites between 2000 and 2005 and was highly critical of the agency because it did not have a database of operational clinical trial sites.” BritishMedicalJournalcitesHistoricFDAFailures November 16, 2022 BritishMedicalJournal
  • 70. January 6, 2023 “The reversal of aging could hinge on one huge decision.” “If the FDA classifies aging as a disease, drug companies can take a new approach to curing death.” https://www.popularmechanics.com/science/health/a42419017/anti-aging-drugs-fda-approval/ “Humans Can Start Living Longer —Once the FDA Does This” “Scientists are already targeting proteins in cells to keep them from degenerating.” “TheWHOsupportsthegrowingtrendofcallingagingadisease.”
  • 71. | Jan. 11, 2023 “FDA Increasingly Halting Human Trials…” Clinical holds by FDA can stifle progress: 2017-2020: 557 clinical holds* 2002-2021: 664 clinical holds 2021-2022: 747 clinical holds “FDA is also saying that's probably part of the reason it's having to press pause on more trials because the technology is just so new.” *average each year
  • 72.  England approves metformin:1957  FDA approves metformin: 1994  37-year delay caused millions of American deaths.  66 years later most people don’t know metformin is anti-aging drug. Regulatory Barriers Must be Abolished! Deadly Delays…Urgent Need for Reform
  • 73. Heart failure kills https://www.cdc.gov/heartdisease/heart_failure.htm Epidemic Killer: Heart Failure About 6.2 million adults in the United States have heart failure. Heart failure cost the United States $30 billion in 2012. 400,000 Americans every year.
  • 74. “Stem cell therapy may reduce risk of heart attack & stroke in certain heart failure patients, study shows” Feb. 27, 2023 https://www.cnn.com/2023/02/27/health/cell-therapy-heart-failure-patients-study One dose of adult stem cells reduced heart attack & stroke risk by 58% in people with heart failure. Riskreducedby75% inthosewithhighinflammation. Largest study of its kind on 565 patients – treatment began a mean of 7.5 years after heart failure diagnosis. The effects lasted for the entire follow up period – 3 years. But human data 10+ years ago suggested this effect… Dr. Emerson Perin holds up adult stem cells - The Texas Heart Institute
  • 75. hopkinsmedicine.org/news/media/releases/stem_cell_therapy_safely_repairs_damaged_heart_muscle_in_chronic_heart_failure_patients_study_shows Backin ,JohnsHopkinshadaverysimilarstudyresultin31peoplewithheartfailure. “Stem cell therapy safely repairs damaged heart muscle in chronic heart failure patients” November 6th, 2012 The2012studywasreportedintheJournalofAmericanMedicalAssociation(JAMA) The study reported that the stem cell therapy “reduced heart muscle scar tissue” and “enhanced heart pumping ability” for many study patients. Why the Lethal Delay in Using Stem Cells in Common Practice
  • 76. March 2002 Life Extension Magazine-March 2002
  • 77. Age Reversal Interventions Autophagy Plasma exchange Remove senescent cells Combat Immune senescence Lengthen telomeres AMPK/ mTOR NAD+ Exosomes
  • 78. Experimental Human Age Reversal Interventions Urgent Need to Rapidly Assess Human Data
  • 79. While Also Delaying Aging NOW? Age Reversal Needed Today! How to Rapidly Assess Efficacy
  • 80.
  • 83. https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging February 20, 2021 “If the results are what they think they will be, the whole world could go on metformin and extend life for everybody.” - Nir Barzilai, lead researcher on “Targeting Aging with Metformin” Clinical Trial
  • 84.
  • 85. While Also Delaying Aging NOW? Age Reversal Needed Today! How to Rapidly Assess Efficacy
  • 86. A SOLUTION: The Perpetual Project Advances to Remain Utilize Scientific Healthy &
  • 87. Fact: FDR died at age 63 of hypertension – a condition his doctors thought “normal for his age”. Reaction: As a result of FDR’s untimely death, doctors started questioning the conventional wisdom about hypertension. Result: FDR’s death was a major reason why the Framingham Heart Study was proposed and funded. Learning from History Dead at
  • 88. Framingham Heart Study Educated the World! Began in 1948 with 5,209 adults in Framingham, Massachusetts Prior to Framingham little was known about cardiovascular risks Doctors did not know how to prevent heart attacks Atherosclerosis was thought to be unavoidable aspect of aging
  • 89. Framingham Heart Study Saved Millions of Lives Framingham findings revealed role of diet and other artery-clogging factors 3,000 medical papers published using Framingham…now in its third generation Framingham source of the term “risk factor”
  • 90. Lyndon Johnson Prematurely Died Due to Technology Delay •First heart attack age 46 (1955) •Suffered chronic angina pain •Resigned re-election age 59 (1968) •Dead age 64 years (1973) (Treatments to reverse coronary blockage lacking)
  • 91. Alive Because of Biomedical Technology Bill Clinton Coronary Bypass Age 58 In 2004 Coronary Stent Age 63 In 2010 George W. Bush Coronary Stent Age 67 in 2013 Dick Cheney Coronary Bypass Age 47 In 1988 Coronary Stent Age 59 in 2000 Ventricular Assist Age 69 in 2010 Heart Transplant Age 71 in 2012 Age 76 Today Age 82 Today Age 76 Today
  • 92. Enormous Decrease in Cardiovascular Deaths 1. “Trends and Patterns of Geographic Variation of Cardiovascular Mortality 1980-2014” Journal of the American Medical Association (JAMA); May 16th 2017 Between 1980 and 2014 ` -50% Decrease in Deaths from Heart Disease
  • 93. Identify your individual “risk factors” Learn about biomarker testing Share data about regenerative treatments Measure effects of self-experimentation APrivateAssociationToDefeatAging! Accelerate science of human age reversal      Identify your individual “risk factors” Learn about biomarker testing Share data about regenerative treatments Measure effects of self-experimentation Accelerate science of human age reversal
  • 94. Open to Everyone…No Exclusion Criteria!  Individualized treatments  Not a clinical study  No termination date Group Effort to Defeat Biological Aging The Perpetual Project Individualized treatments Not a clinical study No termination date
  • 95. OptimizeConventionalRiskFactors Restore Youthful Biochemistry Boost cell energizing NAD+ Reverse Aging Biomarkers SuppressmTOR/BoostAutophagy Perpetual Project Individual Treatment Options
  • 96. Level 1 is essential to progress to Level 2 Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Underlying Risk Factors Individualized Age Reversal Interventions House of Optimal Health Correct Your
  • 97. House of Optimal Health - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation - Senolytics - NAD+ Restoration - mTOR-inhibition - Exosomes - Mesenchymal Stem Cells - Mitochondria Transfer - Young Plasma/Blood filtering Failure to optimize Level 1, preclude benefits of Level 2. Optional Approaches Healthy Aging - Perinatal tissues - Hyperbaric - Gene therapy Level 2 Level 1
  • 98. Level 1 Level 2 The House of Optimal Health
  • 99. Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Death Level 1 …Essential to sustain life Harsh Reality! Failure To Correct Proven Risk Factors
  • 100. Age-Reversal.Net Assess baseline markers of aging/disease risk Correct your markers of aging/disease risk Share your data/experiences with the group Foster strategic alliances Exchange new scientific information Seek to reverse disease risk/aging markers
  • 102. (or use your favorite diagnostics center…preferably LabCorp.) Results help identify factors associated with rapid aging, age-delay, or age-reversal…assist your doctor in decisions. Blood draws available at LabCorp stations in U.S. (Includes Phenotypic Age measure). Lower Priced Panels available starting at $77
  • 103. Commercial Lab: $572 Perpetual Project: $77 + Phenotypic Age at no cost Blood Tests to Calculate Phenotypic Age: A1C + Lipids + Fasting Insulin Complete Blood Count-Chemistry and C-reactive protein Added tests:
  • 104. Enroll at age-reversal.net Use results to adjust your longevity program Re-test to measure age reversal efficacy Adjust interventions based on retest results Upload blood tests/other diagnostic results HowtoParticipateinThePerpetualProject 1 2 3 4 5 No charge to enroll - Open to Everyone - (Patient-Funded Diagnostics/Treatments)
  • 105. In the 1980s, HIV activists pushed FDA to think differently about the way it assessed drug efficacy. AIDS activists wanted FDA to authorize use of: Surrogate data markers-data points that https://www.wsj.com/articles/making-medical-science-more-democratic-2f189fd2 Theagencyagreedandin1992initiatedtheAcceleratedApprovalProgram thatallowedforfasterapprovalofdrugsforHIVandotherconditions. Theagencyagreedandin1992initiatedtheAcceleratedApprovalProgram that allowed for faster approval of drugs for HIV and other conditions. definitive proof they were surviving longer. indicate patients are benefiting…without
  • 106. Clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01112-7 Academic.oup.com/biomedgerontology/article/76/5/741/5992253 “DNAm GrimAge is a strong predictor of mortality independent of genetic influences among female twin pairs.” 1 “GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.”2 2021 findings corroboratedata published 2019-2020 1. 2. The Surrogate Biomarkers of Aging
  • 107. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111 Levine-Horvath Phenotypic Age Model ►‘Phenotypic Age’ estimate based on clinical measures of 9,926 adults with complete biomarker (blood test) data ►Analyzed data from over 23 years of mortality follow-up ►Advanced computational/statistical methods identified 9 phenotypic blood test markers that predict morbidity/mortality risk
  • 108. Beyond formal acceleration of AIDS research, FDA compromised and allowed AIDS victims to try any intervention that might be effective. https://www.tampabay.com/archive/1992/10/15/the-fda-s-cruel-indifference/ AIDS Buyers Clubs were allowed to import unapproveddrugstheybelievedmightbehelpful. Historic Precedent: The result was more rapid development of effective therapies and speedy recognition of worthless ones.
  • 109. A SOLUTION: The Perpetual Project Advances to Remain Utilize Scientific Healthy &
  • 110. We Don’t Have Time for Delayed Age Reversal
  • 111. 1497: Citrus shown to cure scurvy 1747: James Lind proves citrus cures scurvy 1870: Flawed study discredits “citrus cure” 1911: Dr. Robert Scott loses crew to scurvy 1932:Vitamin C proven to cure scurvy Thousands of Deaths After Scurvy Cure Discovered
  • 112. Risk of Delayed Treatment Chronic Diseases May Preclude Systemic Regeneration
  • 113. “…mice with progeria that got the gene-editing treatment lived more than twice as long as the untreated mice.” | Jan. 7, 2021 CRISPR Gene-Editing Treatment
  • 114. CRISPR Gene-Editing Treatment An untreated progeria mouse at 7.5 months of age, with a thin, grayish coat, pronounced spinal curvature, and low activity levels. Untreated progeria mice have an average lifespan of 7.1 months. Three treated progeria mice at 11 months of age, with healthy coats, no apparent spinal curvature, and normal activity levels. The treated progeria mice had an average lifespan of 17 months. CRISPR-Edited Progeroid Mice Unedited Progeroid Mouse https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
  • 115. Untreated Male Progeroid Mouse 7.5 months old https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-020-03086-7/MediaObjects/41586_2020_3086_MOESM9_ESM.mp4  Thin, grayish coat  Spinal curvature  Low activity levels
  • 116. Male progeroid mice injected with CRISPR gene editing virus. 9.75 months old https://static-content.springer.com/esm/art%3A10.1038%2Fs41586- 020-03086-7/MediaObjects/41586_2020_3086_MOESM10_ESM.mp4 (2.25 months older the unedited mouse)
  • 117. https://static-content.springer.com/esm/art%3A10.1038%2Fs41586- 020-03086-7/MediaObjects/41586_2020_3086_MOESM12_ESM.mp4 Male progeroid mice injected with CRISPR gene editing virus. 11 months old (3.25 months older the unedited mouse) Unedited Mice Died around 7.1 months
  • 118. 10 7.5-month-old unedited 9.75-month-old CRISPR-edited male mice 9.75-month-old CRISPR-edited male mice
  • 119. 10 7.5-month-old unedited 9.75-month-old CRISPR-edited female mice
  • 120. 10 7.5-month-old unedited 11.00-month-old CRISPR-edited male mice
  • 121. Crispr-Treated Progeroid Mouse 17 Months >160 Years? 7.1 Months Combination Crispr-Treated Human Untreated Progeroid Mouse https://www.nature.com/articles/s41586-020-03086-7 https://doi.org/10.1073/pnas.1910073116 Extrapolation Assuming Normal Aged People Can Have Multi-Gene Edits via Crispr
  • 122.
  • 123. Perpetual Project Goals Age-Reversal.Net Utilize blood & other tests to evaluate safety & potential efficacy. Robust communications amongst the group members, share test result data & suggestions on potential ways to improve outcomes. Accelerate & validate potential rejuvenation technologies to benefit all of humanity…including Perpetual Project members. Rapidly convey data to members and the public so that medical professionals, scientists, and the lay persons are aware of scientific findings that may save human lives.
  • 124. Join the Perpetual Project private association and receive updates about regenerative medicine initiatives www.age-reversal.net How to Enroll
  • 125. 1980-1986: Anti-Aging News 1986-1994: Life Extension Report 1994-2023:Life Extension Magazine 43 Consecutive Years of Monthly Publication (> 400,000 copies mailed each month)
  • 126. Scientific Conference at Atlantis This Week Focused on Regenerative Medicine Research
  • 127. Bill W. Faloon Bill W. Faloon
  • 128. age-reversal.net This presentation and info about aging research available at:
  • 129. Regenerative Medicine Options Island House Hotel, The Bahamas William Faloon April 20th 2023 The Perpetual Project