The DNA is the most important part of the cell, as it contains all the information needed for cell maintenance, functioning, and life. Checkpoints in the cell cycle ensure this DNA is accurately replicated and passed to daughter cells. Failure of these mechanisms can lead to DNA damage and diseases like cancer. The document discusses DNA repair mechanisms like sister chromatid exchange and non-homologous end joining that help repair breaks, and how certain agents like radiation differently impact these processes. It also examines how polymorphisms in DNA repair genes may increase risk of diseases like cataracts by impacting the ability to repair UV damage.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
4. The DNA is the most important part of the cell, because it has all the information that is fundamental for the maintenance of the cell, the genome and the live; for those reasons is very important to have the check points located phases of the interphase and the beggining of the mitosis. Thanks to this check points, stem cell passed the same information to daughter cells, to mainteing the information complete. When those mechanisms failed, the cell cannot detect the damage and the wrong information, passed through the cells, causing several problems, like cancer, lents opacity and polymorphisms .
5.
6. The sister chromati exchange (SCEs) is a natural molecular process exchanging genetic material between two identical sister chromatids. Since (SCEs) represent recombinogenic events arising DNA lesions, became a widely used endpoint in the study of mutagenic and clastogenic effects of diferents agents.
7. In some investigations the studies revealed that S-phase-dependents agents are strong inducers of SCEs, whereas ionizing radiation (IR) and radiomimetic drugs weak inducers of this.
8. In G2 the majority of DNA double strand breaks (DBSs) are raplidy repaired by NHEJ (non homologous end joinig) in the firs 2-3 hours but a subset of breaks is repaired by HR ( homologous recombination); instead cells damaged by IR remain in G2 for at least 6-8 hours, this is because the IR induced G2 checkpoint provides additional time to repair it.
9. In this point they found that the homologous recombination, is a minor way to repair the cell, and the majority of the process is done by non homologous end joining. When the irradiated cells were observed in metaphase they observed chromatid type aberrations such gaps and chromatid breaks, that is because they found that the repair of de DNA double strand breaks (DSBs) have some changes in the sister chromatid exchange (SCE), such after the irradiation .
10. I think that this article open us the door to keep investigating and searching about the cell DNA reparation mechanism and the cell cycle, because this will be the way to found some diseases even before it expressed in the phenotype, specially in cells that are exposed to irradiation.
11.
12. Many studies, reveal the association between oxidative stress and DNA damage with lens opacities, and in this article specially they refered the damage of the DNA in the lens epithelium, induced by UV light, causing as an effect the development cataract disease.
13. Polymorphisms of xeroderma pigmentosum complementation group D ( XPD) X-ray complementing group I ( XRCC1) have been very studied Requiered for excision repair of UV damaged DNA. Importan part of nucleotide excision repair (NER) Is involved in single strand breaks, and base excision repair (BER). markers to indicate DNA damage.
14. In this article they compare this two DNA repair genes between man and woman (studying differents factors, like lifestyles , genetic predisposition, and the exposition to UV light), indicating high risk for females because them mainly present age related cataracts specially the posterior subcapsular type, and with the XPD-312 Asn/Asn gene in common, increasing the risk.
15. It is suggested that damage to the lens epithelium may result in cataract formation and reported that UV light induced oxidative stress causes the earliest detectable changes in the epithelial cell redox set point and at the DNA and membrane level damage, in this cases cataract formation became inevitable.
16. This article is crucial for the medical studies, because it brings us many variables to detect the formation of cataracts and the relation between the two genes treated in the article, how they prevalence or not, by the increasing of damaged DNA in the prevalence of this disease.
17. The reparation mechanism of DNA, is very important to keep the genome, and to detect some irregular things that affect the patient, and their genetics generations, inducing several genetic predisposition of a disease.
18. The deeply knowledge of Molecular Biology might brings us the possibilities of treatment for people that suffered diseases because of some cellular anomalies , that are not easy to detect with physically diagnosis, and thanks to this branch of medicine we could detect and treat.
19. In a special way this articles illustrated us how we could relate very common diseases like cancer and cataract, wich epicenter of the this sickness were the DNA failed repair mechanism, that expressed it in the development of the disease and how the DNA knowledge give us a lot of vital information.
20. The DNA reparation mechanisms, motivate us like futures doctors to search the minimal expression of common diseases, that could let us to search more about the basis of the live, DNA. And to continue with the studies and searches that could prevent a lot of diseases, just manipulating cells in vitro .
21. MARTINEZ SANCHEZ, Lina María. Biología Molecular. 6ta Edición. UPB Facultad de Medicina. Pp: 81-84 Sister chromatid exchanges occur in G-irradiated cells (January 15, 2011) Polymorphisms in two DNA repair genes (XPD and XRCC1) (Published 12 January 2011)
22. "Perseverance is not a long race; it is many short races one after another." Walter Elliott